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O43283

- M3K13_HUMAN

UniProt

O43283 - M3K13_HUMAN

Protein

Mitogen-activated protein kinase kinase kinase 13

Gene

MAP3K13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.3 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.1 Publication

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by autophosphorylation and homodimerization.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei195 – 1951ATPBy similarityPROSITE-ProRule annotation
    Active sitei279 – 2791Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi174 – 1829ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. identical protein binding Source: IntAct
    3. MAP kinase kinase kinase activity Source: UniProtKB
    4. metal ion binding Source: UniProtKB-KW
    5. protein binding Source: UniProtKB
    6. protein homodimerization activity Source: UniProtKB
    7. protein kinase binding Source: UniProtKB
    8. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. activation of MAPKK activity Source: UniProtKB
    2. JNK cascade Source: UniProtKB
    3. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
    4. protein autophosphorylation Source: UniProtKB
    5. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiO43283.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 13 (EC:2.7.11.25)
    Alternative name(s):
    Leucine zipper-bearing kinase
    Mixed lineage kinase
    Short name:
    MLK
    Gene namesi
    Name:MAP3K13Imported
    Synonyms:LZKImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:6852. MAP3K13.

    Subcellular locationi

    Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi195 – 1951K → A: Kinase inactive. Fails to activate NF-kappa-B. 1 Publication

    Organism-specific databases

    PharmGKBiPA30596.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 966966Mitogen-activated protein kinase kinase kinase 13PRO_0000086264Add
    BLAST

    Post-translational modificationi

    Autophosphorylated on serine and threonine residues.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO43283.
    PRIDEiO43283.

    PTM databases

    PhosphoSiteiO43283.

    Expressioni

    Tissue specificityi

    Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.1 Publication

    Gene expression databases

    ArrayExpressiO43283.
    BgeeiO43283.
    CleanExiHS_MAP3K13.
    GenevestigatoriO43283.

    Organism-specific databases

    HPAiHPA016497.
    HPA036691.
    HPA036692.

    Interactioni

    Subunit structurei

    Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-1168480,EBI-1168480

    Protein-protein interaction databases

    BioGridi114614. 10 interactions.
    IntActiO43283. 3 interactions.
    MINTiMINT-158088.
    STRINGi9606.ENSP00000265026.

    Structurei

    3D structure databases

    ProteinModelPortaliO43283.
    SMRiO43283. Positions 159-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini168 – 409242Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni433 – 45422Leucine-zipper 1Add
    BLAST
    Regioni486 – 50722Leucine-zipper 2Add
    BLAST
    Regioni815 – 82814AcidicCuratedAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG052383.
    InParanoidiO43283.
    KOiK04422.
    OMAiHRRGNSR.
    OrthoDBiEOG7B8S3P.
    PhylomeDBiO43283.
    TreeFamiTF105119.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR017419. MAP3K12_MAP3K13.
    IPR027258. MAPKKK13.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
    PIRSF500742. MAPKKK13. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43283-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MANFQEHLSC SSSPHLPFSE SKTFNGLQDE LTAMGNHPSP KLLEDQQEKG    50
    MVRTELIESV HSPVTTTVLT SVSEDSRDQF ENSVLQLREH DESETAVSQG 100
    NSNTVDGEST SGTEDIKIQF SRSGSGSGGF LEGLFGCLRP VWNIIGKAYS 150
    TDYKLQQQDT WEVPFEEISE LQWLGSGAQG AVFLGKFRAE EVAIKKVREQ 200
    NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ LYEVLRAGRK 250
    ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT 300
    SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 350
    IPYKDVDSSA IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKPRNRPSF 400
    RQTLMHLDIA SADVLATPQE TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL 450
    DEELIRRRRE ELRHALDIRE HYERKLERAN NLYMELSAIM LQLEMREKEL 500
    IKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKGVPH KSGMQTKRPD 550
    LLRSEGIPTT EVAPTASPLS GSPKMSTSSS KSRYRSKPRH RRGNSRGSHS 600
    DFAAILKNQP AQENSPHPTY LHQAQSQYPS LHHHNSLQQQ YQQPPPAMSQ 650
    SHHPRLNMHG QDIATCANNL RYFGPAAALR SPLSNHAQRQ LPGSSPDLIS 700
    TAMAADCWRS SEPDKGQAGP WGCCQADAYD PCLQCRPEQY GSLDIPSAEP 750
    VGRSPDLSKS PAHNPLLENA QSSEKTEENE FSGCRSESSL GTSHLGTPPA 800
    LPRKTRPLQK SGDDSSEEEE GEVDSEVEFP RRQRPHRCIS SCQSYSTFSS 850
    ENFSVSDGEE GNTSDHSNSP DELADKLEDR LAEKLDDLLS QTPEIPIDIS 900
    SHSDGLSDKE CAVRRVKTQM SLGKLCVEER GYENPMQFEE SDCDSSDGEC 950
    SDATVRTNKH YSSATW 966
    Length:966
    Mass (Da):108,296
    Last modified:June 1, 1998 - v1
    Checksum:i9687F38C8AB20AB1
    GO
    Isoform 2 (identifier: O43283-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         159-160: DT → VF
         161-966: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

