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O43345

- ZN208_HUMAN

UniProt

O43345 - ZN208_HUMAN

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Protein

Zinc finger protein 208

Gene
ZNF208, ZNF91L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri173 – 19523C2H2-type 1; degenerateAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 2; degenerateAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 3Add
BLAST
Zinc fingeri257 – 27923C2H2-type 4Add
BLAST
Zinc fingeri285 – 30723C2H2-type 5Add
BLAST
Zinc fingeri313 – 33523C2H2-type 6Add
BLAST
Zinc fingeri341 – 36323C2H2-type 7Add
BLAST
Zinc fingeri369 – 39123C2H2-type 8Add
BLAST
Zinc fingeri397 – 41923C2H2-type 9Add
BLAST
Zinc fingeri425 – 44723C2H2-type 10Add
BLAST
Zinc fingeri453 – 47523C2H2-type 11Add
BLAST
Zinc fingeri497 – 51923C2H2-type 12Add
BLAST
Zinc fingeri525 – 54723C2H2-type 13Add
BLAST
Zinc fingeri553 – 57523C2H2-type 14Add
BLAST
Zinc fingeri581 – 60323C2H2-type 15Add
BLAST
Zinc fingeri609 – 63123C2H2-type 16Add
BLAST
Zinc fingeri637 – 65923C2H2-type 17Add
BLAST
Zinc fingeri665 – 68723C2H2-type 18Add
BLAST
Zinc fingeri693 – 71523C2H2-type 19Add
BLAST
Zinc fingeri721 – 74323C2H2-type 20Add
BLAST
Zinc fingeri749 – 77123C2H2-type 21Add
BLAST
Zinc fingeri777 – 79923C2H2-type 22Add
BLAST
Zinc fingeri805 – 82723C2H2-type 23Add
BLAST
Zinc fingeri833 – 85523C2H2-type 24Add
BLAST
Zinc fingeri861 – 88323C2H2-type 25Add
BLAST
Zinc fingeri889 – 91123C2H2-type 26Add
BLAST
Zinc fingeri917 – 93923C2H2-type 27Add
BLAST
Zinc fingeri945 – 96723C2H2-type 28Add
BLAST
Zinc fingeri973 – 99523C2H2-type 29; degenerateAdd
BLAST
Zinc fingeri1001 – 102323C2H2-type 30Add
BLAST
Zinc fingeri1029 – 105123C2H2-type 31Add
BLAST
Zinc fingeri1057 – 107923C2H2-type 32Add
BLAST
Zinc fingeri1085 – 110723C2H2-type 33Add
BLAST
Zinc fingeri1113 – 113523C2H2-type 34Add
BLAST
Zinc fingeri1141 – 116323C2H2-type 35Add
BLAST
Zinc fingeri1169 – 119123C2H2-type 36Add
BLAST
Zinc fingeri1197 – 121923C2H2-type 37Add
BLAST
Zinc fingeri1225 – 124723C2H2-type 38Add
BLAST
Zinc fingeri1253 – 127523C2H2-type 39Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 208
Alternative name(s):
Zinc finger protein 91-like
Gene namesi
Name:ZNF208
Synonyms:ZNF91L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:12999. ZNF208.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12801280Zinc finger protein 208PRO_0000047454Add
BLAST

Proteomic databases

PaxDbiO43345.
PRIDEiO43345.

PTM databases

PhosphoSiteiO43345.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiO43345.
BgeeiO43345.
CleanExiHS_ZNF208.
GenevestigatoriO43345.

Structurei

3D structure databases

ProteinModelPortaliO43345.
SMRiO43345. Positions 226-448, 494-967, 970-1279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABAdd
BLAST

Sequence similaritiesi

Contains 39 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO43345.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiO43345.
TreeFamiTF350794.

