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Protein

Beta-1,4-galactosyltransferase 5

Gene

B4GALT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.1 Publication

Cofactori

Mn2+By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi236ManganeseBy similarity1
Binding sitei264UDP-alpha-D-galactoseBy similarity1
Binding sitei296UDP-alpha-D-galactoseBy similarity1
Metal bindingi329Manganese; via tele nitrogenBy similarity1
Binding sitei340N-acetyl-D-glucosamineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDAi2.4.1.38 2681
2.4.1.90 2681
ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-975577 N-Glycan antennae elongation
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT7 Glycosyltransferase Family 7

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,4-galactosyltransferase 5 (EC:2.4.1.-)
Short name:
Beta-1,4-GalTase 5
Short name:
Beta4Gal-T5
Short name:
b4Gal-T5
Alternative name(s):
Beta-1,4-GalT II
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5
Gene namesi
Name:B4GALT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000158470.5
HGNCiHGNC:928 B4GALT5
MIMi604016 gene
neXtProtiNX_O43286

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini36 – 388LumenalSequence analysisAdd BLAST353

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9334
OpenTargetsiENSG00000158470
PharmGKBiPA25227

Polymorphism and mutation databases

BioMutaiB4GALT5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805451 – 388Beta-1,4-galactosyltransferase 5Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 158By similarity
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi229 ↔ 248By similarity
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO43286
MaxQBiO43286
PaxDbiO43286
PeptideAtlasiO43286
PRIDEiO43286

PTM databases

iPTMnetiO43286
PhosphoSitePlusiO43286
SwissPalmiO43286

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000158470
CleanExiHS_B4GALT5
GenevisibleiO43286 HS

Interactioni

Protein-protein interaction databases

BioGridi114743, 24 interactors
STRINGi9606.ENSP00000360776

Structurei

3D structure databases

ProteinModelPortaliO43286
SMRiO43286
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 173UDP-alpha-D-galactose bindingBy similarity5
Regioni208 – 210UDP-alpha-D-galactose bindingBy similarity3
Regioni235 – 236UDP-alpha-D-galactose bindingBy similarity2
Regioni298 – 301N-acetyl-D-glucosamine bindingBy similarity4
Regioni329 – 330UDP-alpha-D-galactose bindingBy similarity2

Sequence similaritiesi

Belongs to the glycosyltransferase 7 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3916 Eukaryota
ENOG410ZYYA LUCA
GeneTreeiENSGT00760000119140
HOGENOMiHOG000231027
HOVERGENiHBG058334
InParanoidiO43286
KOiK09905
OMAiRDNMRTI
OrthoDBiEOG091G0P66
PhylomeDBiO43286
TreeFamiTF312834

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR003859 Galactosyl_T
IPR027791 Galactosyl_T_C
IPR027995 Galactosyl_T_N
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR19300 PTHR19300, 1 hit
PfamiView protein in Pfam
PF02709 Glyco_transf_7C, 1 hit
PF13733 Glyco_transf_7N, 1 hit
PRINTSiPR02050 B14GALTRFASE
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

O43286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARRGLLRL PRRSLLAALF FFSLSSSLLY FVYVAPGIVN TYLFMMQAQG
60 70 80 90 100
ILIRDNVRTI GAQVYEQVLR SAYAKRNSSV NDSDYPLDLN HSETFLQTTT
110 120 130 140 150
FLPEDFTYFA NHTCPERLPS MKGPIDINMS EIGMDYIHEL FSKDPTIKLG
160 170 180 190 200
GHWKPSDCMP RWKVAILIPF RNRHEHLPVL FRHLLPMLQR QRLQFAFYVV
210 220 230 240 250
EQVGTQPFNR AMLFNVGFQE AMKDLDWDCL IFHDVDHIPE SDRNYYGCGQ
260 270 280 290 300
MPRHFATKLD KYMYLLPYTE FFGGVSGLTV EQFRKINGFP NAFWGWGGED
310 320 330 340 350
DDLWNRVQNA GYSVSRPEGD TGKYKSIPHH HRGEVQFLGR YALLRKSKER
360 370 380
QGLDGLNNLN YFANITYDAL YKNITVNLTP ELAQVNEY
Length:388
Mass (Da):45,119
Last modified:June 1, 1998 - v1
Checksum:iA71F3F8999B6E13A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02446861G → S. Corresponds to variant dbSNP:rs2273086Ensembl.1
Natural variantiVAR_054022368D → N. Corresponds to variant dbSNP:rs235035Ensembl.1
Natural variantiVAR_033538371Y → D. Corresponds to variant dbSNP:rs35195217Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004550 mRNA Translation: BAA25006.1
AF038663 mRNA Translation: AAC39736.1
AL035683 Genomic DNA No translation available.
AL162615 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75653.1
CH471077 Genomic DNA Translation: EAW75654.1
BC074821 mRNA Translation: AAH74821.1
BC074873 mRNA Translation: AAH74873.1
BC104987 mRNA Translation: AAI04988.1
BC112265 mRNA Translation: AAI12266.1
CCDSiCCDS13420.1
RefSeqiNP_004767.1, NM_004776.3
UniGeneiHs.370487

Genome annotation databases

EnsembliENST00000371711; ENSP00000360776; ENSG00000158470
GeneIDi9334
KEGGihsa:9334
UCSCiuc002xuu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiB4GT5_HUMAN
AccessioniPrimary (citable) accession number: O43286
Secondary accession number(s): E1P625, Q2M394, Q9UJQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

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