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O43374

- RASL2_HUMAN

UniProt

O43374 - RASL2_HUMAN

Protein

Ras GTPase-activating protein 4

Gene

RASA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (15 Aug 2003)
      Previous versions | rss
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    Functioni

    Ca2+-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri675 – 71137Btk-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. Ras GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. negative regulation of Ras protein signal transduction Source: RefGenome
    3. positive regulation of Ras GTPase activity Source: RefGenome

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras GTPase-activating protein 4
    Alternative name(s):
    Calcium-promoted Ras inactivator
    Ras p21 protein activator 4
    RasGAP-activating-like protein 2
    Gene namesi
    Name:RASA4
    Synonyms:CAPRI, GAPL, KIAA0538
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:23181. RASA4.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytosol Source: UniProtKB-SubCell
    3. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134889495.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 803803Ras GTPase-activating protein 4PRO_0000056647Add
    BLAST

    Proteomic databases

    MaxQBiO43374.
    PaxDbiO43374.
    PRIDEiO43374.

    PTM databases

    PhosphoSiteiO43374.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    BgeeiO43374.
    CleanExiHS_RASA4.
    GenevestigatoriO43374.

    Organism-specific databases

    HPAiHPA043010.

    Interactioni

    Protein-protein interaction databases

    BioGridi115458. 3 interactions.
    IntActiO43374. 4 interactions.
    MINTiMINT-1370707.
    STRINGi9606.ENSP00000262940.

    Structurei

    3D structure databases

    ProteinModelPortaliO43374.
    SMRiO43374. Positions 3-562, 573-707.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8888C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini129 – 21688C2 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini302 – 512211Ras-GAPPROSITE-ProRule annotationAdd
    BLAST
    Domaini566 – 673108PHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi500 – 5034Poly-Leu

    Domaini

    The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.

    Sequence similaritiesi

    Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
    Contains 2 C2 domains.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri675 – 71137Btk-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5038.
    HOGENOMiHOG000234324.
    HOVERGENiHBG106587.
    InParanoidiO43374.
    KOiK17630.
    OMAiEVKLGTQ.
    OrthoDBiEOG7J17Z6.
    PhylomeDBiO43374.
    TreeFamiTF105302.

    Family and domain databases

    Gene3Di1.10.506.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 2 hits.
    4.10.1130.10. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001562. Znf_Btk_motif.
    [Graphical view]
    PfamiPF00779. BTK. 1 hit.
    PF00168. C2. 2 hits.
    PF00616. RasGAP. 1 hit.
    [Graphical view]
    PRINTSiPR00360. C2DOMAIN.
    SMARTiSM00107. BTK. 1 hit.
    SM00239. C2. 2 hits.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43374-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKRSSLYIR IVEGKNLPAK DITGSSDPYC IVKVDNEPII RTATVWKTLC    50
    PFWGEEYQVH LPPTFHAVAF YVMDEDALSR DDVIGKVCLT RDTIASHPKG 100
    FSGWAHLTEV DPDEEVQGEI HLRLEVWPGA RACRLRCSVL EARDLAPKDR 150
    NGTSDPFVRV RYKGRTRETS IVKKSCYPRW NETFEFELQE GAMEALCVEA 200
    WDWDLVSRND FLGKVVIDVQ RLRVVQQEEG WFRLQPDQSK SRRHDEGNLG 250
    SLQLEVRLRD ETVLPSSYYQ PLVHLLCHEV KLGMQGPGQL IPLIEETTST 300
    ECRQDVATNL LKLFLGQGLA KDFLDLLFQL ELSRTSETNT LFRSNSLASK 350
    SMESFLKVAG MQYLHGVLGP IINKVFEEKK YVELDPSKVE VKDVGCSGLH 400
    RPQTEAEVLE QSAQTLRAHL GALLSALSRS VRACPAVVRA TFRQLFRRVR 450
    ERFPGAQHEN VPFIAVTSFL CLRFFSPAIM SPKLFHLRER HADARTSRTL 500
    LLLAKAVQNV GNMDTPASRA KEAWMEPLQP TVRQGVAQLK DFITKLVDIE 550
    EKDELDLQRT LSLQAPPVKE GPLFIHRTKG KGPLMSSSFK KLYFSLTTEA 600
    LSFAKTPSSK KSALIKLANI RAAEKVEEKS FGGSHVMQVI YTDDAGRPQT 650
    AYLQCKCVNE LNQWLSALRK VSINNTGLLG SYHPGVFRGD KWSCCHQKEK 700
    TGQGCDKTRS RVTLQEWNDP LDHDLEAQLI YRHLLGVEAM LWERHRELSG 750
    GAEAGTVPTS PGKVPEDSLA RLLRVLQDLR EAHSSSPAGS PPSEPNCLLE 800
    LQT 803
    Length:803
    Mass (Da):90,458
    Last modified:August 15, 2003 - v2
    Checksum:i6E70DBF2F8F5D0E9
    GO
    Isoform 2 (identifier: O43374-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         611-656: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:757
    Mass (Da):85,409
    Checksum:iEEBA12E7214670AB
    GO

    Sequence cautioni

    The sequence BAA25464.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAB97935.2 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAP22345.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti213 – 2131G → V in AK026441. (PubMed:14702039)Curated
    Sequence conflicti260 – 2601D → G in AK026441. (PubMed:14702039)Curated
    Sequence conflicti429 – 4291R → L in AK026441. (PubMed:14702039)Curated
    Sequence conflicti480 – 4801M → V in AK026441. (PubMed:14702039)Curated
    Sequence conflicti606 – 6061T → M in BAA25464. (PubMed:9628581)Curated
    Sequence conflicti752 – 7521A → T in BAA25464. (PubMed:9628581)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti352 – 3521M → V.2 Publications
    Corresponds to variant rs746316 [ dbSNP | Ensembl ].
    VAR_027680
    Natural varianti432 – 4321R → P.
    Corresponds to variant rs886346 [ dbSNP | Ensembl ].
    VAR_027681
    Natural varianti731 – 7311Y → C.
    Corresponds to variant rs1060228 [ dbSNP | Ensembl ].
    VAR_027682

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei611 – 65646Missing in isoform 2. 1 PublicationVSP_039965Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY029206 mRNA. Translation: AAK31582.1.
    AB011110 mRNA. Translation: BAA25464.2. Different initiation.
    AK026441 mRNA. No translation available.
    AC004084 Genomic DNA. Translation: AAB97935.2. Sequence problems.
    AC093668 Genomic DNA. No translation available.
    AC105052 Genomic DNA. Translation: AAP22345.1. Sequence problems.
    BC113663 mRNA. Translation: AAI13664.1.
    CCDSiCCDS47674.1. [O43374-2]
    CCDS5725.1. [O43374-1]
    RefSeqiNP_001073346.2. NM_001079877.2. [O43374-2]
    NP_008920.5. NM_006989.5. [O43374-1]
    UniGeneiHs.530089.
    Hs.656696.

    Genome annotation databases

    EnsembliENST00000262940; ENSP00000262940; ENSG00000105808. [O43374-1]
    ENST00000449970; ENSP00000412876; ENSG00000105808. [O43374-2]
    GeneIDi10156.
    KEGGihsa:10156.
    UCSCiuc003vae.3. human. [O43374-1]
    uc010lih.2. human. [O43374-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY029206 mRNA. Translation: AAK31582.1 .
    AB011110 mRNA. Translation: BAA25464.2 . Different initiation.
    AK026441 mRNA. No translation available.
    AC004084 Genomic DNA. Translation: AAB97935.2 . Sequence problems.
    AC093668 Genomic DNA. No translation available.
    AC105052 Genomic DNA. Translation: AAP22345.1 . Sequence problems.
    BC113663 mRNA. Translation: AAI13664.1 .
    CCDSi CCDS47674.1. [O43374-2 ]
    CCDS5725.1. [O43374-1 ]
    RefSeqi NP_001073346.2. NM_001079877.2. [O43374-2 ]
    NP_008920.5. NM_006989.5. [O43374-1 ]
    UniGenei Hs.530089.
    Hs.656696.

    3D structure databases

    ProteinModelPortali O43374.
    SMRi O43374. Positions 3-562, 573-707.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115458. 3 interactions.
    IntActi O43374. 4 interactions.
    MINTi MINT-1370707.
    STRINGi 9606.ENSP00000262940.

    PTM databases

    PhosphoSitei O43374.

    Proteomic databases

    MaxQBi O43374.
    PaxDbi O43374.
    PRIDEi O43374.

    Protocols and materials databases

    DNASUi 10156.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262940 ; ENSP00000262940 ; ENSG00000105808 . [O43374-1 ]
    ENST00000449970 ; ENSP00000412876 ; ENSG00000105808 . [O43374-2 ]
    GeneIDi 10156.
    KEGGi hsa:10156.
    UCSCi uc003vae.3. human. [O43374-1 ]
    uc010lih.2. human. [O43374-2 ]

    Organism-specific databases

    CTDi 10156.
    GeneCardsi GC07M102220.
    H-InvDB HIX0034020.
    HIX0201129.
    HGNCi HGNC:23181. RASA4.
    HPAi HPA043010.
    MIMi 607943. gene.
    neXtProti NX_O43374.
    PharmGKBi PA134889495.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5038.
    HOGENOMi HOG000234324.
    HOVERGENi HBG106587.
    InParanoidi O43374.
    KOi K17630.
    OMAi EVKLGTQ.
    OrthoDBi EOG7J17Z6.
    PhylomeDBi O43374.
    TreeFami TF105302.

    Miscellaneous databases

    ChiTaRSi RASA4. human.
    GeneWikii RASA4.
    GenomeRNAii 10156.
    NextBioi 38444.
    PROi O43374.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43374.
    CleanExi HS_RASA4.
    Genevestigatori O43374.

    Family and domain databases

    Gene3Di 1.10.506.10. 1 hit.
    2.30.29.30. 1 hit.
    2.60.40.150. 2 hits.
    4.10.1130.10. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001562. Znf_Btk_motif.
    [Graphical view ]
    Pfami PF00779. BTK. 1 hit.
    PF00168. C2. 2 hits.
    PF00616. RasGAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00360. C2DOMAIN.
    SMARTi SM00107. BTK. 1 hit.
    SM00239. C2. 2 hits.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    PS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway."
      Lockyer P.J., Kupzig S., Cullen P.J.
      Curr. Biol. 11:981-986(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-352, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Blood.
    2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-352.
      Tissue: Liver.

    Entry informationi

    Entry nameiRASL2_HUMAN
    AccessioniPrimary (citable) accession number: O43374
    Secondary accession number(s): O60286
    , Q14CQ4, Q86UW3, Q96QU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3