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Protein

Cationic amino acid transporter 4

Gene

SLC7A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

GO - Molecular functioni

  • basic amino acid transmembrane transporter activity Source: ProtInc

GO - Biological processi

  • cellular amino acid metabolic process Source: ProtInc

Keywordsi

Biological processAmino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.3.6 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 4
Short name:
CAT-4
Short name:
CAT4
Alternative name(s):
Solute carrier family 7 member 4
Gene namesi
Name:SLC7A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099960.12
HGNCiHGNC:11062 SLC7A4
MIMi603752 gene
neXtProtiNX_O43246

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6545
OpenTargetsiENSG00000099960
PharmGKBiPA35922

Chemistry databases

DrugBankiDB00125 L-Arginine
DB00123 L-Lysine
DB00129 L-Ornithine

Polymorphism and mutation databases

BioMutaiSLC7A4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542691 – 635Cationic amino acid transporter 4Add BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei422PhosphoserineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi601N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO43246
PeptideAtlasiO43246
PRIDEiO43246

PTM databases

iPTMnetiO43246
PhosphoSitePlusiO43246

Expressioni

Gene expression databases

BgeeiENSG00000099960
CleanExiHS_SLC7A4
ExpressionAtlasiO43246 baseline and differential
GenevisibleiO43246 HS

Organism-specific databases

HPAiHPA031023

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000372390

Structurei

3D structure databases

ProteinModelPortaliO43246
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119151
HOGENOMiHOG000250623
HOVERGENiHBG000280
InParanoidiO43246
KOiK13866
OMAiAVTWVRF
OrthoDBiEOG091G05NM
PhylomeDBiO43246
TreeFamiTF315212

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit

Sequencei

Sequence statusi: Complete.

O43246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGLPTIAS LARLCQKLNR LKPLEDSTME TSLRRCLSTL DLTLLGVGGM
60 70 80 90 100
VGSGLYVLTG AVAKEVAGPA VLLSFGVAAV ASLLAALCYA EFGARVPRTG
110 120 130 140 150
SAYLFTYVSM GELWAFLIGW NVLLEYIIGG AAVARAWSGY LDSMFSHSIR
160 170 180 190 200
NFTETHVGSW QVPLLGHYPD FLAAGIILLA SAFVSCGARV SSWLNHTFSA
210 220 230 240 250
ISLLVILFIV ILGFILAQPH NWSADEGGFA PFGFSGVMAG TASCFYAFVG
260 270 280 290 300
FDVIAASSEE AQNPRRSVPL AIAISLAIAA GAYILVSTVL TLMVPWHSLD
310 320 330 340 350
PDSALADAFY QRGYRWAGFI VAAGSICAMN TVLLSLLFSL PRIVYAMAAD
360 370 380 390 400
GLFFQVFAHV HPRTQVPVAG TLAFGLLTAF LALLLDLESL VQFLSLGTLL
410 420 430 440 450
AYTFVATSII VLRFQKSSPP SSPGPASPGP LTKQQSSFSD HLQLVGTVHA
460 470 480 490 500
SVPEPGELKP ALRPYLGFLD GYSPGAVVTW ALGVMLASAI TIGCVLVFGN
510 520 530 540 550
STLHLPHWGY ILLLLLTSVM FLLSLLVLGA HQQQYREDLF QIPMVPLIPA
560 570 580 590 600
LSIVLNICLM LKLSYLTWVR FSIWLLMGLA VYFGYGIRHS KENQRELPGL
610 620 630
NSTHYVVFPR GSLEETVQAM QPPSQAPAQD PGHME
Length:635
Mass (Da):68,268
Last modified:March 15, 2005 - v3
Checksum:i2E36605489C6EFE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155 – 192THVGS…ARVSS → DPRGFLAGAPPGPLPGLPGC WHHPPWPLPLSPVEPACPP in CAA04263 (PubMed:9598310).CuratedAdd BLAST38

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04815528T → I2 PublicationsCorresponds to variant dbSNP:rs2072550Ensembl.1
Natural variantiVAR_048156349A → T2 PublicationsCorresponds to variant dbSNP:rs2270384Ensembl.1
Natural variantiVAR_060989608F → Y. Corresponds to variant dbSNP:rs55700350Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000730 mRNA Translation: CAA04263.1
CR456580 mRNA Translation: CAG30466.1
BC008814 mRNA Translation: AAH08814.1
BC062565 mRNA Translation: AAH62565.1
BC107160 mRNA Translation: AAI07161.1
BC107161 mRNA Translation: AAI07162.1
CCDSiCCDS33608.1
RefSeqiNP_004164.2, NM_004173.2
UniGeneiHs.197116

Genome annotation databases

EnsembliENST00000382932; ENSP00000372390; ENSG00000099960
ENST00000403586; ENSP00000384278; ENSG00000099960
GeneIDi6545
KEGGihsa:6545
UCSCiuc002zud.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCTR4_HUMAN
AccessioniPrimary (citable) accession number: O43246
Secondary accession number(s): Q0P5U2
, Q3KNQ6, Q4VC45, Q6IBY8, Q96H88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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