Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O43365

- HXA3_HUMAN

UniProt

O43365 - HXA3_HUMAN

Protein

Homeobox protein Hox-A3

Gene

HOXA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi191 – 25060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. anterior/posterior pattern specification Source: Ensembl
    3. blood vessel remodeling Source: Ensembl
    4. cartilage development Source: Ensembl
    5. embryonic skeletal system morphogenesis Source: Ensembl
    6. glossopharyngeal nerve morphogenesis Source: Ensembl
    7. organ formation Source: Ensembl
    8. parathyroid gland development Source: Ensembl
    9. positive regulation of cell proliferation Source: Ensembl
    10. specification of organ position Source: Ensembl
    11. thymus development Source: Ensembl
    12. thyroid gland development Source: Ensembl
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiO43365.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A3
    Alternative name(s):
    Homeobox protein Hox-1E
    Gene namesi
    Name:HOXA3
    Synonyms:HOX1E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:5104. HOXA3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29381.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Homeobox protein Hox-A3PRO_0000200043Add
    BLAST

    Proteomic databases

    PaxDbiO43365.
    PRIDEiO43365.

    PTM databases

    PhosphoSiteiO43365.

    Expressioni

    Gene expression databases

    ArrayExpressiO43365.
    BgeeiO43365.
    CleanExiHS_HOXA3.
    GenevestigatoriO43365.

    Organism-specific databases

    HPAiHPA029157.

    Interactioni

    Protein-protein interaction databases

    BioGridi109440. 6 interactions.
    IntActiO43365. 2 interactions.
    STRINGi9606.ENSP00000324884.

    Structurei

    3D structure databases

    ProteinModelPortaliO43365.
    SMRiO43365. Positions 166-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi155 – 1606Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi78 – 13760Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG284589.
    HOGENOMiHOG000252944.
    HOVERGENiHBG107984.
    InParanoidiO43365.
    KOiK09303.
    OMAiHIQGSPV.
    OrthoDBiEOG754HPS.
    PhylomeDBiO43365.
    TreeFamiTF315938.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43365-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC    50
    SLQSPSSAGG HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP 100
    APQPPQPAPQ PPAPTPAAPP PPSSASPPQN ASNNPTPANA AKSPLLNSPT 150
    VAKQIFPWMK ESRQNTKQKT SSSSSGESCA GDKSPPGQAS SKRARTAYTS 200
    AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ NRRMKYKKDQ 250
    KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP 300
    PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ 350
    GNGSYGTPHI QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG 400
    AGPLGSGHHH GPGPGEPHPT YTDLTGHHPS QGRIQEAPKL THL 443
    Length:443
    Mass (Da):46,369
    Last modified:June 1, 1998 - v1
    Checksum:i365C93E65CA8E8FE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421D → N in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036264
    Natural varianti131 – 1311A → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036265

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004079 Genomic DNA. Translation: AAS00376.1.
    CH236948 Genomic DNA. Translation: EAL24225.1.
    CH471073 Genomic DNA. Translation: EAW93865.1.
    BC015180 mRNA. Translation: AAH15180.1.
    CCDSiCCDS5404.1.
    RefSeqiNP_109377.1. NM_030661.4.
    NP_705895.1. NM_153631.2.
    XP_005249787.1. XM_005249730.1.
    XP_005249788.1. XM_005249731.1.
    XP_005249789.1. XM_005249732.2.
    XP_006715778.1. XM_006715715.1.
    UniGeneiHs.659337.

    Genome annotation databases

    EnsembliENST00000317201; ENSP00000324884; ENSG00000105997.
    ENST00000396352; ENSP00000379640; ENSG00000105997.
    GeneIDi3200.
    KEGGihsa:3200.
    UCSCiuc003syk.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC004079 Genomic DNA. Translation: AAS00376.1 .
    CH236948 Genomic DNA. Translation: EAL24225.1 .
    CH471073 Genomic DNA. Translation: EAW93865.1 .
    BC015180 mRNA. Translation: AAH15180.1 .
    CCDSi CCDS5404.1.
    RefSeqi NP_109377.1. NM_030661.4.
    NP_705895.1. NM_153631.2.
    XP_005249787.1. XM_005249730.1.
    XP_005249788.1. XM_005249731.1.
    XP_005249789.1. XM_005249732.2.
    XP_006715778.1. XM_006715715.1.
    UniGenei Hs.659337.

    3D structure databases

    ProteinModelPortali O43365.
    SMRi O43365. Positions 166-251.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109440. 6 interactions.
    IntActi O43365. 2 interactions.
    STRINGi 9606.ENSP00000324884.

    PTM databases

    PhosphoSitei O43365.

    Proteomic databases

    PaxDbi O43365.
    PRIDEi O43365.

    Protocols and materials databases

    DNASUi 3200.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317201 ; ENSP00000324884 ; ENSG00000105997 .
    ENST00000396352 ; ENSP00000379640 ; ENSG00000105997 .
    GeneIDi 3200.
    KEGGi hsa:3200.
    UCSCi uc003syk.3. human.

    Organism-specific databases

    CTDi 3200.
    GeneCardsi GC07M027113.
    HGNCi HGNC:5104. HOXA3.
    HPAi HPA029157.
    MIMi 142954. gene.
    neXtProti NX_O43365.
    PharmGKBi PA29381.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284589.
    HOGENOMi HOG000252944.
    HOVERGENi HBG107984.
    InParanoidi O43365.
    KOi K09303.
    OMAi HIQGSPV.
    OrthoDBi EOG754HPS.
    PhylomeDBi O43365.
    TreeFami TF315938.

    Enzyme and pathway databases

    SignaLinki O43365.

    Miscellaneous databases

    GeneWikii HOXA3.
    GenomeRNAii 3200.
    NextBioi 12728.
    PROi O43365.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43365.
    Bgeei O43365.
    CleanExi HS_HOXA3.
    Genevestigatori O43365.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-42 AND THR-131.

    Entry informationi

    Entry nameiHXA3_HUMAN
    AccessioniPrimary (citable) accession number: O43365
    Secondary accession number(s): A4D181
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3