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O43257

- ZNHI1_HUMAN

UniProt

O43257 - ZNHI1_HUMAN

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Protein
Zinc finger HIT domain-containing protein 1
Gene
ZNHIT1, CGBP1, ZNFN4A1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri117 – 14933HIT-type
Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of G0 to G1 transition Source: Ensembl
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. regulation of T cell proliferation Source: Ensembl
  4. regulation of histone deacetylation Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger HIT domain-containing protein 1
Alternative name(s):
Cyclin-G1-binding protein 1
Zinc finger protein subfamily 4A member 1
p18 Hamlet
Gene namesi
Name:ZNHIT1
Synonyms:CGBP1, ZNFN4A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21688. ZNHIT1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi103 – 1031T → A: Impairs the p38 MAPK-mediated phosphorylation of ZNHIT1. 1 Publication
Mutagenesisi124 – 1241S → A: No change in the in vitro MAPK14/MAPK11-induced phosphorylation level of ZNHIT1.

Organism-specific databases

PharmGKBiPA134947251.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Zinc finger HIT domain-containing protein 1
PRO_0000173546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031Phosphothreonine; by MAPK11 and MAPK141 Publication

Post-translational modificationi

Phosphorylated on Thr by MAPK11 or MAPK14.1 Publication
Stres-induced ZNHIT1 is mainly regulated at the level of protein.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43257.
PaxDbiO43257.
PRIDEiO43257.

PTM databases

PhosphoSiteiO43257.

Expressioni

Tissue specificityi

Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine.1 Publication

Inductioni

Induced by DNA damage.1 Publication

Gene expression databases

BgeeiO43257.
CleanExiHS_ZNHIT1.
GenevestigatoriO43257.

Organism-specific databases

HPAiHPA019043.

Interactioni

Subunit structurei

Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with NR1D1 and NR2D2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTR6Q9GZN14EBI-347522,EBI-769329
H2AFZP0C0S53EBI-347522,EBI-1199859
MAPK11Q157592EBI-347522,EBI-298304
MAPK14Q165397EBI-347522,EBI-73946
TP53BP1Q128882EBI-347522,EBI-396540

Protein-protein interaction databases

BioGridi115730. 7 interactions.
IntActiO43257. 16 interactions.
MINTiMINT-1036481.
STRINGi9606.ENSP00000304593.

Structurei

3D structure databases

ProteinModelPortaliO43257.
SMRiO43257. Positions 115-146.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni72 – 11039Interaction with NR1D2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili23 – 3917 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 4710Nuclear localization signal

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi66 – 705Poly-Lys

Sequence similaritiesi

Belongs to the ZNHIT1 family.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG282558.
HOGENOMiHOG000264917.
HOVERGENiHBG054274.
InParanoidiO43257.
KOiK11663.
OMAiACGTRYC.
OrthoDBiEOG722JBH.
PhylomeDBiO43257.
TreeFamiTF314330.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43257-1 [UniParc]FASTAAdd to Basket

« Hide

MVEKKTSVRS QDPGQRRVLD RAARQRRINR QLEALENDNF QDDPHAGLPQ    50
LGKRLPQFDD DADTGKKKKK TRGDHFKLRF RKNFQALLEE QNLSVAEGPN 100
YLTACAGPPS RPQRPFCAVC GFPSPYTCVS CGARYCTVRC LGTHQETRCL 150
KWTV 154
Length:154
Mass (Da):17,536
Last modified:June 1, 1998 - v1
Checksum:i6A45F05249DC07A6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341R → W in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035719

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093571 mRNA. Translation: AAF03558.1.
U61837 mRNA. Translation: AAB88578.1.
CR456992 mRNA. Translation: CAG33273.1.
AC004876 Genomic DNA. Translation: AAD45833.1.
CH471197 Genomic DNA. Translation: EAW50209.1.
BC017333 mRNA. Translation: AAH17333.1.
CCDSiCCDS5716.1.
RefSeqiNP_006340.1. NM_006349.2.
UniGeneiHs.211079.

Genome annotation databases

EnsembliENST00000305105; ENSP00000304593; ENSG00000106400.
GeneIDi10467.
KEGGihsa:10467.
UCSCiuc003uye.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093571 mRNA. Translation: AAF03558.1 .
U61837 mRNA. Translation: AAB88578.1 .
CR456992 mRNA. Translation: CAG33273.1 .
AC004876 Genomic DNA. Translation: AAD45833.1 .
CH471197 Genomic DNA. Translation: EAW50209.1 .
BC017333 mRNA. Translation: AAH17333.1 .
CCDSi CCDS5716.1.
RefSeqi NP_006340.1. NM_006349.2.
UniGenei Hs.211079.

3D structure databases

ProteinModelPortali O43257.
SMRi O43257. Positions 115-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115730. 7 interactions.
IntActi O43257. 16 interactions.
MINTi MINT-1036481.
STRINGi 9606.ENSP00000304593.

PTM databases

PhosphoSitei O43257.

Proteomic databases

MaxQBi O43257.
PaxDbi O43257.
PRIDEi O43257.

Protocols and materials databases

DNASUi 10467.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305105 ; ENSP00000304593 ; ENSG00000106400 .
GeneIDi 10467.
KEGGi hsa:10467.
UCSCi uc003uye.3. human.

Organism-specific databases

CTDi 10467.
GeneCardsi GC07P100860.
HGNCi HGNC:21688. ZNHIT1.
HPAi HPA019043.
neXtProti NX_O43257.
PharmGKBi PA134947251.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282558.
HOGENOMi HOG000264917.
HOVERGENi HBG054274.
InParanoidi O43257.
KOi K11663.
OMAi ACGTRYC.
OrthoDBi EOG722JBH.
PhylomeDBi O43257.
TreeFami TF314330.

Miscellaneous databases

ChiTaRSi ZNHIT1. human.
GenomeRNAii 10467.
NextBioi 39695.
PROi O43257.

Gene expression databases

Bgeei O43257.
CleanExi HS_ZNHIT1.
Genevestigatori O43257.

Family and domain databases

InterProi IPR007529. Znf_HIT.
[Graphical view ]
Pfami PF04438. zf-HIT. 1 hit.
[Graphical view ]
PROSITEi PS51083. ZF_HIT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of cyclin G1 binding protein 1 (CGBP1)."
    Wang Y., Underwood L.J., Tanimoto H., Shigemasa K., O'Brien T.J.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Xu F., Hall F.L., Starnes V., Wu L.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  7. "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes."
    Cai Y., Jin J., Florens L., Swanson S.K., Kusch T., Li B., Workman J.L., Washburn M.P., Conaway R.C., Conaway J.W.
    J. Biol. Chem. 280:13665-13670(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SRCAP COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis."
    Cuadrado A., Lafarga V., Cheung P.C., Dolado I., Llanos S., Cohen P., Nebreda A.R.
    EMBO J. 26:2115-2126(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAPK11 AND MAPK14, PHOSPHORYLATION AT THR-103 BY MAPK11 AND MAPK14, INDUCTION BY DNA DAMAGE, FUNCTION, MUTAGENESIS OF THR-103.
  9. "A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription."
    Wang J., Li Y., Zhang M., Liu Z., Wu C., Yuan H., Li Y.Y., Zhao X., Lu H.
    FEBS J. 274:5370-5381(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NR1D1 AND NR1D2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-134.

Entry informationi

Entry nameiZNHI1_HUMAN
AccessioniPrimary (citable) accession number: O43257
Secondary accession number(s): Q6IB12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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