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Protein

RNA-binding protein Musashi homolog 1

Gene

MSI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U1-3AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).By similarity

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • poly(U) RNA binding Source: Ensembl
  • RNA binding Source: ProtInc

GO - Biological processi

  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135097-MONOMER.
SIGNORiO43347.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Musashi homolog 1
Short name:
Musashi-1
Gene namesi
Name:MSI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:7330. MSI1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4440.
OpenTargetsiENSG00000135097.
PharmGKBiPA31137.

Polymorphism and mutation databases

BioMutaiMSI1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816491 – 362RNA-binding protein Musashi homolog 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO43347.
PaxDbiO43347.
PeptideAtlasiO43347.
PRIDEiO43347.

PTM databases

iPTMnetiO43347.
PhosphoSitePlusiO43347.

Expressioni

Tissue specificityi

Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.2 Publications

Gene expression databases

BgeeiENSG00000135097.
CleanExiHS_MSI1.
ExpressionAtlasiO43347. baseline and differential.
GenevisibleiO43347. HS.

Organism-specific databases

HPAiCAB022337.
HPA064401.

Interactioni

Protein-protein interaction databases

BioGridi110577. 4 interactors.
IntActiO43347. 3 interactors.
MINTiMINT-1432501.
STRINGi9606.ENSP00000257552.

Structurei

3D structure databases

ProteinModelPortaliO43347.
SMRiO43347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 110RRM 1PROSITE-ProRule annotationAdd BLAST91
Domaini109 – 186RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi274 – 281Poly-Ala8

Domaini

The first RNA recognition motif binds more strongly to RNA compared to the second one.By similarity

Sequence similaritiesi

Belongs to the Musashi family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4205. Eukaryota.
ENOG410YA8Z. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234441.
HOVERGENiHBG002295.
InParanoidiO43347.
KOiK14411.
OMAiHYFEQFG.
OrthoDBiEOG091G1CPI.
PhylomeDBiO43347.
TreeFamiTF325419.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METDAPQPGL ASPDSPHDPC KMFIGGLSWQ TTQEGLREYF GQFGEVKECL
60 70 80 90 100
VMRDPLTKRS RGFGFVTFMD QAGVDKVLAQ SRHELDSKTI DPKVAFPRRA
110 120 130 140 150
QPKMVTRTKK IFVGGLSVNT TVEDVKQYFE QFGKVDDAML MFDKTTNRHR
160 170 180 190 200
GFGFVTFESE DIVEKVCEIH FHEINNKMVE CKKAQPKEVM SPTGSARGRS
210 220 230 240 250
RVMPYGMDAF MLGIGMLGYP GFQATTYASR SYTGLAPGYT YQFPEFRVER
260 270 280 290 300
TPLPSAPVLP ELTAIPLTAY GPMAAAAAAA AVVRGTGSHP WTMAPPPGST
310 320 330 340 350
PSRTGGFLGT TSPGPMAELY GAANQDSGVS SYISAASPAP STGFGHSLGG
360
PLIATAFTNG YH
Length:362
Mass (Da):39,125
Last modified:June 1, 1998 - v1
Checksum:i26487B0A32CF1F40
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197R → W in BAB70469 (PubMed:12054577).Curated1
Sequence conflicti225T → S in BAB69769 (PubMed:12054577).Curated1
Sequence conflicti232Y → C in BAB69769 (PubMed:12054577).Curated1
Sequence conflicti236A → P in BAB69767 (PubMed:12054577).Curated1
Sequence conflicti245E → K in BAB70469 (PubMed:12054577).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035485160E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012851 mRNA. Translation: BAA33962.1.
AC003982 Genomic DNA. Translation: AAB95636.1.
AB072590 mRNA. Translation: BAB69767.1.
AB072591 mRNA. Translation: BAB69768.1.
AB072592 mRNA. Translation: BAB69769.1.
AB073212 mRNA. Translation: BAB70469.1.
CCDSiCCDS9196.1.
RefSeqiNP_002433.1. NM_002442.3.
XP_011536663.1. XM_011538361.2.
UniGeneiHs.158311.

Genome annotation databases

EnsembliENST00000257552; ENSP00000257552; ENSG00000135097.
GeneIDi4440.
KEGGihsa:4440.
UCSCiuc001tye.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012851 mRNA. Translation: BAA33962.1.
AC003982 Genomic DNA. Translation: AAB95636.1.
AB072590 mRNA. Translation: BAB69767.1.
AB072591 mRNA. Translation: BAB69768.1.
AB072592 mRNA. Translation: BAB69769.1.
AB073212 mRNA. Translation: BAB70469.1.
CCDSiCCDS9196.1.
RefSeqiNP_002433.1. NM_002442.3.
XP_011536663.1. XM_011538361.2.
UniGeneiHs.158311.

3D structure databases

ProteinModelPortaliO43347.
SMRiO43347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110577. 4 interactors.
IntActiO43347. 3 interactors.
MINTiMINT-1432501.
STRINGi9606.ENSP00000257552.

PTM databases

iPTMnetiO43347.
PhosphoSitePlusiO43347.

Polymorphism and mutation databases

BioMutaiMSI1.

Proteomic databases

MaxQBiO43347.
PaxDbiO43347.
PeptideAtlasiO43347.
PRIDEiO43347.

Protocols and materials databases

DNASUi4440.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257552; ENSP00000257552; ENSG00000135097.
GeneIDi4440.
KEGGihsa:4440.
UCSCiuc001tye.2. human.

Organism-specific databases

CTDi4440.
DisGeNETi4440.
GeneCardsiMSI1.
HGNCiHGNC:7330. MSI1.
HPAiCAB022337.
HPA064401.
MIMi603328. gene.
neXtProtiNX_O43347.
OpenTargetsiENSG00000135097.
PharmGKBiPA31137.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4205. Eukaryota.
ENOG410YA8Z. LUCA.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234441.
HOVERGENiHBG002295.
InParanoidiO43347.
KOiK14411.
OMAiHYFEQFG.
OrthoDBiEOG091G1CPI.
PhylomeDBiO43347.
TreeFamiTF325419.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135097-MONOMER.
SIGNORiO43347.

Miscellaneous databases

GeneWikiiMSI1.
GenomeRNAii4440.
PROiO43347.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135097.
CleanExiHS_MSI1.
ExpressionAtlasiO43347. baseline and differential.
GenevisibleiO43347. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSI1H_HUMAN
AccessioniPrimary (citable) accession number: O43347
Secondary accession number(s): Q96PU0
, Q96PU1, Q96PU2, Q96PU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.