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Protein

Zinc finger and SCAN domain-containing protein 12

Gene

ZSCAN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri274 – 296C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 463C2H2-type 7PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri469 – 491C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 578C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 12
Alternative name(s):
Zinc finger protein 305
Zinc finger protein 96
Gene namesi
Name:ZSCAN12
Synonyms:KIAA0426, ZNF305, ZNF96
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000158691.14
HGNCiHGNC:13172 ZSCAN12
MIMi603978 gene
neXtProtiNX_O43309

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158691
PharmGKBiPA37744

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474031 – 604Zinc finger and SCAN domain-containing protein 12Add BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiO43309
PaxDbiO43309
PeptideAtlasiO43309
PRIDEiO43309

PTM databases

iPTMnetiO43309
PhosphoSitePlusiO43309

Expressioni

Gene expression databases

BgeeiENSG00000158691
CleanExiHS_ZSCAN12
ExpressionAtlasiO43309 baseline and differential
GenevisibleiO43309 HS

Organism-specific databases

HPAiHPA006637

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiO43309, 24 interactors
STRINGi9606.ENSP00000354305

Structurei

3D structure databases

ProteinModelPortaliO43309
SMRiO43309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 128SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri274 – 296C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 463C2H2-type 7PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri469 – 491C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 578C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiO43309
OMAiSLIPEWQ
OrthoDBiEOG091G02KC
PhylomeDBiO43309
TreeFamiTF338146

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

O43309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTWAIQAH MDQDEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR
60 70 80 90 100
QFCYQETSGP REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE
110 120 130 140 150
ELQAWVQEQH PESGEEVVTV LEDLERELDE PGEQVSVHTG EQEMFLQETV
160 170 180 190 200
RLRKEGEPSM SLQSMKAQPK YESPELESQQ EQVLDVETGN EYGNLKQEVS
210 220 230 240 250
EEMEPHGKTS SKFENDMSKS ARCGETREPE EITEEPSACS REDKQPTCDE
260 270 280 290 300
NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSHLI EHQRIHTGDR
310 320 330 340 350
PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR
360 370 380 390 400
LHTGEKHYHC NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI
410 420 430 440 450
LTQHQGVHTG AKPYECNECG KAFVYNSSLV SHQEIHHKEK CYQCKECGKS
460 470 480 490 500
FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ RTSLTEHQRI HTGERPYKCD
510 520 530 540 550
KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL IQHQRIHTGE
560 570 580 590 600
KPYQCDECGK AFRQRKKTSY KEILLKNHSE PQAGVNLLLS SLIPEWQSCF

RRDL
Length:604
Mass (Da):70,222
Last modified:June 1, 1998 - v1
Checksum:i6A7F8ECB515A7A73
GO

Sequence cautioni

The sequence BAA24856 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007886 mRNA Translation: BAA24856.2 Different initiation.
Z98745 Genomic DNA No translation available.
BC041661 mRNA Translation: AAH41661.1
UniGeneiHs.134816

Genome annotation databases

EnsembliENST00000361028; ENSP00000354305; ENSG00000158691
ENST00000396827; ENSP00000380039; ENSG00000158691
UCSCiuc063mll.1 human

Similar proteinsi

Entry informationi

Entry nameiZSC12_HUMAN
AccessioniPrimary (citable) accession number: O43309
Secondary accession number(s): O43724
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health