Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43315

- AQP9_HUMAN

UniProt

O43315 - AQP9_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Aquaporin-9

Gene

AQP9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na+, K+, Cl-, and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.1 Publication

GO - Molecular functioni

  1. amine transmembrane transporter activity Source: UniProtKB
  2. carboxylic acid transmembrane transporter activity Source: UniProtKB
  3. glycerol channel activity Source: Reactome
  4. polyol transmembrane transporter activity Source: UniProtKB
  5. porin activity Source: UniProtKB
  6. purine nucleobase transmembrane transporter activity Source: UniProtKB
  7. pyrimidine nucleobase transmembrane transporter activity Source: UniProtKB
  8. water channel activity Source: UniProtKB
  9. water transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. amine transport Source: UniProtKB
  2. canalicular bile acid transport Source: Ensembl
  3. carboxylic acid transport Source: UniProtKB
  4. cellular response to cAMP Source: UniProtKB
  5. excretion Source: UniProtKB
  6. glycerol transport Source: Reactome
  7. immune response Source: ProtInc
  8. metabolic process Source: UniProtKB
  9. polyol transport Source: UniProtKB
  10. purine nucleobase transport Source: UniProtKB
  11. pyrimidine-containing compound transmembrane transport Source: GOC
  12. pyrimidine nucleobase transport Source: UniProtKB
  13. response to mercury ion Source: UniProtKB
  14. response to organic substance Source: UniProtKB
  15. response to osmotic stress Source: UniProtKB
  16. transmembrane transport Source: Reactome
  17. transport Source: UniProtKB
  18. water homeostasis Source: UniProtKB
  19. water transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_23809. Transport of glycerol from adipocytes to the liver by Aquaporins.
REACT_23826. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-9
Short name:
AQP-9
Alternative name(s):
Aquaglyceroporin-9
Small solute channel 1
Gene namesi
Name:AQP9
Synonyms:SSC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:643. AQP9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST
Topological domaini51 – 544ExtracellularSequence Analysis
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 11035CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Topological domaini132 – 15827ExtracellularSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Topological domaini180 – 18910CytoplasmicSequence Analysis
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 24535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence AnalysisAdd
BLAST
Topological domaini267 – 29529CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB
  3. integral component of plasma membrane Source: ProtInc
  4. intracellular membrane-bounded organelle Source: UniProtKB
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

MIMi602914. gene+phenotype.
PharmGKBiPA24927.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Aquaporin-9PRO_0000063964Add
BLAST

Proteomic databases

PaxDbiO43315.
PRIDEiO43315.

PTM databases

PhosphoSiteiO43315.

Expressioni

Tissue specificityi

Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.

Gene expression databases

BgeeiO43315.
CleanExiHS_AQP9.
ExpressionAtlasiO43315. baseline and differential.
GenevestigatoriO43315.

Interactioni

Protein-protein interaction databases

BioGridi106861. 1 interaction.
STRINGi9606.ENSP00000219919.

Structurei

3D structure databases

ProteinModelPortaliO43315.
SMRiO43315. Positions 21-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi84 – 863NPA 1
Motifi216 – 2183NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0580.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiO43315.
KOiK09877.
OMAiMIGENSF.
PhylomeDBiO43315.
TreeFamiTF313173.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR015685. Aquaporin_9.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PTHR19139:SF15. PTHR19139:SF15. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02021. AQUAPORIN9.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43315-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPEGAEKGK SFKQRLVLKS SLAKETLSEF LGTFILIVLG CGCVAQAILS
60 70 80 90 100
RGRFGGVITI NVGFSMAVAM AIYVAGGVSG GHINPAVSLA MCLFGRMKWF
110 120 130 140 150
KLPFYVGAQF LGAFVGAATV FGIYYDGLMS FAGGKLLIVG ENATAHIFAT
160 170 180 190 200
YPAPYLSLAN AFADQVVATM ILLIIVFAIF DSRNLGAPRG LEPIAIGLLI
210 220 230 240 250
IVIASSLGLN SGCAMNPARD LSPRLFTALA GWGFEVFRAG NNFWWIPVVG
260 270 280 290
PLVGAVIGGL IYVLVIEIHH PEPDSVFKTE QSEDKPEKYE LSVIM
Length:295
Mass (Da):31,431
Last modified:January 11, 2011 - v2
Checksum:iB3B416CD9F1F9CAF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti279 – 2791T → A.3 Publications
Corresponds to variant rs1867380 [ dbSNP | Ensembl ].
VAR_024538

