SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43248

- HXC11_HUMAN

UniProt

O43248 - HXC11_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Homeobox protein Hox-C11

Gene
HOXC11, HOX3H
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi232 – 29160HomeoboxAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic digit morphogenesis Source: Ensembl
  3. embryonic skeletal joint morphogenesis Source: Ensembl
  4. endoderm development Source: ProtInc
  5. metanephros development Source: Ensembl
  6. organ induction Source: Ensembl
  7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  8. proximal/distal pattern formation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C11
Alternative name(s):
Homeobox protein Hox-3H
Gene namesi
Name:HOXC11
Synonyms:HOX3H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:5123. HOXC11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29398.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Homeobox protein Hox-C11PRO_0000200192Add
BLAST

Proteomic databases

PaxDbiO43248.
PRIDEiO43248.

PTM databases

PhosphoSiteiO43248.

Expressioni

Gene expression databases

ArrayExpressiO43248.
BgeeiO43248.
CleanExiHS_HOXC11.
GenevestigatoriO43248.

Organism-specific databases

HPAiHPA038291.

Interactioni

Protein-protein interaction databases

BioGridi109467. 13 interactions.
IntActiO43248. 2 interactions.
STRINGi9606.ENSP00000243082.

Structurei

3D structure databases

ProteinModelPortaliO43248.
SMRiO43248. Positions 232-291.

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG298161.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiO43248.
KOiK09296.
OrthoDBiEOG7KWSJ0.
PhylomeDBiO43248.
TreeFamiTF350668.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43248-1 [UniParc]FASTAAdd to Basket

« Hide

MFNSVNLGNF CSPSRKERGA DFGERGSCAS NLYLPSCTYY MPEFSTVSSF    50
LPQAPSRQIS YPYSAQVPPV REVSYGLEPS GKWHHRNSYS SCYAAADELM 100
HRECLPPSTV TEILMKNEGS YGGHHHPSAP HATPAGFYSS VNKNSVLPQA 150
FDRFFDNAYC GGGDPPAEPP CSGKGEAKGE PEAPPASGLA SRAEAGAEAE 200
AEEENTNPSS SGSAHSVAKE PAKGAAPNAP RTRKKRCPYS KFQIRELERE 250
FFFNVYINKE KRLQLSRMLN LTDRQVKIWF QNRRMKEKKL SRDRLQYFSG 300
NPLL 304
Length:304
Mass (Da):33,748
Last modified:June 1, 1998 - v1
Checksum:iEB357DEBB3DE165F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301P → S.1 Publication
Corresponds to variant rs34652380 [ dbSNP | Ensembl ].
VAR_031850
Natural varianti222 – 2221A → V.
Corresponds to variant rs12427129 [ dbSNP | Ensembl ].
VAR_034002

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481S → F in AAH01543. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000041 mRNA. Translation: CAA03876.1.
AK291946 mRNA. Translation: BAF84635.1.
CH471054 Genomic DNA. Translation: EAW96736.1.
BC001543 mRNA. Translation: AAH01543.1.
CCDSiCCDS8867.1.
PIRiA60941.
RefSeqiNP_055027.1. NM_014212.3.
UniGeneiHs.127562.

Genome annotation databases

EnsembliENST00000546378; ENSP00000446680; ENSG00000123388.
GeneIDi3227.
KEGGihsa:3227.
UCSCiuc001sem.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000041 mRNA. Translation: CAA03876.1 .
AK291946 mRNA. Translation: BAF84635.1 .
CH471054 Genomic DNA. Translation: EAW96736.1 .
BC001543 mRNA. Translation: AAH01543.1 .
CCDSi CCDS8867.1.
PIRi A60941.
RefSeqi NP_055027.1. NM_014212.3.
UniGenei Hs.127562.

3D structure databases

ProteinModelPortali O43248.
SMRi O43248. Positions 232-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109467. 13 interactions.
IntActi O43248. 2 interactions.
STRINGi 9606.ENSP00000243082.

PTM databases

PhosphoSitei O43248.

Proteomic databases

PaxDbi O43248.
PRIDEi O43248.

Protocols and materials databases

DNASUi 3227.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000546378 ; ENSP00000446680 ; ENSG00000123388 .
GeneIDi 3227.
KEGGi hsa:3227.
UCSCi uc001sem.3. human.

Organism-specific databases

CTDi 3227.
GeneCardsi GC12P054366.
HGNCi HGNC:5123. HOXC11.
HPAi HPA038291.
MIMi 605559. gene.
neXtProti NX_O43248.
PharmGKBi PA29398.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298161.
HOGENOMi HOG000231898.
HOVERGENi HBG052048.
InParanoidi O43248.
KOi K09296.
OrthoDBi EOG7KWSJ0.
PhylomeDBi O43248.
TreeFami TF350668.

Miscellaneous databases

GeneWikii HOXC11.
GenomeRNAii 3227.
NextBioi 12843.
PROi O43248.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43248.
Bgeei O43248.
CleanExi HS_HOXC11.
Genevestigatori O43248.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription."
    Mitchelmore C.E., Troelsen J.T., Sjoestroem H., Noren O.
    J. Biol. Chem. 273:13297-13306(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  5. Cited for: VARIANT SER-130.

Entry informationi

Entry nameiHXC11_HUMAN
AccessioniPrimary (citable) accession number: O43248
Secondary accession number(s): A8K7D1, Q96DH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi