ATMIN

Functionⁱ

Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	84 – 109	C2H2-type 1Add BLAST		26
Zinc fingerⁱ	165 – 184	C2H2-type 2; degenerateAdd BLAST		20

GO - Molecular functionⁱ

dynein complex binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22167198
metal ion binding Source: UniProtKB-KW
transcription regulatory region DNA binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

cellular response to DNA damage stimulus Source: UniProtKB-KW
motile cilium assembly Source: Ensembl
positive regulation of non-motile cilium assembly Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 22167198
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Activator
Biological process	DNA damage, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATM interactor Alternative name(s): ATM/ATR-substrate CHK2-interacting zinc finger protein Short name: ASCIZ Zinc finger protein 822
Gene namesⁱ	Name:ATMIN Synonyms:KIAA0431, ZNF822
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29034. ATMIN.

HGNCⁱ

HGNC:29034. ATMIN.

Subcellular locationⁱ

Nucleus
2 Publications
Manual assertion based on experiment inⁱ
- Ref.6
  "ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage."
  McNees C.J., Conlan L.A., Tenis N., Heierhorst J.
  EMBO J. 24:2447-2457(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, REGION.
- Ref.7
  "ATMIN defines an NBS1-independent pathway of ATM signalling."
  Kanu N., Behrens A.
  EMBO J. 26:2933-2941(2007) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, INTERACTION WITH ATM, SUBCELLULAR LOCATION.

Note:

Nuclear, in discrete foci during G1 phase.

GO - Cellular componentⁱ

nuclear body Source: HPA

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23300.
Open Targets More...OpenTargetsⁱ	ENSG00000166454.
PharmGKBⁱ	PA162377191.

Polymorphism and mutation databases

BioMutaⁱ	ATMIN.

BioMutaⁱ

ATMIN.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050756	1 – 823	ATM interactorAdd BLAST		823

Proteomic databases

EPDⁱ	O43313.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43313.
PaxDbⁱ	O43313.
PeptideAtlas More...PeptideAtlasⁱ	O43313.
PRIDEⁱ	O43313.

PTM databases

iPTMnetⁱ	O43313.
PhosphoSitePlusⁱ	O43313.

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000166454.
CleanExⁱ	HS_ATMIN.
ExpressionAtlasⁱ	O43313. baseline and differential.
Genevisibleⁱ	O43313. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054967. HPA066900.

HPAⁱ

HPA054967.
HPA066900.

Interactionⁱ

Subunit structureⁱ

Interacts via its C-terminus with ATM. Interacts with DYNLL1; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ATM	Q13315	5	EBI-7422202,EBI-495465

With

Entry

#Exp.

IntAct

Notes

ATM

Q13315

5

EBI-7422202,EBI-495465

GO - Molecular functionⁱ

dynein complex binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22167198

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	116892. 6 interactors.
IntActⁱ	O43313. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4979558.
STRINGⁱ	9606.ENSP00000299575.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43313.
SMRⁱ	O43313.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	223 – 442	Required for formation of RAD51 fociAdd BLAST		220

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	2 – 33	Ala-richAdd BLAST		32

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	84 – 109	C2H2-type 1Add BLAST		26
Zinc fingerⁱ	165 – 184	C2H2-type 2; degenerateAdd BLAST		20

