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Protein

SEC14-like protein 5

Gene

SEC14L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103184-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 5
Gene namesi
Name:SEC14L5
Synonyms:KIAA0420
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29032. SEC14L5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103184.
PharmGKBiPA142670939.

Polymorphism and mutation databases

BioMutaiSEC14L5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338651 – 696SEC14-like protein 5Add BLAST696

Proteomic databases

PaxDbiO43304.
PeptideAtlasiO43304.
PRIDEiO43304.

PTM databases

iPTMnetiO43304.
PhosphoSitePlusiO43304.

Expressioni

Gene expression databases

BgeeiENSG00000103184.
CleanExiHS_SEC14L5.
ExpressionAtlasiO43304. baseline and differential.
GenevisibleiO43304. HS.

Organism-specific databases

HPAiHPA041492.
HPA041825.

Interactioni

Protein-protein interaction databases

IntActiO43304. 1 interactor.
STRINGi9606.ENSP00000251170.

Structurei

3D structure databases

ProteinModelPortaliO43304.
SMRiO43304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 175PRELI/MSF1PROSITE-ProRule annotationAdd BLAST174
Domaini306 – 482CRAL-TRIOPROSITE-ProRule annotationAdd BLAST177
Domaini509 – 653GOLDPROSITE-ProRule annotationAdd BLAST145

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi662 – 695Ser-richAdd BLAST34

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation
Contains 1 PRELI/MSF1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000231147.
HOVERGENiHBG060237.
InParanoidiO43304.
OMAiYCEVLAS.
OrthoDBiEOG091G0V9N.
PhylomeDBiO43304.
TreeFamiTF313988.

Family and domain databases

Gene3Di3.40.525.10. 2 hits.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
IPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
PF04707. PRELI. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
PS50904. PRELI_MSF1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRYQSPVR VYKYPFELVM AAYEKRFPTC PQIPVFLGSE VLRESRSPDG
60 70 80 90 100
AVHVVERSCR LRVDAPRLLR KIAGVEHVVF VQTNILNWKE RTLLIEAHNE
110 120 130 140 150
TFANRVVVNE HCSYTVHPEN EDWTCFEQSA SLDIRSFFGF ENALEKIAMK
160 170 180 190 200
QYTANVKRGK EVIEHYLNEL ISQGTSHIPR WTPAPVREED ARNQAGPRDP
210 220 230 240 250
SSLEAHGPRS TLGPALEAVS MDGDKLDADY IERCLGHLTP MQESCLIQLR
260 270 280 290 300
HWLQETHKGK IPKDEHILRF LRAHDFHLDK AREMLRQSLS WRKQHQVDLL
310 320 330 340 350
LQTWQPPALL EEFYAGGWHY QDIDGRPLYI LRLGQMDTKG LMKAVGEEAL
360 370 380 390 400
LRHVLSVNEE GQKRCEGSTR QLGRPISSWT CLLDLEGLNM RHLWRPGVKA
410 420 430 440 450
LLRMIEVVED NYPETLGRLL IVRAPRVFPV LWTLISPFIN ENTRRKFLIY
460 470 480 490 500
SGSNYQGPGG LVDYLDREVI PDFLGGESVC NVPEGGLVPK SLYMTEEEQE
510 520 530 540 550
HTDQLWQWSE TYHSASVLRG APHEVAVEIL EGESVITWDF DILRGDVVFS
560 570 580 590 600
LYHTKQAPRL GAREPGTRAS GQLIDKGWVL GRDYSRVEAP LVCREGESIQ
610 620 630 640 650
GSHVTRWPGV YLLQWQMHSP PSSVACSLPG VDDVLTALHS PGPKCKLLYY
660 670 680 690
CEVLASEDFR GSMSSLESCT SGFSQLSAAT SSSSSGQSHS SSLVSR
Length:696
Mass (Da):78,942
Last modified:May 20, 2008 - v3
Checksum:i8C94913A7B221730
GO

Sequence cautioni

The sequence BAA24850 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007880 mRNA. Translation: BAA24850.2. Different initiation.
CCDSiCCDS45403.1.
RefSeqiNP_055507.1. NM_014692.1.
UniGeneiHs.512856.

Genome annotation databases

EnsembliENST00000251170; ENSP00000251170; ENSG00000103184.
GeneIDi9717.
KEGGihsa:9717.
UCSCiuc002cye.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007880 mRNA. Translation: BAA24850.2. Different initiation.
CCDSiCCDS45403.1.
RefSeqiNP_055507.1. NM_014692.1.
UniGeneiHs.512856.

3D structure databases

ProteinModelPortaliO43304.
SMRiO43304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43304. 1 interactor.
STRINGi9606.ENSP00000251170.

PTM databases

iPTMnetiO43304.
PhosphoSitePlusiO43304.

Polymorphism and mutation databases

BioMutaiSEC14L5.

Proteomic databases

PaxDbiO43304.
PeptideAtlasiO43304.
PRIDEiO43304.

Protocols and materials databases

DNASUi9717.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251170; ENSP00000251170; ENSG00000103184.
GeneIDi9717.
KEGGihsa:9717.
UCSCiuc002cye.3. human.

Organism-specific databases

CTDi9717.
GeneCardsiSEC14L5.
HGNCiHGNC:29032. SEC14L5.
HPAiHPA041492.
HPA041825.
neXtProtiNX_O43304.
OpenTargetsiENSG00000103184.
PharmGKBiPA142670939.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074580.
HOGENOMiHOG000231147.
HOVERGENiHBG060237.
InParanoidiO43304.
OMAiYCEVLAS.
OrthoDBiEOG091G0V9N.
PhylomeDBiO43304.
TreeFamiTF313988.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103184-MONOMER.

Miscellaneous databases

ChiTaRSiSEC14L5. human.
GenomeRNAii9717.
PROiO43304.

Gene expression databases

BgeeiENSG00000103184.
CleanExiHS_SEC14L5.
ExpressionAtlasiO43304. baseline and differential.
GenevisibleiO43304. HS.

Family and domain databases

Gene3Di3.40.525.10. 2 hits.
InterProiIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD_dom.
IPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
PF04707. PRELI. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
PS50904. PRELI_MSF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS14L5_HUMAN
AccessioniPrimary (citable) accession number: O43304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.