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O43345 (ZN208_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 208
Alternative name(s):
Zinc finger protein 91-like
Gene names
Name:ZNF208
Synonyms:ZNF91L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1280 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 39 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O43345-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: O43345-2)

The sequence of this isoform differs from the canonical sequence as follows:
     464-563: Missing.
     955-983: KSSSTLSYHKKIHTEEKPYKYEECGKGFS → N
     1277-1280: GEKL → GVPNPPTHKKIHAGEKLYK
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12801280Zinc finger protein 208
PRO_0000047454

Regions

Domain4 – 7572KRAB
Zinc finger173 – 19523C2H2-type 1; degenerate
Zinc finger201 – 22323C2H2-type 2; degenerate
Zinc finger229 – 25123C2H2-type 3
Zinc finger257 – 27923C2H2-type 4
Zinc finger285 – 30723C2H2-type 5
Zinc finger313 – 33523C2H2-type 6
Zinc finger341 – 36323C2H2-type 7
Zinc finger369 – 39123C2H2-type 8
Zinc finger397 – 41923C2H2-type 9
Zinc finger425 – 44723C2H2-type 10
Zinc finger453 – 47523C2H2-type 11
Zinc finger497 – 51923C2H2-type 12
Zinc finger525 – 54723C2H2-type 13
Zinc finger553 – 57523C2H2-type 14
Zinc finger581 – 60323C2H2-type 15
Zinc finger609 – 63123C2H2-type 16
Zinc finger637 – 65923C2H2-type 17
Zinc finger665 – 68723C2H2-type 18
Zinc finger693 – 71523C2H2-type 19
Zinc finger721 – 74323C2H2-type 20
Zinc finger749 – 77123C2H2-type 21
Zinc finger777 – 79923C2H2-type 22
Zinc finger805 – 82723C2H2-type 23
Zinc finger833 – 85523C2H2-type 24
Zinc finger861 – 88323C2H2-type 25
Zinc finger889 – 91123C2H2-type 26
Zinc finger917 – 93923C2H2-type 27
Zinc finger945 – 96723C2H2-type 28
Zinc finger973 – 99523C2H2-type 29; degenerate
Zinc finger1001 – 102323C2H2-type 30
Zinc finger1029 – 105123C2H2-type 31
Zinc finger1057 – 107923C2H2-type 32
Zinc finger1085 – 110723C2H2-type 33
Zinc finger1113 – 113523C2H2-type 34
Zinc finger1141 – 116323C2H2-type 35
Zinc finger1169 – 119123C2H2-type 36
Zinc finger1197 – 121923C2H2-type 37
Zinc finger1225 – 124723C2H2-type 38
Zinc finger1253 – 127523C2H2-type 39

Natural variations

Alternative sequence464 – 563100Missing in isoform 2.
VSP_053780
Alternative sequence955 – 98329KSSST…GKGFS → N in isoform 2.
VSP_053781
Alternative sequence1277 – 12804GEKL → GVPNPPTHKKIHAGEKLYK in isoform 2.
VSP_053782
Natural variant2821E → K.
Corresponds to variant rs2007506 [ dbSNP | Ensembl ].
VAR_052791
Natural variant2981S → L.
Corresponds to variant rs12462668 [ dbSNP | Ensembl ].
VAR_052792
Natural variant4561E → Q.
Corresponds to variant rs7255075 [ dbSNP | Ensembl ].
VAR_052793
Natural variant6401K → E.
Corresponds to variant rs10425763 [ dbSNP | Ensembl ].
VAR_059903
Natural variant10351D → G.
Corresponds to variant rs8108957 [ dbSNP | Ensembl ].
VAR_059904

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 19, 2014. Version 2.
Checksum: 296AEB9EF588A8DB

FASTA1,280147,487
        10         20         30         40         50         60 
MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP DLIIFLEEGK 

        70         80         90        100        110        120 
ESWNMKRHEM VEESPVICSH FAQDLWPEQG IEDSFQKVIL RRYEKCGHEN LHLKIGYTNV 

       130        140        150        160        170        180 
DECKVHKEGY NKLNQSLTTT QSKVFQRGKY ANVFHKCSNS NRHKIRHTGK KHLQCKEYVR 

       190        200        210        220        230        240 
SFCMLSHLSQ HKRIYTRENS YKCEEGGKAF NWSSTLTYYK SAHTGEKPYR CKECGKAFSK 

       250        260        270        280        290        300 
FSILTKHKVI HTGEKSYKCE ECGKAFNQSA ILTKHKIIHT GEKPNKCEEC GKAFSKVSTL 

