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O43312

- MTSS1_HUMAN

UniProt

O43312 - MTSS1_HUMAN

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Protein
Metastasis suppressor protein 1
Gene
MTSS1, KIAA0429, MIM
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

GO - Molecular functioni

  1. actin monomer binding Source: UniProtKB
  2. identical protein binding Source: IntAct
  3. protein binding Source: IntAct
  4. receptor binding Source: UniProtKB

GO - Biological processi

  1. actin cytoskeleton organization Source: UniProtKB
  2. actin filament polymerization Source: Ensembl
  3. cell adhesion Source: UniProtKB
  4. cellular component movement Source: UniProtKB
  5. cellular response to fluid shear stress Source: UniProtKB
  6. epithelial cell proliferation involved in renal tubule morphogenesis Source: UniProtKB
  7. filopodium assembly Source: InterPro
  8. glomerulus morphogenesis Source: UniProtKB
  9. microspike assembly Source: UniProtKB
  10. negative regulation of epithelial cell proliferation Source: UniProtKB
  11. nephron tubule epithelial cell differentiation Source: UniProtKB
  12. renal tubule morphogenesis Source: UniProtKB
  13. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

SignaLinkiO43312.

Names & Taxonomyi

Protein namesi
Recommended name:
Metastasis suppressor protein 1
Alternative name(s):
Metastasis suppressor YGL-1
Missing in metastasis protein
Gene namesi
Name:MTSS1
Synonyms:KIAA0429, MIM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:20443. MTSS1.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. endocytic vesicle Source: UniProtKB
  4. ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134892011.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Metastasis suppressor protein 1
PRO_0000096639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei322 – 3221Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43312.
PaxDbiO43312.
PRIDEiO43312.

PTM databases

PhosphoSiteiO43312.

Expressioni

Tissue specificityi

Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.1 Publication

Gene expression databases

ArrayExpressiO43312.
BgeeiO43312.
CleanExiHS_MTSS1.
GenevestigatoriO43312.

Interactioni

Subunit structurei

Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-473954,EBI-473954
CttnQ605982EBI-473954,EBI-397955From a different organism.
HTTP428583EBI-473954,EBI-466029

Protein-protein interaction databases

BioGridi115132. 7 interactions.
DIPiDIP-17022N.
IntActiO43312. 5 interactions.
MINTiMINT-3978135.
STRINGi9606.ENSP00000322804.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi729 – 7379

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D1KX-ray2.50C724-755[»]
ProteinModelPortaliO43312.
SMRiO43312. Positions 1-242, 725-753.

Miscellaneous databases

EvolutionaryTraceiO43312.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 250250IMD
Add
BLAST
Domaini727 – 74418WH2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili108 – 15548 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi238 – 359122Ser-rich
Add
BLAST
Compositional biasi608 – 726119Pro-rich
Add
BLAST

Domaini

The WH2 motif at the C-terminus binds to actin monomers.1 Publication

Sequence similaritiesi

Belongs to the MTSS1 family.
Contains 1 WH2 domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG72831.
HOGENOMiHOG000113691.
HOVERGENiHBG052530.
InParanoidiO43312.
OrthoDBiEOG7T7GSJ.
PhylomeDBiO43312.
TreeFamiTF320619.

