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Protein

Mitogen-activated protein kinase kinase kinase 7

Gene

MAP3K7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.8 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Enzyme regulationi

Activated by proinflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation. Association with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2 promotes activation through autophosphorylation, whereas PPM1B/PP2CB, PP2A and PPP6C dephosphorylation leads to inactivation.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63ATP1
Active sitei156Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi42 – 50ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • magnesium ion binding Source: InterPro
  • MAP kinase kinase kinase activity Source: UniProtKB
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: Reactome
  • scaffold protein binding Source: MGI

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • activation of MAPKK activity Source: UniProtKB
  • activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  • apoptotic process Source: UniProtKB-KW
  • Fc-epsilon receptor signaling pathway Source: Reactome
  • histone H3 acetylation Source: BHF-UCL
  • I-kappaB kinase/NF-kappaB signaling Source: Reactome
  • I-kappaB phosphorylation Source: UniProtKB
  • JNK cascade Source: UniProtKB
  • MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  • nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • positive regulation of interleukin-2 production Source: UniProtKB
  • positive regulation of JUN kinase activity Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: Reactome
  • positive regulation of T cell activation Source: UniProtKB
  • positive regulation of T cell cytokine production Source: UniProtKB
  • stimulatory C-type lectin receptor signaling pathway Source: Reactome
  • stress-activated MAPK cascade Source: UniProtKB
  • T cell receptor signaling pathway Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • transforming growth factor beta receptor signaling pathway Source: ProtInc
  • Wnt signaling pathway, calcium modulating pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Stress response, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS05984-MONOMER.
ReactomeiR-HSA-1169091. Activation of NF-kappaB in B cells.
R-HSA-168638. NOD1/2 Signaling Pathway.
R-HSA-202424. Downstream TCR signaling.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-4086398. Ca2+ pathway.
R-HSA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-HSA-446652. Interleukin-1 signaling.
R-HSA-450302. activated TAK1 mediates p38 MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-937042. IRAK2 mediated activation of TAK1 complex.
R-HSA-937072. TRAF6 mediated induction of TAK1 complex.
R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
SignaLinkiO43318.
SIGNORiO43318.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 7 (EC:2.7.11.25)
Alternative name(s):
Transforming growth factor-beta-activated kinase 1
Short name:
TGF-beta-activated kinase 1
Gene namesi
Name:MAP3K7
Synonyms:TAK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6859. MAP3K7.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

  • Note: Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: BHF-UCL
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • endosome membrane Source: Reactome
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63K → W: Loss of kinase activity. 1 Publication1

Organism-specific databases

DisGeNETi6885.
OpenTargetsiENSG00000135341.
PharmGKBiPA30603.

Chemistry databases

ChEMBLiCHEMBL5776.
GuidetoPHARMACOLOGYi2082.

Polymorphism and mutation databases

BioMutaiMAP3K7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862521 – 606Mitogen-activated protein kinase kinase kinase 7Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei184Phosphothreonine; by autocatalysis1 Publication1
Modified residuei187Phosphothreonine; by autocatalysis4 Publications1
Modified residuei192Phosphoserine; by autocatalysis2 Publications1
Modified residuei367PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1

Post-translational modificationi

Association with TAB1/MAP3K7IP1 promotes autophosphorylation at Ser-192 and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Ser-192 by PPM1B/PP2CB and at Thr-187 by PP2A and PPP6C leads to inactivation.6 Publications
'Lys-48'-linked polyubiquitination at Lys-72 is induced by TNFalpha, and leads to proteasomal degradation. Requires 'Lys-63'-linked polyubiquitination for autophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomal degradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains. Deubiquitinated by Y.enterocolitica YopP.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43318.
MaxQBiO43318.
PaxDbiO43318.
PeptideAtlasiO43318.
PRIDEiO43318.

PTM databases

iPTMnetiO43318.
PhosphoSitePlusiO43318.

Expressioni

Tissue specificityi

Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.1 Publication

Gene expression databases

BgeeiENSG00000135341.
CleanExiHS_MAP3K7.
ExpressionAtlasiO43318. baseline and differential.
GenevisibleiO43318. HS.

Organism-specific databases

HPAiHPA007633.

