O43320 (FGF16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 16
Short name=FGF-16

Gene names

Name:

FGF16

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Ref.2
Subunit structure	Interacts with FGFR1 and FGFR2. Ref.2
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Growth factor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell-cell signaling Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome organ morphogenesis Traceable author statement. Source: ProtInc response to temperature stimulus Traceable author statement. Source: ProtInc
Cellular component	extracellular space Traceable author statement. Source: ProtInc
Molecular function	growth factor activity Traceable author statement. Source: ProtInc protein tyrosine kinase activity Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Fibroblast growth factor 16		PRO_0000147613
Amino acid modifications
	Glycosylation	78	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O43320 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: D8AD160BDABDB5F8	FASTA	207	23,759
	10 20 30 40 50 60 MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL 70 80 90 100 110 120 RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER 130 140 150 160 170 180 GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH 190 200 QKFTHFLPRP VDPSKLPSMS RDLFHYR

References

[1]	"Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family." Miyake A., Konishi M., Martin F.H., Hernday N.A., Ozaki K., Yamamoto S., Mikami T., Arakawa T., Itoh N. Biochem. Biophys. Res. Commun. 243:148-152(1998) [PubMed: 9473496] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M. J. Biol. Chem. 281:15694-15700(2006) [PubMed: 16597617] [Abstract] Cited for: INTERACTION WITH FGFR2 AND FGFR3, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[3]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed: 20094046] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009391 mRNA. Translation: BAA24956.1.
IPI	IPI00011975.
PIR	JC5941.
RefSeq	NP_003859.1. NM_003868.1.
UniGene	Hs.666364.
3D structure databases
ProteinModelPortal	O43320.
SMR	O43320. Positions 51-202.
ModBase	Search...
Protein-protein interaction databases
STRING	O43320.
PTM databases
PhosphoSite	O43320.
Proteomic databases
PRIDE	O43320.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8823.
KEGG	hsa:8823.
Organism-specific databases
CTD	8823.
GeneCards	GC0XP076709.
HGNC	HGNC:3672. FGF16.
MIM	300827. gene.
neXtProt	NX_O43320.
PharmGKB	PA28111.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG007580.
OrthoDB	EOG46WZ9V.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_FGF16.
Genevestigator	O43320.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
KO	K04358.
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	33100.
SOURCE	Search...

Entry information

Entry name

FGF16_HUMAN

Accession

Primary (citable) accession number: O43320

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.