O43300 (LRRT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat transmembrane neuronal protein 2

Alternative name(s):
Leucine-rich repeat neuronal 2 protein

Gene names

Name:	LRRTM2
Synonyms:	KIAA0416, LRRN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B By similarity.
Subunit structure	Interacts with DLG4 and NRXN1 By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Cell junction › synapse › postsynaptic cell membrane; Single-pass type I membrane protein By similarity. Note: Localized to excitatory synapses By similarity.
Tissue specificity	Expressed in neuronal tissues. Ref.1
Domain	Synaptogenic effects are mediated by the extracellular LRR region By similarity.
Sequence similarities	Belongs to the LRRTM family. Contains 10 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.
Sequence caution	The sequence BAA24846.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Leucine-rich repeat Repeat Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synapse organization Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW excitatory synapse Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 516	483	Leucine-rich repeat transmembrane neuronal protein 2		PRO_0000018353
Regions
	Topological domain	34 – 422	389	Extracellular Potential
	Transmembrane	423 – 443	21	Helical; Potential
	Topological domain	444 – 516	73	Cytoplasmic Potential
	Domain	34 – 61	28	LRRNT
	Repeat	63 – 83	21	LRR 1
	Repeat	86 – 107	22	LRR 2
	Repeat	110 – 131	22	LRR 3
	Repeat	134 – 155	22	LRR 4
	Repeat	158 – 179	22	LRR 5
	Repeat	182 – 203	22	LRR 6
	Repeat	206 – 227	22	LRR 7
	Repeat	230 – 251	22	LRR 8
	Repeat	254 – 275	22	LRR 9
	Repeat	278 – 299	22	LRR 10
	Domain	311 – 362	52	LRRCT
	Motif	513 – 516	4	Involved in DLG4-binding By similarity
Amino acid modifications
	Glycosylation	57	1	N-linked (GlcNAc...) Potential
	Glycosylation	126	1	N-linked (GlcNAc...) Potential
	Glycosylation	243	1	N-linked (GlcNAc...) Potential
	Glycosylation	362	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	334	1	E → G in BAF83753. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	O43300 [UniParc]. Last modified July 19, 2004. Version 3. Checksum: F2EDD45C854BC3A6	FASTA	516	59,076
	10 20 30 40 50 60 MGLHFKWPLG APMLAAIYAM SMVLKMLPAL GMACPPKCRC EKLLFYCDSQ GFHSVPNATD 70 80 90 100 110 120 KGSLGLSLRH NHITELERDQ FASFSQLTWL HLDHNQISTV KEDAFQGLYK LKELILSSNK 130 140 150 160 170 180 IFYLPNTTFT QLINLQNLDL SFNQLSSLHP ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC 190 200 210 220 230 240 RSLEFLDLST NRLRSLARNG FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK 250 260 270 280 290 300 ISNLTCGMEW TWGTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL 310 320 330 340 350 360 RSLTTVGLSG NLWECSARIC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI LDAVHGFQLC 370 380 390 400 410 420 WNLSTTVTVM ATTYRDPTTE YTKRISSSSY HVGDKEIPTT AGIAVTTEEH FPEPDNAIFT 430 440 450 460 470 480 QRVITGTMAL LFSFFFIIFI VFISRKCCPP TLRRIRQCSM VQNHRQLRSQ TRLHMSNMSD 490 500 510 QGPYNEYEPT HEGPFIIING YGQCKCQQLP YKECEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system." Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T. Genomics 81:411-421(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro." Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY182026 mRNA. Translation: AAO67547.1. AB007876 mRNA. Translation: BAA24846.2. Different initiation. AK291064 mRNA. Translation: BAF83753.1. BC126408 mRNA. Translation: AAI26409.1. BC126410 mRNA. Translation: AAI26411.1. BC143926 mRNA. Translation: AAI43927.1.
IPI	IPI00023576.
RefSeq	NP_056379.1. NM_015564.2.
UniGene	Hs.656653.
3D structure databases
ProteinModelPortal	O43300.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000274711.
PTM databases
PhosphoSite	O43300.
Proteomic databases
PaxDb	O43300.
PRIDE	O43300.
Protocols and materials databases
DNASU	26045.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274711; ENSP00000274711; ENSG00000146006.
GeneID	26045.
KEGG	hsa:26045.
UCSC	uc011cyz.1. human.
Organism-specific databases
CTD	26045.
GeneCards	GC05M138205.
HGNC	HGNC:19409. LRRTM2.
HPA	HPA017323.
MIM	610868. gene.
neXtProt	NX_O43300.
PharmGKB	PA134993038.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4886.
HOGENOM	HOG000290681.
HOVERGEN	HBG052362.
InParanoid	O43300.
OMA	IRQCSMI.
OrthoDB	EOG4PG60Z.
Gene expression databases
ArrayExpress	O43300.
Bgee	O43300.
CleanEx	HS_LRRN2. HS_LRRTM2.
Genevestigator	O43300.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR025875. Leu-rich_rpt_4. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF12799. LRR_4. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 4 hits. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 10 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26045.
NextBio	47883.
SOURCE	Search...

Entry information

Entry name

LRRT2_HUMAN

Accession

Primary (citable) accession number: O43300
Secondary accession number(s): A0AVL3 , A8K4U9, B7ZLN8, Q7L770

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.