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013091.
HOGENOMⁱ	HOG000034178.
HOVERGENⁱ	HBG106238.
InParanoidⁱ	O43313.
OMAⁱ	CPRGPNR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EJB.
PhylomeDBⁱ	O43313.
TreeFamⁱ	TF331171.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013087. Znf_C2H2_type.
SMARTⁱ	View protein in SMART SM00355. ZnF_C2H2. 4 hits.
PROSITEⁱ	View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: O43313-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASEAAAAA GSAALAAGAR AVPAATTGAA AAASGPWVPP GPRLRGSRPR 
        60         70         80         90        100
PAGATQQPAV PAPPAGELIQ PSVSELSRAV RTNILCTVRG CGKILPNSPA 
       110        120        130        140        150
LNMHLVKSHR LQDGIVNPTI RKDLKTGPKF YCCPIEGCPR GPERPFSQFS 
       160        170        180        190        200
LVKQHFMKMH AEKKHKCSKC SNSYGTEWDL KRHAEDCGKT FRCTCGCPYA 
       210        220        230        240        250
SRTALQSHIY RTGHEIPAEH RDPPSKKRKM ENCAQNQKLS NKTIESLNNQ 
       260        270        280        290        300
PIPRPDTQEL EASEIKLEPS FEDSCGSNTD KQTLTTPPRY PQKLLLPKPK 
       310        320        330        340        350
VALVKLPVMQ FSVMPVFVPT ADSSAQPVVL GVDQGSATGA VHLMPLSVGT 
       360        370        380        390        400
LILGLDSEAC SLKESLPLFK IANPIAGEPI STGVQVNFGK SPSNPLQELG 
       410        420        430        440        450
NTCQKNSISS INVQTDLSYA SQNFIPSAQW ATADSSVSSC SQTDLSFDSQ 
       460        470        480        490        500
VSLPISVHTQ TFLPSSKVTS SIAAQTDAFM DTCFQSGGVS RETQTSGIES 
       510        520        530        540        550
PTDDHVQMDQ AGMCGDIFES VHSSYNVATG NIISNSLVAE TVTHSLLPQN 
       560        570        580        590        600
EPKTLNQDIE KSAPIINFSA QNSMLPSQNM TDNQTQTIDL LSDLENILSS 
       610        620        630        640        650
NLPAQTLDHR SLLSDTNPGP DTQLPSGPAQ NPGIDFDIEE FFSASNIQTQ 
       660        670        680        690        700
TEESELSTMT TEPVLESLDI ETQTDFLLAD TSAQSYGCRG NSNFLGLEMF 
       710        720        730        740        750
DTQTQTDLNF FLDSSPHLPL GSILKHSSFS VSTDSSDTET QTEGVSTAKN 
       760        770        780        790        800
IPALESKVQL NSTETQTMSS GFETLGSLFF TSNETQTAMD DFLLADLAWN 
       810        820 
TMESQFSSVE TQTSAEPHTV SNF

Length:823

Mass (Da):88,348

Last modified:November 25, 2008 - v2

Checksum:ⁱ59CDBD56381539E9

GO

Isoform 2 (identifier: O43313-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-156: Missing.

« Hide

        10         20         30         40         50
MKMHAEKKHK CSKCSNSYGT EWDLKRHAED CGKTFRCTCG CPYASRTALQ 
        60         70         80         90        100
SHIYRTGHEI PAEHRDPPSK KRKMENCAQN QKLSNKTIES LNNQPIPRPD 
       110        120        130        140        150
TQELEASEIK LEPSFEDSCG SNTDKQTLTT PPRYPQKLLL PKPKVALVKL 
       160        170        180        190        200
PVMQFSVMPV FVPTADSSAQ PVVLGVDQGS ATGAVHLMPL SVGTLILGLD 
       210        220        230        240        250
SEACSLKESL PLFKIANPIA GEPISTGVQV NFGKSPSNPL QELGNTCQKN 
       260        270        280        290        300
SISSINVQTD LSYASQNFIP SAQWATADSS VSSCSQTDLS FDSQVSLPIS 
       310        320        330        340        350
VHTQTFLPSS KVTSSIAAQT DAFMDTCFQS GGVSRETQTS GIESPTDDHV 
       360        370        380        390        400
QMDQAGMCGD IFESVHSSYN VATGNIISNS LVAETVTHSL LPQNEPKTLN 
       410        420        430        440        450
QDIEKSAPII NFSAQNSMLP SQNMTDNQTQ TIDLLSDLEN ILSSNLPAQT 
       460        470        480        490        500
LDHRSLLSDT NPGPDTQLPS GPAQNPGIDF DIEEFFSASN IQTQTEESEL 
       510        520        530        540        550
STMTTEPVLE SLDIETQTDF LLADTSAQSY GCRGNSNFLG LEMFDTQTQT 
       560        570        580        590        600
DLNFFLDSSP HLPLGSILKH SSFSVSTDSS DTETQTEGVS TAKNIPALES 
       610        620        630        640        650
KVQLNSTETQ TMSSGFETLG SLFFTSNETQ TAMDDFLLAD LAWNTMESQF 
       660 
SSVETQTSAE PHTVSNF

