Reviewed, UniProtKB/Swiss-Prot O43320 (FGF16_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 16
      Short name=FGF-16

Gene names

Name:

FGF16

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Induces hepatocellular proliferation. Has no biological effect on the heart By similarity.
Subcellular location	SecretedBy similarity.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Growth factor
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from Experiment. Source: Reactome metabolic process Ref.1 Traceable author statement. Source: ProtInc organ morphogenesis Ref.1 Traceable author statement. Source: ProtInc response to temperature stimulus Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Ref.1 Traceable author statement. Source: ProtInc
Molecular function	growth factor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Fibroblast growth factor 16		PRO_0000147613
Amino acid modifications
	Glycosylation	78	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O43320-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: D8AD160BDABDB5F8	FASTA	207	23,759
	10 20 30 40 50 60 MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL 70 80 90 100 110 120 RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER 130 140 150 160 170 180 GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH 190 200 QKFTHFLPRP VDPSKLPSMS RDLFHYR

References

[1]	"Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family." Miyake A., Konishi M., Martin F.H., Hernday N.A., Ozaki K., Yamamoto S., Mikami T., Arakawa T., Itoh N. Biochem. Biophys. Res. Commun. 243:148-152(1998) [PubMed: 9473496] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB009391 mRNA. Translation: BAA24956.1.
PIR	JC5941.
RefSeq	NP_003859.1.
UniGene	Hs.666364
3D structure databases
HSSP	HSSP built from PDB template 1IHK based on UniProtKB P31371.
SMR	O43320. Positions 51-204.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000196468. Homo sapiens. [Contig view]
GeneID	8823.
KEGG	hsa:8823.
Organism-specific databases
H-InvDB	HIX0056594.
HGNC	HGNC:3672. FGF16.
MIM	603724. gene.
PharmGKB	PA28111.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	O43320.
Enzyme and pathway databases
Reactome	REACT_9470. Signaling by FGFR.
Gene expression databases
CleanEx	HS_FGF16.
Family and domain databases
InterPro	IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33100.
SOURCE	Search...

Entry information

Entry name

FGF16_HUMAN

Accession

Primary (citable) accession number: O43320

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 1, 1998
Last modified:	November 4, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)