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O43320

- FGF16_HUMAN

UniProt

O43320 - FGF16_HUMAN

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Protein

Fibroblast growth factor 16

Gene

FGF16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.1 Publication

GO - Molecular functioni

  1. growth factor activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. epidermal growth factor receptor signaling pathway Source: Reactome
  3. Fc-epsilon receptor signaling pathway Source: Reactome
  4. fibroblast growth factor receptor signaling pathway Source: Reactome
  5. innate immune response Source: Reactome
  6. insulin receptor signaling pathway Source: Reactome
  7. metabolic process Source: ProtInc
  8. neurotrophin TRK receptor signaling pathway Source: Reactome
  9. organ morphogenesis Source: ProtInc
  10. phosphatidylinositol-mediated signaling Source: Reactome
  11. positive regulation of brown fat cell proliferation Source: Ensembl
  12. response to temperature stimulus Source: ProtInc
  13. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121249. Signaling by FGFR3 mutants.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_976. PI3K Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 16
Short name:
FGF-16
Gene namesi
Name:FGF16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:3672. FGF16.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Metacarpal 4-5 fusion (MF4) [MIM:309630]: A rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi309630. phenotype.
Orphaneti2498. Syndactyly type 8.
PharmGKBiPA28111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Fibroblast growth factor 16PRO_0000147613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
Modified residuei111 – 1111Phosphoserine1 Publication
Modified residuei114 – 1141Phosphotyrosine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO43320.
PRIDEiO43320.

PTM databases

PhosphoSiteiO43320.

Expressioni

Gene expression databases

CleanExiHS_FGF16.
GenevestigatoriO43320.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2.1 Publication

Protein-protein interaction databases

BioGridi114350. 1 interaction.
STRINGi9606.ENSP00000346253.

Structurei

3D structure databases

ProteinModelPortaliO43320.
SMRiO43320. Positions 51-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG269618.
GeneTreeiENSGT00760000118859.
HOVERGENiHBG007580.
InParanoidiO43320.
KOiK04358.
PhylomeDBiO43320.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028285. FGF16.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF27. PTHR11486:SF27. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43320 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP
60 70 80 90 100
TDFAHLKGIL RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA
110 120 130 140 150
VGLISIRGVD SGLYLGMNER GELYGSKKLT RECVFREQFE ENWYNTYAST
160 170 180 190 200
LYKHSDSERQ YYVALNKDGS PREGYRTKRH QKFTHFLPRP VDPSKLPSMS

RDLFHYR
Length:207
Mass (Da):23,759
Last modified:June 1, 1998 - v1
Checksum:iD8AD160BDABDB5F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009391 mRNA. Translation: BAA24956.1.
CCDSiCCDS75996.1.
PIRiJC5941.
RefSeqiNP_003859.1. NM_003868.2.
UniGeneiHs.666364.

Genome annotation databases

EnsembliENST00000618154; ENSP00000484364; ENSG00000196468.
GeneIDi8823.
KEGGihsa:8823.
UCSCiuc011mqp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009391 mRNA. Translation: BAA24956.1 .
CCDSi CCDS75996.1.
PIRi JC5941.
RefSeqi NP_003859.1. NM_003868.2.
UniGenei Hs.666364.

3D structure databases

ProteinModelPortali O43320.
SMRi O43320. Positions 51-202.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114350. 1 interaction.
STRINGi 9606.ENSP00000346253.

PTM databases

PhosphoSitei O43320.

Proteomic databases

PaxDbi O43320.
PRIDEi O43320.

Protocols and materials databases

DNASUi 8823.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000618154 ; ENSP00000484364 ; ENSG00000196468 .
GeneIDi 8823.
KEGGi hsa:8823.
UCSCi uc011mqp.2. human.

Organism-specific databases

CTDi 8823.
GeneCardsi GC0XP076709.
HGNCi HGNC:3672. FGF16.
MIMi 300827. gene.
309630. phenotype.
neXtProti NX_O43320.
Orphaneti 2498. Syndactyly type 8.
PharmGKBi PA28111.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG269618.
GeneTreei ENSGT00760000118859.
HOVERGENi HBG007580.
InParanoidi O43320.
KOi K04358.
PhylomeDBi O43320.

Enzyme and pathway databases

Reactomei REACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121249. Signaling by FGFR3 mutants.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_976. PI3K Cascade.

Miscellaneous databases

GenomeRNAii 8823.
NextBioi 33100.
PROi O43320.
SOURCEi Search...

Gene expression databases

CleanExi HS_FGF16.
Genevestigatori O43320.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028285. FGF16.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF27. PTHR11486:SF27. 1 hit.
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family."
    Miyake A., Konishi M., Martin F.H., Hernday N.A., Ozaki K., Yamamoto S., Mikami T., Arakawa T., Itoh N.
    Biochem. Biophys. Res. Commun. 243:148-152(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
    Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
    J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR2 AND FGFR3, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111 AND TYR-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  5. "Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion."
    Jamsheer A., Zemojtel T., Kolanczyk M., Stricker S., Hecht J., Krawitz P., Doelken S.C., Glazar R., Socha M., Mundlos S.
    J. Med. Genet. 50:579-584(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN MF4.

Entry informationi

Entry nameiFGF16_HUMAN
AccessioniPrimary (citable) accession number: O43320
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3