Reviewed,
UniProtKB/Swiss-Prot O43299 (K0415_HUMAN)
Last modified
June 16, 2009.
Version 47.
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Names and origin · Protein attributes · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Uncharacterized protein KIAA0415 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 807 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O43299-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O43299-2) The sequence of this isoform differs from the canonical sequence as follows: 602-625: SVLSSQFLALCTLKPSLVVELARD → RPDACRPILVPL 626-807: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: O43299-3) The sequence of this isoform differs from the canonical sequence as follows: 1-156: Missing. 602-602: S → R 603-807: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 807 | 807 | Uncharacterized protein KIAA0415 | PRO_0000261357 | |||||
Regions | |||||||||
| Compositional bias | 579 – 584 | 6 | Poly-Leu | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 156 | 156 | Missing in isoform 3. | VSP_021672 | |||||
| Alternative sequence | 602 – 625 | 24 | SVLSS…ELARD → RPDACRPILVPL in isoform 2. | VSP_021673 | |||||
| Alternative sequence | 602 | 1 | S → R in isoform 3. | VSP_021674 | |||||
| Alternative sequence | 603 – 807 | 205 | Missing in isoform 3. | VSP_021675 | |||||
| Alternative sequence | 626 – 807 | 182 | Missing in isoform 2. | VSP_021676 | |||||
| Natural variant | 94 | 1 | S → C: dbSNP rs11549839. | VAR_049511 | |||||
Sequences
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References
| [1] | "The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. Wilson R.K.Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro." Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:307-313(1997) [PubMed: 9455477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-807 (ISOFORM 1). Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AC092610 Genomic DNA. No translation available. AB007875 mRNA. Translation: BAA24845.1. Different initiation. BC008841 mRNA. Translation: AAH08841.2. BC037399 mRNA. Translation: AAH37399.1. | |
| IPI | IPI00465123. IPI00807569. IPI00872712. |
| PIR | T00054. |
| RefSeq | NP_055670.1. |
| UniGene | Hs.558440 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O43299. 1 interaction. |
Proteomic databases | |
| PRIDE | O43299. |
Genome annotation databases | |
| Ensembl | ENSG00000164917. Homo sapiens. [Contig view] |
| GeneID | 9907. |
| KEGG | hsa:9907. |
Organism-specific databases | |
| GeneCards | GC07P004781. |
| HGNC | HGNC:22197. KIAA0415. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O43299. |
| HOVERGEN | O43299. |
| OMA | O43299. LFEVTQS. |
Gene expression databases | |
| ArrayExpress | O43299. |
| Bgee | O43299. |
| CleanEx | HS_KIAA0415. |
| GermOnline | ENSG00000164917. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 37361. |
Entry information
| Entry name | K0415_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O43299 Secondary accession number(s): Q8N3X2, Q96H80 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |

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