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O43365

- HXA3_HUMAN

UniProt

O43365 - HXA3_HUMAN

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Protein

Homeobox protein Hox-A3

Gene

HOXA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi191 – 25060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiO43365.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A3
Alternative name(s):
Homeobox protein Hox-1E
Gene namesi
Name:HOXA3
Synonyms:HOX1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:5104. HOXA3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Homeobox protein Hox-A3PRO_0000200043Add
BLAST

Proteomic databases

MaxQBiO43365.
PaxDbiO43365.
PRIDEiO43365.

PTM databases

PhosphoSiteiO43365.

Expressioni

Gene expression databases

BgeeiO43365.
CleanExiHS_HOXA3.
ExpressionAtlasiO43365. baseline and differential.
GenevestigatoriO43365.

Organism-specific databases

HPAiHPA029157.

Interactioni

Protein-protein interaction databases

BioGridi109440. 6 interactions.
IntActiO43365. 2 interactions.
STRINGi9606.ENSP00000324884.

Structurei

3D structure databases

ProteinModelPortaliO43365.
SMRiO43365. Positions 166-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi155 – 1606Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 13760Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiO43365.
KOiK09303.
OMAiHIQGSPV.
OrthoDBiEOG754HPS.
PhylomeDBiO43365.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43365-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKATYYDSS AIYGGYPYQA ANGFAYNANQ QPYPASAALG ADGEYHRPAC
60 70 80 90 100
SLQSPSSAGG HPKAHELSEA CLRTLSAPPS QPPSLGEPPL HPPPPQAAPP
110 120 130 140 150
APQPPQPAPQ PPAPTPAAPP PPSSASPPQN ASNNPTPANA AKSPLLNSPT
160 170 180 190 200
VAKQIFPWMK ESRQNTKQKT SSSSSGESCA GDKSPPGQAS SKRARTAYTS
210 220 230 240 250
AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ NRRMKYKKDQ
260 270 280 290 300
KGKGMLTSSG GQSPSRSPVP PGAGGYLNSM HSLVNSVPYE PQSPPPFSKP
310 320 330 340 350
PQGTYGLPPA SYPASLPSCA PPPPPQKRYT AAGAGAGGTP DYDPHAHGLQ
360 370 380 390 400
GNGSYGTPHI QGSPVFVGGS YVEPMSNSGP ALFGLTHLPH AASGAMDYGG
410 420 430 440
AGPLGSGHHH GPGPGEPHPT YTDLTGHHPS QGRIQEAPKL THL
Length:443
Mass (Da):46,369
Last modified:June 1, 1998 - v1
Checksum:i365C93E65CA8E8FE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421D → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_036264
Natural varianti131 – 1311A → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036265

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004079 Genomic DNA. Translation: AAS00376.1.
CH236948 Genomic DNA. Translation: EAL24225.1.
CH471073 Genomic DNA. Translation: EAW93865.1.
BC015180 mRNA. Translation: AAH15180.1.
CCDSiCCDS5404.1.
RefSeqiNP_109377.1. NM_030661.4.
NP_705895.1. NM_153631.2.
XP_005249787.1. XM_005249730.1.
XP_005249788.1. XM_005249731.1.
XP_005249789.1. XM_005249732.2.
XP_006715778.1. XM_006715715.1.
UniGeneiHs.659337.

Genome annotation databases

EnsembliENST00000317201; ENSP00000324884; ENSG00000105997.
ENST00000396352; ENSP00000379640; ENSG00000105997.
ENST00000612286; ENSP00000484411; ENSG00000105997.
GeneIDi3200.
KEGGihsa:3200.
UCSCiuc003syk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004079 Genomic DNA. Translation: AAS00376.1 .
CH236948 Genomic DNA. Translation: EAL24225.1 .
CH471073 Genomic DNA. Translation: EAW93865.1 .
BC015180 mRNA. Translation: AAH15180.1 .
CCDSi CCDS5404.1.
RefSeqi NP_109377.1. NM_030661.4.
NP_705895.1. NM_153631.2.
XP_005249787.1. XM_005249730.1.
XP_005249788.1. XM_005249731.1.
XP_005249789.1. XM_005249732.2.
XP_006715778.1. XM_006715715.1.
UniGenei Hs.659337.

3D structure databases

ProteinModelPortali O43365.
SMRi O43365. Positions 166-251.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109440. 6 interactions.
IntActi O43365. 2 interactions.
STRINGi 9606.ENSP00000324884.

PTM databases

PhosphoSitei O43365.

Proteomic databases

MaxQBi O43365.
PaxDbi O43365.
PRIDEi O43365.

Protocols and materials databases

DNASUi 3200.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317201 ; ENSP00000324884 ; ENSG00000105997 .
ENST00000396352 ; ENSP00000379640 ; ENSG00000105997 .
ENST00000612286 ; ENSP00000484411 ; ENSG00000105997 .
GeneIDi 3200.
KEGGi hsa:3200.
UCSCi uc003syk.3. human.

Organism-specific databases

CTDi 3200.
GeneCardsi GC07M027113.
HGNCi HGNC:5104. HOXA3.
HPAi HPA029157.
MIMi 142954. gene.
neXtProti NX_O43365.
PharmGKBi PA29381.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284589.
GeneTreei ENSGT00760000118940.
HOGENOMi HOG000252944.
HOVERGENi HBG107984.
InParanoidi O43365.
KOi K09303.
OMAi HIQGSPV.
OrthoDBi EOG754HPS.
PhylomeDBi O43365.
TreeFami TF315938.

Enzyme and pathway databases

SignaLinki O43365.

Miscellaneous databases

GeneWikii HOXA3.
GenomeRNAii 3200.
NextBioi 12728.
PROi O43365.
SOURCEi Search...

Gene expression databases

Bgeei O43365.
CleanExi HS_HOXA3.
ExpressionAtlasi O43365. baseline and differential.
Genevestigatori O43365.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-42 AND THR-131.

Entry informationi

Entry nameiHXA3_HUMAN
AccessioniPrimary (citable) accession number: O43365
Secondary accession number(s): A4D181
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3