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O43312

- MTSS1_HUMAN

UniProt

O43312 - MTSS1_HUMAN

Protein

Metastasis suppressor protein 1

Gene

MTSS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (16 May 2003)
      Previous versions | rss
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    Functioni

    May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

    GO - Molecular functioni

    1. actin monomer binding Source: UniProtKB
    2. identical protein binding Source: IntAct
    3. protein binding Source: IntAct
    4. receptor binding Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton organization Source: UniProtKB
    2. actin filament polymerization Source: Ensembl
    3. cell adhesion Source: UniProtKB
    4. cellular component movement Source: UniProtKB
    5. cellular response to fluid shear stress Source: UniProtKB
    6. epithelial cell proliferation involved in renal tubule morphogenesis Source: UniProtKB
    7. filopodium assembly Source: InterPro
    8. glomerulus morphogenesis Source: UniProtKB
    9. microspike assembly Source: UniProtKB
    10. negative regulation of epithelial cell proliferation Source: UniProtKB
    11. nephron tubule epithelial cell differentiation Source: UniProtKB
    12. renal tubule morphogenesis Source: UniProtKB
    13. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    SignaLinkiO43312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metastasis suppressor protein 1
    Alternative name(s):
    Metastasis suppressor YGL-1
    Missing in metastasis protein
    Gene namesi
    Name:MTSS1
    Synonyms:KIAA0429, MIM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:20443. MTSS1.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. endocytic vesicle Source: UniProtKB
    4. ruffle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA134892011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 755755Metastasis suppressor protein 1PRO_0000096639Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei322 – 3221PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO43312.
    PaxDbiO43312.
    PRIDEiO43312.

    PTM databases

    PhosphoSiteiO43312.

    Expressioni

    Tissue specificityi

    Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.1 Publication

    Gene expression databases

    ArrayExpressiO43312.
    BgeeiO43312.
    CleanExiHS_MTSS1.
    GenevestigatoriO43312.

    Interactioni

    Subunit structurei

    Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-473954,EBI-473954
    CttnQ605982EBI-473954,EBI-397955From a different organism.
    HTTP428583EBI-473954,EBI-466029

    Protein-protein interaction databases

    BioGridi115132. 7 interactions.
    DIPiDIP-17022N.
    IntActiO43312. 5 interactions.
    MINTiMINT-3978135.
    STRINGi9606.ENSP00000322804.

    Structurei

    Secondary structure

    1
    755
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi729 – 7379

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D1KX-ray2.50C724-755[»]
    ProteinModelPortaliO43312.
    SMRiO43312. Positions 1-242, 725-753.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43312.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 250250IMDPROSITE-ProRule annotationAdd
    BLAST
    Domaini727 – 74418WH2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili108 – 15548Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi238 – 359122Ser-richAdd
    BLAST
    Compositional biasi608 – 726119Pro-richAdd
    BLAST

    Domaini

    The WH2 motif at the C-terminus binds to actin monomers.

    Sequence similaritiesi

    Belongs to the MTSS1 family.Curated
    Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
    Contains 1 WH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG72831.
    HOGENOMiHOG000113691.
    HOVERGENiHBG052530.
    InParanoidiO43312.
    OrthoDBiEOG7T7GSJ.
    PhylomeDBiO43312.
    TreeFamiTF320619.

