Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O43313 (ATMIN_HUMAN)

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

ATM interactor

Gene

ATMIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 109C2H2-type 1Add BLAST26
Zinc fingeri165 – 184C2H2-type 2; degenerateAdd BLAST20

GO - Molecular functioni

  • dynein complex binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • transcription regulatory region DNA binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionActivator
Biological processDNA damage, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATM interactor
Alternative name(s):
ATM/ATR-substrate CHK2-interacting zinc finger protein
Short name:
ASCIZ
Zinc finger protein 822
Gene namesi
Name:ATMIN
Synonyms:KIAA0431, ZNF822
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29034. ATMIN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166454.
PharmGKBiPA162377191.

Polymorphism and mutation databases

BioMutaiATMIN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507561 – 823ATM interactorAdd BLAST823

Proteomic databases

EPDiO43313.
MaxQBiO43313.
PaxDbiO43313.
PeptideAtlasiO43313.
PRIDEiO43313.

PTM databases

iPTMnetiO43313.
PhosphoSitePlusiO43313.

Expressioni

Tissue specificityi

Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000166454.
CleanExiHS_ATMIN.
ExpressionAtlasiO43313. baseline and differential.
GenevisibleiO43313. HS.

Organism-specific databases

HPAiHPA054967.
HPA066900.

Interactioni

Subunit structurei

Interacts via its C-terminus with ATM. Interacts with DYNLL1; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATMQ133155EBI-7422202,EBI-495465

GO - Molecular functioni

  • dynein complex binding Source: UniProtKB
Complete GO annotation...

Protein-protein interaction databases

BioGridi116892. 6 interactors.
IntActiO43313. 2 interactors.
MINTiMINT-4979558.
STRINGi9606.ENSP00000299575.

Structurei

3D structure databases

ProteinModelPortaliO43313.
SMRiO43313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 442Required for formation of RAD51 fociAdd BLAST220

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 33Ala-richAdd BLAST32

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 109C2H2-type 1Add BLAST26
Zinc fingeri165 – 184C2H2-type 2; degenerateAdd BLAST20

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000013091.
HOGENOMiHOG000034178.
HOVERGENiHBG106238.
InParanoidiO43313.
OMAiCPRGPNR.
OrthoDBiEOG091G0EJB.
PhylomeDBiO43313.
TreeFamiTF331171.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43313-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASEAAAAA GSAALAAGAR AVPAATTGAA AAASGPWVPP GPRLRGSRPR 
        60         70         80         90        100
PAGATQQPAV PAPPAGELIQ PSVSELSRAV RTNILCTVRG CGKILPNSPA 
       110        120        130        140        150
LNMHLVKSHR LQDGIVNPTI RKDLKTGPKF YCCPIEGCPR GPERPFSQFS 
       160        170        180        190        200
LVKQHFMKMH AEKKHKCSKC SNSYGTEWDL KRHAEDCGKT FRCTCGCPYA 
       210        220        230        240        250
SRTALQSHIY RTGHEIPAEH RDPPSKKRKM ENCAQNQKLS NKTIESLNNQ 
       260        270        280        290        300
PIPRPDTQEL EASEIKLEPS FEDSCGSNTD KQTLTTPPRY PQKLLLPKPK 
       310        320        330        340        350
VALVKLPVMQ FSVMPVFVPT ADSSAQPVVL GVDQGSATGA VHLMPLSVGT 
       360        370        380        390        400
LILGLDSEAC SLKESLPLFK IANPIAGEPI STGVQVNFGK SPSNPLQELG 
       410        420        430        440        450
NTCQKNSISS INVQTDLSYA SQNFIPSAQW ATADSSVSSC SQTDLSFDSQ 
       460        470        480        490        500
VSLPISVHTQ TFLPSSKVTS SIAAQTDAFM DTCFQSGGVS RETQTSGIES 
       510        520        530        540        550
PTDDHVQMDQ AGMCGDIFES VHSSYNVATG NIISNSLVAE TVTHSLLPQN 
       560        570        580        590        600
EPKTLNQDIE KSAPIINFSA QNSMLPSQNM TDNQTQTIDL LSDLENILSS 
       610        620        630        640        650
NLPAQTLDHR SLLSDTNPGP DTQLPSGPAQ NPGIDFDIEE FFSASNIQTQ 
       660        670        680        690        700
TEESELSTMT TEPVLESLDI ETQTDFLLAD TSAQSYGCRG NSNFLGLEMF 
       710        720        730        740        750
DTQTQTDLNF FLDSSPHLPL GSILKHSSFS VSTDSSDTET QTEGVSTAKN 
       760        770        780        790        800
IPALESKVQL NSTETQTMSS GFETLGSLFF TSNETQTAMD DFLLADLAWN 
       810        820 
TMESQFSSVE TQTSAEPHTV SNF
Length:823
Mass (Da):88,348
Last modified:November 25, 2008 - v2
Checksum:i59CDBD56381539E9
GO
Isoform 2 (identifier: O43313-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.

Show »
Length:667
Mass (Da):72,334
Checksum:iE23D09D9C4F60210
GO

Sequence cautioni

The sequence BAA24861 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAF83632 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174Y → C in CAH18291 (PubMed:17974005).Curated1
Sequence conflicti309M → V in BAF83632 (PubMed:14702039).Curated1
Sequence conflicti338T → A in CAH18291 (PubMed:17974005).Curated1
Sequence conflicti433A → T in CAH18291 (PubMed:17974005).Curated1
Sequence conflicti474A → P in CAH18291 (PubMed:17974005).Curated1
Sequence conflicti525Y → H in CAH18291 (PubMed:17974005).Curated1
Sequence conflicti703Q → R in BAF83632 (PubMed:14702039).Curated1
Sequence conflicti814S → P in CAH18291 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050681240S → P. Corresponds to variant dbSNP:rs2278022Ensembl.1
Natural variantiVAR_050682305K → E. Corresponds to variant dbSNP:rs2278023Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0358201 – 156Missing in isoform 2. 2 PublicationsAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007891 mRNA. Translation: BAA24861.2. Different initiation.
CR749457 mRNA. Translation: CAH18291.1.
AC092718 Genomic DNA. No translation available.
BC002701 mRNA. Translation: AAH02701.2.
AK290943 mRNA. Translation: BAF83632.1. Different initiation.
CCDSiCCDS32494.1. [O43313-1]
CCDS73917.1. [O43313-2]
PIRiT00061.
RefSeqiNP_001287657.1. NM_001300728.1. [O43313-2]
NP_056066.2. NM_015251.2. [O43313-1]
UniGeneiHs.16349.
Hs.589959.

Genome annotation databases

EnsembliENST00000299575; ENSP00000299575; ENSG00000166454. [O43313-1]
ENST00000564241; ENSP00000463478; ENSG00000166454. [O43313-2]
ENST00000566488; ENSP00000455497; ENSG00000166454. [O43313-2]
GeneIDi23300.
KEGGihsa:23300.
UCSCiuc002ffz.2. human. [O43313-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiATMIN_HUMAN
AccessioniPrimary (citable) accession number: O43313
Secondary accession number(s): A8K4H8, Q68DC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 25, 2008
Last modified: June 7, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot