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Protein

SEC14-like protein 5

Gene

SEC14L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 5
Gene namesi
Name:SEC14L5
Synonyms:KIAA0420
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103184.11
HGNCiHGNC:29032 SEC14L5
neXtProtiNX_O43304

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103184
PharmGKBiPA142670939

Polymorphism and mutation databases

BioMutaiSEC14L5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338651 – 696SEC14-like protein 5Add BLAST696

Proteomic databases

PaxDbiO43304
PeptideAtlasiO43304
PRIDEiO43304

PTM databases

iPTMnetiO43304
PhosphoSitePlusiO43304

Expressioni

Gene expression databases

BgeeiENSG00000103184
CleanExiHS_SEC14L5
ExpressionAtlasiO43304 baseline and differential
GenevisibleiO43304 HS

Organism-specific databases

HPAiHPA041492
HPA041825

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMC6P623334EBI-12224055,EBI-357669

Protein-protein interaction databases

BioGridi115066, 1 interactor
IntActiO43304, 1 interactor
STRINGi9606.ENSP00000251170

Structurei

3D structure databases

ProteinModelPortaliO43304
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 175PRELI/MSF1PROSITE-ProRule annotationAdd BLAST174
Domaini306 – 482CRAL-TRIOPROSITE-ProRule annotationAdd BLAST177
Domaini509 – 653GOLDPROSITE-ProRule annotationAdd BLAST145

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi662 – 695Ser-richAdd BLAST34

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074580
HOGENOMiHOG000231147
HOVERGENiHBG060237
InParanoidiO43304
OMAiLQTWQPP
OrthoDBiEOG091G0V9N
PhylomeDBiO43304
TreeFamiTF313988

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR006797 PRELI/MSF1_dom
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit
PF04707 PRELI, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50866 GOLD, 1 hit
PS50904 PRELI_MSF1, 1 hit

Sequencei

Sequence statusi: Complete.

O43304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRYQSPVR VYKYPFELVM AAYEKRFPTC PQIPVFLGSE VLRESRSPDG
60 70 80 90 100
AVHVVERSCR LRVDAPRLLR KIAGVEHVVF VQTNILNWKE RTLLIEAHNE
110 120 130 140 150
TFANRVVVNE HCSYTVHPEN EDWTCFEQSA SLDIRSFFGF ENALEKIAMK
160 170 180 190 200
QYTANVKRGK EVIEHYLNEL ISQGTSHIPR WTPAPVREED ARNQAGPRDP
210 220 230 240 250
SSLEAHGPRS TLGPALEAVS MDGDKLDADY IERCLGHLTP MQESCLIQLR
260 270 280 290 300
HWLQETHKGK IPKDEHILRF LRAHDFHLDK AREMLRQSLS WRKQHQVDLL
310 320 330 340 350
LQTWQPPALL EEFYAGGWHY QDIDGRPLYI LRLGQMDTKG LMKAVGEEAL
360 370 380 390 400
LRHVLSVNEE GQKRCEGSTR QLGRPISSWT CLLDLEGLNM RHLWRPGVKA
410 420 430 440 450
LLRMIEVVED NYPETLGRLL IVRAPRVFPV LWTLISPFIN ENTRRKFLIY
460 470 480 490 500
SGSNYQGPGG LVDYLDREVI PDFLGGESVC NVPEGGLVPK SLYMTEEEQE
510 520 530 540 550
HTDQLWQWSE TYHSASVLRG APHEVAVEIL EGESVITWDF DILRGDVVFS
560 570 580 590 600
LYHTKQAPRL GAREPGTRAS GQLIDKGWVL GRDYSRVEAP LVCREGESIQ
610 620 630 640 650
GSHVTRWPGV YLLQWQMHSP PSSVACSLPG VDDVLTALHS PGPKCKLLYY
660 670 680 690
CEVLASEDFR GSMSSLESCT SGFSQLSAAT SSSSSGQSHS SSLVSR
Length:696
Mass (Da):78,942
Last modified:May 20, 2008 - v3
Checksum:i8C94913A7B221730
GO

Sequence cautioni

The sequence BAA24850 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007880 mRNA Translation: BAA24850.2 Different initiation.
CCDSiCCDS45403.1
RefSeqiNP_055507.1, NM_014692.1
UniGeneiHs.512856

Genome annotation databases

EnsembliENST00000251170; ENSP00000251170; ENSG00000103184
GeneIDi9717
KEGGihsa:9717
UCSCiuc002cye.3 human

Similar proteinsi

Entry informationi

Entry nameiS14L5_HUMAN
AccessioniPrimary (citable) accession number: O43304
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health