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Protein

Homeobox protein Hox-C11

Gene

HOXC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi232 – 291HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123388-MONOMER.
SIGNORiO43248.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C11
Alternative name(s):
Homeobox protein Hox-3H
Gene namesi
Name:HOXC11
Synonyms:HOX3H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5123. HOXC11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3227.
OpenTargetsiENSG00000123388.
PharmGKBiPA29398.

Polymorphism and mutation databases

BioMutaiHOXC11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001921 – 304Homeobox protein Hox-C11Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiO43248.
PaxDbiO43248.
PeptideAtlasiO43248.
PRIDEiO43248.

PTM databases

iPTMnetiO43248.
PhosphoSitePlusiO43248.

Expressioni

Gene expression databases

BgeeiENSG00000123388.
CleanExiHS_HOXC11.
ExpressionAtlasiO43248. baseline and differential.
GenevisibleiO43248. HS.

Organism-specific databases

HPAiHPA038291.

Interactioni

Protein-protein interaction databases

BioGridi109467. 14 interactors.
IntActiO43248. 3 interactors.
STRINGi9606.ENSP00000446680.

Structurei

3D structure databases

ProteinModelPortaliO43248.
SMRiO43248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiO43248.
KOiK09296.
PhylomeDBiO43248.
TreeFamiTF350668.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNSVNLGNF CSPSRKERGA DFGERGSCAS NLYLPSCTYY MPEFSTVSSF
60 70 80 90 100
LPQAPSRQIS YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM
110 120 130 140 150
HRECLPPSTV TEILMKNEGS YGGHHHPSAP HATPAGFYSS VNKNSVLPQA
160 170 180 190 200
FDRFFDNAYC GGGDPPAEPP CSGKGEAKGE PEAPPASGLA SRAEAGAEAE
210 220 230 240 250
AEEENTNPSS SGSAHSVAKE PAKGAAPNAP RTRKKRCPYS KFQIRELERE
260 270 280 290 300
FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG

NPLL
Length:304
Mass (Da):33,748
Last modified:June 1, 1998 - v1
Checksum:iEB357DEBB3DE165F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48S → F in AAH01543 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031850130P → S.1 PublicationCorresponds to variant rs34652380dbSNPEnsembl.1
Natural variantiVAR_034002222A → V.Corresponds to variant rs12427129dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000041 mRNA. Translation: CAA03876.1.
AK291946 mRNA. Translation: BAF84635.1.
CH471054 Genomic DNA. Translation: EAW96736.1.
BC001543 mRNA. Translation: AAH01543.1.
CCDSiCCDS8867.1.
PIRiA60941.
RefSeqiNP_055027.1. NM_014212.3.
UniGeneiHs.127562.

Genome annotation databases

EnsembliENST00000546378; ENSP00000446680; ENSG00000123388.
GeneIDi3227.
KEGGihsa:3227.
UCSCiuc058oto.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000041 mRNA. Translation: CAA03876.1.
AK291946 mRNA. Translation: BAF84635.1.
CH471054 Genomic DNA. Translation: EAW96736.1.
BC001543 mRNA. Translation: AAH01543.1.
CCDSiCCDS8867.1.
PIRiA60941.
RefSeqiNP_055027.1. NM_014212.3.
UniGeneiHs.127562.

3D structure databases

ProteinModelPortaliO43248.
SMRiO43248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109467. 14 interactors.
IntActiO43248. 3 interactors.
STRINGi9606.ENSP00000446680.

PTM databases

iPTMnetiO43248.
PhosphoSitePlusiO43248.

Polymorphism and mutation databases

BioMutaiHOXC11.

Proteomic databases

MaxQBiO43248.
PaxDbiO43248.
PeptideAtlasiO43248.
PRIDEiO43248.

Protocols and materials databases

DNASUi3227.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000546378; ENSP00000446680; ENSG00000123388.
GeneIDi3227.
KEGGihsa:3227.
UCSCiuc058oto.1. human.

Organism-specific databases

CTDi3227.
DisGeNETi3227.
GeneCardsiHOXC11.
HGNCiHGNC:5123. HOXC11.
HPAiHPA038291.
MIMi605559. gene.
neXtProtiNX_O43248.
OpenTargetsiENSG00000123388.
PharmGKBiPA29398.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiO43248.
KOiK09296.
PhylomeDBiO43248.
TreeFamiTF350668.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123388-MONOMER.
SIGNORiO43248.

Miscellaneous databases

GeneWikiiHOXC11.
GenomeRNAii3227.
PROiO43248.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123388.
CleanExiHS_HOXC11.
ExpressionAtlasiO43248. baseline and differential.
GenevisibleiO43248. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXC11_HUMAN
AccessioniPrimary (citable) accession number: O43248
Secondary accession number(s): A8K7D1, Q96DH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.