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O43345 (ZN208_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 208
Alternative name(s):
Zinc finger protein 91-like
Gene names
Name:ZNF208
Synonyms:ZNF91L
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length1167 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 34 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Non-traceable author statement. Source: UniProtKB

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Non-traceable author statement. Source: UniProtKB

   Molecular functionDNA binding

Non-traceable author statement. Source: UniProtKB

zinc ion binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11671167Zinc finger protein 208
PRO_0000047454

Regions

Domain7 – 7569KRAB
Zinc finger201 – 22323C2H2-type 1; degenerate
Zinc finger229 – 25123C2H2-type 2
Zinc finger257 – 27923C2H2-type 3
Zinc finger285 – 30723C2H2-type 4
Zinc finger313 – 33523C2H2-type 5
Zinc finger341 – 36323C2H2-type 6
Zinc finger369 – 39123C2H2-type 7
Zinc finger397 – 41923C2H2-type 8
Zinc finger425 – 44723C2H2-type 9
Zinc finger453 – 47523C2H2-type 10
Zinc finger481 – 50323C2H2-type 11
Zinc finger509 – 53123C2H2-type 12
Zinc finger537 – 55923C2H2-type 13
Zinc finger565 – 58723C2H2-type 14
Zinc finger593 – 61523C2H2-type 15
Zinc finger621 – 64323C2H2-type 16
Zinc finger649 – 67123C2H2-type 17
Zinc finger677 – 69923C2H2-type 18
Zinc finger705 – 72723C2H2-type 19
Zinc finger733 – 75523C2H2-type 20
Zinc finger761 – 78323C2H2-type 21
Zinc finger789 – 81123C2H2-type 22
Zinc finger817 – 83923C2H2-type 23
Zinc finger845 – 86723C2H2-type 24
Zinc finger873 – 89523C2H2-type 25
Zinc finger901 – 92323C2H2-type 26
Zinc finger929 – 95123C2H2-type 27
Zinc finger957 – 97923C2H2-type 28
Zinc finger985 – 100723C2H2-type 29
Zinc finger1013 – 103523C2H2-type 30
Zinc finger1041 – 106323C2H2-type 31
Zinc finger1069 – 109123C2H2-type 32
Zinc finger1097 – 111923C2H2-type 33
Zinc finger1125 – 114723C2H2-type 34

Natural variations

Natural variant2821E → K.
Corresponds to variant rs2007506 [ dbSNP | Ensembl ].
VAR_052791
Natural variant2981S → L.
Corresponds to variant rs12462668 [ dbSNP | Ensembl ].
VAR_052792
Natural variant4561E → Q.
Corresponds to variant rs7255075 [ dbSNP | Ensembl ].
VAR_052793
Natural variant5401K → E.
Corresponds to variant rs10425763 [ dbSNP | Ensembl ].
VAR_059903
Natural variant9071D → G.
Corresponds to variant rs8108957 [ dbSNP | Ensembl ].
VAR_059904
Natural variant11651L → H.
Corresponds to variant rs2359812 [ dbSNP | Ensembl ].
VAR_059905

Sequences

Sequence LengthMass (Da)Tools
O43345 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: E2184DF23B0D35E9

FASTA1,167134,353
        10         20         30         40         50         60 
MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP DLIIFLEEGK 

        70         80         90        100        110        120 
ESWNMKRHEM VEESPVICSH FAQDLWPEQG IEDSFQKVIL RRYEKCGHEN LHLKIGYTNV 

       130        140        150        160        170        180 
DECKVHKEGY NKLNQSLTTT QSKVFQRGKY ANVFHKCSNS NRHKIRHTGK KHLQCKEYVR 

       190        200        210        220        230        240 
SFCMLSHLSQ HKRIYTRENS YKCEEGGKAF NWSSTLTYYK SAHTGEKPYR CKECGKAFSK 

       250        260        270        280        290        300 
FSILTKHKVI HTGEKSYKCE ECGKAFNQSA ILTKHKIIHT GEKPNKCEEC GKAFSKVSTL 

       310        320        330        340        350        360 
TTHKAIHAGE KPYKCKECGK AFSKVSTLIT HKAIHAGEKP YKCKECGKAF SKFSILTKHK 

