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Protein

Metastasis suppressor protein 1

Gene

MTSS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

GO - Molecular functioni

  • actin monomer binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SignaLinkiO43312.
SIGNORiO43312.

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis suppressor protein 1
Alternative name(s):
Metastasis suppressor YGL-1
Missing in metastasis protein
Gene namesi
Name:MTSS1
Synonyms:KIAA0429, MIM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000170873.18.
HGNCiHGNC:20443. MTSS1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi9788.
OpenTargetsiENSG00000170873.
PharmGKBiPA134892011.

Polymorphism and mutation databases

BioMutaiMTSS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966391 – 755Metastasis suppressor protein 1Add BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258PhosphothreonineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei262PhosphoserineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei322PhosphoserineBy similarity1
Modified residuei425PhosphothreonineBy similarity1
Modified residuei603PhosphothreonineBy similarity1
Modified residuei644PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO43312.
MaxQBiO43312.
PaxDbiO43312.
PeptideAtlasiO43312.
PRIDEiO43312.

PTM databases

iPTMnetiO43312.
PhosphoSitePlusiO43312.

Expressioni

Tissue specificityi

Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.1 Publication

Gene expression databases

BgeeiENSG00000170873.
CleanExiHS_MTSS1.
ExpressionAtlasiO43312. baseline and differential.
GenevisibleiO43312. HS.

Organism-specific databases

HPAiHPA075540.

Interactioni

Subunit structurei

Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin monomer binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115132. 7 interactors.
DIPiDIP-17022N.
ELMiO43312.
IntActiO43312. 6 interactors.
MINTiMINT-3978135.
STRINGi9606.ENSP00000429064.

Structurei

Secondary structure

1755
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi729 – 737Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D1KX-ray2.50C724-755[»]
ProteinModelPortaliO43312.
SMRiO43312.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43312.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 250IMDAdd BLAST250
Domaini727 – 744WH2Add BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili108 – 155Sequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi238 – 359Ser-richAdd BLAST122
Compositional biasi608 – 726Pro-richAdd BLAST119

Domaini

The WH2 motif at the C-terminus binds to actin monomers.

Sequence similaritiesi

Belongs to the MTSS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGVU. Eukaryota.
ENOG410XRT4. LUCA.
GeneTreeiENSGT00390000002637.
HOGENOMiHOG000113691.
HOVERGENiHBG052530.
InParanoidiO43312.
KOiK20128.
OMAiTMGAWAS.
OrthoDBiEOG091G083M.
PhylomeDBiO43312.
TreeFamiTF320619.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR_dom_sf.
IPR013606. I-BAR_dom.
IPR027682. MIM.
IPR030127. MIM/ABBA.
IPR003124. WH2_dom.
PANTHERiPTHR15708. PTHR15708. 1 hit.
PTHR15708:SF10. PTHR15708:SF10. 1 hit.
PfamiView protein in Pfam
PF08397. IMD. 1 hit.
PF02205. WH2. 1 hit.
SUPFAMiSSF103657. SSF103657. 1 hit.
PROSITEiView protein in PROSITE
PS51338. IMD. 1 hit.
PS51082. WH2. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43312-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA
60 70 80 90 100
AAAFLDAFQK VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL
110 120 130 140 150
IDCLINPLQE QMEEWKKVAN QLDKDHAKEY KKARQEIKKK SSDTLKLQKK
160 170 180 190 200
AKKGRGDIQP QLDSALQDVN DKYLLLEETE KQAVRKALIE ERGRFCTFIS
210 220 230 240 250
MLRPVIEEEI SMLGEITHLQ TISEDLKSLT MDPHKLPSSS EQVILDLKGS
260 270 280 290 300
DYSWSYQTPP SSPSTTMSRK SSVCSSLNSV NSSDSRSSGS HSHSPSSHYR
310 320 330 340 350
YRSSNLAQQA PVRLSSVSSH DSGFISQDAF QSKSPSPMPP EAPNQLSNGF
360 370 380 390 400
SHYSLSSESH VGPTGAGLFP HCLPASRLLP RVTSVHLPDY AHYYTIGPGM
410 420 430 440 450
FPSSQIPSWK DWAKPGPYDQ PLVNTLQRRK EKREPDPNGG GPTTASGPPA
460 470 480 490 500
AAEEAQRPRS MTVSAATRPG EEMEACEELA LALSRGLQLD TQRSSRDSLQ
510 520 530 540 550
CSSGYSTQTT TPCCSEDTIP SQVSDYDYFS VSGDQEADQQ EFDKSSTIPR
560 570 580 590 600
NSDISQSYRR MFQAKRPAST AGLPTTLGPA MVTPGVATIR RTPSTKPSVR
610 620 630 640 650
RGTIGAGPIP IKTPVIPVKT PTVPDLPGVL PAPPDGPEER GEHSPESPSV
660 670 680 690 700
GEGPQGVTSM PSSMWSGQAS VNPPLPGPKP SIPEEHRQAI PESEAEDQER
710 720 730 740 750
EPPSATVSPG QIPESDPADL SPRDTPQGED MLNAIRRGVK LKKTTTNDRS

APRFS
Length:755
Mass (Da):82,251
Last modified:May 16, 2003 - v2
Checksum:i76FEE3224CBA9287
GO
Isoform 2 (identifier: O43312-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.
     345-426: Missing.

Note: No experimental confirmation available.
Show »
Length:473
Mass (Da):50,650
Checksum:iBD0E62304BD0C447
GO
Isoform 3 (identifier: O43312-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-409: LSNGFSHYSL...MFPSSQIPSW → NSSSSASSEA...STMGAWVSTE

Note: No experimental confirmation available.
Show »
Length:730
Mass (Da):79,144
Checksum:iFB45648CFA440449
GO
Isoform 4 (identifier: O43312-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: K → KVDTL

Show »
Length:759
Mass (Da):82,680
Checksum:i1F637EB4E5B2E7BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti586V → A in AK027015 (PubMed:14702039).Curated1
Sequence conflicti630L → M in AAF15947 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054010305N → I. Corresponds to variant dbSNP:rs2303956Ensembl.1
Natural variantiVAR_054011725T → A. Corresponds to variant dbSNP:rs3829037Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0074201 – 200Missing in isoform 2. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_054702153K → KVDTL in isoform 4. 1 Publication1
Alternative sequenceiVSP_007421345 – 426Missing in isoform 2. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_016216346 – 409LSNGF…QIPSW → NSSSSASSEASETCQSVSEC SSPTSVSSGSTMGAWVSTE in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086645 mRNA. Translation: AAF15947.1.
AK027015 mRNA. No translation available.
AC090198 Genomic DNA. No translation available.
AC090922 Genomic DNA. No translation available.
BC023998 mRNA. Translation: AAH23998.1.
AB007889 mRNA. Translation: BAA24859.3.
CCDSiCCDS6353.1. [O43312-1]
CCDS64968.1. [O43312-4]
CCDS64969.1. [O43312-5]
RefSeqiNP_001269900.1. NM_001282971.1. [O43312-5]
NP_001269903.1. NM_001282974.1. [O43312-4]
NP_055566.3. NM_014751.5. [O43312-1]
UniGeneiHs.336994.
Hs.700429.

Genome annotation databases

EnsembliENST00000325064; ENSP00000322804; ENSG00000170873. [O43312-5]
ENST00000378017; ENSP00000367256; ENSG00000170873. [O43312-4]
ENST00000431961; ENSP00000393606; ENSG00000170873. [O43312-2]
ENST00000518547; ENSP00000429064; ENSG00000170873. [O43312-1]
GeneIDi9788.
KEGGihsa:9788.
UCSCiuc003yri.4. human. [O43312-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMTSS1_HUMAN
AccessioniPrimary (citable) accession number: O43312
Secondary accession number(s): J3KNK6, Q8TCA2, Q96RX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 16, 2003
Last modified: November 22, 2017
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families