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Protein

Zinc finger and BTB domain-containing protein 43

Gene

ZBTB43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiO43298.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 43
Alternative name(s):
Zinc finger and BTB domain-containing protein 22B
Zinc finger protein 297B
ZnF-x
Gene namesi
Name:ZBTB43
Synonyms:KIAA0414, ZBTB22B, ZNF297B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17908. ZBTB43.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169155.
PharmGKBiPA38257.

Polymorphism and mutation databases

BioMutaiZBTB43.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475191 – 467Zinc finger and BTB domain-containing protein 43Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki247Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei423PhosphothreonineCombined sources1
Cross-linki458Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43298.
PaxDbiO43298.
PeptideAtlasiO43298.
PRIDEiO43298.

PTM databases

iPTMnetiO43298.
PhosphoSitePlusiO43298.

Expressioni

Gene expression databases

BgeeiENSG00000169155.
CleanExiHS_ZBTB43.
ExpressionAtlasiO43298. baseline and differential.
GenevisibleiO43298. HS.

Organism-specific databases

HPAiHPA016825.

Interactioni

Subunit structurei

Interacts with BDP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116727. 29 interactors.
IntActiO43298. 27 interactors.
MINTiMINT-2796003.
STRINGi9606.ENSP00000362556.

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi380 – 383Combined sources4
Helixi384 – 394Combined sources11
Beta strandi399 – 401Combined sources3
Turni403 – 405Combined sources3
Beta strandi408 – 412Combined sources5
Helixi413 – 419Combined sources7
Turni420 – 422Combined sources3
Beta strandi431 – 433Combined sources3
Beta strandi436 – 438Combined sources3
Helixi440 – 458Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSHNMR-A370-466[»]
ProteinModelPortaliO43298.
SMRiO43298.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43298.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 394C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri400 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231975.
HOVERGENiHBG056510.
InParanoidiO43298.
KOiK10514.
OMAiTESINTM.
OrthoDBiEOG091G04SQ.
PhylomeDBiO43298.
TreeFamiTF333162.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00651. BTB. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

O43298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGTNSFRV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFRAHKAV
60 70 80 90 100
LAASSPYFCD QVLLKNSRRI VLPDVMNPRV FENILLSSYT GRLVMPAPEI
110 120 130 140 150
VSYLTAASFL QMWHVVDKCT EVLEGNPTVL CQKLNHGSDH QSPSSSSYNG
160 170 180 190 200
LVESFELGSG GHTDFPKAQE LRDGENEEES TKDELSSQLT EHEYLPSNSS
210 220 230 240 250
TEHDRLSTEM ASQDGEEGAS DSAEFHYTRP MYSKPSIMAH KRWIHVKPER
260 270 280 290 300
LEQACEGMDV HATYDEHQVT ESINTVQTEH TVQPSGVEED FHIGEKKVEA
310 320 330 340 350
EFDEQADESN YDEQVDFYGS SMEEFSGERS DGNLIGHRQE AALAAGYSEN
360 370 380 390 400
IEMVTGIKEE ASHLGFSATD KLYPCQCGKS FTHKSQRDRH MSMHLGLRPY
410 420 430 440 450
GCGVCGKKFK MKHHLVGHMK IHTGIKPYEC NICAKRFMWR DSFHRHVTSC
460
TKSYEAAKAE QNTTEAN
Length:467
Mass (Da):52,630
Last modified:June 1, 1998 - v1
Checksum:i9DFB6CEEB8562425
GO

Sequence cautioni

The sequence BAA24844 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007874 mRNA. Translation: BAA24844.2. Different initiation.
AF049907 mRNA. Translation: AAC05500.1.
BT007194 mRNA. Translation: AAP35858.1.
AL161731 Genomic DNA. Translation: CAI40920.1.
CH471090 Genomic DNA. Translation: EAW87643.1.
BC008828 mRNA. Translation: AAH08828.1.
CCDSiCCDS6867.1.
RefSeqiNP_001129248.1. NM_001135776.1.
NP_054726.1. NM_014007.3.
XP_005251892.1. XM_005251835.3.
XP_011516711.1. XM_011518409.1.
XP_011516713.1. XM_011518411.2.
UniGeneiHs.355581.

Genome annotation databases

EnsembliENST00000373457; ENSP00000362556; ENSG00000169155.
ENST00000373464; ENSP00000362563; ENSG00000169155.
ENST00000449886; ENSP00000390344; ENSG00000169155.
GeneIDi23099.
KEGGihsa:23099.
UCSCiuc004bql.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007874 mRNA. Translation: BAA24844.2. Different initiation.
AF049907 mRNA. Translation: AAC05500.1.
BT007194 mRNA. Translation: AAP35858.1.
AL161731 Genomic DNA. Translation: CAI40920.1.
CH471090 Genomic DNA. Translation: EAW87643.1.
BC008828 mRNA. Translation: AAH08828.1.
CCDSiCCDS6867.1.
RefSeqiNP_001129248.1. NM_001135776.1.
NP_054726.1. NM_014007.3.
XP_005251892.1. XM_005251835.3.
XP_011516711.1. XM_011518409.1.
XP_011516713.1. XM_011518411.2.
UniGeneiHs.355581.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSHNMR-A370-466[»]
ProteinModelPortaliO43298.
SMRiO43298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116727. 29 interactors.
IntActiO43298. 27 interactors.
MINTiMINT-2796003.
STRINGi9606.ENSP00000362556.

PTM databases

iPTMnetiO43298.
PhosphoSitePlusiO43298.

Polymorphism and mutation databases

BioMutaiZBTB43.

Proteomic databases

EPDiO43298.
PaxDbiO43298.
PeptideAtlasiO43298.
PRIDEiO43298.

Protocols and materials databases

DNASUi23099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373457; ENSP00000362556; ENSG00000169155.
ENST00000373464; ENSP00000362563; ENSG00000169155.
ENST00000449886; ENSP00000390344; ENSG00000169155.
GeneIDi23099.
KEGGihsa:23099.
UCSCiuc004bql.4. human.

Organism-specific databases

CTDi23099.
GeneCardsiZBTB43.
HGNCiHGNC:17908. ZBTB43.
HPAiHPA016825.
neXtProtiNX_O43298.
OpenTargetsiENSG00000169155.
PharmGKBiPA38257.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231975.
HOVERGENiHBG056510.
InParanoidiO43298.
KOiK10514.
OMAiTESINTM.
OrthoDBiEOG091G04SQ.
PhylomeDBiO43298.
TreeFamiTF333162.

Enzyme and pathway databases

SIGNORiO43298.

Miscellaneous databases

ChiTaRSiZBTB43. human.
EvolutionaryTraceiO43298.
GenomeRNAii23099.
PROiPR:O43298.

Gene expression databases

BgeeiENSG00000169155.
CleanExiHS_ZBTB43.
ExpressionAtlasiO43298. baseline and differential.
GenevisibleiO43298. HS.

Family and domain databases

InterProiView protein in InterPro
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00651. BTB. 1 hit.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZBT43_HUMAN
AccessioniPrimary (citable) accession number: O43298
Secondary accession number(s): Q5JU96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 1998
Last modified: May 10, 2017
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.