    Show »
    Length:160
    Mass (Da):17,575
    Checksum:i95152C01C501AEFC
    GO
    Isoform 3 (identifier: O43283-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-144: Missing.
         145-159: IGKAYSTDYKLQQQD → MSYVECKCLQLENKN

    Show »
    Length:822
    Mass (Da):92,654
    Checksum:i22B40649EEF108AB
    GO
    Isoform 4 (identifier: O43283-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-207: Missing.
         208-220: LRKLKHPNIIAFK → MYCGIQILALWER

    Show »
    Length:759
    Mass (Da):85,404
    Checksum:i6E1DCE6581A1A2DC
    GO
    Isoform 5 (identifier: O43283-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         122-128: RSGSGSG → RYLGSAI
         129-966: Missing.

    Show »
    Length:128
    Mass (Da):14,073
    Checksum:i9000EE02899AC48D
    GO

    Sequence cautioni

    The sequence BAG59505.1 differs from that shown. Reason: Erroneous termination at position 740. Translated as Tyr.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061D → G in BAG59505. (PubMed:14702039)Curated
    Sequence conflicti230 – 2323CII → YLY in CAA80915. (PubMed:8274451)Curated
    Sequence conflicti268 – 2681N → D in BAG59505. (PubMed:14702039)Curated
    Sequence conflicti339 – 3402FG → MV in CAA80915. (PubMed:8274451)Curated
    Sequence conflicti508 – 5081E → G in BAG64106. (PubMed:14702039)Curated
    Sequence conflicti821 – 8211G → R in BAG60014. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441E → K.
    Corresponds to variant rs35266179 [ dbSNP | Ensembl ].
    VAR_051640
    Natural varianti517 – 5171R → G.1 Publication
    Corresponds to variant rs56408536 [ dbSNP | Ensembl ].
    VAR_040708
    Natural varianti712 – 7121E → K.1 Publication
    Corresponds to variant rs56309231 [ dbSNP | Ensembl ].
    VAR_040709
    Natural varianti746 – 7461P → L in a metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_040710
    Natural varianti915 – 9151R → H.
    Corresponds to variant rs3732576 [ dbSNP | Ensembl ].
    VAR_030577

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 207207Missing in isoform 4. 1 PublicationVSP_036562Add
    BLAST
    Alternative sequencei1 – 144144Missing in isoform 3. 1 PublicationVSP_036563Add
    BLAST
    Alternative sequencei122 – 1287RSGSGSG → RYLGSAI in isoform 5. 1 PublicationVSP_036564
    Alternative sequencei129 – 966838Missing in isoform 5. 1 PublicationVSP_036565Add
    BLAST
    Alternative sequencei145 – 15915IGKAY…LQQQD → MSYVECKCLQLENKN in isoform 3. 1 PublicationVSP_036566Add
    BLAST
    Alternative sequencei159 – 1602DT → VF in isoform 2. 1 PublicationVSP_036567
    Alternative sequencei161 – 966806Missing in isoform 2. 1 PublicationVSP_036568Add
    BLAST
    Alternative sequencei208 – 22013LRKLK…IIAFK → MYCGIQILALWER in isoform 4. 1 PublicationVSP_036569Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001872 mRNA. Translation: BAA24817.1.
    AK296961 mRNA. Translation: BAG59505.1. Sequence problems.
    AK297646 mRNA. Translation: BAG60014.1.
    AK302951 mRNA. Translation: BAG64106.1.
    AK312714 mRNA. Translation: BAG35589.1.
    AC099661 Genomic DNA. No translation available.
    AC128680 Genomic DNA. No translation available.
    AC132516 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78224.1.
    CH471052 Genomic DNA. Translation: EAW78225.1.
    BC031677 mRNA. Translation: AAH31677.1.
    BC111726 mRNA. Translation: AAI11727.1. Sequence problems.
    Z25428 mRNA. Translation: CAA80915.1.
    CCDSiCCDS3270.1. [O43283-1]
    CCDS56298.1. [O43283-5]
    PIRiI38218.
    RefSeqiNP_001229243.1. NM_001242314.1. [O43283-1]
    NP_001229246.1. NM_001242317.1. [O43283-5]
    NP_004712.1. NM_004721.4. [O43283-1]
    UniGeneiHs.591306.
    Hs.634586.

