##gff-version 3
O43316	UniProtKB	Chain	1	350	.	.	.	ID=PRO_0000050180;Note=Paired box protein Pax-4	
O43316	UniProtKB	DNA binding	5	131	.	.	.	Note=Paired;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00381	
O43316	UniProtKB	DNA binding	170	229	.	.	.	Note=Homeobox;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00108	
O43316	UniProtKB	Region	8	64	.	.	.	Note=PAI subdomain;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00381	
O43316	UniProtKB	Region	83	131	.	.	.	Note=RED subdomain;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00381	
O43316	UniProtKB	Region	153	172	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O43316	UniProtKB	Region	278	350	.	.	.	Note=Transcription repression	
O43316	UniProtKB	Compositional bias	158	172	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O43316	UniProtKB	Alternative sequence	1	8	.	.	.	ID=VSP_036448;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9753306;Dbxref=PMID:15489334,PMID:9753306	
O43316	UniProtKB	Alternative sequence	239	257	.	.	.	ID=VSP_002359;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O43316	UniProtKB	Alternative sequence	258	350	.	.	.	ID=VSP_002360;Note=In isoform 2. QSPGSVPTAALPALEPLGPSCYQLCWATAPERCLSDTPPKACLKPCWDCGSFLLPVIAPSCVDVAWPCLDASLAHHLIGGAGKATPTHFSHWP->AVPWQCAHSSPACPGTTGSLLLSAVLGNSTRKVSE;Ontology_term=ECO:0000305;evidence=ECO:0000305	
O43316	UniProtKB	Alternative sequence	305	350	.	.	.	ID=VSP_036449;Note=In isoform 3. DCGSFLLPVIAPSCVDVAWPCLDASLAHHLIGGAGKATPTHFSHWP->GHLPPQPNSLDSGLLCLPCPSSHCHLASLSGSQALLWPGCPLLYGLE;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9753306;Dbxref=PMID:15489334,PMID:9753306	
O43316	UniProtKB	Natural variant	39	39	.	.	.	ID=VAR_054879;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17426099;Dbxref=dbSNP:rs115887120,PMID:17426099	
O43316	UniProtKB	Natural variant	45	45	.	.	.	ID=VAR_054880;Note=In KPD%3B uncertain significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15509590;Dbxref=dbSNP:rs35155575,PMID:15509590	
O43316	UniProtKB	Natural variant	129	129	.	.	.	ID=VAR_054881;Note=In T2D%3B uncertain significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11723072;Dbxref=dbSNP:rs114202595,PMID:11723072	
O43316	UniProtKB	Natural variant	141	141	.	.	.	ID=VAR_054882;Note=In KPD%3B uncertain significance. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15509590;Dbxref=dbSNP:rs2233578,PMID:15509590	
O43316	UniProtKB	Natural variant	172	172	.	.	.	ID=VAR_054883;Note=In MODY9%3B the mutant sequence represses the activity of the insulin and glucagon promoters by only 35%25 compared to 50%25 and 57%25 respectively with wild-type sequence. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17426099;Dbxref=PMID:17426099	
O43316	UniProtKB	Natural variant	191	191	.	.	.	ID=VAR_054884;Note=R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17426099;Dbxref=dbSNP:rs114315130,PMID:17426099	
O43316	UniProtKB	Natural variant	200	200	.	.	.	ID=VAR_054885;Note=R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17426099;Dbxref=dbSNP:rs2233580,PMID:17426099	
O43316	UniProtKB	Natural variant	200	200	.	.	.	ID=VAR_054886;Note=R->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17426099;Dbxref=dbSNP:rs3824004,PMID:17426099	
O43316	UniProtKB	Natural variant	321	321	.	.	.	ID=VAR_082834;Note=H->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15834548,ECO:0000269|PubMed:17426099;Dbxref=dbSNP:rs712701,PMID:15834548,PMID:17426099