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Protein

Zinc finger HIT domain-containing protein 1

Gene

ZNHIT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 149HIT-typePROSITE-ProRule annotationAdd BLAST33

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106400-MONOMER.
SIGNORiO43257.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger HIT domain-containing protein 1
Alternative name(s):
Cyclin-G1-binding protein 1
Zinc finger protein subfamily 4A member 1
p18 Hamlet
Gene namesi
Name:ZNHIT1
Synonyms:CGBP1, ZNFN4A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21688. ZNHIT1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • Swr1 complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi103T → A: Impairs the p38 MAPK-mediated phosphorylation of ZNHIT1. 1 Publication1
Mutagenesisi124S → A: No change in the in vitro MAPK14/MAPK11-induced phosphorylation level of ZNHIT1. 1

Organism-specific databases

OpenTargetsiENSG00000106400.
PharmGKBiPA134947251.

Polymorphism and mutation databases

BioMutaiZNHIT1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735461 – 154Zinc finger HIT domain-containing protein 1Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103Phosphothreonine; by MAPK11 and MAPK141 Publication1

Post-translational modificationi

Phosphorylated on Thr by MAPK11 or MAPK14.1 Publication
Stres-induced ZNHIT1 is mainly regulated at the level of protein.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO43257.
MaxQBiO43257.
PaxDbiO43257.
PeptideAtlasiO43257.
PRIDEiO43257.

PTM databases

iPTMnetiO43257.
PhosphoSitePlusiO43257.

Expressioni

Tissue specificityi

Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine.1 Publication

Inductioni

Induced by DNA damage.1 Publication

Gene expression databases

BgeeiENSG00000106400.
CleanExiHS_ZNHIT1.
GenevisibleiO43257. HS.

Organism-specific databases

HPAiHPA019043.

Interactioni

Subunit structurei

Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with NR1D1 and NR2D2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTR6Q9GZN14EBI-347522,EBI-769329
H2AFZP0C0S53EBI-347522,EBI-1199859
KRTAP10-7P604093EBI-347522,EBI-10172290
MAPK11Q157592EBI-347522,EBI-298304
MAPK14Q165397EBI-347522,EBI-73946
TNIP1Q150253EBI-347522,EBI-357849
TP53BP1Q128882EBI-347522,EBI-396540

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115730. 19 interactors.
IntActiO43257. 29 interactors.
MINTiMINT-1036481.
STRINGi9606.ENSP00000304593.

Structurei

3D structure databases

ProteinModelPortaliO43257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 110Interaction with NR1D21 PublicationAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 39Sequence analysisAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 47Nuclear localization signal10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi66 – 70Poly-Lys5

Sequence similaritiesi

Belongs to the ZNHIT1 family.Curated
Contains 1 HIT-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 149HIT-typePROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3362. Eukaryota.
ENOG4111HZU. LUCA.
GeneTreeiENSGT00390000018426.
HOGENOMiHOG000264917.
HOVERGENiHBG054274.
InParanoidiO43257.
KOiK11663.
OMAiTRYCRVR.
OrthoDBiEOG091G0OU8.
PhylomeDBiO43257.
TreeFamiTF314330.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEKKTSVRS QDPGQRRVLD RAARQRRINR QLEALENDNF QDDPHAGLPQ
60 70 80 90 100
LGKRLPQFDD DADTGKKKKK TRGDHFKLRF RKNFQALLEE QNLSVAEGPN
110 120 130 140 150
YLTACAGPPS RPQRPFCAVC GFPSPYTCVS CGARYCTVRC LGTHQETRCL

KWTV
Length:154
Mass (Da):17,536
Last modified:June 1, 1998 - v1
Checksum:i6A45F05249DC07A6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035719134R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs369664812dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093571 mRNA. Translation: AAF03558.1.
U61837 mRNA. Translation: AAB88578.1.
CR456992 mRNA. Translation: CAG33273.1.
AC004876 Genomic DNA. Translation: AAD45833.1.
CH471197 Genomic DNA. Translation: EAW50209.1.
BC017333 mRNA. Translation: AAH17333.1.
CCDSiCCDS5716.1.
RefSeqiNP_006340.1. NM_006349.2.
UniGeneiHs.211079.

Genome annotation databases

EnsembliENST00000305105; ENSP00000304593; ENSG00000106400.
GeneIDi10467.
KEGGihsa:10467.
UCSCiuc003uye.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093571 mRNA. Translation: AAF03558.1.
U61837 mRNA. Translation: AAB88578.1.
CR456992 mRNA. Translation: CAG33273.1.
AC004876 Genomic DNA. Translation: AAD45833.1.
CH471197 Genomic DNA. Translation: EAW50209.1.
BC017333 mRNA. Translation: AAH17333.1.
CCDSiCCDS5716.1.
RefSeqiNP_006340.1. NM_006349.2.
UniGeneiHs.211079.

3D structure databases

ProteinModelPortaliO43257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115730. 19 interactors.
IntActiO43257. 29 interactors.
MINTiMINT-1036481.
STRINGi9606.ENSP00000304593.

PTM databases

iPTMnetiO43257.
PhosphoSitePlusiO43257.

Polymorphism and mutation databases

BioMutaiZNHIT1.

Proteomic databases

EPDiO43257.
MaxQBiO43257.
PaxDbiO43257.
PeptideAtlasiO43257.
PRIDEiO43257.

Protocols and materials databases

DNASUi10467.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305105; ENSP00000304593; ENSG00000106400.
GeneIDi10467.
KEGGihsa:10467.
UCSCiuc003uye.4. human.

Organism-specific databases

CTDi10467.
GeneCardsiZNHIT1.
HGNCiHGNC:21688. ZNHIT1.
HPAiHPA019043.
neXtProtiNX_O43257.
OpenTargetsiENSG00000106400.
PharmGKBiPA134947251.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3362. Eukaryota.
ENOG4111HZU. LUCA.
GeneTreeiENSGT00390000018426.
HOGENOMiHOG000264917.
HOVERGENiHBG054274.
InParanoidiO43257.
KOiK11663.
OMAiTRYCRVR.
OrthoDBiEOG091G0OU8.
PhylomeDBiO43257.
TreeFamiTF314330.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106400-MONOMER.
SIGNORiO43257.

Miscellaneous databases

ChiTaRSiZNHIT1. human.
GenomeRNAii10467.
PROiO43257.

Gene expression databases

BgeeiENSG00000106400.
CleanExiHS_ZNHIT1.
GenevisibleiO43257. HS.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNHI1_HUMAN
AccessioniPrimary (citable) accession number: O43257
Secondary accession number(s): Q6IB12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.