Interactioni

Subunit structurei

Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1, TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3. Identified in the TRIKA2 complex composed of MAP3K7/TAK1, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L and PPM1B/PP2CB. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via WD domains). Interacts with CYLD and RBCK1. Interacts with TGFBR1; induces MAP3K7/TAK1 activation by TRAF6. Interacts with MAPK8IP1 and SMAD6 (By similarity). Interacts with isoform 1 of VRK2. Interacts with DAB2; the interaction is induced by TGF-beta stimulation and may mediate TGF-beta stimulated JNK activation. Interacts with TRIM5.By similarity22 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
cagAB5Z6S04EBI-358684,EBI-7287204From a different organism.
CDC37Q165435EBI-358700,EBI-295634
HSP90AA1P079005EBI-358700,EBI-296047
MAP2K7O147333EBI-358684,EBI-492605
MAPK8IP1Q9UQF211EBI-358684,EBI-78404
NLKQ9UBE83EBI-358684,EBI-366978
PPP6CO007434EBI-358684,EBI-359751
STAT3P407634EBI-358684,EBI-518675
TAB1Q157503EBI-358700,EBI-358643
TAB2Q9NYJ85EBI-358684,EBI-358708
TAB3Q8N5C83EBI-358684,EBI-359964
TRAF6Q9Y4K32EBI-358684,EBI-359276
UBCP0CG484EBI-358684,EBI-3390054

GO - Molecular functioni

  • scaffold protein binding Source: MGI

Protein-protein interaction databases

BioGridi112748. 152 interactors.
DIPiDIP-27523N.
IntActiO43318. 50 interactors.
MINTiMINT-88554.
STRINGi9606.ENSP00000358335.

Chemistry databases

BindingDBiO43318.

Structurei

Secondary structure

1606
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 35Combined sources3
Beta strandi36 – 43Combined sources8
Beta strandi46 – 55Combined sources10
Beta strandi58 – 64Combined sources7
Helixi70 – 83Combined sources14
Beta strandi92 – 95Combined sources4
Turni97 – 100Combined sources4
Beta strandi101 – 105Combined sources5
Helixi112 – 117Combined sources6
Beta strandi119 – 123Combined sources5
Helixi127 – 145Combined sources19
Beta strandi148 – 150Combined sources3
Helixi159 – 161Combined sources3
Beta strandi162 – 165Combined sources4
Turni166 – 169Combined sources4
Beta strandi170 – 173Combined sources4
Helixi193 – 195Combined sources3
Helixi198 – 201Combined sources4
Helixi209 – 224Combined sources16
Turni228 – 232Combined sources5
Helixi236 – 244Combined sources9
Helixi257 – 266Combined sources10
Helixi271 – 273Combined sources3
Helixi277 – 287Combined sources11
Helixi288 – 290Combined sources3
Turni292 – 295Combined sources4
Beta strandi300 – 302Combined sources3
Helixi402 – 411Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EVAX-ray2.00A31-412[»]
2YIYX-ray2.49A31-303[»]
4GS6X-ray2.20A31-303[»]
4L3PX-ray2.68A31-303[»]
4L52X-ray2.54A31-303[»]
4L53X-ray2.55A31-303[»]
4O91X-ray2.39A31-303[»]
5E7RX-ray2.11A31-303[»]
5JGAX-ray2.00A31-303[»]
5JGBX-ray2.80A31-303[»]
5JGDX-ray3.10A31-303[»]
ProteinModelPortaliO43318.
SMRiO43318.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43318.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 291Protein kinasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 300Interaction with MAPK8IP1By similarityAdd BLAST300

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 14Poly-Ser7

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118807.
HOGENOMiHOG000231735.
HOVERGENiHBG003485.
InParanoidiO43318.
KOiK04427.
OMAiPARSHPW.
OrthoDBiEOG091G03QO.
PhylomeDBiO43318.
TreeFamiTF105116.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR017421. MAPKKK7.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR26392:SF74. PTHR26392:SF74. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF038168. MAPKKK7. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1B (identifier: O43318-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV
60 70 80 90 100
CKAKWRAKDV AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV
110 120 130 140 150
CLVMEYAEGG SLYNVLHGAE PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK
160 170 180 190 200
ALIHRDLKPP NLLLVAGGTV LKICDFGTAC DIQTHMTNNK GSAAWMAPEV
210 220 230 240 250
FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM WAVHNGTRPP
260 270 280 290 300
LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY
310 320 330 340 350
PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES
360 370 380 390 400
KLLKNQAKQQ SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA
410 420 430 440 450
ATTAYSKPKR GHRKTASFGN ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP
460 470 480 490 500
GQVSSRSSSP SVRMITTSGP TSEKPTRSHP WTPDDSTDTN GSDNSIPMAY
510 520 530 540 550
LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI ALLLQRKQEL
560 570 580 590 600
VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ

KRQGTS
Length:606
Mass (Da):67,196
Last modified:June 1, 1998 - v1
Checksum:i3D8F8147CD174013
GO
Isoform 1A (identifier: O43318-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     404-430: Missing.

