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Reviewed, UniProtKB/Swiss-Prot O43318 (M3K7_HUMAN)

Last modified February 9, 2010. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Mitogen-activated protein kinase kinase kinase 7
    EC=2.7.11.25
Alternative name(s):
    Transforming growth factor-beta-activated kinase 1
      Short name=TGF-beta-activated kinase 1
Gene names
Name: MAP3K7
Synonyms: TAK1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length606 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF-kappa-B activation and the p38 MAPK pathway. Ref.12

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium.

Subunit structure

Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and MAP3K7IP1; during IL-1 signaling. Ref.12 Ref.7 Ref.9 Ref.10 Ref.11 Ref.14

Post-translational modification

Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation. Association with MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Contains 1 protein kinase domain.

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1B (identifier: O43318-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1A (identifier: O43318-2)

The sequence of this isoform differs from the canonical sequence as follows:
     404-430: Missing.
Isoform 1C (identifier: O43318-3)

The sequence of this isoform differs from the canonical sequence as follows:
     509-518: PLAPCPNSKE → ARTSCRTGPG
     519-606: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 606606Mitogen-activated protein kinase kinase kinase 7
PRO_0000086252

Regions

Domain36 – 291256Protein kinase
Nucleotide binding42 – 509ATP By similarity
Compositional bias8 – 147Poly-Ser

Sites

Active site1561Proton acceptor By similarity
Binding site631ATP

Amino acid modifications

Modified residue1841Phosphothreonine; by autocatalysis Probable
Modified residue1871Phosphothreonine; by autocatalysis Probable
Modified residue1921Phosphoserine; by autocatalysis Probable
Modified residue3891Phosphoserine Ref.17 Ref.22
Modified residue4391Phosphoserine Ref.17 Ref.22 Ref.13 Ref.15 Ref.16 Ref.19
Modified residue4441Phosphothreonine
Modified residue4551Phosphoserine Ref.19

Natural variations

Alternative sequence404 – 43027Missing in isoform 1A.
VSP_004886
Alternative sequence509 – 51810PLAPCPNSKE → ARTSCRTGPG in isoform 1C.
VSP_004887
Alternative sequence519 – 60688Missing in isoform 1C.
VSP_004888

Experimental info

Mutagenesis631K → W: Loss of kinase activity. Ref.12

Secondary structure

1 ............................................. 606
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1B [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 3D8F8147CD174013

FASTA60667,196
        10         20         30         40         50         60 
MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 

        70         80         90        100        110        120 
AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 

       130        140        150        160        170        180 
PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 

       190        200        210        220        230        240 
DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 

       250        260        270        280        290        300 
WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 

       310        320        330        340        350        360 
PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ 

       370        380        390        400        410        420 
SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTAYSKPKR GHRKTASFGN 

       430        440        450        460        470        480 
ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPTRSHP 

       490        500        510        520        530        540 
WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI 

       550        560        570        580        590        600 
ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ 


KRQGTS

« Hide

Isoform 1A.

Checksum: 40EDE237BBB568EE
Show »

FASTA57964,230
Isoform 1C.

Checksum: A92C927A8621AF90
Show »

