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Protein

Homeobox protein Hox-A3

Gene

HOXA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi191 – 250HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SignaLinkiO43365

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A3
Alternative name(s):
Homeobox protein Hox-1E
Gene namesi
Name:HOXA3
Synonyms:HOX1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105997.22
HGNCiHGNC:5104 HOXA3
MIMi142954 gene
neXtProtiNX_O43365

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3200
OpenTargetsiENSG00000105997
PharmGKBiPA29381

Polymorphism and mutation databases

BioMutaiHOXA3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000431 – 443Homeobox protein Hox-A3Add BLAST443

Proteomic databases

MaxQBiO43365
PaxDbiO43365
PeptideAtlasiO43365
PRIDEiO43365

PTM databases

iPTMnetiO43365
PhosphoSitePlusiO43365

Expressioni

Gene expression databases

BgeeiENSG00000105997
CleanExiHS_HOXA3
ExpressionAtlasiO43365 baseline and differential
GenevisibleiO43365 HS

Organism-specific databases

HPAiHPA029157

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109440, 9 interactors
IntActiO43365, 6 interactors
MINTiO43365
STRINGi9606.ENSP00000324884

Structurei

3D structure databases

ProteinModelPortaliO43365
SMRiO43365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi155 – 160Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi78 – 137Pro-richAdd BLAST60

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000252944
HOVERGENiHBG107984
InParanoidiO43365
KOiK09303
OMAiVEPMSNS
OrthoDBiEOG091G0PFO
PhylomeDBiO43365
TreeFamiTF315938

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O43365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC
60 70 80 90 100
SLQSPSSAGG HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP
110 120 130 140 150
APQPPQPAPQ PPAPTPAAPP PPSSASPPQN ASNNPTPANA AKSPLLNSPT
160 170 180 190 200
VAKQIFPWMK ESRQNTKQKT SSSSSGESCA GDKSPPGQAS SKRARTAYTS
210 220 230 240 250
AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ NRRMKYKKDQ
260 270 280 290 300
KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP
310 320 330 340 350
PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ
360 370 380 390 400
GNGSYGTPHI QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG
410 420 430 440
AGPLGSGHHH GPGPGEPHPT YTDLTGHHPS QGRIQEAPKL THL
Length:443
Mass (Da):46,369
Last modified:June 1, 1998 - v1
Checksum:i365C93E65CA8E8FE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03626442D → N in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764656757Ensembl.1
Natural variantiVAR_036265131A → T in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004079 Genomic DNA Translation: AAS00376.1
CH236948 Genomic DNA Translation: EAL24225.1
CH471073 Genomic DNA Translation: EAW93865.1
BC015180 mRNA Translation: AAH15180.1
CCDSiCCDS5404.1
RefSeqiNP_109377.1, NM_030661.4
NP_705895.1, NM_153631.2
XP_005249787.1, XM_005249730.2
XP_005249788.1, XM_005249731.2
XP_005249789.1, XM_005249732.3
XP_006715778.1, XM_006715715.2
XP_011513645.1, XM_011515343.2
UniGeneiHs.659337
Hs.732333

Genome annotation databases

EnsembliENST00000317201; ENSP00000324884; ENSG00000105997
ENST00000396352; ENSP00000379640; ENSG00000105997
ENST00000612286; ENSP00000484411; ENSG00000105997
GeneIDi3200
KEGGihsa:3200
UCSCiuc003syk.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHXA3_HUMAN
AccessioniPrimary (citable) accession number: O43365
Secondary accession number(s): A4D181
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health