Show »
Length:579
Mass (Da):64,230
Checksum:i40EDE237BBB568EE
GO
Isoform 1C (identifier: O43318-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     509-518: PLAPCPNSKE → ARTSCRTGPG
     519-606: Missing.

Show »
Length:518
Mass (Da):56,706
Checksum:iA92C927A8621AF90
GO
Isoform 1D (identifier: O43318-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     404-430: Missing.
     509-518: PLAPCPNSKE → ARTSCRTGPG
     519-606: Missing.

Show »
Length:491
Mass (Da):53,740
Checksum:iB7D8832E286A99C5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004886404 – 430Missing in isoform 1A and isoform 1D. 4 PublicationsAdd BLAST27
Alternative sequenceiVSP_004887509 – 518PLAPCPNSKE → ARTSCRTGPG in isoform 1C and isoform 1D. 2 Publications10
Alternative sequenceiVSP_004888519 – 606Missing in isoform 1C and isoform 1D. 2 PublicationsAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009357 mRNA. Translation: BAA25026.1.
AB009356 mRNA. Translation: BAA25025.1.
AB009358 mRNA. Translation: BAA25027.2.
AF218074 mRNA. Translation: AAF27652.1.
DQ314875 Genomic DNA. Translation: ABC40734.1.
AK315774 mRNA. Translation: BAG38124.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19609.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19610.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19611.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19612.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23530.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23531.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23532.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23533.1.
CH471051 Genomic DNA. Translation: EAW48525.1.
CH471051 Genomic DNA. Translation: EAW48526.1.
CH471051 Genomic DNA. Translation: EAW48527.1.
CH471051 Genomic DNA. Translation: EAW48529.1.
BC017715 mRNA. Translation: AAH17715.1.
CCDSiCCDS5027.1. [O43318-2]
CCDS5028.1. [O43318-1]
CCDS5029.1. [O43318-3]
CCDS5030.1. [O43318-4]
PIRiJC5955.
JC5956.
RefSeqiNP_003179.1. NM_003188.3. [O43318-2]
NP_663304.1. NM_145331.2. [O43318-1]
NP_663305.1. NM_145332.2. [O43318-3]
NP_663306.1. NM_145333.2. [O43318-4]
UniGeneiHs.594838.

Genome annotation databases

EnsembliENST00000369325; ENSP00000358331; ENSG00000135341. [O43318-3]
ENST00000369327; ENSP00000358333; ENSG00000135341. [O43318-4]
ENST00000369329; ENSP00000358335; ENSG00000135341. [O43318-1]
ENST00000369332; ENSP00000358338; ENSG00000135341. [O43318-2]
GeneIDi6885.
KEGGihsa:6885.
UCSCiuc003pnz.3. human. [O43318-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009357 mRNA. Translation: BAA25026.1.
AB009356 mRNA. Translation: BAA25025.1.
AB009358 mRNA. Translation: BAA25027.2.
AF218074 mRNA. Translation: AAF27652.1.
DQ314875 Genomic DNA. Translation: ABC40734.1.
AK315774 mRNA. Translation: BAG38124.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19609.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19610.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19611.1.
AL121964, AL121837 Genomic DNA. Translation: CAI19612.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23530.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23531.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23532.1.
AL121837, AL121964 Genomic DNA. Translation: CAI23533.1.
CH471051 Genomic DNA. Translation: EAW48525.1.
CH471051 Genomic DNA. Translation: EAW48526.1.
CH471051 Genomic DNA. Translation: EAW48527.1.
CH471051 Genomic DNA. Translation: EAW48529.1.
BC017715 mRNA. Translation: AAH17715.1.
CCDSiCCDS5027.1. [O43318-2]
CCDS5028.1. [O43318-1]
CCDS5029.1. [O43318-3]
CCDS5030.1. [O43318-4]
PIRiJC5955.
JC5956.
RefSeqiNP_003179.1. NM_003188.3. [O43318-2]
NP_663304.1. NM_145331.2. [O43318-1]
NP_663305.1. NM_145332.2. [O43318-3]
NP_663306.1. NM_145333.2. [O43318-4]
UniGeneiHs.594838.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EVAX-ray2.00A31-412[»]
2YIYX-ray2.49A31-303[»]
4GS6X-ray2.20A31-303[»]
4L3PX-ray2.68A31-303[»]
4L52X-ray2.54A31-303[»]
4L53X-ray2.55A31-303[»]
4O91X-ray2.39A31-303[»]
5E7RX-ray2.11A31-303[»]
5JGAX-ray2.00A31-303[»]
5JGBX-ray2.80A31-303[»]
5JGDX-ray3.10A31-303[»]
ProteinModelPortaliO43318.
SMRiO43318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112748. 152 interactors.
DIPiDIP-27523N.
IntActiO43318. 50 interactors.
MINTiMINT-88554.
STRINGi9606.ENSP00000358335.

