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Protein

Leucine-rich repeat transmembrane neuronal protein 2

Gene

LRRTM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane neuronal protein 2
Alternative name(s):
Leucine-rich repeat neuronal 2 protein
Gene namesi
Name:LRRTM2
Synonyms:KIAA0416, LRRN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19409. LRRTM2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 422389ExtracellularSequence analysisAdd
BLAST
Transmembranei423 – 44321HelicalSequence analysisAdd
BLAST
Topological domaini444 – 51673CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993038.

Polymorphism and mutation databases

BioMutaiLRRTM2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 516483Leucine-rich repeat transmembrane neuronal protein 2PRO_0000018353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO43300.
PeptideAtlasiO43300.
PRIDEiO43300.

PTM databases

iPTMnetiO43300.
PhosphoSiteiO43300.

Expressioni

Tissue specificityi

Expressed in neuronal tissues.1 Publication

Gene expression databases

BgeeiENSG00000146006.
CleanExiHS_LRRN2.
HS_LRRTM2.
ExpressionAtlasiO43300. baseline and differential.
GenevisibleiO43300. HS.

Interactioni

Subunit structurei

Interacts with DLG4 and NRXN1.By similarity

Protein-protein interaction databases

BioGridi117508. 12 interactions.
STRINGi9606.ENSP00000274711.

Structurei

3D structure databases

ProteinModelPortaliO43300.
SMRiO43300. Positions 17-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 6128LRRNTAdd
BLAST
Repeati63 – 8321LRR 1Add
BLAST
Repeati86 – 10722LRR 2Add
BLAST
Repeati110 – 13122LRR 3Add
BLAST
Repeati134 – 15522LRR 4Add
BLAST
Repeati158 – 17922LRR 5Add
BLAST
Repeati182 – 20322LRR 6Add
BLAST
Repeati206 – 22722LRR 7Add
BLAST
Repeati230 – 25122LRR 8Add
BLAST
Repeati254 – 27522LRR 9Add
BLAST
Repeati278 – 29922LRR 10Add
BLAST
Domaini311 – 36252LRRCTAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi513 – 5164Involved in DLG4-bindingBy similarity

Domaini

Synaptogenic effects are mediated by the extracellular LRR region.By similarity

Sequence similaritiesi

Belongs to the LRRTM family.Curated
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiO43300.
KOiK16665.
OMAiAMATTYR.
OrthoDBiEOG091G03BI.
PhylomeDBiO43300.
TreeFamiTF332659.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLHFKWPLG APMLAAIYAM SMVLKMLPAL GMACPPKCRC EKLLFYCDSQ
60 70 80 90 100
GFHSVPNATD KGSLGLSLRH NHITELERDQ FASFSQLTWL HLDHNQISTV
110 120 130 140 150
KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP
160 170 180 190 200
ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG
210 220 230 240 250
FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMEW
260 270 280 290 300
TWGTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL
310 320 330 340 350
RSLTTVGLSG NLWECSARIC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI
360 370 380 390 400
LDAVHGFQLC WNLSTTVTVM ATTYRDPTTE YTKRISSSSY HVGDKEIPTT
410 420 430 440 450
AGIAVTTEEH FPEPDNAIFT QRVITGTMAL LFSFFFIIFI VFISRKCCPP
460 470 480 490 500
TLRRIRQCSM VQNHRQLRSQ TRLHMSNMSD QGPYNEYEPT HEGPFIIING
510
YGQCKCQQLP YKECEV
Length:516
Mass (Da):59,076
Last modified:July 19, 2004 - v3
Checksum:iF2EDD45C854BC3A6
GO

Sequence cautioni

The sequence BAA24846 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti334 – 3341E → G in BAF83753 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182026 mRNA. Translation: AAO67547.1.
AB007876 mRNA. Translation: BAA24846.2. Different initiation.
AK291064 mRNA. Translation: BAF83753.1.
BC126408 mRNA. Translation: AAI26409.1.
BC126410 mRNA. Translation: AAI26411.1.
BC143926 mRNA. Translation: AAI43927.1.
CCDSiCCDS47272.1.
RefSeqiNP_056379.1. NM_015564.2.
UniGeneiHs.656653.

Genome annotation databases

EnsembliENST00000274711; ENSP00000274711; ENSG00000146006.
GeneIDi26045.
KEGGihsa:26045.
UCSCiuc011cyz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY182026 mRNA. Translation: AAO67547.1.
AB007876 mRNA. Translation: BAA24846.2. Different initiation.
AK291064 mRNA. Translation: BAF83753.1.
BC126408 mRNA. Translation: AAI26409.1.
BC126410 mRNA. Translation: AAI26411.1.
BC143926 mRNA. Translation: AAI43927.1.
CCDSiCCDS47272.1.
RefSeqiNP_056379.1. NM_015564.2.
UniGeneiHs.656653.

3D structure databases

ProteinModelPortaliO43300.
SMRiO43300. Positions 17-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117508. 12 interactions.
STRINGi9606.ENSP00000274711.

PTM databases

iPTMnetiO43300.
PhosphoSiteiO43300.

Polymorphism and mutation databases

BioMutaiLRRTM2.

Proteomic databases

PaxDbiO43300.
PeptideAtlasiO43300.
PRIDEiO43300.

Protocols and materials databases

DNASUi26045.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274711; ENSP00000274711; ENSG00000146006.
GeneIDi26045.
KEGGihsa:26045.
UCSCiuc011cyz.2. human.

Organism-specific databases

CTDi26045.
GeneCardsiLRRTM2.
HGNCiHGNC:19409. LRRTM2.
MIMi610868. gene.
neXtProtiNX_O43300.
PharmGKBiPA134993038.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000290681.
HOVERGENiHBG052362.
InParanoidiO43300.
KOiK16665.
OMAiAMATTYR.
OrthoDBiEOG091G03BI.
PhylomeDBiO43300.
TreeFamiTF332659.

Miscellaneous databases

GenomeRNAii26045.
PROiO43300.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146006.
CleanExiHS_LRRN2.
HS_LRRTM2.
ExpressionAtlasiO43300. baseline and differential.
GenevisibleiO43300. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRT2_HUMAN
AccessioniPrimary (citable) accession number: O43300
Secondary accession number(s): A0AVL3
, A8K4U9, B7ZLN8, Q7L770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.