Reviewed, UniProtKB/Swiss-Prot O43299 (K0415_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein KIAA0415

Gene names

Name:

KIAA0415

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	807 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43299-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43299-2)

The sequence of this isoform differs from the canonical sequence as follows:
     602-625: SVLSSQFLALCTLKPSLVVELARD → RPDACRPILVPL
     626-807: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: O43299-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     602-602: S → R
     603-807: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 807	807	Uncharacterized protein KIAA0415		PRO_0000261357
Regions
	Compositional bias	579 – 584	6	Poly-Leu
Natural variations
	Alternative sequence	1 – 156	156	Missing in isoform 3.		VSP_021672
	Alternative sequence	602 – 625	24	SVLSS…ELARD → RPDACRPILVPL in isoform 2.		VSP_021673
	Alternative sequence	602	1	S → R in isoform 3.		VSP_021674
	Alternative sequence	603 – 807	205	Missing in isoform 3.		VSP_021675
	Alternative sequence	626 – 807	182	Missing in isoform 2.		VSP_021676
	Natural variant	94	1	S → C: dbSNP rs11549839.		VAR_049511

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: AD02B2664838B739	FASTA	807	88,605
	10 20 30 40 50 60 MFSAGAESLL HQAREIQDEE LKKFCSRICK LLQAEDLGPD TLDSLQRLFL IISATKYSRR 70 80 90 100 110 120 LEKTCVDLLQ ATLGLPACPE QLQVLCAAIL REMSPSDSLS LAWDHTQNSR QLSLVASVLL 130 140 150 160 170 180 AQGDRNEEVR AVGQGVLRAL ESRQPEGPSL RHLLPVMAKV VVLSPGTLQE DQATLLSKRL 190 200 210 220 230 240 VDWLRYASLQ QGLPHSGGFF STPRARQPGP VTEVDGAVAT DFFTVLSSGH RFTDDQWLNV 250 260 270 280 290 300 QAFSMLRAWL LHSGPEGPGT LDTDDRSEQE GSTLSVISAT SSAGRLLPPR ERLREVAFEY 310 320 330 340 350 360 CQRLIEQSNR RALRKGDSDL QKACLVEAVL VLDVLCRQDP SFLYRSLSCL KALHGRVRGD 370 380 390 400 410 420 PASVRVLLPL AHFFLSHGEA AAVDSEAVYQ HLFTRIPVEQ FHSPMLAFEF IQFCRDNLHL 430 440 450 460 470 480 FSGHLSTLRL SFPNLFKFLA WNSPPLTSEF VALLPALVDA GTALEMLHAL LDLPCLTAVL 490 500 510 520 530 540 DLQLRSAPAA SERPLWDTSL RAPSCLEAFR DPQFQGLFQY LLRPKASGAT ERLAPLHQLL 550 560 570 580 590 600 QPMAGCARVA QCAQAVPTLL QAFFSAVTQV ADGSLINQLA LLLLGRSDSL YPAPGYAAGV 610 620 630 640 650 660 HSVLSSQFLA LCTLKPSLVV ELARDLLEFL GSVNGLCSRA SLVTSVVWAI GEYLSVTYDR 670 680 690 700 710 720 RCTVEQINKF FEALEALLFE VTQCRPSAAL PRCPPQVVTV LMTTLTKLAS RSQDLIPRAS 730 740 750 760 770 780 LLLSKMRTLA HSPATSSTHS EEGAEAIRTR ATELLTLLKM PSVAQFVLTP STEVCSPRYH 790 800 RDANTALPLA LRTVSRLVER EAGLMPG
	Isoform 2. Checksum: 05CA8723DAE26D36	FASTA	613	67,454
	10 20 30 40 50 60 MFSAGAESLL HQAREIQDEE LKKFCSRICK LLQAEDLGPD TLDSLQRLFL IISATKYSRR 70 80 90 100 110 120 LEKTCVDLLQ ATLGLPACPE QLQVLCAAIL REMSPSDSLS LAWDHTQNSR QLSLVASVLL 130 140 150 160 170 180 AQGDRNEEVR AVGQGVLRAL ESRQPEGPSL RHLLPVMAKV VVLSPGTLQE DQATLLSKRL 190 200 210 220 230 240 VDWLRYASLQ QGLPHSGGFF STPRARQPGP VTEVDGAVAT DFFTVLSSGH RFTDDQWLNV 250 260 270 280 290 300 QAFSMLRAWL LHSGPEGPGT LDTDDRSEQE GSTLSVISAT SSAGRLLPPR ERLREVAFEY 310 320 330 340 350 360 CQRLIEQSNR RALRKGDSDL QKACLVEAVL VLDVLCRQDP SFLYRSLSCL KALHGRVRGD 370 380 390 400 410 420 PASVRVLLPL AHFFLSHGEA AAVDSEAVYQ HLFTRIPVEQ FHSPMLAFEF IQFCRDNLHL 430 440 450 460 470 480 FSGHLSTLRL SFPNLFKFLA WNSPPLTSEF VALLPALVDA GTALEMLHAL LDLPCLTAVL 490 500 510 520 530 540 DLQLRSAPAA SERPLWDTSL RAPSCLEAFR DPQFQGLFQY LLRPKASGAT ERLAPLHQLL 550 560 570 580 590 600 QPMAGCARVA QCAQAVPTLL QAFFSAVTQV ADGSLINQLA LLLLGRSDSL YPAPGYAAGV 610 HRPDACRPIL VPL
	Isoform 3. Checksum: 4B48C08285BAE35D	FASTA	446	49,020
	10 20 30 40 50 60 MAKVVVLSPG TLQEDQATLL SKRLVDWLRY ASLQQGLPHS GGFFSTPRAR QPGPVTEVDG 70 80 90 100 110 120 AVATDFFTVL SSGHRFTDDQ WLNVQAFSML RAWLLHSGPE GPGTLDTDDR SEQEGSTLSV 130 140 150 160 170 180 ISATSSAGRL LPPRERLREV AFEYCQRLIE QSNRRALRKG DSDLQKACLV EAVLVLDVLC 190 200 210 220 230 240 RQDPSFLYRS LSCLKALHGR VRGDPASVRV LLPLAHFFLS HGEAAAVDSE AVYQHLFTRI 250 260 270 280 290 300 PVEQFHSPML AFEFIQFCRD NLHLFSGHLS TLRLSFPNLF KFLAWNSPPL TSEFVALLPA 310 320 330 340 350 360 LVDAGTALEM LHALLDLPCL TAVLDLQLRS APAASERPLW DTSLRAPSCL EAFRDPQFQG 370 380 390 400 410 420 LFQYLLRPKA SGATERLAPL HQLLQPMAGC ARVAQCAQAV PTLLQAFFSA VTQVADGSLI 430 440 NQLALLLLGR SDSLYPAPGY AAGVHR

References

[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro." Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:307-313(1997) [PubMed: 9455477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-807 (ISOFORM 1). Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC092610 Genomic DNA. No translation available. AB007875 mRNA. Translation: BAA24845.1. Different initiation. BC008841 mRNA. Translation: AAH08841.2. BC037399 mRNA. Translation: AAH37399.1.
IPI	IPI00465123. IPI00807569. IPI00872712.
PIR	T00054.
RefSeq	NP_055670.1.
UniGene	Hs.558440
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O43299. 1 interaction.
Proteomic databases
PRIDE	O43299.
Genome annotation databases
Ensembl	ENSG00000164917. Homo sapiens. [Contig view]
GeneID	9907.
KEGG	hsa:9907.
Organism-specific databases
GeneCards	GC07P004781.
HGNC	HGNC:22197. KIAA0415.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O43299.
HOVERGEN	O43299.
OMA	O43299. LFEVTQS.
Gene expression databases
ArrayExpress	O43299.
Bgee	O43299.
CleanEx	HS_KIAA0415.
GermOnline	ENSG00000164917. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	37361.

Entry information

Entry name

K0415_HUMAN

Accession

Primary (citable) accession number: O43299
Secondary accession number(s): Q8N3X2, Q96H80

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 28, 2006
Last modified:	June 16, 2009
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)