Chemistry databases

BindingDBiO43318.
ChEMBLiCHEMBL5776.
GuidetoPHARMACOLOGYi2082.

PTM databases

iPTMnetiO43318.
PhosphoSitePlusiO43318.

Polymorphism and mutation databases

BioMutaiMAP3K7.

Proteomic databases

EPDiO43318.
MaxQBiO43318.
PaxDbiO43318.
PeptideAtlasiO43318.
PRIDEiO43318.

Protocols and materials databases

DNASUi6885.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369325; ENSP00000358331; ENSG00000135341. [O43318-3]
ENST00000369327; ENSP00000358333; ENSG00000135341. [O43318-4]
ENST00000369329; ENSP00000358335; ENSG00000135341. [O43318-1]
ENST00000369332; ENSP00000358338; ENSG00000135341. [O43318-2]
GeneIDi6885.
KEGGihsa:6885.
UCSCiuc003pnz.3. human. [O43318-1]

Organism-specific databases

CTDi6885.
DisGeNETi6885.
GeneCardsiMAP3K7.
HGNCiHGNC:6859. MAP3K7.
HPAiHPA007633.
MIMi602614. gene.
neXtProtiNX_O43318.
OpenTargetsiENSG00000135341.
PharmGKBiPA30603.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0192. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118807.
HOGENOMiHOG000231735.
HOVERGENiHBG003485.
InParanoidiO43318.
KOiK04427.
OMAiPARSHPW.
OrthoDBiEOG091G03QO.
PhylomeDBiO43318.
TreeFamiTF105116.

Enzyme and pathway databases

BioCyciZFISH:HS05984-MONOMER.
ReactomeiR-HSA-1169091. Activation of NF-kappaB in B cells.
R-HSA-168638. NOD1/2 Signaling Pathway.
R-HSA-202424. Downstream TCR signaling.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-4086398. Ca2+ pathway.
R-HSA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-HSA-446652. Interleukin-1 signaling.
R-HSA-450302. activated TAK1 mediates p38 MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-HSA-5607764. CLEC7A (Dectin-1) signaling.
R-HSA-5689880. Ub-specific processing proteases.
R-HSA-937042. IRAK2 mediated activation of TAK1 complex.
R-HSA-937072. TRAF6 mediated induction of TAK1 complex.
R-HSA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
SignaLinkiO43318.
SIGNORiO43318.

Miscellaneous databases

ChiTaRSiMAP3K7. human.
EvolutionaryTraceiO43318.
GeneWikiiMAP3K7.
GenomeRNAii6885.
PROiO43318.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135341.
CleanExiHS_MAP3K7.
ExpressionAtlasiO43318. baseline and differential.
GenevisibleiO43318. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR017421. MAPKKK7.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR26392:SF74. PTHR26392:SF74. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF038168. MAPKKK7. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiM3K7_HUMAN
AccessioniPrimary (citable) accession number: O43318
Secondary accession number(s): B2RE27
, E1P523, O43317, O43319, Q5TDN2, Q5TDN3, Q5TDT7, Q9NTR3, Q9NZ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 185 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.