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Protein

Beta-1,4-galactosyltransferase 5

Gene

B4GALT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.1 Publication

Cofactori

Mn2+By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi236ManganeseBy similarity1
Binding sitei264UDP-alpha-D-galactoseBy similarity1
Binding sitei296UDP-alpha-D-galactoseBy similarity1
Metal bindingi329Manganese; via tele nitrogenBy similarity1
Binding sitei340N-acetyl-D-glucosamineBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158470-MONOMER.
BRENDAi2.4.1.38. 2681.
2.4.1.90. 2681.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-975577. N-Glycan antennae elongation.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT7. Glycosyltransferase Family 7.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,4-galactosyltransferase 5 (EC:2.4.1.-)
Short name:
Beta-1,4-GalTase 5
Short name:
Beta4Gal-T5
Short name:
b4Gal-T5
Alternative name(s):
Beta-1,4-GalT II
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5
Gene namesi
Name:B4GALT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:928. B4GALT5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini36 – 388LumenalSequence analysisAdd BLAST353

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9334.
OpenTargetsiENSG00000158470.
PharmGKBiPA25227.

Polymorphism and mutation databases

BioMutaiB4GALT5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805451 – 388Beta-1,4-galactosyltransferase 5Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 158By similarity
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi229 ↔ 248By similarity
Glycosylationi364N-linked (GlcNAc...)Sequence analysis1
Glycosylationi373N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO43286.
MaxQBiO43286.
PaxDbiO43286.
PeptideAtlasiO43286.
PRIDEiO43286.

PTM databases

iPTMnetiO43286.
PhosphoSitePlusiO43286.
SwissPalmiO43286.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000158470.
CleanExiHS_B4GALT5.
GenevisibleiO43286. HS.

Interactioni

Protein-protein interaction databases

BioGridi114743. 20 interactors.
STRINGi9606.ENSP00000360776.

Structurei

3D structure databases

ProteinModelPortaliO43286.
SMRiO43286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 173UDP-alpha-D-galactose bindingBy similarity5
Regioni208 – 210UDP-alpha-D-galactose bindingBy similarity3
Regioni235 – 236UDP-alpha-D-galactose bindingBy similarity2
Regioni298 – 301N-acetyl-D-glucosamine bindingBy similarity4
Regioni329 – 330UDP-alpha-D-galactose bindingBy similarity2

Sequence similaritiesi

Belongs to the glycosyltransferase 7 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3916. Eukaryota.
ENOG410ZYYA. LUCA.
GeneTreeiENSGT00760000119140.
HOGENOMiHOG000231027.
HOVERGENiHBG058334.
InParanoidiO43286.
KOiK09905.
OMAiVPRWKVA.
OrthoDBiEOG091G0P66.
PhylomeDBiO43286.
TreeFamiTF312834.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003859. Galactosyl_T.
IPR027791. Galactosyl_T_C.
IPR027995. Galactosyl_T_N.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR19300. PTHR19300. 1 hit.
PfamiPF02709. Glyco_transf_7C. 1 hit.
PF13733. Glyco_transf_7N. 1 hit.
[Graphical view]
PRINTSiPR02050. B14GALTRFASE.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

O43286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARRGLLRL PRRSLLAALF FFSLSSSLLY FVYVAPGIVN TYLFMMQAQG
60 70 80 90 100
ILIRDNVRTI GAQVYEQVLR SAYAKRNSSV NDSDYPLDLN HSETFLQTTT
110 120 130 140 150
FLPEDFTYFA NHTCPERLPS MKGPIDINMS EIGMDYIHEL FSKDPTIKLG
160 170 180 190 200
GHWKPSDCMP RWKVAILIPF RNRHEHLPVL FRHLLPMLQR QRLQFAFYVV
210 220 230 240 250
EQVGTQPFNR AMLFNVGFQE AMKDLDWDCL IFHDVDHIPE SDRNYYGCGQ
260 270 280 290 300
MPRHFATKLD KYMYLLPYTE FFGGVSGLTV EQFRKINGFP NAFWGWGGED
310 320 330 340 350
DDLWNRVQNA GYSVSRPEGD TGKYKSIPHH HRGEVQFLGR YALLRKSKER
360 370 380
QGLDGLNNLN YFANITYDAL YKNITVNLTP ELAQVNEY
Length:388
Mass (Da):45,119
Last modified:June 1, 1998 - v1
Checksum:iA71F3F8999B6E13A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02446861G → S.Corresponds to variant rs2273086dbSNPEnsembl.1
Natural variantiVAR_054022368D → N.Corresponds to variant rs235035dbSNPEnsembl.1
Natural variantiVAR_033538371Y → D.Corresponds to variant rs35195217dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004550 mRNA. Translation: BAA25006.1.
AF038663 mRNA. Translation: AAC39736.1.
AL035683, AL162615 Genomic DNA. Translation: CAI19038.1.
AL162615, AL035683 Genomic DNA. Translation: CAI18968.1.
CH471077 Genomic DNA. Translation: EAW75653.1.
CH471077 Genomic DNA. Translation: EAW75654.1.
BC074821 mRNA. Translation: AAH74821.1.
BC074873 mRNA. Translation: AAH74873.1.
BC104987 mRNA. Translation: AAI04988.1.
BC112265 mRNA. Translation: AAI12266.1.
CCDSiCCDS13420.1.
RefSeqiNP_004767.1. NM_004776.3.
UniGeneiHs.370487.

Genome annotation databases

EnsembliENST00000371711; ENSP00000360776; ENSG00000158470.
GeneIDi9334.
KEGGihsa:9334.
UCSCiuc002xuu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Beta-1,4-galactosyltransferase 5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004550 mRNA. Translation: BAA25006.1.
AF038663 mRNA. Translation: AAC39736.1.
AL035683, AL162615 Genomic DNA. Translation: CAI19038.1.
AL162615, AL035683 Genomic DNA. Translation: CAI18968.1.
CH471077 Genomic DNA. Translation: EAW75653.1.
CH471077 Genomic DNA. Translation: EAW75654.1.
BC074821 mRNA. Translation: AAH74821.1.
BC074873 mRNA. Translation: AAH74873.1.
BC104987 mRNA. Translation: AAI04988.1.
BC112265 mRNA. Translation: AAI12266.1.
CCDSiCCDS13420.1.
RefSeqiNP_004767.1. NM_004776.3.
UniGeneiHs.370487.

3D structure databases

ProteinModelPortaliO43286.
SMRiO43286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114743. 20 interactors.
STRINGi9606.ENSP00000360776.

Protein family/group databases

CAZyiGT7. Glycosyltransferase Family 7.

PTM databases

iPTMnetiO43286.
PhosphoSitePlusiO43286.
SwissPalmiO43286.

Polymorphism and mutation databases

BioMutaiB4GALT5.

Proteomic databases

EPDiO43286.
MaxQBiO43286.
PaxDbiO43286.
PeptideAtlasiO43286.
PRIDEiO43286.

Protocols and materials databases

DNASUi9334.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371711; ENSP00000360776; ENSG00000158470.
GeneIDi9334.
KEGGihsa:9334.
UCSCiuc002xuu.5. human.

Organism-specific databases

CTDi9334.
DisGeNETi9334.
GeneCardsiB4GALT5.
HGNCiHGNC:928. B4GALT5.
MIMi604016. gene.
neXtProtiNX_O43286.
OpenTargetsiENSG00000158470.
PharmGKBiPA25227.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3916. Eukaryota.
ENOG410ZYYA. LUCA.
GeneTreeiENSGT00760000119140.
HOGENOMiHOG000231027.
HOVERGENiHBG058334.
InParanoidiO43286.
KOiK09905.
OMAiVPRWKVA.
OrthoDBiEOG091G0P66.
PhylomeDBiO43286.
TreeFamiTF312834.

Enzyme and pathway databases

UniPathwayiUPA00378.
BioCyciZFISH:ENSG00000158470-MONOMER.
BRENDAi2.4.1.38. 2681.
2.4.1.90. 2681.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-975577. N-Glycan antennae elongation.

Miscellaneous databases

ChiTaRSiB4GALT5. human.
GeneWikiiB4GALT5.
GenomeRNAii9334.
PROiO43286.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158470.
CleanExiHS_B4GALT5.
GenevisibleiO43286. HS.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003859. Galactosyl_T.
IPR027791. Galactosyl_T_C.
IPR027995. Galactosyl_T_N.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR19300. PTHR19300. 1 hit.
PfamiPF02709. Glyco_transf_7C. 1 hit.
PF13733. Glyco_transf_7N. 1 hit.
[Graphical view]
PRINTSiPR02050. B14GALTRFASE.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB4GT5_HUMAN
AccessioniPrimary (citable) accession number: O43286
Secondary accession number(s): E1P625, Q2M394, Q9UJQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.