##gff-version 3 O43257 UniProtKB Chain 1 154 . . . ID=PRO_0000173546;Note=Zinc finger HIT domain-containing protein 1 O43257 UniProtKB Zinc finger 117 149 . . . Note=HIT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453 O43257 UniProtKB Region 1 72 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O43257 UniProtKB Region 72 110 . . . Note=Interaction with NR1D2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17892483;Dbxref=PMID:17892483 O43257 UniProtKB Coiled coil 23 39 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O43257 UniProtKB Motif 38 47 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17892483;Dbxref=PMID:17892483 O43257 UniProtKB Compositional bias 1 40 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O43257 UniProtKB Binding site 117 117 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453 O43257 UniProtKB Binding site 120 120 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453 O43257 UniProtKB Binding site 128 128 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453 O43257 UniProtKB Binding site 131 131 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453 O43257 UniProtKB Binding site 136 136 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453 O43257 UniProtKB Binding site 140 140 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453 O43257 UniProtKB Binding site 144 144 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453 O43257 UniProtKB Binding site 149 149 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00453 O43257 UniProtKB Modified residue 103 103 . . . Note=Phosphothreonine%3B by MAPK11 and MAPK14;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17380123;Dbxref=PMID:17380123 O43257 UniProtKB Natural variant 134 134 . . . ID=VAR_035719;Note=In a colorectal cancer sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs369664812,PMID:16959974 O43257 UniProtKB Mutagenesis 103 103 . . . Note=Impairs the p38 MAPK-mediated phosphorylation of ZNHIT1. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17380123;Dbxref=PMID:17380123 O43257 UniProtKB Mutagenesis 124 124 . . . Note=No change in the in vitro MAPK14/MAPK11-induced phosphorylation level of ZNHIT1. S->A