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008775 mRNA. Translation: BAA24864.1.
AF016495 mRNA. Translation: AAF16677.1.
AF102870 Genomic DNA. Translation: AAF27983.1.
AC025431 Genomic DNA. No translation available.
AC066616 Genomic DNA. No translation available.
BC026258 mRNA. Translation: AAH26258.1.
CCDSiCCDS10165.1.
PIRiJC5973.
RefSeqiNP_066190.2. NM_020980.3.
UniGeneiHs.104624.

Genome annotation databases

EnsembliENST00000219919; ENSP00000219919; ENSG00000103569.
ENST00000536493; ENSP00000441390; ENSG00000103569.
GeneIDi366.
KEGGihsa:366.
UCSCiuc002aez.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008775 mRNA. Translation: BAA24864.1 .
AF016495 mRNA. Translation: AAF16677.1 .
AF102870 Genomic DNA. Translation: AAF27983.1 .
AC025431 Genomic DNA. No translation available.
AC066616 Genomic DNA. No translation available.
BC026258 mRNA. Translation: AAH26258.1 .
CCDSi CCDS10165.1.
PIRi JC5973.
RefSeqi NP_066190.2. NM_020980.3.
UniGenei Hs.104624.

3D structure databases

ProteinModelPortali O43315.
SMRi O43315. Positions 21-269.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106861. 1 interaction.
STRINGi 9606.ENSP00000219919.

Chemistry

GuidetoPHARMACOLOGYi 696.

PTM databases

PhosphoSitei O43315.

Proteomic databases

PaxDbi O43315.
PRIDEi O43315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000219919 ; ENSP00000219919 ; ENSG00000103569 .
ENST00000536493 ; ENSP00000441390 ; ENSG00000103569 .
GeneIDi 366.
KEGGi hsa:366.
UCSCi uc002aez.2. human.

Organism-specific databases

CTDi 366.
GeneCardsi GC15P058430.
H-InvDB HIX0012281.
HGNCi HGNC:643. AQP9.
MIMi 602914. gene+phenotype.
neXtProti NX_O43315.
PharmGKBi PA24927.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0580.
GeneTreei ENSGT00510000046311.
HOGENOMi HOG000288287.
HOVERGENi HBG106057.
InParanoidi O43315.
KOi K09877.
OMAi MIGENSF.
PhylomeDBi O43315.
TreeFami TF313173.

Enzyme and pathway databases

Reactomei REACT_23809. Transport of glycerol from adipocytes to the liver by Aquaporins.
REACT_23826. Passive transport by Aquaporins.

Miscellaneous databases

GeneWikii AQP9.
GenomeRNAii 366.
NextBioi 1527.
PROi O43315.
SOURCEi Search...

Gene expression databases

Bgeei O43315.
CleanExi HS_AQP9.
ExpressionAtlasi O43315. baseline and differential.
Genevestigatori O43315.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR015685. Aquaporin_9.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view ]
PANTHERi PTHR19139. PTHR19139. 1 hit.
PTHR19139:SF15. PTHR19139:SF15. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PRINTSi PR02021. AQUAPORIN9.
PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
TIGRFAMsi TIGR00861. MIP. 1 hit.
PROSITEi PS00221. MIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol."
    Ishibashi K., Kuwahara M., Gu Y., Tanaka Y., Marumo F., Sasaki S.
    Biochem. Biophys. Res. Commun. 244:268-274(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-279.
    Tissue: Liver.
  2. "Functional and molecular characterization of the human neutral solute channel aquaporin-9."
    Tsukaguchi H., Weremowicz S., Morton C.C., Hediger M.A.
    Am. J. Physiol. 277:F685-F696(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, VARIANT ALA-279.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-279.
    Tissue: Liver.

Entry informationi

Entry nameiAQP9_HUMAN
AccessioniPrimary (citable) accession number: O43315
Secondary accession number(s): Q9NP32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3