    Genome annotation databases

    EnsembliENST00000265026; ENSP00000265026; ENSG00000073803. [O43283-1]
    ENST00000424227; ENSP00000399910; ENSG00000073803. [O43283-1]
    ENST00000433092; ENSP00000389798; ENSG00000073803. [O43283-6]
    ENST00000438053; ENSP00000403561; ENSG00000073803. [O43283-3]
    ENST00000443863; ENSP00000409325; ENSG00000073803. [O43283-4]
    ENST00000446828; ENSP00000411483; ENSG00000073803. [O43283-5]
    GeneIDi9175.
    KEGGihsa:9175.
    UCSCiuc003fpi.3. human. [O43283-1]
    uc011brt.2. human. [O43283-5]
    uc011bru.2. human. [O43283-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001872 mRNA. Translation: BAA24817.1 .
    AK296961 mRNA. Translation: BAG59505.1 . Sequence problems.
    AK297646 mRNA. Translation: BAG60014.1 .
    AK302951 mRNA. Translation: BAG64106.1 .
    AK312714 mRNA. Translation: BAG35589.1 .
    AC099661 Genomic DNA. No translation available.
    AC128680 Genomic DNA. No translation available.
    AC132516 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78224.1 .
    CH471052 Genomic DNA. Translation: EAW78225.1 .
    BC031677 mRNA. Translation: AAH31677.1 .
    BC111726 mRNA. Translation: AAI11727.1 . Sequence problems.
    Z25428 mRNA. Translation: CAA80915.1 .
    CCDSi CCDS3270.1. [O43283-1 ]
    CCDS56298.1. [O43283-5 ]
    PIRi I38218.
    RefSeqi NP_001229243.1. NM_001242314.1. [O43283-1 ]
    NP_001229246.1. NM_001242317.1. [O43283-5 ]
    NP_004712.1. NM_004721.4. [O43283-1 ]
    UniGenei Hs.591306.
    Hs.634586.

    3D structure databases

    ProteinModelPortali O43283.
    SMRi O43283. Positions 159-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114614. 10 interactions.
    IntActi O43283. 3 interactions.
    MINTi MINT-158088.
    STRINGi 9606.ENSP00000265026.

    Chemistry

    BindingDBi O43283.
    ChEMBLi CHEMBL1163124.
    GuidetoPHARMACOLOGYi 2073.

    PTM databases

    PhosphoSitei O43283.

    Proteomic databases

    PaxDbi O43283.
    PRIDEi O43283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265026 ; ENSP00000265026 ; ENSG00000073803 . [O43283-1 ]
    ENST00000424227 ; ENSP00000399910 ; ENSG00000073803 . [O43283-1 ]
    ENST00000433092 ; ENSP00000389798 ; ENSG00000073803 . [O43283-6 ]
    ENST00000438053 ; ENSP00000403561 ; ENSG00000073803 . [O43283-3 ]
    ENST00000443863 ; ENSP00000409325 ; ENSG00000073803 . [O43283-4 ]
    ENST00000446828 ; ENSP00000411483 ; ENSG00000073803 . [O43283-5 ]
    GeneIDi 9175.
    KEGGi hsa:9175.
    UCSCi uc003fpi.3. human. [O43283-1 ]
    uc011brt.2. human. [O43283-5 ]
    uc011bru.2. human. [O43283-4 ]

    Organism-specific databases

    CTDi 9175.
    GeneCardsi GC03P185000.
    HGNCi HGNC:6852. MAP3K13.
    HPAi HPA016497.
    HPA036691.
    HPA036692.
    MIMi 604915. gene.
    neXtProti NX_O43283.
    PharmGKBi PA30596.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG052383.
    InParanoidi O43283.
    KOi K04422.
    OMAi HRRGNSR.
    OrthoDBi EOG7B8S3P.
    PhylomeDBi O43283.
    TreeFami TF105119.

    Enzyme and pathway databases

    SignaLinki O43283.

    Miscellaneous databases

    ChiTaRSi MAP3K13. human.
    GeneWikii MAP3K13.
    GenomeRNAii 9175.
    NextBioi 34405.
    PROi O43283.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43283.
    Bgeei O43283.
    CleanExi HS_MAP3K13.
    Genevestigatori O43283.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR017419. MAP3K12_MAP3K13.
    IPR027258. MAPKKK13.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
    PIRSF500742. MAPKKK13. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain."
      Sakuma H., Ikeda A., Oka S., Kozutsumi Y., Zanetta J., Kawasaki T.
      J. Biol. Chem. 272:28622-28629(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AUTOPHOSPHORYLATION.
      Tissue: Cerebellum1 Publication.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
      Tissue: Brain, Testis and Tongue.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
      Tissue: Brain.
    6. "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans."
      Schultz S.J., Nigg E.A.
      Cell Growth Differ. 4:821-830(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 230-340 (ISOFORM 1).
    7. "Identification and characterization of functional domains in a mixed lineage kinase LZK."
      Ikeda A., Masaki M., Kozutsumi Y., Oka S., Kawasaki T.
      FEBS Lett. 488:190-195(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: HOMODIMERIZATION.
    8. "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway."
      Ikeda A., Hasegawa K., Masaki M., Moriguchi T., Nishida E., Kozutsumi Y., Oka S., Kawasaki T.
      J. Biochem. 130:773-781(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MAPK8IP1.
    9. "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically."
      Masaki M., Ikeda A., Shiraki E., Oka S., Kawasaki T.
      Eur. J. Biochem. 270:76-83(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PRDX3, MUTAGENESIS OF LYS-195.
    10. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-517; LYS-712 AND LEU-746.

    Entry informationi

    Entry nameiM3K13_HUMAN
    AccessioniPrimary (citable) accession number: O43283
    Secondary accession number(s): B2R6U2
    , B4DLE3, B4DMV2, B4DZJ4, D3DNU1, Q05BY6, Q15450, Q2NKN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3