Family and domain databases

InterProiIPR013606. IRSp53/MIM_homology_IMD.
IPR027682. MTSS1.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR15708:SF10. PTHR15708:SF10. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51338. IMD. 1 hit.
PS51082. WH2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43312-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA    50
AAAFLDAFQK VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL 100
IDCLINPLQE QMEEWKKVAN QLDKDHAKEY KKARQEIKKK SSDTLKLQKK 150
AKKGRGDIQP QLDSALQDVN DKYLLLEETE KQAVRKALIE ERGRFCTFIS 200
MLRPVIEEEI SMLGEITHLQ TISEDLKSLT MDPHKLPSSS EQVILDLKGS 250
DYSWSYQTPP SSPSTTMSRK SSVCSSLNSV NSSDSRSSGS HSHSPSSHYR 300
YRSSNLAQQA PVRLSSVSSH DSGFISQDAF QSKSPSPMPP EAPNQLSNGF 350
SHYSLSSESH VGPTGAGLFP HCLPASRLLP RVTSVHLPDY AHYYTIGPGM 400
FPSSQIPSWK DWAKPGPYDQ PLVNTLQRRK EKREPDPNGG GPTTASGPPA 450
AAEEAQRPRS MTVSAATRPG EEMEACEELA LALSRGLQLD TQRSSRDSLQ 500
CSSGYSTQTT TPCCSEDTIP SQVSDYDYFS VSGDQEADQQ EFDKSSTIPR 550
NSDISQSYRR MFQAKRPAST AGLPTTLGPA MVTPGVATIR RTPSTKPSVR 600
RGTIGAGPIP IKTPVIPVKT PTVPDLPGVL PAPPDGPEER GEHSPESPSV 650
GEGPQGVTSM PSSMWSGQAS VNPPLPGPKP SIPEEHRQAI PESEAEDQER 700
EPPSATVSPG QIPESDPADL SPRDTPQGED MLNAIRRGVK LKKTTTNDRS 750
APRFS 755
Length:755
Mass (Da):82,251
Last modified:May 16, 2003 - v2
Checksum:i76FEE3224CBA9287
GO
Isoform 2 (identifier: O43312-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.
     345-426: Missing.

Note: No experimental confirmation available.

Show »
Length:473
Mass (Da):50,650
Checksum:iBD0E62304BD0C447
GO
Isoform 3 (identifier: O43312-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-409: LSNGFSHYSL...MFPSSQIPSW → NSSSSASSEA...STMGAWVSTE

Note: No experimental confirmation available.

Show »
Length:730
Mass (Da):79,144
Checksum:iFB45648CFA440449
GO
Isoform 4 (identifier: O43312-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: K → KVDTL

Show »
Length:759
Mass (Da):82,680
Checksum:i1F637EB4E5B2E7BE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti305 – 3051N → I.
Corresponds to variant rs2303956 [ dbSNP | Ensembl ].
VAR_054010
Natural varianti725 – 7251T → A.
Corresponds to variant rs3829037 [ dbSNP | Ensembl ].
VAR_054011

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 200200Missing in isoform 2.
VSP_007420Add
BLAST
Alternative sequencei153 – 1531K → KVDTL in isoform 4.
VSP_054702
Alternative sequencei345 – 42682Missing in isoform 2.
VSP_007421Add
BLAST
Alternative sequencei346 – 40964LSNGF…QIPSW → NSSSSASSEASETCQSVSEC SSPTSVSSGSTMGAWVSTE in isoform 3.
VSP_016216Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti586 – 5861V → A in AK027015. 1 Publication
Sequence conflicti630 – 6301L → M in AAF15947. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086645 mRNA. Translation: AAF15947.1.
AK027015 mRNA. No translation available.
AC090198 Genomic DNA. No translation available.
AC090922 Genomic DNA. No translation available.
BC023998 mRNA. Translation: AAH23998.1.
AB007889 mRNA. Translation: BAA24859.3.
CCDSiCCDS6353.1. [O43312-1]
CCDS64968.1. [O43312-4]
CCDS64969.1. [O43312-5]
RefSeqiNP_001269900.1. NM_001282971.1. [O43312-5]
NP_001269903.1. NM_001282974.1. [O43312-4]
NP_055566.3. NM_014751.5. [O43312-1]
UniGeneiHs.336994.
Hs.700429.

