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Protein

Heat shock 70 kDa protein 12A

Gene

HSPA12A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165868-MONOMER.
ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 12A
Gene namesi
Name:HSPA12A
Synonyms:KIAA0417
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:19022. HSPA12A.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi259217.
OpenTargetsiENSG00000165868.
PharmGKBiPA38779.

Polymorphism and mutation databases

BioMutaiHSPA12A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000782922 – 675Heat shock 70 kDa protein 12AAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO43301.
MaxQBiO43301.
PaxDbiO43301.
PeptideAtlasiO43301.
PRIDEiO43301.

PTM databases

iPTMnetiO43301.
PhosphoSitePlusiO43301.

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain, kidney and muscle.1 Publication

Gene expression databases

BgeeiENSG00000165868.
CleanExiHS_HSPA12A.
ExpressionAtlasiO43301. baseline and differential.
GenevisibleiO43301. HS.

Organism-specific databases

HPAiHPA011273.

Interactioni

Protein-protein interaction databases

BioGridi129226. 23 interactors.
IntActiO43301. 6 interactors.
STRINGi9606.ENSP00000358211.

Structurei

3D structure databases

ProteinModelPortaliO43301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000014360.
HOGENOMiHOG000231707.
HOVERGENiHBG051928.
InParanoidiO43301.
OMAiFTQAKEH.
OrthoDBiEOG091G03BF.
PhylomeDBiO43301.
TreeFamiTF329492.

Family and domain databases

InterProiIPR026685. HSPA12A.
[Graphical view]
PANTHERiPTHR14187:SF46. PTHR14187:SF46. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKEAGGSD GPRETAPTSA YSSPARSLGD TGITPLSPSH IVNDTDSNVS
60 70 80 90 100
EQQSFLVVVA VDFGTTSSGY AYSFTKEPEC IHVMRRWEGG DPGVSNQKTP
110 120 130 140 150
TTILLTPERK FHSFGYAARD FYHDLDPNEA KQWLYLEKFK MKLHTTGDLT
160 170 180 190 200
MDTDLTAANG KKVKALEIFA YALQYFKEQA LKELSDQAGS EFENSDVRWV
210 220 230 240 250
ITVPAIWKQP AKQFMRQAAY QAGLASPENS EQLIIALEPE AASIYCRKLR
260 270 280 290 300
LHQMIELSSK AAVNGYSGSD TVGAGFTQAK EHIRRNRQSR TFLVENVIGE
310 320 330 340 350
IWSELEEGDK YVVVDSGGGT VDLTVHQIRL PEGHLKELYK ATGGPYGSLG
360 370 380 390 400
VDYEFEKLLY KIFGEDFIEQ FKIKRPAAWV DLMIAFESRK RAAAPDRTNP
410 420 430 440 450
LNITLPFSFI DYYKKFRGHS VEHALRKSNV DFVKWSSQGM LRMSPDAMNA
460 470 480 490 500
LFKPTIDSII EHLRDLFQKP EVSTVKFLFL VGGFAEAPLL QQAVQAAFGD
510 520 530 540 550
QCRIIIPQDV GLTILKGAVL FGLDPAVIKV RRSPLTYGVG VLNRYVEGKH
560 570 580 590 600
PPEKLLVKDG TRWCTDVFDK FISADQSVAL GELVKRSYTP AKPSQLVIVI
610 620 630 640 650
NIYSSEHDNV SFITDPGVKK CGTLRLDLTG TSGTAVPARR EIQTLMQFGD
660 670
TEIKATAIDI ATSKSVKVGI DFLNY
Length:675
Mass (Da):74,978
Last modified:July 19, 2003 - v2
Checksum:i5DF35D68F9D76437
GO

Sequence cautioni

The sequence BAA24847 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007877 mRNA. Translation: BAA24847.1. Different initiation.
CCDSiCCDS41569.1.
PIRiT00055.
RefSeqiNP_079291.2. NM_025015.2.
UniGeneiHs.648448.

Genome annotation databases

EnsembliENST00000369209; ENSP00000358211; ENSG00000165868.
GeneIDi259217.
KEGGihsa:259217.
UCSCiuc001lct.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007877 mRNA. Translation: BAA24847.1. Different initiation.
CCDSiCCDS41569.1.
PIRiT00055.
RefSeqiNP_079291.2. NM_025015.2.
UniGeneiHs.648448.

3D structure databases

ProteinModelPortaliO43301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129226. 23 interactors.
IntActiO43301. 6 interactors.
STRINGi9606.ENSP00000358211.

PTM databases

iPTMnetiO43301.
PhosphoSitePlusiO43301.

Polymorphism and mutation databases

BioMutaiHSPA12A.

Proteomic databases

EPDiO43301.
MaxQBiO43301.
PaxDbiO43301.
PeptideAtlasiO43301.
PRIDEiO43301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369209; ENSP00000358211; ENSG00000165868.
GeneIDi259217.
KEGGihsa:259217.
UCSCiuc001lct.3. human.

Organism-specific databases

CTDi259217.
DisGeNETi259217.
GeneCardsiHSPA12A.
HGNCiHGNC:19022. HSPA12A.
HPAiHPA011273.
MIMi610701. gene.
neXtProtiNX_O43301.
OpenTargetsiENSG00000165868.
PharmGKBiPA38779.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000014360.
HOGENOMiHOG000231707.
HOVERGENiHBG051928.
InParanoidiO43301.
OMAiFTQAKEH.
OrthoDBiEOG091G03BF.
PhylomeDBiO43301.
TreeFamiTF329492.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165868-MONOMER.
ReactomeiR-HSA-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

ChiTaRSiHSPA12A. human.
GenomeRNAii259217.
PROiO43301.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165868.
CleanExiHS_HSPA12A.
ExpressionAtlasiO43301. baseline and differential.
GenevisibleiO43301. HS.

Family and domain databases

InterProiIPR026685. HSPA12A.
[Graphical view]
PANTHERiPTHR14187:SF46. PTHR14187:SF46. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHS12A_HUMAN
AccessioniPrimary (citable) accession number: O43301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 19, 2003
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.