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O43246

- CTR4_HUMAN

UniProt

O43246 - CTR4_HUMAN

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Protein
Cationic amino acid transporter 4
Gene
SLC7A4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

GO - Molecular functioni

  1. basic amino acid transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. basic amino acid transport Source: GOC
  2. cellular amino acid metabolic process Source: ProtInc
  3. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.3.6. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 4
Short name:
CAT-4
Short name:
CAT4
Alternative name(s):
Solute carrier family 7 member 4
Gene namesi
Name:SLC7A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:11062. SLC7A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Reviewed prediction
Add
BLAST
Transmembranei66 – 8621Helical; Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Reviewed prediction
Add
BLAST
Transmembranei197 – 21721Helical; Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Reviewed prediction
Add
BLAST
Transmembranei270 – 29021Helical; Reviewed prediction
Add
BLAST
Transmembranei318 – 33821Helical; Reviewed prediction
Add
BLAST
Transmembranei365 – 38521Helical; Reviewed prediction
Add
BLAST
Transmembranei391 – 41121Helical; Reviewed prediction
Add
BLAST
Transmembranei478 – 49821Helical; Reviewed prediction
Add
BLAST
Transmembranei508 – 52821Helical; Reviewed prediction
Add
BLAST
Transmembranei539 – 55921Helical; Reviewed prediction
Add
BLAST
Transmembranei567 – 58721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35922.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Cationic amino acid transporter 4
PRO_0000054269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi195 – 1951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi221 – 2211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi601 – 6011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO43246.
PRIDEiO43246.

PTM databases

PhosphoSiteiO43246.

Expressioni

Gene expression databases

ArrayExpressiO43246.
BgeeiO43246.
CleanExiHS_SLC7A4.
GenevestigatoriO43246.

Organism-specific databases

HPAiHPA031023.

Interactioni

Protein-protein interaction databases

MINTiMINT-2999274.

Structurei

3D structure databases

ProteinModelPortaliO43246.
SMRiO43246. Positions 37-412.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiO43246.
KOiK13866.
OMAiDHLQLVG.
OrthoDBiEOG72C501.
PhylomeDBiO43246.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

O43246-1 [UniParc]FASTAAdd to Basket

« Hide

MARGLPTIAS LARLCQKLNR LKPLEDSTME TSLRRCLSTL DLTLLGVGGM    50
VGSGLYVLTG AVAKEVAGPA VLLSFGVAAV ASLLAALCYA EFGARVPRTG 100
SAYLFTYVSM GELWAFLIGW NVLLEYIIGG AAVARAWSGY LDSMFSHSIR 150
NFTETHVGSW QVPLLGHYPD FLAAGIILLA SAFVSCGARV SSWLNHTFSA 200
ISLLVILFIV ILGFILAQPH NWSADEGGFA PFGFSGVMAG TASCFYAFVG 250
FDVIAASSEE AQNPRRSVPL AIAISLAIAA GAYILVSTVL TLMVPWHSLD 300
PDSALADAFY QRGYRWAGFI VAAGSICAMN TVLLSLLFSL PRIVYAMAAD 350
GLFFQVFAHV HPRTQVPVAG TLAFGLLTAF LALLLDLESL VQFLSLGTLL 400
AYTFVATSII VLRFQKSSPP SSPGPASPGP LTKQQSSFSD HLQLVGTVHA 450
SVPEPGELKP ALRPYLGFLD GYSPGAVVTW ALGVMLASAI TIGCVLVFGN 500
STLHLPHWGY ILLLLLTSVM FLLSLLVLGA HQQQYREDLF QIPMVPLIPA 550
LSIVLNICLM LKLSYLTWVR FSIWLLMGLA VYFGYGIRHS KENQRELPGL 600
NSTHYVVFPR GSLEETVQAM QPPSQAPAQD PGHME 635
Length:635
Mass (Da):68,268
Last modified:March 15, 2005 - v3
Checksum:i2E36605489C6EFE9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281T → I.2 Publications
Corresponds to variant rs2072550 [ dbSNP | Ensembl ].
VAR_048155
Natural varianti349 – 3491A → T.2 Publications
Corresponds to variant rs2270384 [ dbSNP | Ensembl ].
VAR_048156
Natural varianti608 – 6081F → Y.
Corresponds to variant rs55700350 [ dbSNP | Ensembl ].
VAR_060989

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 19238THVGS…ARVSS → DPRGFLAGAPPGPLPGLPGC WHHPPWPLPLSPVEPACPP in CAA04263. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000730 mRNA. Translation: CAA04263.1.
CR456580 mRNA. Translation: CAG30466.1.
BC008814 mRNA. Translation: AAH08814.1.
BC062565 mRNA. Translation: AAH62565.1.
BC107160 mRNA. Translation: AAI07161.1.
BC107161 mRNA. Translation: AAI07162.1.
CCDSiCCDS33608.1.
RefSeqiNP_004164.2. NM_004173.2.
XP_005261773.1. XM_005261716.1.
XP_005261774.1. XM_005261717.2.
UniGeneiHs.197116.

Genome annotation databases

EnsembliENST00000382932; ENSP00000372390; ENSG00000099960.
ENST00000403586; ENSP00000384278; ENSG00000099960.
GeneIDi6545.
KEGGihsa:6545.
UCSCiuc002zud.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000730 mRNA. Translation: CAA04263.1 .
CR456580 mRNA. Translation: CAG30466.1 .
BC008814 mRNA. Translation: AAH08814.1 .
BC062565 mRNA. Translation: AAH62565.1 .
BC107160 mRNA. Translation: AAI07161.1 .
BC107161 mRNA. Translation: AAI07162.1 .
CCDSi CCDS33608.1.
RefSeqi NP_004164.2. NM_004173.2.
XP_005261773.1. XM_005261716.1.
XP_005261774.1. XM_005261717.2.
UniGenei Hs.197116.

3D structure databases

ProteinModelPortali O43246.
SMRi O43246. Positions 37-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-2999274.

Chemistry

BindingDBi O43246.
DrugBanki DB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Protein family/group databases

TCDBi 2.A.3.3.6. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSitei O43246.

Proteomic databases

PaxDbi O43246.
PRIDEi O43246.

Protocols and materials databases

DNASUi 6545.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382932 ; ENSP00000372390 ; ENSG00000099960 .
ENST00000403586 ; ENSP00000384278 ; ENSG00000099960 .
GeneIDi 6545.
KEGGi hsa:6545.
UCSCi uc002zud.3. human.

Organism-specific databases

CTDi 6545.
GeneCardsi GC22M021383.
HGNCi HGNC:11062. SLC7A4.
HPAi HPA031023.
MIMi 603752. gene.
neXtProti NX_O43246.
PharmGKBi PA35922.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0531.
HOGENOMi HOG000250623.
HOVERGENi HBG000280.
InParanoidi O43246.
KOi K13866.
OMAi DHLQLVG.
OrthoDBi EOG72C501.
PhylomeDBi O43246.
TreeFami TF315212.

Miscellaneous databases

GeneWikii SLC7A4.
GenomeRNAii 6545.
NextBioi 25465.
PROi O43246.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43246.
Bgeei O43246.
CleanExi HS_SLC7A4.
Genevestigatori O43246.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome."
    Sperandeo M.P., Borsani G., Incerti B., Zollo M., Rossi E., Zuffardi O., Castaldo P., Taglialatela M., Andria G., Sebastio G.
    Genomics 49:230-236(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-28 AND THR-349.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-28 AND THR-349.
    Tissue: Brain and Placenta.

Entry informationi

Entry nameiCTR4_HUMAN
AccessioniPrimary (citable) accession number: O43246
Secondary accession number(s): Q0P5U2
, Q3KNQ6, Q4VC45, Q6IBY8, Q96H88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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