ID   FGF16_HUMAN             Reviewed;         207 AA.
AC   O43320;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   13-OCT-2009, entry version 66.
DE   RecName: Full=Fibroblast growth factor 16;
DE            Short=FGF-16;
GN   Name=FGF16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   MEDLINE=98139883; PubMed=9473496; DOI=10.1006/bbrc.1998.8073;
RA   Miyake A., Konishi M., Martin F.H., Hernday N.A., Ozaki K.,
RA   Yamamoto S., Mikami T., Arakawa T., Itoh N.;
RT   "Structure and expression of a novel member, FGF-16, on the fibroblast
RT   growth factor family.";
RL   Biochem. Biophys. Res. Commun. 243:148-152(1998).
CC   -!- FUNCTION: Induces hepatocellular proliferation. Has no biological
CC       effect on the heart (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; AB009391; BAA24956.1; -; mRNA.
DR   IPI; IPI00011975; -.
DR   PIR; JC5941; JC5941.
DR   RefSeq; NP_003859.1; -.
DR   UniGene; Hs.666364; -.
DR   HSSP; P31371; 1IHK.
DR   SMR; O43320; 51-204.
DR   STRING; O43320; -.
DR   PRIDE; O43320; -.
DR   GeneID; 8823; -.
DR   KEGG; hsa:8823; -.
DR   CTD; 8823; -.
DR   GeneCards; GC0XP076516; -.
DR   H-InvDB; HIX0056594; -.
DR   HGNC; HGNC:3672; FGF16.
DR   MIM; 603724; gene.
DR   PharmGKB; PA28111; -.
DR   HOVERGEN; O43320; -.
DR   Reactome; REACT_9470; Signaling by FGFR.
DR   NextBio; 33100; -.
DR   CleanEx; HS_FGF16; -.
DR   Genevestigator; O43320; -.
DR   GO; GO:0005615; C:extracellular space; TAS:ProtInc.
DR   GO; GO:0008083; F:growth factor activity; TAS:ProtInc.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling...; EXP:Reactome.
DR   GO; GO:0008152; P:metabolic process; TAS:ProtInc.
DR   GO; GO:0009887; P:organ morphogenesis; TAS:ProtInc.
DR   GO; GO:0009266; P:response to temperature stimulus; TAS:ProtInc.
DR   InterPro; IPR002209; GF_heparin_bd.
DR   InterPro; IPR002348; IL1_HBGF.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   ProDom; PD000831; IL1_HBGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Growth factor; Secreted.
FT   CHAIN         1    207       Fibroblast growth factor 16.
FT                                /FTId=PRO_0000147613.
FT   CARBOHYD     78     78       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   207 AA;  23759 MW;  D8AD160BDABDB5F8 CRC64;
     MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL
     RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER
     GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH
     QKFTHFLPRP VDPSKLPSMS RDLFHYR
//