FASTA51856,706

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References

« Hide 'large scale' references
[1]"TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism."
Sakurai H., Shigemori N., Hasegawa K., Sugita T.
Biochem. Biophys. Res. Commun. 243:545-549(1998) [PubMed: 9480845] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B AND 1C).
Tissue: Lung.
[2]NHLBI resequencing and genotyping service (RS&G)
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A).
Tissue: Trachea.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A).
Tissue: Uterus.
[7]"TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction."
Shibuya H., Yamaguchi K., Shirakabe K., Tonegawa A., Gotoh Y., Ueno N., Irie K., Nishida E., Matsumoto K.
Science 272:1179-1182(1996) [PubMed: 8638164] [Abstract]
Cited for: INTERACTION WITH MAP3K7IP1.
[8]"The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."
Ninomiya-Tsuji J., Kishimoto K., Hiyama A., Inoue J., Cao Z., Matsumoto K.
Nature 398:252-256(1999) [PubMed: 10094049] [Abstract]
Cited for: INTERACTION WITH TRAF6 AND MAP3K7IP1.
[9]"Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1."
Sakurai H., Miyoshi H., Mizukami J., Sugita T.
FEBS Lett. 474:141-145(2000) [PubMed: 10838074] [Abstract]
Cited for: INTERACTION WITH MAP3K7IP1, PHOSPHORYLATION AT THR-184; THR-187 AND SER-192, ACTIVATION.
[10]"Pellino2 activates the mitogen activated protein kinase pathway."
Jensen L.E., Whitehead A.S.
FEBS Lett. 545:199-202(2003) [PubMed: 12804775] [Abstract]
Cited for: INTERACTION WITH PELI1 AND PELI2.
[11]"Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein."
Jensen L.E., Whitehead A.S.
J. Immunol. 171:1500-1506(2003) [PubMed: 12874243] [Abstract]
Cited for: INTERACTION WITH PELI3.
[12]"Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3."
Edlund S., Bu S., Schuster N., Aspenstroem P., Heuchel R., Heldin N.E., ten Dijke P., Heldin C.H., Landstrom M.
Mol. Biol. Cell 14:529-544(2003) [PubMed: 12589052] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SMAD7; MAP2K3 AND P38 KINASE, MUTAGENESIS OF LYS-63.
[13]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, MASS SPECTROMETRY.
Tissue: Epithelium.
[14]"Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway."
Kajino T., Ren H., Iemura S., Natsume T., Stefansson B., Brautigan D.L., Matsumoto K., Ninomiya-Tsuji J.
J. Biol. Chem. 281:39891-39896(2006) [PubMed: 17079228] [Abstract]
Cited for: INTERACTION WITH PP2A AND PPP6C, DEPHOSPHORYLATION AT THR-187 BY PP2A AND PPP6C.
[15]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, MASS SPECTROMETRY.
Tissue: Platelet.
[16]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, MASS SPECTROMETRY.
[17]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439, MASS SPECTROMETRY.
[18]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[19]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439 AND SER-455, MASS SPECTROMETRY.
[20]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389; SER-439 AND THR-444, MASS SPECTROMETRY.
[21]"Direct activation of protein kinases by unanchored polyubiquitin chains."
Xia Z.-P., Sun L., Chen X., Pineda G., Jiang X., Adhikari A., Zeng W., Chen Z.J.
Nature 461:114-119(2009) [PubMed: 19675569] [Abstract]
Cited for: INTERACTION WITH MAP3K7IP2, PHOSPHORYLATION.
[22]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-439, MASS SPECTROMETRY.
Tissue: T-cell.
[23]"Structural basis for the interaction of TAK1 kinase with its activating protein TAB1."
Brown K., Vial S.C., Dedi N., Long J.M., Dunster N.J., Cheetham G.M.T.
J. Mol. Biol. 354:1013-1020(2005) [PubMed: 16289117] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 31-328 IN COMPLEX WITH MAP3K7IP1 AND ADENOSINE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB009357 mRNA. Translation: BAA25026.1.
AB009356 mRNA. Translation: BAA25025.1.
AB009358 mRNA. Translation: BAA25027.2.
DQ314875 Genomic DNA. Translation: ABC40734.1.
AK315774 mRNA. Translation: BAG38124.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19610.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19611.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19612.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23530.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23532.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23533.1.
CH471051 Genomic DNA. Translation: EAW48525.1.
CH471051 Genomic DNA. Translation: EAW48526.1.
BC017715 mRNA. Translation: AAH17715.1.
IPIIPI00218566.
IPI00218567.
IPI00295738.
PIRJC5955.
JC5956.
RefSeqNP_003179.1.
NP_663304.1.
NP_663305.1.
NP_663306.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2EVAX-ray2.00A31-303[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-27523N.
IntActO43318. 56 interactions.
STRINGO43318.

PTM databases

PhosphoSiteO43318.

Proteomic databases

PRIDEO43318.

Genome annotation databases

EnsemblENST00000369329; ENSP00000358335; ENSG00000135341; Homo sapiens. [Genome view]
GeneID6885.
KEGGhsa:6885.
UCSCuc003pnz.1. human.
uc003pob.1. human.

Organism-specific databases

CTD6885.
GeneCardsGC06M091282.
H-InvDBHIX0006075.
HGNCHGNC:6859. MAP3K7.
HPAHPA007633.
MIM602614. gene.
PharmGKBPA30603.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18976.
HOGENOMHBG716529.
HOVERGENO43318.
InParanoidO43318.
OMAFMDITST.
OrthoDBEOG9N337N.
PhylomeDBO43318.

Enzyme and pathway databases

BRENDA2.7.11.25. 247.
Pathway_Interaction_DBbcr_5pathway. BCR signaling pathway.
bmppathway. BMP receptor signaling.
ephrinbrevpathway. Ephrin B reverse signaling.
faspathway. FAS signaling pathway (CD95).
il1pathway. IL1-mediated signaling events.
tcrjnkpathway. JNK signaling in the CD4+ TCR pathway.
wnt_calcium_pathway. Noncanonical Wnt signaling pathway.
p38_mkk3_6pathway. p38 MAPK signaling pathway.
ps1pathway. Presenilin action in Notch and Wnt signaling.
tgfbrpathway. TGF-beta receptor signaling.
tnfpathway. TNF receptor signaling pathway.
ReactomeREACT_6900. Signaling in Immune system.

Gene expression databases

ArrayExpressO43318.
BgeeO43318.
CleanExHS_MAP3K7.
GenevestigatorO43318.
GermOnlineENSG00000135341. Homo sapiens.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR015786. MAPKKK-related.
IPR017421. MAPKKK7.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_prot_kinase_AS.
[Graphical view]
PANTHERPTHR23257:SF92. MAPKKK-related. 1 hit.
PIRSFPIRSF038168. MAPKKK7. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio26899.
SOURCESearch...

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Entry information

Entry nameM3K7_HUMAN
AccessionPrimary (citable) accession number: O43318
Secondary accession number(s): B2RE27 expand/collapse secondary AC list , O43317, O43319, Q5TDN2, Q5TDN3, Q5TDT7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: February 9, 2010
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 6: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

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Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents