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O43298

- ZBT43_HUMAN

UniProt

O43298 - ZBT43_HUMAN

Protein

Zinc finger and BTB domain-containing protein 43

Gene

ZBTB43

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri373 – 39422C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 43
    Alternative name(s):
    Zinc finger and BTB domain-containing protein 22B
    Zinc finger protein 297B
    ZnF-x
    Gene namesi
    Name:ZBTB43
    Synonyms:KIAA0414, ZBTB22B, ZNF297B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:17908. ZBTB43.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38257.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 467467Zinc finger and BTB domain-containing protein 43PRO_0000047519Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO43298.
    PaxDbiO43298.
    PRIDEiO43298.

    PTM databases

    PhosphoSiteiO43298.

    Expressioni

    Gene expression databases

    ArrayExpressiO43298.
    BgeeiO43298.
    CleanExiHS_ZBTB43.
    GenevestigatoriO43298.

    Organism-specific databases

    HPAiHPA016825.

    Interactioni

    Subunit structurei

    Interacts with BDP1.1 Publication

    Protein-protein interaction databases

    BioGridi116727. 14 interactions.
    IntActiO43298. 7 interactions.
    MINTiMINT-2796003.
    STRINGi9606.ENSP00000362556.

    Structurei

    Secondary structure

    1
    467
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi380 – 3834
    Helixi384 – 39411
    Beta strandi399 – 4013
    Turni403 – 4053
    Beta strandi408 – 4125
    Helixi413 – 4197
    Turni420 – 4223
    Beta strandi431 – 4333
    Beta strandi436 – 4383
    Helixi440 – 45819

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CSHNMR-A370-466[»]
    ProteinModelPortaliO43298.
    SMRiO43298. Positions 7-121, 367-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43298.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 9765BTBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri373 – 39422C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000231975.
    HOVERGENiHBG056510.
    InParanoidiO43298.
    KOiK10514.
    OMAiTESINTM.
    OrthoDBiEOG7Q8CN4.
    PhylomeDBiO43298.
    TreeFamiTF333162.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43298-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGTNSFRV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFRAHKAV    50
    LAASSPYFCD QVLLKNSRRI VLPDVMNPRV FENILLSSYT GRLVMPAPEI 100
    VSYLTAASFL QMWHVVDKCT EVLEGNPTVL CQKLNHGSDH QSPSSSSYNG 150
    LVESFELGSG GHTDFPKAQE LRDGENEEES TKDELSSQLT EHEYLPSNSS 200
    TEHDRLSTEM ASQDGEEGAS DSAEFHYTRP MYSKPSIMAH KRWIHVKPER 250
    LEQACEGMDV HATYDEHQVT ESINTVQTEH TVQPSGVEED FHIGEKKVEA 300
    EFDEQADESN YDEQVDFYGS SMEEFSGERS DGNLIGHRQE AALAAGYSEN 350
    IEMVTGIKEE ASHLGFSATD KLYPCQCGKS FTHKSQRDRH MSMHLGLRPY 400
    GCGVCGKKFK MKHHLVGHMK IHTGIKPYEC NICAKRFMWR DSFHRHVTSC 450
    TKSYEAAKAE QNTTEAN 467
    Length:467
    Mass (Da):52,630
    Last modified:June 1, 1998 - v1
    Checksum:i9DFB6CEEB8562425
    GO

    Sequence cautioni

    The sequence BAA24844.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB007874 mRNA. Translation: BAA24844.2. Different initiation.
    AF049907 mRNA. Translation: AAC05500.1.
    BT007194 mRNA. Translation: AAP35858.1.
    AL161731 Genomic DNA. Translation: CAI40920.1.
    CH471090 Genomic DNA. Translation: EAW87643.1.
    BC008828 mRNA. Translation: AAH08828.1.
    CCDSiCCDS6867.1.
    RefSeqiNP_001129248.1. NM_001135776.1.
    NP_054726.1. NM_014007.3.
    XP_005251892.1. XM_005251835.1.
    XP_005251893.1. XM_005251836.1.
    UniGeneiHs.355581.

    Genome annotation databases

    EnsembliENST00000373457; ENSP00000362556; ENSG00000169155.
    ENST00000373464; ENSP00000362563; ENSG00000169155.
    ENST00000449886; ENSP00000390344; ENSG00000169155.
    GeneIDi23099.
    KEGGihsa:23099.
    UCSCiuc004bql.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB007874 mRNA. Translation: BAA24844.2 . Different initiation.
    AF049907 mRNA. Translation: AAC05500.1 .
    BT007194 mRNA. Translation: AAP35858.1 .
    AL161731 Genomic DNA. Translation: CAI40920.1 .
    CH471090 Genomic DNA. Translation: EAW87643.1 .
    BC008828 mRNA. Translation: AAH08828.1 .
    CCDSi CCDS6867.1.
    RefSeqi NP_001129248.1. NM_001135776.1.
    NP_054726.1. NM_014007.3.
    XP_005251892.1. XM_005251835.1.
    XP_005251893.1. XM_005251836.1.
    UniGenei Hs.355581.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CSH NMR - A 370-466 [» ]
    ProteinModelPortali O43298.
    SMRi O43298. Positions 7-121, 367-467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116727. 14 interactions.
    IntActi O43298. 7 interactions.
    MINTi MINT-2796003.
    STRINGi 9606.ENSP00000362556.

    PTM databases

    PhosphoSitei O43298.

    Proteomic databases

    MaxQBi O43298.
    PaxDbi O43298.
    PRIDEi O43298.

    Protocols and materials databases

    DNASUi 23099.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373457 ; ENSP00000362556 ; ENSG00000169155 .
    ENST00000373464 ; ENSP00000362563 ; ENSG00000169155 .
    ENST00000449886 ; ENSP00000390344 ; ENSG00000169155 .
    GeneIDi 23099.
    KEGGi hsa:23099.
    UCSCi uc004bql.3. human.

    Organism-specific databases

    CTDi 23099.
    GeneCardsi GC09P129567.
    HGNCi HGNC:17908. ZBTB43.
    HPAi HPA016825.
    neXtProti NX_O43298.
    PharmGKBi PA38257.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000231975.
    HOVERGENi HBG056510.
    InParanoidi O43298.
    KOi K10514.
    OMAi TESINTM.
    OrthoDBi EOG7Q8CN4.
    PhylomeDBi O43298.
    TreeFami TF333162.

    Miscellaneous databases

    EvolutionaryTracei O43298.
    GenomeRNAii 23099.
    NextBioi 44277.
    PROi O43298.

    Gene expression databases

    ArrayExpressi O43298.
    Bgeei O43298.
    CleanExi HS_ZBTB43.
    Genevestigatori O43298.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
      Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Zhang X., Liu C.-X., Lisitsina M.N., Musco S., Lisitsyn N.A.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    7. "The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB."
      Schoenen F., Wirth B.
      Biol. Chem. 387:277-284(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BDP1.
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Solution structure of tandem repeat of the ZF-C2H2 domains of human zinc finger protein 297B."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 370-466.

    Entry informationi

    Entry nameiZBT43_HUMAN
    AccessioniPrimary (citable) accession number: O43298
    Secondary accession number(s): Q5JU96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3