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O43320

- FGF16_HUMAN

UniProt

O43320 - FGF16_HUMAN

Protein

Fibroblast growth factor 16

Gene

FGF16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.1 Publication

    GO - Molecular functioni

    1. growth factor activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. epidermal growth factor receptor signaling pathway Source: Reactome
    3. Fc-epsilon receptor signaling pathway Source: Reactome
    4. fibroblast growth factor receptor signaling pathway Source: Reactome
    5. innate immune response Source: Reactome
    6. insulin receptor signaling pathway Source: Reactome
    7. metabolic process Source: ProtInc
    8. neurotrophin TRK receptor signaling pathway Source: Reactome
    9. organ morphogenesis Source: ProtInc
    10. phosphatidylinositol-mediated signaling Source: Reactome
    11. response to temperature stimulus Source: ProtInc
    12. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_976. PI3K Cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 16
    Short name:
    FGF-16
    Gene namesi
    Name:FGF16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:3672. FGF16.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Metacarpal 4-5 fusion (MF4) [MIM:309630]: A rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi309630. phenotype.
    Orphaneti2498. Syndactyly type 8.
    PharmGKBiPA28111.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Fibroblast growth factor 16PRO_0000147613Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Modified residuei111 – 1111Phosphoserine1 Publication
    Modified residuei114 – 1141Phosphotyrosine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO43320.
    PRIDEiO43320.

    PTM databases

    PhosphoSiteiO43320.

    Expressioni

    Gene expression databases

    CleanExiHS_FGF16.
    GenevestigatoriO43320.

    Interactioni

    Subunit structurei

    Interacts with FGFR1 and FGFR2.1 Publication

    Protein-protein interaction databases

    BioGridi114350. 1 interaction.
    STRINGi9606.ENSP00000346253.

    Structurei

    3D structure databases

    ProteinModelPortaliO43320.
    SMRiO43320. Positions 51-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG269618.
    HOVERGENiHBG007580.
    KOiK04358.
    PhylomeDBiO43320.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028285. FGF16.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF27. PTHR11486:SF27. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43320-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP    50
    TDFAHLKGIL RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA 100
    VGLISIRGVD SGLYLGMNER GELYGSKKLT RECVFREQFE ENWYNTYAST 150
    LYKHSDSERQ YYVALNKDGS PREGYRTKRH QKFTHFLPRP VDPSKLPSMS 200
    RDLFHYR 207
    Length:207
    Mass (Da):23,759
    Last modified:June 1, 1998 - v1
    Checksum:iD8AD160BDABDB5F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009391 mRNA. Translation: BAA24956.1.
    PIRiJC5941.
    RefSeqiNP_003859.1. NM_003868.2.
    UniGeneiHs.666364.

    Genome annotation databases

    GeneIDi8823.
    KEGGihsa:8823.
    UCSCiuc011mqp.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009391 mRNA. Translation: BAA24956.1 .
    PIRi JC5941.
    RefSeqi NP_003859.1. NM_003868.2.
    UniGenei Hs.666364.

    3D structure databases

    ProteinModelPortali O43320.
    SMRi O43320. Positions 51-202.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114350. 1 interaction.
    STRINGi 9606.ENSP00000346253.

    PTM databases

    PhosphoSitei O43320.

    Proteomic databases

    PaxDbi O43320.
    PRIDEi O43320.

    Protocols and materials databases

    DNASUi 8823.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8823.
    KEGGi hsa:8823.
    UCSCi uc011mqp.2. human.

    Organism-specific databases

    CTDi 8823.
    GeneCardsi GC0XP076709.
    HGNCi HGNC:3672. FGF16.
    MIMi 300827. gene.
    309630. phenotype.
    neXtProti NX_O43320.
    Orphaneti 2498. Syndactyly type 8.
    PharmGKBi PA28111.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269618.
    HOVERGENi HBG007580.
    KOi K04358.
    PhylomeDBi O43320.

    Enzyme and pathway databases

    Reactomei REACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_976. PI3K Cascade.

    Miscellaneous databases

    GenomeRNAii 8823.
    NextBioi 33100.
    PROi O43320.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_FGF16.
    Genevestigatori O43320.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028285. FGF16.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF27. PTHR11486:SF27. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family."
      Miyake A., Konishi M., Martin F.H., Hernday N.A., Ozaki K., Yamamoto S., Mikami T., Arakawa T., Itoh N.
      Biochem. Biophys. Res. Commun. 243:148-152(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
      Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
      J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFR2 AND FGFR3, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
    3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111 AND TYR-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    4. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    5. "Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion."
      Jamsheer A., Zemojtel T., Kolanczyk M., Stricker S., Hecht J., Krawitz P., Doelken S.C., Glazar R., Socha M., Mundlos S.
      J. Med. Genet. 50:579-584(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN MF4.

    Entry informationi

    Entry nameiFGF16_HUMAN
    AccessioniPrimary (citable) accession number: O43320
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3