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Protein

Leukemia-associated protein 1

Gene

DLEU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May act as a tumor suppressor.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukemia-associated protein 1
Alternative name(s):
Deleted in lymphocytic leukemia 1
HBV X-transactivated gene 6 protein
HBV XAg-transactivated protein 6
Gene namesi
Name:DLEU1
Synonyms:LEU1, XTP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:13747. DLEU1.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7878Leukemia-associated protein 1PRO_0000084409Add
BLAST

Expressioni

Gene expression databases

BgeeiO43261.
CleanExiHS_DLEU1.
ExpressionAtlasiO43261. baseline.
GenevestigatoriO43261.

Organism-specific databases

HPAiCAB017848.
HPA039465.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KAT5Q929932EBI-710057,EBI-399080

Protein-protein interaction databases

IntActiO43261. 19 interactions.
MINTiMINT-1370081.
STRINGi9606.ENSP00000367422.

Structurei

3D structure databases

ProteinModelPortaliO43261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000007612.
HOGENOMiHOG000113316.
HOVERGENiHBG036908.
InParanoidiO43261.
OMAiPERNEEQ.
OrthoDBiEOG7M0NV3.
PhylomeDBiO43261.
TreeFamiTF341071.

Sequencei

Sequence statusi: Complete.

O43261-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPCIWIHVH LKPPCRLVEL LPFSSALQGL SHLSLGTTLP VILPERNEEQ
60 70
NLQELSHNAD KYQMGDCCKE EIDDSIFY
Length:78
Mass (Da):8,962
Last modified:February 12, 2003 - v2
Checksum:i19D780086C5FFF21
GO

Sequence cautioni

The sequence CAA75515.1 differs from that shown. Reason: Frameshift at position 73. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15227 mRNA. Translation: CAA75515.1. Frameshift.
Y15381 Genomic DNA. Translation: CAA75600.1.
AF490255 mRNA. Translation: AAO85463.1.
AL137060 Genomic DNA. Translation: CAC43393.1.
CH471075 Genomic DNA. Translation: EAX08858.1.
BC020692 mRNA. No translation available.
AF328925 Genomic DNA. Translation: AAL95698.1.

Genome annotation databases

EnsembliENST00000378180; ENSP00000367422; ENSG00000176124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15227 mRNA. Translation: CAA75515.1. Frameshift.
Y15381 Genomic DNA. Translation: CAA75600.1.
AF490255 mRNA. Translation: AAO85463.1.
AL137060 Genomic DNA. Translation: CAC43393.1.
CH471075 Genomic DNA. Translation: EAX08858.1.
BC020692 mRNA. No translation available.
AF328925 Genomic DNA. Translation: AAL95698.1.

3D structure databases

ProteinModelPortaliO43261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43261. 19 interactions.
MINTiMINT-1370081.
STRINGi9606.ENSP00000367422.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378180; ENSP00000367422; ENSG00000176124.

Organism-specific databases

GeneCardsiGC13P050656.
H-InvDBHIX0011324.
HGNCiHGNC:13747. DLEU1.
HPAiCAB017848.
HPA039465.
MIMi605765. gene.
neXtProtiNX_O43261.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000007612.
HOGENOMiHOG000113316.
HOVERGENiHBG036908.
InParanoidiO43261.
OMAiPERNEEQ.
OrthoDBiEOG7M0NV3.
PhylomeDBiO43261.
TreeFamiTF341071.

Miscellaneous databases

ChiTaRSiDLEU1. human.
NextBioi35537558.
PROiO43261.
SOURCEiSearch...

Gene expression databases

BgeeiO43261.
CleanExiHS_DLEU1.
ExpressionAtlasiO43261. baseline.
GenevestigatoriO43261.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia."
    Liu Y., Corcoran M., Rasool O., Ivanova G., Ibbotson R., Grander D., Iyengar A., Baranova A., Kashuba V., Merup M., Wu X., Gardiner A., Mullenbach R., Poltaraus A., Hulstrom A.L., Juliusson G., Chapman R., Tiller M.
    , Cotter F., Gahrton G., Yankovsky N., Zabarovsky E., Einhorn S., Oscier D.
    Oncogene 15:2463-2473(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Cloning and identification of human gene 6 transactivated by hepatitis B virus X antigen."
    Liu Y., Cheng J., Lu Y., Wang G., Li K., Chen J., Li L.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14."
    Kapanadze B., Makeeva N., Corcoran M., Jareborg N., Hammarsund M., Baranova A., Zabarovsky E., Vorontsova O., Merup M., Gahrton G., Jansson M., Yankovsky N., Einhorn S., Oscier D., Grander D., Sangfelt O.
    Genomics 70:327-334(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.

Entry informationi

Entry nameiLEU1_HUMAN
AccessioniPrimary (citable) accession number: O43261
Secondary accession number(s): Q547G6, Q8TE10, Q96QY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 12, 2003
Last modified: January 7, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.