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Protein

Zinc finger protein 749

Gene

ZNF749

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 662C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 690C2H2-type 17; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri751 – 773C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32165-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 749
Gene namesi
Name:ZNF749
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32783. ZNF749.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186230.

Polymorphism and mutation databases

BioMutaiZNF749.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743971 – 778Zinc finger protein 749Add BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei466N6-acetyllysineCombined sources1
Modified residuei539N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO43361.
PaxDbiO43361.
PeptideAtlasiO43361.
PRIDEiO43361.

PTM databases

iPTMnetiO43361.
PhosphoSitePlusiO43361.

Expressioni

Gene expression databases

BgeeiENSG00000186230.
CleanExiHS_ZNF749.
ExpressionAtlasiO43361. baseline and differential.
GenevisibleiO43361. HS.

Organism-specific databases

HPAiHPA042082.
HPA042091.
HPA056001.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333980.

Structurei

3D structure databases

ProteinModelPortaliO43361.
SMRiO43361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 101KRABPROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri584 – 606C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri612 – 634C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 662C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 690C2H2-type 17; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri751 – 773C2H2-type 19; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO43361.
KOiK09228.
OMAiHTDAFSK.
OrthoDBiEOG091G02KC.
PhylomeDBiO43361.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLTEDCMVF EDVAIYFSQE EWGILNDAQR HLHSNVMLEN FALLSSVGCW
60 70 80 90 100
HGAKDEEVPS KQCVSVRVLQ VTIPKPALST LKAQPCKMCS SILKDILHLA
110 120 130 140 150
EHDGTHPEQG LYTCAAEHDL HQKEQIREKL TRSDEWRPSF VNHSAHVGER
160 170 180 190 200
NFTCTQGGKD FTASSDLLQQ QVLNSGWKLY RDTQDGEAFQ GEQNDFNSSQ
210 220 230 240 250
GGKDFCHQHG LFEHQKTHNG ERPYEFSECG ELFRYNSNLI KYQQNHAGER
260 270 280 290 300
PYEGTEYGKT FIRKSNLVQH QKIHSEGFLS KRSDPIEHQE ILSRPTPYEC
310 320 330 340 350
TQCGKAFLTQ AHLVGHQKTH TGEQPYECNK CGKFFMYNSK LIRHQKVHTG
360 370 380 390 400
ERRYECSECG KLFMDSFTLG RHQRVHTGER PFECSICGKF FSHRSTLNMH
410 420 430 440 450
QRVHAGKRLY KCSECGKAFS LKHNVVQHLK IHTGERPYEC TECEKAFVRK
460 470 480 490 500
SHLVQHQKIH TDAFSKRSDL IQHKRIDIRP RPYTCSECGK AFLTQAHLVG
510 520 530 540 550
HQKIHTGERP YECTQCAKAF VRKSHLVQHE KIHTDAFSKR SDLIQHKRID
560 570 580 590 600
LRPRPYVCSE CGKAFLTQAH LDGHQKIQTG ERRYECNECG KFFLDSYKLV
610 620 630 640 650
IHQRIHTGEK PYKCSKCGKF FRYRCTLSRH QKVHTGERPY ECSECGKFFR
660 670 680 690 700
DSYKLIIHQR VHTGEKPYEC SNCGKFLRYR STFIKHHKVC TGEKPHECSK
710 720 730 740 750
CRELFRTKSS LIIHQQSHTG ESPFKLRECG KDFNKCNTGQ RQKTHTGERS
760 770
YECGESSKVF KYNSSLIKHQ IIHTGKRP
Length:778
Mass (Da):90,364
Last modified:November 30, 2010 - v2
Checksum:iFB08226F2E47856B
GO

Sequence cautioni

The sequence AAB97932 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177Missing in AK122794 (PubMed:14702039).Curated1
Sequence conflicti679Y → C in AK122794 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030278243Q → R.Corresponds to variant rs12986235dbSNPEnsembl.1
Natural variantiVAR_030279405A → T.Corresponds to variant rs2240038dbSNPEnsembl.1
Natural variantiVAR_030280771I → R.Corresponds to variant rs7246856dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004076 Genomic DNA. Translation: AAB97932.1. Sequence problems.
AK122794 mRNA. No translation available.
CCDSiCCDS33132.2.
RefSeqiNP_001018855.2. NM_001023561.3.
NP_001308882.1. NM_001321953.1.
NP_001308883.1. NM_001321954.1.
XP_016882291.1. XM_017026802.1.
UniGeneiHs.467358.

Genome annotation databases

EnsembliENST00000334181; ENSP00000333980; ENSG00000186230.
GeneIDi388567.
KEGGihsa:388567.
UCSCiuc002qoq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004076 Genomic DNA. Translation: AAB97932.1. Sequence problems.
AK122794 mRNA. No translation available.
CCDSiCCDS33132.2.
RefSeqiNP_001018855.2. NM_001023561.3.
NP_001308882.1. NM_001321953.1.
NP_001308883.1. NM_001321954.1.
XP_016882291.1. XM_017026802.1.
UniGeneiHs.467358.

3D structure databases

ProteinModelPortaliO43361.
SMRiO43361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333980.

PTM databases

iPTMnetiO43361.
PhosphoSitePlusiO43361.

Polymorphism and mutation databases

BioMutaiZNF749.

Proteomic databases

MaxQBiO43361.
PaxDbiO43361.
PeptideAtlasiO43361.
PRIDEiO43361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334181; ENSP00000333980; ENSG00000186230.
GeneIDi388567.
KEGGihsa:388567.
UCSCiuc002qoq.3. human.

Organism-specific databases

CTDi388567.
GeneCardsiZNF749.
HGNCiHGNC:32783. ZNF749.
HPAiHPA042082.
HPA042091.
HPA056001.
neXtProtiNX_O43361.
OpenTargetsiENSG00000186230.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO43361.
KOiK09228.
OMAiHTDAFSK.
OrthoDBiEOG091G02KC.
PhylomeDBiO43361.
TreeFamiTF339848.

Enzyme and pathway databases

BioCyciZFISH:G66-32165-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii388567.
PROiO43361.

Gene expression databases

BgeeiENSG00000186230.
CleanExiHS_ZNF749.
ExpressionAtlasiO43361. baseline and differential.
GenevisibleiO43361. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN749_HUMAN
AccessioniPrimary (citable) accession number: O43361
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.