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O43320 (FGF16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 16

Short name=FGF-16
Gene names
Name:FGF16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Ref.2

Subunit structure

Interacts with FGFR1 and FGFR2. Ref.2

Subcellular location

Secreted By similarity.

Involvement in disease

Metacarpal 4-5 fusion (MF4) [MIM:309630]: A rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5

Sequence similarities

Belongs to the heparin-binding growth factors family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Fibroblast growth factor 16
PRO_0000147613

Amino acid modifications

Modified residue1111Phosphoserine Ref.3
Modified residue1141Phosphotyrosine Ref.3
Glycosylation781N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O43320 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: D8AD160BDABDB5F8

FASTA20723,759
        10         20         30         40         50         60 
MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL 

        70         80         90        100        110        120 
RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER 

       130        140        150        160        170        180 
GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH 

       190        200 
QKFTHFLPRP VDPSKLPSMS RDLFHYR 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family."
Miyake A., Konishi M., Martin F.H., Hernday N.A., Ozaki K., Yamamoto S., Mikami T., Arakawa T., Itoh N.
Biochem. Biophys. Res. Commun. 243:148-152(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR2 AND FGFR3, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[3]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111 AND TYR-114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[4]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[5]"Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion."
Jamsheer A., Zemojtel T., Kolanczyk M., Stricker S., Hecht J., Krawitz P., Doelken S.C., Glazar R., Socha M., Mundlos S.
J. Med. Genet. 50:579-584(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN MF4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009391 mRNA. Translation: BAA24956.1.
PIRJC5941.
RefSeqNP_003859.1. NM_003868.2.
UniGeneHs.666364.

3D structure databases

ProteinModelPortalO43320.
SMRO43320. Positions 51-202.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114350. 1 interaction.
STRING9606.ENSP00000346253.

PTM databases

PhosphoSiteO43320.

Proteomic databases

PaxDbO43320.
PRIDEO43320.

Protocols and materials databases

DNASU8823.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8823.
KEGGhsa:8823.
UCSCuc011mqp.2. human.

Organism-specific databases

CTD8823.
GeneCardsGC0XP076709.
HGNCHGNC:3672. FGF16.
MIM300827. gene.
309630. phenotype.
neXtProtNX_O43320.
Orphanet2498. Syndactyly type 8.
PharmGKBPA28111.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG269618.
HOVERGENHBG007580.
KOK04358.
PhylomeDBO43320.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

CleanExHS_FGF16.
GenevestigatorO43320.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028285. FGF16.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF27. PTHR11486:SF27. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8823.
NextBio33100.
PROO43320.
SOURCESearch...

Entry information

Entry nameFGF16_HUMAN
AccessionPrimary (citable) accession number: O43320
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM