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O43261

- LEU1_HUMAN

UniProt

O43261 - LEU1_HUMAN

Protein

Leukemia-associated protein 1

Gene

DLEU1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May act as a tumor suppressor.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukemia-associated protein 1
    Alternative name(s):
    Deleted in lymphocytic leukemia 1
    HBV X-transactivated gene 6 protein
    HBV XAg-transactivated protein 6
    Gene namesi
    Name:DLEU1
    Synonyms:LEU1, XTP6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:13747. DLEU1.

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7878Leukemia-associated protein 1PRO_0000084409Add
    BLAST

    Expressioni

    Gene expression databases

    ArrayExpressiO43261.
    BgeeiO43261.
    CleanExiHS_DLEU1.
    GenevestigatoriO43261.

    Organism-specific databases

    HPAiCAB017848.
    HPA039465.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KAT5Q929932EBI-710057,EBI-399080

    Protein-protein interaction databases

    IntActiO43261. 19 interactions.
    MINTiMINT-1370081.
    STRINGi9606.ENSP00000367422.

    Structurei

    3D structure databases

    ProteinModelPortaliO43261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000113316.
    HOVERGENiHBG036908.
    InParanoidiO43261.
    OMAiTPNCEES.
    OrthoDBiEOG7M0NV3.
    PhylomeDBiO43261.
    TreeFamiTF341071.

    Sequencei

    Sequence statusi: Complete.

    O43261-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPCIWIHVH LKPPCRLVEL LPFSSALQGL SHLSLGTTLP VILPERNEEQ   50
    NLQELSHNAD KYQMGDCCKE EIDDSIFY 78
    Length:78
    Mass (Da):8,962
    Last modified:February 12, 2003 - v2
    Checksum:i19D780086C5FFF21
    GO

    Sequence cautioni

    The sequence CAA75515.1 differs from that shown. Reason: Frameshift at position 73.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15227 mRNA. Translation: CAA75515.1. Frameshift.
    Y15381 Genomic DNA. Translation: CAA75600.1.
    AF490255 mRNA. Translation: AAO85463.1.
    AL137060 Genomic DNA. Translation: CAC43393.1.
    CH471075 Genomic DNA. Translation: EAX08858.1.
    BC020692 mRNA. No translation available.
    AF328925 Genomic DNA. Translation: AAL95698.1.

    Genome annotation databases

    EnsembliENST00000378180; ENSP00000367422; ENSG00000176124.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15227 mRNA. Translation: CAA75515.1 . Frameshift.
    Y15381 Genomic DNA. Translation: CAA75600.1 .
    AF490255 mRNA. Translation: AAO85463.1 .
    AL137060 Genomic DNA. Translation: CAC43393.1 .
    CH471075 Genomic DNA. Translation: EAX08858.1 .
    BC020692 mRNA. No translation available.
    AF328925 Genomic DNA. Translation: AAL95698.1 .

    3D structure databases

    ProteinModelPortali O43261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O43261. 19 interactions.
    MINTi MINT-1370081.
    STRINGi 9606.ENSP00000367422.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378180 ; ENSP00000367422 ; ENSG00000176124 .

    Organism-specific databases

    GeneCardsi GC13P050656.
    H-InvDB HIX0011324.
    HGNCi HGNC:13747. DLEU1.
    HPAi CAB017848.
    HPA039465.
    MIMi 605765. gene.
    neXtProti NX_O43261.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000113316.
    HOVERGENi HBG036908.
    InParanoidi O43261.
    OMAi TPNCEES.
    OrthoDBi EOG7M0NV3.
    PhylomeDBi O43261.
    TreeFami TF341071.

    Miscellaneous databases

    NextBioi 35537558.
    PROi O43261.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43261.
    Bgeei O43261.
    CleanExi HS_DLEU1.
    Genevestigatori O43261.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia."
      Liu Y., Corcoran M., Rasool O., Ivanova G., Ibbotson R., Grander D., Iyengar A., Baranova A., Kashuba V., Merup M., Wu X., Gardiner A., Mullenbach R., Poltaraus A., Hulstrom A.L., Juliusson G., Chapman R., Tiller M.
      , Cotter F., Gahrton G., Yankovsky N., Zabarovsky E., Einhorn S., Oscier D.
      Oncogene 15:2463-2473(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "Cloning and identification of human gene 6 transactivated by hepatitis B virus X antigen."
      Liu Y., Cheng J., Lu Y., Wang G., Li K., Chen J., Li L.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. "Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14."
      Kapanadze B., Makeeva N., Corcoran M., Jareborg N., Hammarsund M., Baranova A., Zabarovsky E., Vorontsova O., Merup M., Gahrton G., Jansson M., Yankovsky N., Einhorn S., Oscier D., Grander D., Sangfelt O.
      Genomics 70:327-334(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.

    Entry informationi

    Entry nameiLEU1_HUMAN
    AccessioniPrimary (citable) accession number: O43261
    Secondary accession number(s): Q547G6, Q8TE10, Q96QY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: February 12, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3