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Protein

Zinc finger and SCAN domain-containing protein 12

Gene

ZSCAN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri274 – 296C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 463C2H2-type 7PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri469 – 491C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 578C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173439-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 12
Alternative name(s):
Zinc finger protein 305
Zinc finger protein 96
Gene namesi
Name:ZSCAN12
Synonyms:KIAA0426, ZNF305, ZNF96
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13172. ZSCAN12.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158691.
PharmGKBiPA37744.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474031 – 604Zinc finger and SCAN domain-containing protein 12Add BLAST604

Proteomic databases

MaxQBiO43309.
PaxDbiO43309.
PeptideAtlasiO43309.
PRIDEiO43309.

PTM databases

iPTMnetiO43309.
PhosphoSitePlusiO43309.

Expressioni

Gene expression databases

BgeeiENSG00000158691.
CleanExiHS_ZSCAN12.
ExpressionAtlasiO43309. baseline and differential.
GenevisibleiO43309. HS.

Organism-specific databases

HPAiHPA006637.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-1210440,EBI-739624
MID2Q9UJV3-25EBI-1210440,EBI-10172526
MTUS2Q5JR593EBI-1210440,EBI-742948
SSX2IPQ9Y2D83EBI-1210440,EBI-2212028
TFIP11Q9UBB93EBI-1210440,EBI-1105213
ZKSCAN7Q9P0L13EBI-1210440,EBI-743851
ZNF446A0A087WUM84EBI-1210440,EBI-11955977
ZNF473Q8WTR73EBI-1210440,EBI-751409
ZNF496Q96IT13EBI-1210440,EBI-743906
ZSCAN32I3L3J25EBI-1210440,EBI-10178206

Protein-protein interaction databases

IntActiO43309. 20 interactors.
STRINGi9606.ENSP00000354305.

Structurei

3D structure databases

ProteinModelPortaliO43309.
SMRiO43309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 128SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri274 – 296C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 463C2H2-type 7PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri469 – 491C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 578C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiO43309.
OMAiSLIPEWQ.
OrthoDBiEOG091G02KC.
PhylomeDBiO43309.
TreeFamiTF338146.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTWAIQAH MDQDEPLEVK IEEEKYTTRQ DWDLRKNNTH SREVFRQYFR
60 70 80 90 100
QFCYQETSGP REALSRLREL CHQWLRPETH TKEQILELLV LEQFLTILPE
110 120 130 140 150
ELQAWVQEQH PESGEEVVTV LEDLERELDE PGEQVSVHTG EQEMFLQETV
160 170 180 190 200
RLRKEGEPSM SLQSMKAQPK YESPELESQQ EQVLDVETGN EYGNLKQEVS
210 220 230 240 250
EEMEPHGKTS SKFENDMSKS ARCGETREPE EITEEPSACS REDKQPTCDE
260 270 280 290 300
NGVSLTENSD HTEHQRICPG EESYGCDDCG KAFSQHSHLI EHQRIHTGDR
310 320 330 340 350
PYKCEECGKA FRGRTVLIRH KIIHTGEKPY KCNECGKAFG RWSALNQHQR
360 370 380 390 400
LHTGEKHYHC NDCGKAFSQK AGLFHHIKIH TRDKPYQCTQ CNKSFSRRSI
410 420 430 440 450
LTQHQGVHTG AKPYECNECG KAFVYNSSLV SHQEIHHKEK CYQCKECGKS
460 470 480 490 500
FSQSGLIQHQ RIHTGEKPYK CDVCEKAFIQ RTSLTEHQRI HTGERPYKCD
510 520 530 540 550
KCGKAFTQRS VLTEHQRIHT GERPYKCDEC GNAFRGITSL IQHQRIHTGE
560 570 580 590 600
KPYQCDECGK AFRQRKKTSY KEILLKNHSE PQAGVNLLLS SLIPEWQSCF

RRDL
Length:604
Mass (Da):70,222
Last modified:June 1, 1998 - v1
Checksum:i6A7F8ECB515A7A73
GO

Sequence cautioni

The sequence BAA24856 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007886 mRNA. Translation: BAA24856.2. Different initiation.
Z98745 Genomic DNA. Translation: CAB11428.2.
BC041661 mRNA. Translation: AAH41661.1.
UniGeneiHs.134816.

Genome annotation databases

EnsembliENST00000361028; ENSP00000354305; ENSG00000158691.
ENST00000396827; ENSP00000380039; ENSG00000158691.
UCSCiuc063mll.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007886 mRNA. Translation: BAA24856.2. Different initiation.
Z98745 Genomic DNA. Translation: CAB11428.2.
BC041661 mRNA. Translation: AAH41661.1.
UniGeneiHs.134816.

3D structure databases

ProteinModelPortaliO43309.
SMRiO43309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43309. 20 interactors.
STRINGi9606.ENSP00000354305.

PTM databases

iPTMnetiO43309.
PhosphoSitePlusiO43309.

Proteomic databases

MaxQBiO43309.
PaxDbiO43309.
PeptideAtlasiO43309.
PRIDEiO43309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361028; ENSP00000354305; ENSG00000158691.
ENST00000396827; ENSP00000380039; ENSG00000158691.
UCSCiuc063mll.1. human.

Organism-specific databases

GeneCardsiZSCAN12.
HGNCiHGNC:13172. ZSCAN12.
HPAiHPA006637.
MIMi603978. gene.
neXtProtiNX_O43309.
OpenTargetsiENSG00000158691.
PharmGKBiPA37744.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118881.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiO43309.
OMAiSLIPEWQ.
OrthoDBiEOG091G02KC.
PhylomeDBiO43309.
TreeFamiTF338146.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173439-MONOMER.

Miscellaneous databases

PROiO43309.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158691.
CleanExiHS_ZSCAN12.
ExpressionAtlasiO43309. baseline and differential.
GenevisibleiO43309. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSC12_HUMAN
AccessioniPrimary (citable) accession number: O43309
Secondary accession number(s): O43724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.