Genome annotation databases

EnsembliENST00000325064; ENSP00000322804; ENSG00000170873.
ENST00000354184; ENSP00000346119; ENSG00000170873. [O43312-2]
ENST00000378017; ENSP00000367256; ENSG00000170873. [O43312-4]
ENST00000431961; ENSP00000393606; ENSG00000170873. [O43312-2]
ENST00000518547; ENSP00000429064; ENSG00000170873. [O43312-1]
GeneIDi9788.
KEGGihsa:9788.
UCSCiuc003yri.2. human. [O43312-2]
uc003yrj.2. human. [O43312-4]
uc003yrk.2. human. [O43312-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086645 mRNA. Translation: AAF15947.1 .
AK027015 mRNA. No translation available.
AC090198 Genomic DNA. No translation available.
AC090922 Genomic DNA. No translation available.
BC023998 mRNA. Translation: AAH23998.1 .
AB007889 mRNA. Translation: BAA24859.3 .
CCDSi CCDS6353.1. [O43312-1 ]
CCDS64968.1. [O43312-4 ]
CCDS64969.1. [O43312-5 ]
RefSeqi NP_001269900.1. NM_001282971.1. [O43312-5 ]
NP_001269903.1. NM_001282974.1. [O43312-4 ]
NP_055566.3. NM_014751.5. [O43312-1 ]
UniGenei Hs.336994.
Hs.700429.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D1K X-ray 2.50 C 724-755 [» ]
ProteinModelPortali O43312.
SMRi O43312. Positions 1-242, 725-753.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115132. 7 interactions.
DIPi DIP-17022N.
IntActi O43312. 5 interactions.
MINTi MINT-3978135.
STRINGi 9606.ENSP00000322804.

PTM databases

PhosphoSitei O43312.

Proteomic databases

MaxQBi O43312.
PaxDbi O43312.
PRIDEi O43312.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000325064 ; ENSP00000322804 ; ENSG00000170873 .
ENST00000354184 ; ENSP00000346119 ; ENSG00000170873 . [O43312-2 ]
ENST00000378017 ; ENSP00000367256 ; ENSG00000170873 . [O43312-4 ]
ENST00000431961 ; ENSP00000393606 ; ENSG00000170873 . [O43312-2 ]
ENST00000518547 ; ENSP00000429064 ; ENSG00000170873 . [O43312-1 ]
GeneIDi 9788.
KEGGi hsa:9788.
UCSCi uc003yri.2. human. [O43312-2 ]
uc003yrj.2. human. [O43312-4 ]
uc003yrk.2. human. [O43312-1 ]

Organism-specific databases

CTDi 9788.
GeneCardsi GC08M125563.
HGNCi HGNC:20443. MTSS1.
MIMi 608486. gene.
neXtProti NX_O43312.
PharmGKBi PA134892011.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72831.
HOGENOMi HOG000113691.
HOVERGENi HBG052530.
InParanoidi O43312.
OrthoDBi EOG7T7GSJ.
PhylomeDBi O43312.
TreeFami TF320619.

Enzyme and pathway databases

SignaLinki O43312.

Miscellaneous databases

EvolutionaryTracei O43312.
GeneWikii MTSS1.
GenomeRNAii 9788.
NextBioi 35534939.
PROi O43312.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43312.
Bgeei O43312.
CleanExi HS_MTSS1.
Genevestigatori O43312.

Family and domain databases

InterProi IPR013606. IRSp53/MIM_homology_IMD.
IPR027682. MTSS1.
IPR003124. WH2_dom.
[Graphical view ]
PANTHERi PTHR15708:SF10. PTHR15708:SF10. 1 hit.
Pfami PF08397. IMD. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view ]
SMARTi SM00246. WH2. 1 hit.
[Graphical view ]
PROSITEi PS51338. IMD. 1 hit.
PS51082. WH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of potential metastasis suppressor gene (YGL-1) in bladder cancer."
    Lee Y.-G., Macoska J.A., Schwab E.D., Korenchuk S., Pienta K.J.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  5. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-755 (ISOFORM 3).
    Tissue: Brain.
  6. "MIM, a potential metastasis suppressor gene in bladder cancer."
    Lee Y.-G., Macoska J.A., Korenchuk S., Pienta K.J.
    Neoplasia 4:291-294(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 400-755 (ISOFORM 1), TISSUE SPECIFICITY.
  7. "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta."
    Woodings J.A., Sharp S.J., Machesky L.M.
    Biochem. J. 371:463-471(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION OF WH2 DOMAIN WITH ACTIN, SUBUNIT.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.

Entry informationi

Entry nameiMTSS1_HUMAN
AccessioniPrimary (citable) accession number: O43312
Secondary accession number(s): J3KNK6, Q8TCA2, Q96RX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 16, 2003
Last modified: September 3, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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