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O43320 (FGF16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 16

Short name=FGF-16
Gene names
Name:FGF16
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Ref.2

Subunit structure

Interacts with FGFR1 and FGFR2. Ref.2

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Fibroblast growth factor 16
PRO_0000147613

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O43320 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: D8AD160BDABDB5F8

FASTA20723,759
        10         20         30         40         50         60 
MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL 

        70         80         90        100        110        120 
RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER 

       130        140        150        160        170        180 
GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH 

       190        200 
QKFTHFLPRP VDPSKLPSMS RDLFHYR 

« Hide

References

[1]"Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family."
Miyake A., Konishi M., Martin F.H., Hernday N.A., Ozaki K., Yamamoto S., Mikami T., Arakawa T., Itoh N.
Biochem. Biophys. Res. Commun. 243:148-152(1998) [PubMed: 9473496] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
J. Biol. Chem. 281:15694-15700(2006) [PubMed: 16597617] [Abstract]
Cited for: INTERACTION WITH FGFR2 AND FGFR3, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[3]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed: 20094046] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009391 mRNA. Translation: BAA24956.1.
IPIIPI00011975.
PIRJC5941.
RefSeqNP_003859.1. NM_003868.1.
UniGeneHs.666364.

3D structure databases

ProteinModelPortalO43320.
SMRO43320. Positions 51-202.
ModBaseSearch...

Protein-protein interaction databases

STRINGO43320.

PTM databases

PhosphoSiteO43320.

Proteomic databases

PRIDEO43320.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8823.
KEGGhsa:8823.

Organism-specific databases

CTD8823.
GeneCardsGC0XP076709.
HGNCHGNC:3672. FGF16.
MIM300827. gene.
neXtProtNX_O43320.
PharmGKBPA28111.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG007580.
OrthoDBEOG46WZ9V.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_FGF16.
GenevestigatorO43320.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR002209. GF_heparin-bd.
IPR002348. IL1_HBGF.
[Graphical view]
KOK04358.
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. Cytok_IL1_like. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio33100.
SOURCESearch...

Entry information

Entry nameFGF16_HUMAN
AccessionPrimary (citable) accession number: O43320
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families