Show »

Length:667

Mass (Da):72,334

Checksum:ⁱE23D09D9C4F60210

GO

Sequence cautionⁱ

The sequence BAA24861 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAF83632 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	174	Y → C in CAH18291 (PubMed:17974005).Curated	1
Sequence conflictⁱ	309	M → V in BAF83632 (PubMed:14702039).Curated	1
Sequence conflictⁱ	338	T → A in CAH18291 (PubMed:17974005).Curated	1
Sequence conflictⁱ	433	A → T in CAH18291 (PubMed:17974005).Curated	1
Sequence conflictⁱ	474	A → P in CAH18291 (PubMed:17974005).Curated	1
Sequence conflictⁱ	525	Y → H in CAH18291 (PubMed:17974005).Curated	1
Sequence conflictⁱ	703	Q → R in BAF83632 (PubMed:14702039).Curated	1
Sequence conflictⁱ	814	S → P in CAH18291 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050681	240	S → P. Corresponds to variant dbSNP:rs2278022Ensembl.		1
Natural variantⁱVAR_050682	305	K → E. Corresponds to variant dbSNP:rs2278023Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035820	1 – 156	Missing in isoform 2. 2 PublicationsAdd BLAST		156

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB007891 mRNA. Translation: BAA24861.2. Different initiation. CR749457 mRNA. Translation: CAH18291.1. AC092718 Genomic DNA. No translation available. BC002701 mRNA. Translation: AAH02701.2. AK290943 mRNA. Translation: BAF83632.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32494.1. [O43313-1] CCDS73917.1. [O43313-2]
PIRⁱ	T00061.
NCBI Reference Sequences More...RefSeqⁱ	NP_001287657.1. NM_001300728.1. [O43313-2] NP_056066.2. NM_015251.2. [O43313-1]
UniGeneⁱ	Hs.16349. Hs.589959.

Genome annotation databases

Ensemblⁱ	ENST00000299575; ENSP00000299575; ENSG00000166454. [O43313-1] ENST00000564241; ENSP00000463478; ENSG00000166454. [O43313-2] ENST00000566488; ENSP00000455497; ENSG00000166454. [O43313-2]
GeneIDⁱ	23300.
KEGGⁱ	hsa:23300.
UCSC genome browser More...UCSCⁱ	uc002ffz.2. human. [O43313-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
O43313	D3DUL0 O43313-2 J3QRX7	Homo sapiens (Human)	823	UniRef100_O43313	Cluster: ATM interactor	4

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
O43313	D3DUL0 O43313-2 J3QRX7 UPI00080A3957 UPI000B50DAD5 U3C6V0 F7A5T6 F6WWC3 UPI0004F03A9C A0A1D5QHW0 +45	Homo sapiens (Human) Cebus capucinus imitator Aotus nancymaae (Ma's night monkey) Callithrix jacchus (White-tufted-ear marmoset) Macaca mulatta (Rhesus macaque) Macaca nemestrina (Pig-tailed macaque) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Papio anubis (Olive baboon) And more	823	UniRef90_O43313	Cluster: ATM interactor	56

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
O43313	D3DUL0 O43313-2 J3QRX7 UPI00080A3957 UPI000B50DAD5 UPI0005F49844 U3C6V0 F7A5T6 F6WWC3 UPI0004F03A9C +60	Homo sapiens (Human) Cebus capucinus imitator Aotus nancymaae (Ma's night monkey) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Callithrix jacchus (White-tufted-ear marmoset) Macaca nemestrina (Pig-tailed macaque) Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Gorilla gorilla gorilla (Western lowland gorilla) Papio anubis (Olive baboon) And more	823	UniRef50_O43313	Cluster: ATM interactor	71

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB007891 mRNA. Translation: BAA24861.2. Different initiation. CR749457 mRNA. Translation: CAH18291.1. AC092718 Genomic DNA. No translation available. BC002701 mRNA. Translation: AAH02701.2. AK290943 mRNA. Translation: BAF83632.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32494.1. [O43313-1] CCDS73917.1. [O43313-2]
PIRⁱ	T00061.
NCBI Reference Sequences More...RefSeqⁱ	NP_001287657.1. NM_001300728.1. [O43313-2] NP_056066.2. NM_015251.2. [O43313-1]
UniGeneⁱ	Hs.16349. Hs.589959.

3D structure databases

ProteinModelPortalⁱ	O43313.
SMRⁱ	O43313.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116892. 6 interactors.
IntActⁱ	O43313. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4979558.
STRINGⁱ	9606.ENSP00000299575.

PTM databases

iPTMnetⁱ	O43313.
PhosphoSitePlusⁱ	O43313.

Polymorphism and mutation databases

BioMutaⁱ	ATMIN.

BioMutaⁱ

ATMIN.

Proteomic databases

EPDⁱ	O43313.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43313.
PaxDbⁱ	O43313.
PeptideAtlas More...PeptideAtlasⁱ	O43313.
PRIDEⁱ	O43313.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000299575; ENSP00000299575; ENSG00000166454. [O43313-1] ENST00000564241; ENSP00000463478; ENSG00000166454. [O43313-2] ENST00000566488; ENSP00000455497; ENSG00000166454. [O43313-2]
GeneIDⁱ	23300.
KEGGⁱ	hsa:23300.
UCSC genome browser More...UCSCⁱ	uc002ffz.2. human. [O43313-1]

Organism-specific databases

CTDⁱ	23300.
DisGeNET More...DisGeNETⁱ	23300.
GeneCardsⁱ	ATMIN.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29034. ATMIN.
Human Protein Atlas More...HPAⁱ	HPA054967. HPA066900.
MIMⁱ	614693. gene.
neXtProtⁱ	NX_O43313.
Open Targets More...OpenTargetsⁱ	ENSG00000166454.
PharmGKBⁱ	PA162377191.
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013091.
HOGENOMⁱ	HOG000034178.
HOVERGENⁱ	HBG106238.
InParanoidⁱ	O43313.
OMAⁱ	CPRGPNR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EJB.
PhylomeDBⁱ	O43313.
TreeFamⁱ	TF331171.

Miscellaneous databases

ChiTaRSⁱ	ATMIN. human.
GenomeRNAiⁱ	23300.
Protein Ontology More...PROⁱ	PR:O43313.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166454.
CleanExⁱ	HS_ATMIN.
ExpressionAtlasⁱ	O43313. baseline and differential.
Genevisibleⁱ	O43313. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013087. Znf_C2H2_type.
SMARTⁱ	View protein in SMART SM00355. ZnF_C2H2. 4 hits.
PROSITEⁱ	View protein in PROSITE PS00028. ZINC_FINGER_C2H2_1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATMIN_HUMAN
Accessionⁱ	O43313Primary (citable) accession number: O43313 Secondary accession number(s): A8K4H8, Q68DC9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	November 25, 2008
	Last modified:	August 30, 2017
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

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Supporting data

UniProtKB - O43313 (ATMIN_HUMAN)

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ATM interactor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

Zinc finger

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