    Family and domain databases

    InterProiIPR013606. IRSp53/MIM_homology_IMD.
    IPR027682. MTSS1.
    IPR003124. WH2_dom.
    [Graphical view]
    PANTHERiPTHR15708:SF10. PTHR15708:SF10. 1 hit.
    PfamiPF08397. IMD. 1 hit.
    PF02205. WH2. 1 hit.
    [Graphical view]
    SMARTiSM00246. WH2. 1 hit.
    [Graphical view]
    PROSITEiPS51338. IMD. 1 hit.
    PS51082. WH2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43312-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA    50
    AAAFLDAFQK VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL 100
    IDCLINPLQE QMEEWKKVAN QLDKDHAKEY KKARQEIKKK SSDTLKLQKK 150
    AKKGRGDIQP QLDSALQDVN DKYLLLEETE KQAVRKALIE ERGRFCTFIS 200
    MLRPVIEEEI SMLGEITHLQ TISEDLKSLT MDPHKLPSSS EQVILDLKGS 250
    DYSWSYQTPP SSPSTTMSRK SSVCSSLNSV NSSDSRSSGS HSHSPSSHYR 300
    YRSSNLAQQA PVRLSSVSSH DSGFISQDAF QSKSPSPMPP EAPNQLSNGF 350
    SHYSLSSESH VGPTGAGLFP HCLPASRLLP RVTSVHLPDY AHYYTIGPGM 400
    FPSSQIPSWK DWAKPGPYDQ PLVNTLQRRK EKREPDPNGG GPTTASGPPA 450
    AAEEAQRPRS MTVSAATRPG EEMEACEELA LALSRGLQLD TQRSSRDSLQ 500
    CSSGYSTQTT TPCCSEDTIP SQVSDYDYFS VSGDQEADQQ EFDKSSTIPR 550
    NSDISQSYRR MFQAKRPAST AGLPTTLGPA MVTPGVATIR RTPSTKPSVR 600
    RGTIGAGPIP IKTPVIPVKT PTVPDLPGVL PAPPDGPEER GEHSPESPSV 650
    GEGPQGVTSM PSSMWSGQAS VNPPLPGPKP SIPEEHRQAI PESEAEDQER 700
    EPPSATVSPG QIPESDPADL SPRDTPQGED MLNAIRRGVK LKKTTTNDRS 750
    APRFS 755
    Length:755
    Mass (Da):82,251
    Last modified:May 16, 2003 - v2
    Checksum:i76FEE3224CBA9287
    GO
    Isoform 2 (identifier: O43312-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-200: Missing.
         345-426: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:473
    Mass (Da):50,650
    Checksum:iBD0E62304BD0C447
    GO
    Isoform 3 (identifier: O43312-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         346-409: LSNGFSHYSL...MFPSSQIPSW → NSSSSASSEA...STMGAWVSTE

    Note: No experimental confirmation available.

    Show »
    Length:730
    Mass (Da):79,144
    Checksum:iFB45648CFA440449
    GO
    Isoform 4 (identifier: O43312-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         153-153: K → KVDTL

    Show »
    Length:759
    Mass (Da):82,680
    Checksum:i1F637EB4E5B2E7BE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti586 – 5861V → A in AK027015. (PubMed:14702039)Curated
    Sequence conflicti630 – 6301L → M in AAF15947. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti305 – 3051N → I.
    Corresponds to variant rs2303956 [ dbSNP | Ensembl ].
    VAR_054010
    Natural varianti725 – 7251T → A.
    Corresponds to variant rs3829037 [ dbSNP | Ensembl ].
    VAR_054011

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 200200Missing in isoform 2. 1 PublicationVSP_007420Add
    BLAST
    Alternative sequencei153 – 1531K → KVDTL in isoform 4. 1 PublicationVSP_054702
    Alternative sequencei345 – 42682Missing in isoform 2. 1 PublicationVSP_007421Add
    BLAST
    Alternative sequencei346 – 40964LSNGF…QIPSW → NSSSSASSEASETCQSVSEC SSPTSVSSGSTMGAWVSTE in isoform 3. 1 PublicationVSP_016216Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF086645 mRNA. Translation: AAF15947.1.
    AK027015 mRNA. No translation available.
    AC090198 Genomic DNA. No translation available.
    AC090922 Genomic DNA. No translation available.
    BC023998 mRNA. Translation: AAH23998.1.
    AB007889 mRNA. Translation: BAA24859.3.
    CCDSiCCDS6353.1. [O43312-1]
    CCDS64968.1. [O43312-4]
    CCDS64969.1. [O43312-5]
    RefSeqiNP_001269900.1. NM_001282971.1. [O43312-5]
    NP_001269903.1. NM_001282974.1. [O43312-4]
    NP_055566.3. NM_014751.5. [O43312-1]
    UniGeneiHs.336994.
    Hs.700429.

    Genome annotation databases

    EnsembliENST00000325064; ENSP00000322804; ENSG00000170873. [O43312-5]
    ENST00000378017; ENSP00000367256; ENSG00000170873. [O43312-4]
    ENST00000431961; ENSP00000393606; ENSG00000170873. [O43312-2]
    ENST00000518547; ENSP00000429064; ENSG00000170873. [O43312-1]
    GeneIDi9788.
    KEGGihsa:9788.
    UCSCiuc003yri.2. human. [O43312-2]
    uc003yrj.2. human. [O43312-4]
    uc003yrk.2. human. [O43312-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF086645 mRNA. Translation: AAF15947.1 .
    AK027015 mRNA. No translation available.
    AC090198 Genomic DNA. No translation available.
    AC090922 Genomic DNA. No translation available.
    BC023998 mRNA. Translation: AAH23998.1 .
    AB007889 mRNA. Translation: BAA24859.3 .
    CCDSi CCDS6353.1. [O43312-1 ]
    CCDS64968.1. [O43312-4 ]
    CCDS64969.1. [O43312-5 ]
    RefSeqi NP_001269900.1. NM_001282971.1. [O43312-5 ]
    NP_001269903.1. NM_001282974.1. [O43312-4 ]
    NP_055566.3. NM_014751.5. [O43312-1 ]
    UniGenei Hs.336994.
    Hs.700429.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D1K X-ray 2.50 C 724-755 [» ]
    ProteinModelPortali O43312.
    SMRi O43312. Positions 1-242, 725-753.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115132. 7 interactions.
    DIPi DIP-17022N.
    IntActi O43312. 5 interactions.
    MINTi MINT-3978135.
    STRINGi 9606.ENSP00000322804.

    PTM databases

    PhosphoSitei O43312.

    Proteomic databases

    MaxQBi O43312.
    PaxDbi O43312.
    PRIDEi O43312.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325064 ; ENSP00000322804 ; ENSG00000170873 . [O43312-5 ]
    ENST00000378017 ; ENSP00000367256 ; ENSG00000170873 . [O43312-4 ]
    ENST00000431961 ; ENSP00000393606 ; ENSG00000170873 . [O43312-2 ]
    ENST00000518547 ; ENSP00000429064 ; ENSG00000170873 . [O43312-1 ]
    GeneIDi 9788.
    KEGGi hsa:9788.
    UCSCi uc003yri.2. human. [O43312-2 ]
    uc003yrj.2. human. [O43312-4 ]
    uc003yrk.2. human. [O43312-1 ]

    Organism-specific databases

    CTDi 9788.
    GeneCardsi GC08M125563.
    HGNCi HGNC:20443. MTSS1.
    MIMi 608486. gene.
    neXtProti NX_O43312.
    PharmGKBi PA134892011.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72831.
    HOGENOMi HOG000113691.
    HOVERGENi HBG052530.
    InParanoidi O43312.
    OrthoDBi EOG7T7GSJ.
    PhylomeDBi O43312.
    TreeFami TF320619.

    Enzyme and pathway databases

    SignaLinki O43312.

    Miscellaneous databases

    EvolutionaryTracei O43312.
    GeneWikii MTSS1.
    GenomeRNAii 9788.
    NextBioi 35534939.
    PROi O43312.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43312.
    Bgeei O43312.
    CleanExi HS_MTSS1.
    Genevestigatori O43312.

    Family and domain databases

    InterProi IPR013606. IRSp53/MIM_homology_IMD.
    IPR027682. MTSS1.
    IPR003124. WH2_dom.
    [Graphical view ]
    PANTHERi PTHR15708:SF10. PTHR15708:SF10. 1 hit.
    Pfami PF08397. IMD. 1 hit.
    PF02205. WH2. 1 hit.
    [Graphical view ]
    SMARTi SM00246. WH2. 1 hit.
    [Graphical view ]
    PROSITEi PS51338. IMD. 1 hit.
    PS51082. WH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of potential metastasis suppressor gene (YGL-1) in bladder cancer."
      Lee Y.-G., Macoska J.A., Schwab E.D., Korenchuk S., Pienta K.J.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    5. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
      Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-755 (ISOFORM 3).
      Tissue: Brain.
    6. "MIM, a potential metastasis suppressor gene in bladder cancer."
      Lee Y.-G., Macoska J.A., Korenchuk S., Pienta K.J.
      Neoplasia 4:291-294(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 400-755 (ISOFORM 1), TISSUE SPECIFICITY.
    7. "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta."
      Woodings J.A., Sharp S.J., Machesky L.M.
      Biochem. J. 371:463-471(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION OF WH2 DOMAIN WITH ACTIN, SUBUNIT.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.

    Entry informationi

    Entry nameiMTSS1_HUMAN
    AccessioniPrimary (citable) accession number: O43312
    Secondary accession number(s): J3KNK6, Q8TCA2, Q96RX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 16, 2003
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3