ID   HXC11_HUMAN             Reviewed;         304 AA.
AC   O43248; A8K7D1; Q96DH2;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   27-MAR-2024, entry version 197.
DE   RecName: Full=Homeobox protein Hox-C11;
DE   AltName: Full=Homeobox protein Hox-3H;
GN   Name=HOXC11; Synonyms=HOX3H;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9582375; DOI=10.1074/jbc.273.21.13297;
RA   Mitchelmore C.E., Troelsen J.T., Sjoestroem H., Noren O.;
RT   "The HOXC11 homeodomain protein interacts with the lactase-phlorizin
RT   hydrolase promoter and stimulates HNF1alpha-dependent transcription.";
RL   J. Biol. Chem. 273:13297-13306(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-178, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25218447; DOI=10.1038/nsmb.2890;
RA   Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA   Vertegaal A.C.;
RT   "Uncovering global SUMOylation signaling networks in a site-specific
RT   manner.";
RL   Nat. Struct. Mol. Biol. 21:927-936(2014).
RN   [6]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-178, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA   Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA   Vertegaal A.C.;
RT   "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL   Cell Rep. 10:1778-1791(2015).
RN   [7]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-82; LYS-116 AND LYS-178, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733; DOI=10.1038/nsmb.3366;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-modification
RT   with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
RN   [8]
RP   VARIANT SER-130.
RX   PubMed=11857506; DOI=10.1002/tera.10009;
RA   Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K.,
RA   Tomita M., McGinnis W., Matsuo N.;
RT   "Complete mutation analysis panel of the 39 human HOX genes.";
RL   Teratology 65:50-62(2002).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Binds to a
CC       promoter element of the lactase-phlorizin hydrolase gene.
CC   -!- INTERACTION:
CC       O43248; P22607: FGFR3; NbExp=3; IntAct=EBI-2652631, EBI-348399;
CC       O43248; P01112: HRAS; NbExp=3; IntAct=EBI-2652631, EBI-350145;
CC       O43248; P42858: HTT; NbExp=7; IntAct=EBI-2652631, EBI-466029;
CC       O43248; D3DTS7: PMP22; NbExp=3; IntAct=EBI-2652631, EBI-25882629;
CC       O43248; P25786: PSMA1; NbExp=3; IntAct=EBI-2652631, EBI-359352;
CC       O43248; Q15642-2: TRIP10; NbExp=3; IntAct=EBI-2652631, EBI-6550597;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; AJ000041; CAA03876.1; -; mRNA.
DR   EMBL; AK291946; BAF84635.1; -; mRNA.
DR   EMBL; CH471054; EAW96736.1; -; Genomic_DNA.
DR   EMBL; BC001543; AAH01543.1; -; mRNA.
DR   CCDS; CCDS8867.1; -.
DR   PIR; A60941; A60941.
DR   RefSeq; NP_055027.1; NM_014212.3.
DR   AlphaFoldDB; O43248; -.
DR   SMR; O43248; -.
DR   BioGRID; 109467; 22.
DR   IntAct; O43248; 18.
DR   STRING; 9606.ENSP00000446680; -.
DR   iPTMnet; O43248; -.
DR   PhosphoSitePlus; O43248; -.
DR   BioMuta; HOXC11; -.
DR   EPD; O43248; -.
DR   jPOST; O43248; -.
DR   MassIVE; O43248; -.
DR   MaxQB; O43248; -.
DR   PaxDb; 9606-ENSP00000446680; -.
DR   PeptideAtlas; O43248; -.
DR   ProteomicsDB; 48826; -.
DR   Pumba; O43248; -.
DR   Antibodypedia; 15309; 375 antibodies from 28 providers.
DR   DNASU; 3227; -.
DR   Ensembl; ENST00000546378.1; ENSP00000446680.1; ENSG00000123388.4.
DR   GeneID; 3227; -.
DR   KEGG; hsa:3227; -.
DR   MANE-Select; ENST00000546378.1; ENSP00000446680.1; NM_014212.4; NP_055027.1.
DR   UCSC; uc058oto.1; human.
DR   AGR; HGNC:5123; -.
DR   CTD; 3227; -.
DR   DisGeNET; 3227; -.
DR   GeneCards; HOXC11; -.
DR   HGNC; HGNC:5123; HOXC11.
DR   HPA; ENSG00000123388; Tissue enhanced (skeletal muscle, skin).
DR   MIM; 605559; gene.
DR   neXtProt; NX_O43248; -.
DR   OpenTargets; ENSG00000123388; -.
DR   PharmGKB; PA29398; -.
DR   VEuPathDB; HostDB:ENSG00000123388; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000160009; -.
DR   HOGENOM; CLU_079662_0_0_1; -.
DR   InParanoid; O43248; -.
DR   OMA; AYCGADN; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; O43248; -.
DR   TreeFam; TF350668; -.
DR   PathwayCommons; O43248; -.
DR   SignaLink; O43248; -.
DR   SIGNOR; O43248; -.
DR   BioGRID-ORCS; 3227; 18 hits in 1170 CRISPR screens.
DR   ChiTaRS; HOXC11; human.
DR   GeneWiki; HOXC11; -.
DR   GenomeRNAi; 3227; -.
DR   Pharos; O43248; Tbio.
DR   PRO; PR:O43248; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; O43248; Protein.
DR   Bgee; ENSG00000123388; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 49 other cell types or tissues.
DR   ExpressionAtlas; O43248; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR   GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
DR   GO; GO:0007492; P:endoderm development; TAS:ProtInc.
DR   GO; GO:0001656; P:metanephros development; IEA:Ensembl.
DR   GO; GO:0001759; P:organ induction; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR021918; DUF3528.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR46092; HOMEOBOX PROTEIN HOX-A11-RELATED; 1.
DR   PANTHER; PTHR46092:SF1; HOMEOBOX PROTEIN HOX-C11; 1.
DR   Pfam; PF12045; DUF3528; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; O43248; HS.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..304
FT                   /note="Homeobox protein Hox-C11"
FT                   /id="PRO_0000200192"
FT   DNA_BIND        232..291
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          166..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        82
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:28112733"
FT   CROSSLNK        116
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:28112733"
FT   CROSSLNK        178
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:25218447,
FT                   ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733"
FT   VARIANT         130
FT                   /note="P -> S (in dbSNP:rs34652380)"
FT                   /evidence="ECO:0000269|PubMed:11857506"
FT                   /id="VAR_031850"
FT   VARIANT         222
FT                   /note="A -> V (in dbSNP:rs12427129)"
FT                   /id="VAR_034002"
FT   CONFLICT        48
FT                   /note="S -> F (in Ref. 4; AAH01543)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   304 AA;  33748 MW;  EB357DEBB3DE165F CRC64;
     MFNSVNLGNF CSPSRKERGA DFGERGSCAS NLYLPSCTYY MPEFSTVSSF LPQAPSRQIS
     YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM HRECLPPSTV TEILMKNEGS
     YGGHHHPSAP HATPAGFYSS VNKNSVLPQA FDRFFDNAYC GGGDPPAEPP CSGKGEAKGE
     PEAPPASGLA SRAEAGAEAE AEEENTNPSS SGSAHSVAKE PAKGAAPNAP RTRKKRCPYS
     KFQIRELERE FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG
     NPLL
//