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Protein

Heterogeneous nuclear ribonucleoprotein R

Gene

HNRNPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: Ensembl
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • circadian rhythm Source: Ensembl
  • gene expression Source: Reactome
  • mRNA destabilization Source: Ensembl
  • mRNA processing Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB
  • negative regulation of catalytic activity Source: Ensembl
  • positive regulation of mRNA catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein R
Short name:
hnRNP R
Gene namesi
Name:HNRNPR
Synonyms:HNRPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:5047. HNRNPR.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: Ensembl
  • catalytic step 2 spliceosome Source: UniProtKB
  • dendrite Source: Ensembl
  • endoplasmic reticulum Source: UniProtKB-KW
  • growth cone Source: Ensembl
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • spliceosomal complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391459.

Polymorphism and mutation databases

BioMutaiHNRNPR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 633632Heterogeneous nuclear ribonucleoprotein RPRO_0000081870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources1 Publication
Cross-linki13 – 13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei366 – 3661N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO43390.
MaxQBiO43390.
PaxDbiO43390.
PeptideAtlasiO43390.
PRIDEiO43390.
TopDownProteomicsiO43390-1. [O43390-1]

PTM databases

iPTMnetiO43390.
PhosphoSiteiO43390.
SwissPalmiO43390.

Miscellaneous databases

PMAP-CutDBO43390.

Expressioni

Gene expression databases

BgeeiENSG00000125944.
CleanExiHS_HNRNPR.
ExpressionAtlasiO43390. baseline and differential.
GenevisibleiO43390. HS.

Organism-specific databases

HPAiCAB011687.
HPA026092.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with GTPBP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KHDRBS2Q5VWX13EBI-713419,EBI-742808
NCK1P163332EBI-713419,EBI-389883
PRMT1Q998734EBI-713419,EBI-78738

Protein-protein interaction databases

BioGridi115530. 207 interactions.
IntActiO43390. 56 interactions.
MINTiMINT-2796101.
STRINGi9606.ENSP00000363745.

Structurei

Secondary structure

1
633
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi334 – 3385Combined sources
Beta strandi342 – 3476Combined sources
Helixi354 – 3629Combined sources
Beta strandi367 – 3737Combined sources
Beta strandi376 – 3838Combined sources
Helixi384 – 39411Combined sources
Beta strandi405 – 4084Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DK2NMR-A333-416[»]
ProteinModelPortaliO43390.
SMRiO43390. Positions 27-416.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43390.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 24480RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini246 – 32883RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini341 – 41171RRM 3PROSITE-ProRule annotationAdd
BLAST
Repeati462 – 471101; approximate
Repeati472 – 482112Add
BLAST
Repeati488 – 497103; approximate

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni447 – 567121RNA-binding RGG-boxAdd
BLAST
Regioni462 – 497363 X 11 AA approximate repeats of D-D-Y-Y-G-Y-D-Y-H-D-YAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi412 – 4187Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 153152Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi579 – 63355Asn/Gln-richAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0117. Eukaryota.
ENOG410XTJ5. LUCA.
GeneTreeiENSGT00550000074366.
HOGENOMiHOG000186082.
HOVERGENiHBG051917.
InParanoidiO43390.
KOiK13161.
OMAiYYPPPRM.
OrthoDBiEOG091G0EUB.
PhylomeDBiO43390.
TreeFamiTF314932.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR006535. HnRNP_R/Q_splicing_fac.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01648. hnRNP-R-Q. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43390-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANQVNGNAV QLKEEEEPMD TSSVTHTEHY KTLIEAGLPQ KVAERLDEIF
60 70 80 90 100
QTGLVAYVDL DERAIDALRE FNEEGALSVL QQFKESDLSH VQNKSAFLCG
110 120 130 140 150
VMKTYRQREK QGSKVQESTK GPDEAKIKAL LERTGYTLDV TTGQRKYGGP
160 170 180 190 200
PPDSVYSGVQ PGIGTEVFVG KIPRDLYEDE LVPLFEKAGP IWDLRLMMDP
210 220 230 240 250
LSGQNRGYAF ITFCGKEAAQ EAVKLCDSYE IRPGKHLGVC ISVANNRLFV
260 270 280 290 300
GSIPKNKTKE NILEEFSKVT EGLVDVILYH QPDDKKKNRG FCFLEYEDHK
310 320 330 340 350
SAAQARRRLM SGKVKVWGNV VTVEWADPVE EPDPEVMAKV KVLFVRNLAT
360 370 380 390 400
TVTEEILEKS FSEFGKLERV KKLKDYAFVH FEDRGAAVKA MDEMNGKEIE
410 420 430 440 450
GEEIEIVLAK PPDKKRKERQ AARQASRSTA YEDYYYHPPP RMPPPIRGRG
460 470 480 490 500
RGGGRGGYGY PPDYYGYEDY YDDYYGYDYH DYRGGYEDPY YGYDDGYAVR
510 520 530 540 550
GRGGGRGGRG APPPPRGRGA PPPRGRAGYS QRGAPLGPPR GSRGGRGGPA
560 570 580 590 600
QQQRGRGSRG SRGNRGGNVG GKRKADGYNQ PDSKRRQTNN QQNWGSQPIA
610 620 630
QQPLQQGGDY SGNYGYNNDN QEFYQDTYGQ QWK
Length:633
Mass (Da):70,943
Last modified:June 1, 1998 - v1
Checksum:i088341F6465ED46F
GO
Isoform 2 (identifier: O43390-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-269: V → VTGL

Show »
Length:636
Mass (Da):71,214
Checksum:i4319EA79A1A6DED2
GO
Isoform 3 (identifier: O43390-3) [UniParc]FASTAAdd to basket
Also known as: hnRNP-R2

The sequence of this isoform differs from the canonical sequence as follows:
     129-166: Missing.

Note: Expression is low and neural-specific.
Show »
Length:595
Mass (Da):66,980
Checksum:iC9C67D917E7BCC44
GO
Isoform 4 (identifier: O43390-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     269-269: V → VTGL

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:535
Mass (Da):59,953
Checksum:iEDEE799FB18DE444
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 101101Missing in isoform 4. CuratedVSP_054703Add
BLAST
Alternative sequencei129 – 16638Missing in isoform 3. 1 PublicationVSP_047647Add
BLAST
Alternative sequencei269 – 2691V → VTGL in isoform 2 and isoform 4. 1 PublicationVSP_038360

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000364 mRNA. Translation: AAC39540.1.
DQ351905 mRNA. Translation: ABC73063.1.
AL109936 Genomic DNA. Translation: CAI19026.1.
AL109936 Genomic DNA. Translation: CAI19027.1.
BC001449 mRNA. Translation: AAH01449.1.
CCDSiCCDS232.1. [O43390-1]
CCDS44085.1. [O43390-2]
CCDS60020.1. [O43390-4]
CCDS72727.1. [O43390-3]
PIRiT02673.
RefSeqiNP_001095868.1. NM_001102398.2. [O43390-2]
NP_001284549.1. NM_001297620.1. [O43390-3]
NP_005817.1. NM_005826.4. [O43390-1]
XP_005245768.1. XM_005245711.4. [O43390-1]
XP_011538773.1. XM_011540471.2. [O43390-2]
UniGeneiHs.373763.

Genome annotation databases

EnsembliENST00000302271; ENSP00000304405; ENSG00000125944. [O43390-1]
ENST00000374612; ENSP00000363741; ENSG00000125944. [O43390-1]
ENST00000374616; ENSP00000363745; ENSG00000125944. [O43390-2]
ENST00000427764; ENSP00000392799; ENSG00000125944. [O43390-3]
ENST00000478691; ENSP00000474437; ENSG00000125944. [O43390-4]
ENST00000634263; ENSP00000489371; ENSG00000282958. [O43390-1]
ENST00000634634; ENSP00000488941; ENSG00000282958. [O43390-3]
ENST00000634713; ENSP00000488945; ENSG00000282958. [O43390-2]
ENST00000634766; ENSP00000489252; ENSG00000282958. [O43390-1]
ENST00000635150; ENSP00000489275; ENSG00000282958. [O43390-4]
GeneIDi10236.
KEGGihsa:10236.
UCSCiuc001bgp.5. human. [O43390-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000364 mRNA. Translation: AAC39540.1.
DQ351905 mRNA. Translation: ABC73063.1.
AL109936 Genomic DNA. Translation: CAI19026.1.
AL109936 Genomic DNA. Translation: CAI19027.1.
BC001449 mRNA. Translation: AAH01449.1.
CCDSiCCDS232.1. [O43390-1]
CCDS44085.1. [O43390-2]
CCDS60020.1. [O43390-4]
CCDS72727.1. [O43390-3]
PIRiT02673.
RefSeqiNP_001095868.1. NM_001102398.2. [O43390-2]
NP_001284549.1. NM_001297620.1. [O43390-3]
NP_005817.1. NM_005826.4. [O43390-1]
XP_005245768.1. XM_005245711.4. [O43390-1]
XP_011538773.1. XM_011540471.2. [O43390-2]
UniGeneiHs.373763.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DK2NMR-A333-416[»]
ProteinModelPortaliO43390.
SMRiO43390. Positions 27-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115530. 207 interactions.
IntActiO43390. 56 interactions.
MINTiMINT-2796101.
STRINGi9606.ENSP00000363745.

PTM databases

iPTMnetiO43390.
PhosphoSiteiO43390.
SwissPalmiO43390.

Polymorphism and mutation databases

BioMutaiHNRNPR.

Proteomic databases

EPDiO43390.
MaxQBiO43390.
PaxDbiO43390.
PeptideAtlasiO43390.
PRIDEiO43390.
TopDownProteomicsiO43390-1. [O43390-1]

Protocols and materials databases

DNASUi10236.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302271; ENSP00000304405; ENSG00000125944. [O43390-1]
ENST00000374612; ENSP00000363741; ENSG00000125944. [O43390-1]
ENST00000374616; ENSP00000363745; ENSG00000125944. [O43390-2]
ENST00000427764; ENSP00000392799; ENSG00000125944. [O43390-3]
ENST00000478691; ENSP00000474437; ENSG00000125944. [O43390-4]
ENST00000634263; ENSP00000489371; ENSG00000282958. [O43390-1]
ENST00000634634; ENSP00000488941; ENSG00000282958. [O43390-3]
ENST00000634713; ENSP00000488945; ENSG00000282958. [O43390-2]
ENST00000634766; ENSP00000489252; ENSG00000282958. [O43390-1]
ENST00000635150; ENSP00000489275; ENSG00000282958. [O43390-4]
GeneIDi10236.
KEGGihsa:10236.
UCSCiuc001bgp.5. human. [O43390-1]

Organism-specific databases

CTDi10236.
GeneCardsiHNRNPR.
HGNCiHGNC:5047. HNRNPR.
HPAiCAB011687.
HPA026092.
MIMi607201. gene.
neXtProtiNX_O43390.
PharmGKBiPA162391459.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0117. Eukaryota.
ENOG410XTJ5. LUCA.
GeneTreeiENSGT00550000074366.
HOGENOMiHOG000186082.
HOVERGENiHBG051917.
InParanoidiO43390.
KOiK13161.
OMAiYYPPPRM.
OrthoDBiEOG091G0EUB.
PhylomeDBiO43390.
TreeFamiTF314932.

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

ChiTaRSiHNRNPR. human.
EvolutionaryTraceiO43390.
GeneWikiiHNRNPR.
GenomeRNAii10236.
PMAP-CutDBO43390.
PROiO43390.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125944.
CleanExiHS_HNRNPR.
ExpressionAtlasiO43390. baseline and differential.
GenevisibleiO43390. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR006535. HnRNP_R/Q_splicing_fac.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01648. hnRNP-R-Q. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRPR_HUMAN
AccessioniPrimary (citable) accession number: O43390
Secondary accession number(s): Q2L7G6
, Q5TEH1, Q9BV64, S4R3J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.