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Protein

LYR motif-containing protein 1

Gene

LYRM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May promote cell proliferation and inhibition of apoptosis of preadipocytes.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
LYR motif-containing protein 1
Gene namesi
Name:LYRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25074. LYRM1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

When overexpressed, may be involved in obesity-associated insulin resistance, possibly by causing mitochondrial dysfunction in adipocytes.

Organism-specific databases

PharmGKBiPA162394735.

Polymorphism and mutation databases

BioMutaiLYRM1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 122122LYR motif-containing protein 1PRO_0000174310Add
BLAST

Proteomic databases

MaxQBiO43325.
PaxDbiO43325.
PeptideAtlasiO43325.
PRIDEiO43325.

PTM databases

iPTMnetiO43325.
PhosphoSiteiO43325.

Expressioni

Tissue specificityi

High levels in adipose tissue.1 Publication

Gene expression databases

BgeeiENSG00000102897.
CleanExiHS_LYRM1.
ExpressionAtlasiO43325. baseline and differential.
GenevisibleiO43325. HS.

Organism-specific databases

HPAiHPA059840.

Interactioni

Protein-protein interaction databases

BioGridi121406. 1 interaction.
IntActiO43325. 1 interaction.
STRINGi9606.ENSP00000219168.

Structurei

3D structure databases

ProteinModelPortaliO43325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiENOG410IX7X. Eukaryota.
ENOG4111PGA. LUCA.
GeneTreeiENSGT00390000006695.
HOGENOMiHOG000113418.
HOVERGENiHBG009252.
InParanoidiO43325.
OMAiGLYRRIF.
OrthoDBiEOG091G15YA.
PhylomeDBiO43325.
TreeFamiTF324686.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTATRQEVL GLYRSIFRLA RKWQATSGQM EDTIKEKQYI LNEARTLFRK
60 70 80 90 100
NKNLTDTDLI KQCIDECTAR IEIGLHYKIP YPRPIHLPPM GLTPLRGRGL
110 120
RSQEKLRKLS KPVYLRSHDE VS
Length:122
Mass (Da):14,282
Last modified:June 1, 1998 - v1
Checksum:i3A30D86F9296E82B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311881 mRNA. Translation: BAG34822.1.
AC002394 Genomic DNA. Translation: AAC05810.1.
CH471228 Genomic DNA. Translation: EAW66847.1.
BC017039 mRNA. Translation: AAH17039.1.
CCDSiCCDS10593.1.
RefSeqiNP_001121773.1. NM_001128301.2.
NP_001121774.1. NM_001128302.2.
NP_001289764.1. NM_001302835.1.
NP_001289765.1. NM_001302836.1.
NP_065157.1. NM_020424.4.
XP_005255501.1. XM_005255444.1.
UniGeneiHs.745012.

Genome annotation databases

EnsembliENST00000219168; ENSP00000219168; ENSG00000102897.
ENST00000396052; ENSP00000379367; ENSG00000102897.
ENST00000439021; ENSP00000407883; ENSG00000102897.
ENST00000567954; ENSP00000457333; ENSG00000102897.
ENST00000568663; ENSP00000454826; ENSG00000102897.
ENST00000569023; ENSP00000454551; ENSG00000102897.
GeneIDi57149.
KEGGihsa:57149.
UCSCiuc002dia.6. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311881 mRNA. Translation: BAG34822.1.
AC002394 Genomic DNA. Translation: AAC05810.1.
CH471228 Genomic DNA. Translation: EAW66847.1.
BC017039 mRNA. Translation: AAH17039.1.
CCDSiCCDS10593.1.
RefSeqiNP_001121773.1. NM_001128301.2.
NP_001121774.1. NM_001128302.2.
NP_001289764.1. NM_001302835.1.
NP_001289765.1. NM_001302836.1.
NP_065157.1. NM_020424.4.
XP_005255501.1. XM_005255444.1.
UniGeneiHs.745012.

3D structure databases

ProteinModelPortaliO43325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121406. 1 interaction.
IntActiO43325. 1 interaction.
STRINGi9606.ENSP00000219168.

PTM databases

iPTMnetiO43325.
PhosphoSiteiO43325.

Polymorphism and mutation databases

BioMutaiLYRM1.

Proteomic databases

MaxQBiO43325.
PaxDbiO43325.
PeptideAtlasiO43325.
PRIDEiO43325.

Protocols and materials databases

DNASUi57149.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219168; ENSP00000219168; ENSG00000102897.
ENST00000396052; ENSP00000379367; ENSG00000102897.
ENST00000439021; ENSP00000407883; ENSG00000102897.
ENST00000567954; ENSP00000457333; ENSG00000102897.
ENST00000568663; ENSP00000454826; ENSG00000102897.
ENST00000569023; ENSP00000454551; ENSG00000102897.
GeneIDi57149.
KEGGihsa:57149.
UCSCiuc002dia.6. human.

Organism-specific databases

CTDi57149.
GeneCardsiLYRM1.
HGNCiHGNC:25074. LYRM1.
HPAiHPA059840.
MIMi614709. gene.
neXtProtiNX_O43325.
PharmGKBiPA162394735.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX7X. Eukaryota.
ENOG4111PGA. LUCA.
GeneTreeiENSGT00390000006695.
HOGENOMiHOG000113418.
HOVERGENiHBG009252.
InParanoidiO43325.
OMAiGLYRRIF.
OrthoDBiEOG091G15YA.
PhylomeDBiO43325.
TreeFamiTF324686.

Miscellaneous databases

ChiTaRSiLYRM1. human.
GenomeRNAii57149.
PROiO43325.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102897.
CleanExiHS_LYRM1.
ExpressionAtlasiO43325. baseline and differential.
GenevisibleiO43325. HS.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
[Graphical view]
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYRM1_HUMAN
AccessioniPrimary (citable) accession number: O43325
Secondary accession number(s): B2R4M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.