       310        320        330        340        350        360 
TTHKAIHAGE KPYKCKECGK AFSKVSTLIT HKAIHAGEKP YKCKECGKAF SKFSILTKHK 

       370        380        390        400        410        420 
VIHTGEKPYK CEECGKAYKW PSTLSYHKKI HTGEKPYKCE ECGKGFSMFS ILTKHEVIHT 

       430        440        450        460        470        480 
GEKPYKCEEC GKAFNWSSNL MEHKKIHTGE TPYKCEECGK GFSMFSILTK HKVIHNGEKP 

       490        500        510        520        530        540 
YKCEECDKAT HAGEKPYKCE ECGKAFNWSS NLMEHKRIHT GEKPYKCEEC GKSFSTFSIL 

       550        560        570        580        590        600 
TKHKVIHTGE KPYKCEECGK AYKWSSTLSY HKKIHTVEKP YKCEECGKAF NQSAILIKHK 

       610        620        630        640        650        660 
RIHTGEKPYK CEECGKTFSK VSTLTTHKAI HAGEKPYKCK ECGKTFIKVS TLTTHKAIHA 

       670        680        690        700        710        720 
GEKPYKCKEC GKAFSKFSIL TKHKVIHTGE KPYKCEECGK AFNWSSNLME HKRIHTGEKP 

       730        740        750        760        770        780 
YKCEECGKSF STFSVLTKHK VIHTGEKPYK CEECGKAYKW SSTLSYHKKI HTVEKPYKCE 

       790        800        810        820        830        840 
ECGKAFNRSA ILIKHKRIHT DEKPYKCEEC GKTFSKVSTL TTHKAIHAGE KPYKCKECGK 

       850        860        870        880        890        900 
AFSKFSILTK HKVIHTGEKP YKCEECGKAY KWPSTLSYHK KIHTGEKPYK CEECGKGFSM 

       910        920        930        940        950        960 
FSILTKHEVI HTGEKPYKCE ECGKAFSWLS VFSKHKKTHA GEKFYKCEAC GKAYKSSSTL 

       970        980        990       1000       1010       1020 
SYHKKIHTEE KPYKYEECGK GFSTFSILTK HKVIHTGEKP YKCEECGKAF NWSSNLMEHK 

      1030       1040       1050       1060       1070       1080 
KIHTGETPYK CEECDKAFSW PSSLTEHKAT HAGEKPYKCE ECGKAFSWPS RLTEHKATHA 

      1090       1100       1110       1120       1130       1140 
GEEPYKCEEC GKAFNWSSNL MEHKRIHTGE KPYKCEECGK SFSTFSILTK HKVIHTGEKP 

      1150       1160       1170       1180       1190       1200 
YKCEECGKAY KWSSTLSYHK KIHTVEKPYK CEECGKGFVM FSILAKHKVI HTGEKLYKCE 

      1210       1220       1230       1240       1250       1260 
ECGKAYKWPS TLRYHKKIHT GEKPYKCEEC GKAFSTFSIL TKHKVIHTGE KPYKCEECGK 

      1270       1280 
AFSWLSVFSK HKKIHTGEKL 

« Hide

Isoform 2 [UniParc].

Checksum: E2184DF23B0D35E9
Show »

FASTA1,167134,353

References

« Hide 'large scale' references
[1]"Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12."
Eichler E.E., Hoffman S.M., Adamson A.A., Gordon L.A., McCready P., Lamerdin J.E., Mohrenweiser H.W.
Genome Res. 8:791-808(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC003973 Genomic DNA. Translation: AAB94784.1.
RefSeqNP_009084.2. NM_007153.3.
UniGeneHs.732975.

3D structure databases

ProteinModelPortalO43345.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO43345.

Proteomic databases

PaxDbO43345.
PRIDEO43345.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397126; ENSP00000380315; ENSG00000160321.
GeneID7757.

Organism-specific databases

GeneCardsGC19M022148.
HGNCHGNC:12999. ZNF208.
MIM603977. gene.
neXtProtNX_O43345.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidO43345.
OrthoDBEOG7KSX7Q.
PhylomeDBO43345.
TreeFamTF350794.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressO43345.
BgeeO43345.
CleanExHS_ZNF208.
GenevestigatorO43345.

Family and domain databases

Gene3D3.30.160.60. 39 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 37 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 33 hits.
PS50157. ZINC_FINGER_C2H2_2. 34 hits.
[Graphical view]
ProtoNetSearch...

Other

PROO43345.
SOURCESearch...

Entry information

Entry nameZN208_HUMAN
AccessionPrimary (citable) accession number: O43345
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 19, 2014
Last modified: April 16, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM