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Protein

Zinc finger and BTB domain-containing protein 43

Gene

ZBTB43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiO43298

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 43
Alternative name(s):
Zinc finger and BTB domain-containing protein 22B
Zinc finger protein 297B
ZnF-x
Gene namesi
Name:ZBTB43
Synonyms:KIAA0414, ZBTB22B, ZNF297B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000169155.9
HGNCiHGNC:17908 ZBTB43
neXtProtiNX_O43298

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169155
PharmGKBiPA38257

Polymorphism and mutation databases

BioMutaiZBTB43

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475191 – 467Zinc finger and BTB domain-containing protein 43Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki241Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki247Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei423PhosphothreonineCombined sources1
Cross-linki458Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43298
PaxDbiO43298
PeptideAtlasiO43298
PRIDEiO43298

PTM databases

iPTMnetiO43298
PhosphoSitePlusiO43298

Expressioni

Gene expression databases

BgeeiENSG00000169155
CleanExiHS_ZBTB43
ExpressionAtlasiO43298 baseline and differential
GenevisibleiO43298 HS

Organism-specific databases

HPAiHPA016825

Interactioni

Subunit structurei

Interacts with BDP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116727, 31 interactors
IntActiO43298, 27 interactors
STRINGi9606.ENSP00000362556

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi380 – 383Combined sources4
Helixi384 – 394Combined sources11
Beta strandi399 – 401Combined sources3
Turni403 – 405Combined sources3
Beta strandi408 – 412Combined sources5
Helixi413 – 419Combined sources7
Turni420 – 422Combined sources3
Beta strandi431 – 433Combined sources3
Beta strandi436 – 438Combined sources3
Helixi440 – 458Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSHNMR-A370-466[»]
ProteinModelPortaliO43298
SMRiO43298
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43298

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000231975
HOVERGENiHBG056510
InParanoidiO43298
KOiK10514
OMAiTESINTM
OrthoDBiEOG091G04SQ
PhylomeDBiO43298
TreeFamiTF333162

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

O43298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGTNSFRV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFRAHKAV
60 70 80 90 100
LAASSPYFCD QVLLKNSRRI VLPDVMNPRV FENILLSSYT GRLVMPAPEI
110 120 130 140 150
VSYLTAASFL QMWHVVDKCT EVLEGNPTVL CQKLNHGSDH QSPSSSSYNG
160 170 180 190 200
LVESFELGSG GHTDFPKAQE LRDGENEEES TKDELSSQLT EHEYLPSNSS
210 220 230 240 250
TEHDRLSTEM ASQDGEEGAS DSAEFHYTRP MYSKPSIMAH KRWIHVKPER
260 270 280 290 300
LEQACEGMDV HATYDEHQVT ESINTVQTEH TVQPSGVEED FHIGEKKVEA
310 320 330 340 350
EFDEQADESN YDEQVDFYGS SMEEFSGERS DGNLIGHRQE AALAAGYSEN
360 370 380 390 400
IEMVTGIKEE ASHLGFSATD KLYPCQCGKS FTHKSQRDRH MSMHLGLRPY
410 420 430 440 450
GCGVCGKKFK MKHHLVGHMK IHTGIKPYEC NICAKRFMWR DSFHRHVTSC
460
TKSYEAAKAE QNTTEAN
Length:467
Mass (Da):52,630
Last modified:June 1, 1998 - v1
Checksum:i9DFB6CEEB8562425
GO

Sequence cautioni

The sequence BAA24844 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007874 mRNA Translation: BAA24844.2 Different initiation.
AF049907 mRNA Translation: AAC05500.1
BT007194 mRNA Translation: AAP35858.1
AL161731 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87643.1
BC008828 mRNA Translation: AAH08828.1
CCDSiCCDS6867.1
RefSeqiNP_001129248.1, NM_001135776.1
NP_054726.1, NM_014007.3
XP_005251892.1, XM_005251835.3
XP_011516711.1, XM_011518409.1
XP_011516713.1, XM_011518411.2
UniGeneiHs.355581

Genome annotation databases

EnsembliENST00000373457; ENSP00000362556; ENSG00000169155
ENST00000373464; ENSP00000362563; ENSG00000169155
ENST00000449886; ENSP00000390344; ENSG00000169155
GeneIDi23099
KEGGihsa:23099
UCSCiuc004bql.4 human

Similar proteinsi

Entry informationi

Entry nameiZBT43_HUMAN
AccessioniPrimary (citable) accession number: O43298
Secondary accession number(s): Q5JU96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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