       370        380        390        400        410        420 
VIHTGEKPYK CEECGKAYKW PSTLSYHKKI HTGEKPYKCE ECGKGFSMFS ILTKHEVIHT 

       430        440        450        460        470        480 
GEKPYKCEEC GKAFNWSSNL MEHKKIHTGE TPYKCEECGK GFSWSSTLSY HKKIHTVEKP 

       490        500        510        520        530        540 
YKCEECGKAF NQSAILIKHK RIHTGEKPYK CEECGKTFSK VSTLTTHKAI HAGEKPYKCK 

       550        560        570        580        590        600 
ECGKTFIKVS TLTTHKAIHA GEKPYKCKEC GKAFSKFSIL TKHKVIHTGE KPYKCEECGK 

       610        620        630        640        650        660 
AFNWSSNLME HKRIHTGEKP YKCEECGKSF STFSVLTKHK VIHTGEKPYK CEECGKAYKW 

       670        680        690        700        710        720 
SSTLSYHKKI HTVEKPYKCE ECGKAFNRSA ILIKHKRIHT DEKPYKCEEC GKTFSKVSTL 

       730        740        750        760        770        780 
TTHKAIHAGE KPYKCKECGK AFSKFSILTK HKVIHTGEKP YKCEECGKAY KWPSTLSYHK 

       790        800        810        820        830        840 
KIHTGEKPYK CEECGKGFSM FSILTKHEVI HTGEKPYKCE ECGKAFSWLS VFSKHKKTHA 

       850        860        870        880        890        900 
GEKFYKCEAC GKAYNTFSIL TKHKVIHTGE KPYKCEECGK AFNWSSNLME HKKIHTGETP 

       910        920        930        940        950        960 
YKCEECDKAF SWPSSLTEHK ATHAGEKPYK CEECGKAFSW PSRLTEHKAT HAGEEPYKCE 

       970        980        990       1000       1010       1020 
ECGKAFNWSS NLMEHKRIHT GEKPYKCEEC GKSFSTFSIL TKHKVIHTGE KPYKCEECGK 

      1030       1040       1050       1060       1070       1080 
AYKWSSTLSY HKKIHTVEKP YKCEECGKGF VMFSILAKHK VIHTGEKLYK CEECGKAYKW 

      1090       1100       1110       1120       1130       1140 
PSTLRYHKKI HTGEKPYKCE ECGKAFSTFS ILTKHKVIHT GEKPYKCEEC GKAFSWLSVF 

      1150       1160 
SKHKKIHTGV PNPPTHKKIH AGEKLYK

« Hide

References

« Hide 'large scale' references
[1]"Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12."
Eichler E.E., Hoffman S.M., Adamson A.A., Gordon L.A., McCready P., Lamerdin J.E., Mohrenweiser H.W.
Genome Res. 8:791-808(1998) [PubMed: 9724325] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC003973 Genomic DNA. Translation: AAB94784.1.
IPIIPI00941719.
UniGeneHs.541334.

3D structure databases

ProteinModelPortalO43345.
SMRO43345. Positions 1-52, 171-839, 842-1147.
ModBaseSearch...

PTM databases

PhosphoSiteO43345.

Proteomic databases

PRIDEO43345.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397126; ENSP00000380315; ENSG00000160321.
UCSCuc002nqp.1. human.

Organism-specific databases

GeneCardsGC19M022148.
HGNCHGNC:12999. ZNF208.
MIM603977. gene.
neXtProtNX_O43345.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG16882.
GeneTreeENSGT00600000084165.
HOGENOMHBG717200.
HOVERGENHBG018163.
InParanoidO43345.
OMANWSSNLM.
OrthoDBEOG4VT5WC.
PhylomeDBO43345.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressO43345.
BgeeO43345.
CleanExHS_ZNF208.
GenevestigatorO43345.
GermOnlineENSG00000160321. Homo sapiens.

Family and domain databases

InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 35 hits.
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 29 hits.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 33 hits.
[Graphical view]
SUPFAMSSF109640. Krueppel-associated_box. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 33 hits.
PS50157. ZINC_FINGER_C2H2_2. 34 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio30033.
SOURCESearch...

Entry information

Entry nameZN208_HUMAN
AccessionPrimary (citable) accession number: O43345
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 1, 1998
Last modified: January 25, 2012
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents