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Protein

Zinc finger protein 264

Gene

ZNF264

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 264
Gene namesi
Name:ZNF264
Synonyms:KIAA0412
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13057. ZNF264.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37635.

Polymorphism and mutation databases

BioMutaiZNF264.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Zinc finger protein 264PRO_0000047492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801PhosphoserineCombined sources
Modified residuei343 – 3431PhosphotyrosineCombined sources
Modified residuei511 – 5111PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43296.
PaxDbiO43296.
PeptideAtlasiO43296.
PRIDEiO43296.

PTM databases

iPTMnetiO43296.
PhosphoSiteiO43296.

Expressioni

Tissue specificityi

Relatively highly expressed in kidney, thymus, testis, ovary, brain, lung, placenta, and prostate, and relatively low expression in heart, liver, skeletal muscle, pancreas, spleen, and small intestine.

Gene expression databases

BgeeiENSG00000083844.
CleanExiHS_ZNF264.
ExpressionAtlasiO43296. baseline and differential.
GenevisibleiO43296. HS.

Organism-specific databases

HPAiHPA057665.

Interactioni

Protein-protein interaction databases

BioGridi114815. 24 interactions.
IntActiO43296. 1 interaction.
STRINGi9606.ENSP00000263095.

Structurei

3D structure databases

ProteinModelPortaliO43296.
SMRiO43296. Positions 197-568.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO43296.
KOiK09228.
OMAiCSRIGQE.
OrthoDBiEOG091G02KC.
PhylomeDBiO43296.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVLTDRA QVSVTFDDVA VTFTKEEWGQ LDLAQRTLYQ EVMLENCGLL
60 70 80 90 100
VSLGCPVPKA ELICHLEHGQ EPWTRKEDLS QDTCPGDKGK PKTTEPTTCE
110 120 130 140 150
PALSEGISLQ GQVTQGNSVD SQLGQAEDQD GLSEMQEGHF RPGIDPQEKS
160 170 180 190 200
PGKMSPECDG LGTADGVCSR IGQEQVSPGD RVRSHNSCES GKDPMIQEEE
210 220 230 240 250
NNFKCSECGK VFNKKHLLAG HEKIHSGVKP YECTECGKTF IKSTHLLQHH
260 270 280 290 300
MIHTGERPYE CMECGKAFNR KSYLTQHQRI HSGEKPYKCN ECGKAFTHRS
310 320 330 340 350
NFVLHNRRHT GEKSFVCTEC GQVFRHRPGF LRHYVVHSGE NPYECLECGK
360 370 380 390 400
VFKHRSYLMW HQQTHTGEKP YECSECGKVF LESAALIHHY VIHTGEKPFE
410 420 430 440 450
CLECGKAFNH RSYLKRHQRI HTGEKPFVCS ECGKAFTHCS TFILHKRAHT
460 470 480 490 500
GEKPFECKEC GKAFSNRKDL IRHFSIHTGE KPYECVECGK AFTRMSGLTR
510 520 530 540 550
HKRIHSGEKP YECVECGKSF CWSTNLIRHA IIHTGEKPYK CSECGKAFSR
560 570 580 590 600
SSSLTQHQRM HTGKNPISVT DVGRPFTSGQ TSVTLRELLL GKDFLNVTTE
610 620
ANILPEETSS SASDQPYQRE TPQVSSL
Length:627
Mass (Da):70,587
Last modified:June 1, 1998 - v1
Checksum:iBF0A6460AD07CECB
GO

Sequence cautioni

The sequence BAA24842 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811R → T.
Corresponds to variant rs2074858 [ dbSNP | Ensembl ].
VAR_052803
Natural varianti183 – 1831R → H.
Corresponds to variant rs917340 [ dbSNP | Ensembl ].
VAR_052804

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007872 mRNA. Translation: BAA24842.2. Different initiation.
AK292504 mRNA. Translation: BAF85193.1.
AC005261 Genomic DNA. No translation available.
AC025588 Genomic DNA. Translation: AAF42766.1.
CCDSiCCDS33127.1.
RefSeqiNP_003408.1. NM_003417.4.
UniGeneiHs.515634.

Genome annotation databases

EnsembliENST00000263095; ENSP00000263095; ENSG00000083844.
ENST00000536056; ENSP00000440376; ENSG00000083844.
GeneIDi9422.
KEGGihsa:9422.
UCSCiuc002qob.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007872 mRNA. Translation: BAA24842.2. Different initiation.
AK292504 mRNA. Translation: BAF85193.1.
AC005261 Genomic DNA. No translation available.
AC025588 Genomic DNA. Translation: AAF42766.1.
CCDSiCCDS33127.1.
RefSeqiNP_003408.1. NM_003417.4.
UniGeneiHs.515634.

3D structure databases

ProteinModelPortaliO43296.
SMRiO43296. Positions 197-568.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114815. 24 interactions.
IntActiO43296. 1 interaction.
STRINGi9606.ENSP00000263095.

PTM databases

iPTMnetiO43296.
PhosphoSiteiO43296.

Polymorphism and mutation databases

BioMutaiZNF264.

Proteomic databases

MaxQBiO43296.
PaxDbiO43296.
PeptideAtlasiO43296.
PRIDEiO43296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263095; ENSP00000263095; ENSG00000083844.
ENST00000536056; ENSP00000440376; ENSG00000083844.
GeneIDi9422.
KEGGihsa:9422.
UCSCiuc002qob.3. human.

Organism-specific databases

CTDi9422.
GeneCardsiZNF264.
HGNCiHGNC:13057. ZNF264.
HPAiHPA057665.
MIMi604668. gene.
neXtProtiNX_O43296.
PharmGKBiPA37635.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00750000117699.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO43296.
KOiK09228.
OMAiCSRIGQE.
OrthoDBiEOG091G02KC.
PhylomeDBiO43296.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF264.
GenomeRNAii9422.
PROiO43296.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000083844.
CleanExiHS_ZNF264.
ExpressionAtlasiO43296. baseline and differential.
GenevisibleiO43296. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN264_HUMAN
AccessioniPrimary (citable) accession number: O43296
Secondary accession number(s): A8K8Y9, Q9P1V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.