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O43261 (LEU1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukemia-associated protein 1
Alternative name(s):
Deleted in lymphocytic leukemia 1
HBV X-transactivated gene 6 protein
HBV XAg-transactivated protein 6
Gene names
Name:DLEU1
Synonyms:LEU1, XTP6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length78 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a tumor suppressor.

Sequence caution

The sequence CAA75515.1 differs from that shown. Reason: Frameshift at position 73.

Ontologies

Keywords
   DiseaseTumor suppressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KAT5Q929932EBI-710057,EBI-399080

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7878Leukemia-associated protein 1
PRO_0000084409

Sequences

Sequence LengthMass (Da)Tools
O43261 [UniParc].

Last modified February 12, 2003. Version 2.
Checksum: 19D780086C5FFF21

FASTA788,962
        10         20         30         40         50         60 
MRPCIWIHVH LKPPCRLVEL LPFSSALQGL SHLSLGTTLP VILPERNEEQ NLQELSHNAD 

        70 
KYQMGDCCKE EIDDSIFY 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia."
Liu Y., Corcoran M., Rasool O., Ivanova G., Ibbotson R., Grander D., Iyengar A., Baranova A., Kashuba V., Merup M., Wu X., Gardiner A., Mullenbach R., Poltaraus A., Hulstrom A.L., Juliusson G., Chapman R., Tiller M. expand/collapse author list , Cotter F., Gahrton G., Yankovsky N., Zabarovsky E., Einhorn S., Oscier D.
Oncogene 15:2463-2473(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Cloning and identification of human gene 6 transactivated by hepatitis B virus X antigen."
Liu Y., Cheng J., Lu Y., Wang G., Li K., Chen J., Li L.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]"Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14."
Kapanadze B., Makeeva N., Corcoran M., Jareborg N., Hammarsund M., Baranova A., Zabarovsky E., Vorontsova O., Merup M., Gahrton G., Jansson M., Yankovsky N., Einhorn S., Oscier D., Grander D., Sangfelt O.
Genomics 70:327-334(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y15227 mRNA. Translation: CAA75515.1. Frameshift.
Y15381 Genomic DNA. Translation: CAA75600.1.
AF490255 mRNA. Translation: AAO85463.1.
AL137060 Genomic DNA. Translation: CAC43393.1.
CH471075 Genomic DNA. Translation: EAX08858.1.
BC020692 mRNA. No translation available.
AF328925 Genomic DNA. Translation: AAL95698.1.

3D structure databases

ProteinModelPortalO43261.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO43261. 19 interactions.
MINTMINT-1370081.
STRING9606.ENSP00000367422.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378180; ENSP00000367422; ENSG00000176124.

Organism-specific databases

GeneCardsGC13P050656.
H-InvDBHIX0011324.
HGNCHGNC:13747. DLEU1.
HPACAB017848.
HPA039465.
MIM605765. gene.
neXtProtNX_O43261.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000113316.
HOVERGENHBG036908.
InParanoidO43261.
OMAPERNEEQ.
OrthoDBEOG7M0NV3.
PhylomeDBO43261.
TreeFamTF341071.

Gene expression databases

ArrayExpressO43261.
BgeeO43261.
CleanExHS_DLEU1.
GenevestigatorO43261.

Family and domain databases

ProtoNetSearch...

Other

NextBio35537558.
PROO43261.
SOURCESearch...

Entry information

Entry nameLEU1_HUMAN
AccessionPrimary (citable) accession number: O43261
Secondary accession number(s): Q547G6, Q8TE10, Q96QY5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 12, 2003
Last modified: February 19, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM