O43298 (ZBT43_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 43

Alternative name(s):
Zinc finger and BTB domain-containing protein 22B
Zinc finger protein 297B
ZnF-x

Gene names

Name:	ZBTB43
Synonyms:	KIAA0414, ZBTB22B, ZNF297B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subunit structure	Interacts with BDP1. Ref.4
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 1 BTB (POZ) domain. Contains 3 C2H2-type zinc fingers.
Sequence caution	The sequence BAA24844.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Acetylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 467

467

Zinc finger and BTB domain-containing protein 43

PRO_0000047519

Regions

Domain

33 – 97

65

BTB

Zinc finger

373 – 394

22

C2H2-type 1; atypical

Zinc finger

400 – 422

23

C2H2-type 2

Zinc finger

428 – 450

23

C2H2-type 3; atypical

Amino acid modifications

Modified residue

247

1

N6-acetyllysine Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

467

Helix Strand Turn

Details...

Beta strand

380 – 383

4

Helix

384 – 394

11

Beta strand

399 – 401

3

Turn

403 – 405

3

Beta strand

408 – 412

5

Helix

413 – 419

7

Turn

420 – 422

3

Beta strand

431 – 433

3

Beta strand

436 – 438

3

Helix

440 – 458

19

Sequences

	Sequence		Length	Mass (Da)
	O43298 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 9DFB6CEEB8562425	FASTA	467	52,630
	10 20 30 40 50 60 MEPGTNSFRV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFRAHKAV LAASSPYFCD 70 80 90 100 110 120 QVLLKNSRRI VLPDVMNPRV FENILLSSYT GRLVMPAPEI VSYLTAASFL QMWHVVDKCT 130 140 150 160 170 180 EVLEGNPTVL CQKLNHGSDH QSPSSSSYNG LVESFELGSG GHTDFPKAQE LRDGENEEES 190 200 210 220 230 240 TKDELSSQLT EHEYLPSNSS TEHDRLSTEM ASQDGEEGAS DSAEFHYTRP MYSKPSIMAH 250 260 270 280 290 300 KRWIHVKPER LEQACEGMDV HATYDEHQVT ESINTVQTEH TVQPSGVEED FHIGEKKVEA 310 320 330 340 350 360 EFDEQADESN YDEQVDFYGS SMEEFSGERS DGNLIGHRQE AALAAGYSEN IEMVTGIKEE 370 380 390 400 410 420 ASHLGFSATD KLYPCQCGKS FTHKSQRDRH MSMHLGLRPY GCGVCGKKFK MKHHLVGHMK 430 440 450 460 IHTGIKPYEC NICAKRFMWR DSFHRHVTSC TKSYEAAKAE QNTTEAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro." Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:307-313(1997) [PubMed: 9455477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	Zhang X., Liu C.-X., Lisitsina M.N., Musco S., Lisitsyn N.A. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[4]	"The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB." Schoenen F., Wirth B. Biol. Chem. 387:277-284(2006) [PubMed: 16542149] [Abstract] Cited for: INTERACTION WITH BDP1.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-247, MASS SPECTROMETRY.
[6]	"Solution structure of tandem repeat of the ZF-C2H2 domains of human zinc finger protein 297B." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 370-466.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB007874 mRNA. Translation: BAA24844.2. Different initiation.
AF049907 mRNA. Translation: AAC05500.1.
BC008828 mRNA. Translation: AAH08828.1.

IPI

IPI00022264.

RefSeq

NP_001129248.1. NM_001135776.1.
NP_054726.1. NM_014007.3.

UniGene

Hs.355581.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CSH	NMR	-	A	370-466	[»]

ProteinModelPortal

O43298.

SMR

O43298. Positions 5-124, 343-467.

ModBase

Search...

Protein-protein interaction databases

IntAct

O43298. 7 interactions.

STRING

O43298.

PTM databases

PhosphoSite

O43298.

Proteomic databases

PRIDE

O43298.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000373457; ENSP00000362556; ENSG00000169155.
ENST00000373464; ENSP00000362563; ENSG00000169155.
ENST00000449886; ENSP00000390344; ENSG00000169155.

GeneID

23099.

KEGG

hsa:23099.

UCSC

uc004bql.1. human.

Organism-specific databases

CTD

23099.

GeneCards

GC09P129567.

H-InvDB

HIX0018366.

HGNC

HGNC:17908. ZBTB43.

HPA

HPA016825.

neXtProt

NX_O43298.

PharmGKB

PA38257.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG14535.

HOGENOM

HBG716388.

HOVERGEN

HBG056510.

InParanoid

O43298.

OMA

TESINTM.

OrthoDB

EOG4N04DT.

PhylomeDB

O43298.

Gene expression databases

ArrayExpress

O43298.

Bgee

O43298.

CleanEx

HS_ZBTB43.

Genevestigator

O43298.

GermOnline

ENSG00000169155. Homo sapiens.

Family and domain databases

InterPro

IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Gene3D

G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.

KO

K10514.

Pfam

PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]

SMART

SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]

SUPFAM

SSF54695. BTB/POZ_fold. 1 hit.

PROSITE

PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

44277.

Entry information

Entry name

ZBT43_HUMAN

Accession

Primary (citable) accession number: O43298

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.