Family and domain databases

Gene3Di3.30.160.60. 39 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 37 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 33 hits.
PS50157. ZINC_FINGER_C2H2_2. 34 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43345-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP     50
DLIIFLEEGK ESWNMKRHEM VEESPVICSH FAQDLWPEQG IEDSFQKVIL 100
RRYEKCGHEN LHLKIGYTNV DECKVHKEGY NKLNQSLTTT QSKVFQRGKY 150
ANVFHKCSNS NRHKIRHTGK KHLQCKEYVR SFCMLSHLSQ HKRIYTRENS 200
YKCEEGGKAF NWSSTLTYYK SAHTGEKPYR CKECGKAFSK FSILTKHKVI 250
HTGEKSYKCE ECGKAFNQSA ILTKHKIIHT GEKPNKCEEC GKAFSKVSTL 300
TTHKAIHAGE KPYKCKECGK AFSKVSTLIT HKAIHAGEKP YKCKECGKAF 350
SKFSILTKHK VIHTGEKPYK CEECGKAYKW PSTLSYHKKI HTGEKPYKCE 400
ECGKGFSMFS ILTKHEVIHT GEKPYKCEEC GKAFNWSSNL MEHKKIHTGE 450
TPYKCEECGK GFSMFSILTK HKVIHNGEKP YKCEECDKAT HAGEKPYKCE 500
ECGKAFNWSS NLMEHKRIHT GEKPYKCEEC GKSFSTFSIL TKHKVIHTGE 550
KPYKCEECGK AYKWSSTLSY HKKIHTVEKP YKCEECGKAF NQSAILIKHK 600
RIHTGEKPYK CEECGKTFSK VSTLTTHKAI HAGEKPYKCK ECGKTFIKVS 650
TLTTHKAIHA GEKPYKCKEC GKAFSKFSIL TKHKVIHTGE KPYKCEECGK 700
AFNWSSNLME HKRIHTGEKP YKCEECGKSF STFSVLTKHK VIHTGEKPYK 750
CEECGKAYKW SSTLSYHKKI HTVEKPYKCE ECGKAFNRSA ILIKHKRIHT 800
DEKPYKCEEC GKTFSKVSTL TTHKAIHAGE KPYKCKECGK AFSKFSILTK 850
HKVIHTGEKP YKCEECGKAY KWPSTLSYHK KIHTGEKPYK CEECGKGFSM 900
FSILTKHEVI HTGEKPYKCE ECGKAFSWLS VFSKHKKTHA GEKFYKCEAC 950
GKAYKSSSTL SYHKKIHTEE KPYKYEECGK GFSTFSILTK HKVIHTGEKP 1000
YKCEECGKAF NWSSNLMEHK KIHTGETPYK CEECDKAFSW PSSLTEHKAT 1050
HAGEKPYKCE ECGKAFSWPS RLTEHKATHA GEEPYKCEEC GKAFNWSSNL 1100
MEHKRIHTGE KPYKCEECGK SFSTFSILTK HKVIHTGEKP YKCEECGKAY 1150
KWSSTLSYHK KIHTVEKPYK CEECGKGFVM FSILAKHKVI HTGEKLYKCE 1200
ECGKAYKWPS TLRYHKKIHT GEKPYKCEEC GKAFSTFSIL TKHKVIHTGE 1250
KPYKCEECGK AFSWLSVFSK HKKIHTGEKL 1280

Note: No experimental confirmation available.

Length:1,280
Mass (Da):147,487
Last modified:March 19, 2014 - v2
Checksum:i296AEB9EF588A8DB
GO
Isoform 2 (identifier: O43345-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     464-563: Missing.
     955-983: KSSSTLSYHKKIHTEEKPYKYEECGKGFS → N
     1277-1280: GEKL → GVPNPPTHKKIHAGEKLYK

Note: No experimental confirmation available.

Show »
Length:1,167
Mass (Da):134,353
Checksum:iE2184DF23B0D35E9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti282 – 2821E → K.
Corresponds to variant rs2007506 [ dbSNP | Ensembl ].
VAR_052791
Natural varianti298 – 2981S → L.
Corresponds to variant rs12462668 [ dbSNP | Ensembl ].
VAR_052792
Natural varianti456 – 4561E → Q.
Corresponds to variant rs7255075 [ dbSNP | Ensembl ].
VAR_052793
Natural varianti640 – 6401K → E.
Corresponds to variant rs10425763 [ dbSNP | Ensembl ].
VAR_059903
Natural varianti1035 – 10351D → G.
Corresponds to variant rs8108957 [ dbSNP | Ensembl ].
VAR_059904

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei464 – 563100Missing in isoform 2. VSP_053780Add
BLAST
Alternative sequencei955 – 98329KSSST…GKGFS → N in isoform 2. VSP_053781Add
BLAST
Alternative sequencei1277 – 12804GEKL → GVPNPPTHKKIHAGEKLYK in isoform 2. VSP_053782

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC003973 Genomic DNA. Translation: AAB94784.1.
CCDSiCCDS54240.1. [O43345-1]
RefSeqiNP_009084.2. NM_007153.3. [O43345-1]
UniGeneiHs.732975.

Genome annotation databases

EnsembliENST00000397126; ENSP00000380315; ENSG00000160321.
GeneIDi7757.
KEGGihsa:7757.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC003973 Genomic DNA. Translation: AAB94784.1 .
CCDSi CCDS54240.1. [O43345-1 ]
RefSeqi NP_009084.2. NM_007153.3. [O43345-1 ]
UniGenei Hs.732975.

3D structure databases

ProteinModelPortali O43345.
SMRi O43345. Positions 226-448, 494-967, 970-1279.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O43345.

Proteomic databases

PaxDbi O43345.
PRIDEi O43345.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397126 ; ENSP00000380315 ; ENSG00000160321 .
GeneIDi 7757.
KEGGi hsa:7757.

Organism-specific databases

CTDi 7757.
GeneCardsi GC19M022148.
HGNCi HGNC:12999. ZNF208.
MIMi 603977. gene.
neXtProti NX_O43345.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi O43345.
KOi K09228.
OrthoDBi EOG7KSX7Q.
PhylomeDBi O43345.
TreeFami TF350794.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

PROi O43345.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43345.
Bgeei O43345.
CleanExi HS_ZNF208.
Genevestigatori O43345.

Family and domain databases

Gene3Di 3.30.160.60. 39 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 37 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 33 hits.
PS50157. ZINC_FINGER_C2H2_2. 34 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12."
    Eichler E.E., Hoffman S.M., Adamson A.A., Gordon L.A., McCready P., Lamerdin J.E., Mohrenweiser H.W.
    Genome Res. 8:791-808(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN208_HUMAN
AccessioniPrimary (citable) accession number: O43345
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 19, 2014
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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