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O43246

- CTR4_HUMAN

UniProt

O43246 - CTR4_HUMAN

Protein

Cationic amino acid transporter 4

Gene

SLC7A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

    GO - Molecular functioni

    1. basic amino acid transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. basic amino acid transport Source: GOC
    2. cellular amino acid metabolic process Source: ProtInc
    3. transport Source: ProtInc

    Keywords - Biological processi

    Amino-acid transport, Transport

    Protein family/group databases

    TCDBi2.A.3.3.6. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cationic amino acid transporter 4
    Short name:
    CAT-4
    Short name:
    CAT4
    Alternative name(s):
    Solute carrier family 7 member 4
    Gene namesi
    Name:SLC7A4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:11062. SLC7A4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35922.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 635635Cationic amino acid transporter 4PRO_0000054269Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO43246.
    PRIDEiO43246.

    PTM databases

    PhosphoSiteiO43246.

    Expressioni

    Gene expression databases

    ArrayExpressiO43246.
    BgeeiO43246.
    CleanExiHS_SLC7A4.
    GenevestigatoriO43246.

    Organism-specific databases

    HPAiHPA031023.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-2999274.

    Structurei

    3D structure databases

    ProteinModelPortaliO43246.
    SMRiO43246. Positions 37-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei508 – 52821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei539 – 55921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei567 – 58721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOGENOMiHOG000250623.
    HOVERGENiHBG000280.
    InParanoidiO43246.
    KOiK13866.
    OMAiDHLQLVG.
    OrthoDBiEOG72C501.
    PhylomeDBiO43246.
    TreeFamiTF315212.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR029485. CAT_C.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O43246-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGLPTIAS LARLCQKLNR LKPLEDSTME TSLRRCLSTL DLTLLGVGGM    50
    VGSGLYVLTG AVAKEVAGPA VLLSFGVAAV ASLLAALCYA EFGARVPRTG 100
    SAYLFTYVSM GELWAFLIGW NVLLEYIIGG AAVARAWSGY LDSMFSHSIR 150
    NFTETHVGSW QVPLLGHYPD FLAAGIILLA SAFVSCGARV SSWLNHTFSA 200
    ISLLVILFIV ILGFILAQPH NWSADEGGFA PFGFSGVMAG TASCFYAFVG 250
    FDVIAASSEE AQNPRRSVPL AIAISLAIAA GAYILVSTVL TLMVPWHSLD 300
    PDSALADAFY QRGYRWAGFI VAAGSICAMN TVLLSLLFSL PRIVYAMAAD 350
    GLFFQVFAHV HPRTQVPVAG TLAFGLLTAF LALLLDLESL VQFLSLGTLL 400
    AYTFVATSII VLRFQKSSPP SSPGPASPGP LTKQQSSFSD HLQLVGTVHA 450
    SVPEPGELKP ALRPYLGFLD GYSPGAVVTW ALGVMLASAI TIGCVLVFGN 500
    STLHLPHWGY ILLLLLTSVM FLLSLLVLGA HQQQYREDLF QIPMVPLIPA 550
    LSIVLNICLM LKLSYLTWVR FSIWLLMGLA VYFGYGIRHS KENQRELPGL 600
    NSTHYVVFPR GSLEETVQAM QPPSQAPAQD PGHME 635
    Length:635
    Mass (Da):68,268
    Last modified:March 15, 2005 - v3
    Checksum:i2E36605489C6EFE9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti155 – 19238THVGS…ARVSS → DPRGFLAGAPPGPLPGLPGC WHHPPWPLPLSPVEPACPP in CAA04263. (PubMed:9598310)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281T → I.2 Publications
    Corresponds to variant rs2072550 [ dbSNP | Ensembl ].
    VAR_048155
    Natural varianti349 – 3491A → T.2 Publications
    Corresponds to variant rs2270384 [ dbSNP | Ensembl ].
    VAR_048156
    Natural varianti608 – 6081F → Y.
    Corresponds to variant rs55700350 [ dbSNP | Ensembl ].
    VAR_060989

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ000730 mRNA. Translation: CAA04263.1.
    CR456580 mRNA. Translation: CAG30466.1.
    BC008814 mRNA. Translation: AAH08814.1.
    BC062565 mRNA. Translation: AAH62565.1.
    BC107160 mRNA. Translation: AAI07161.1.
    BC107161 mRNA. Translation: AAI07162.1.
    CCDSiCCDS33608.1.
    RefSeqiNP_004164.2. NM_004173.2.
    XP_005261773.1. XM_005261716.1.
    XP_005261774.1. XM_005261717.2.
    UniGeneiHs.197116.

    Genome annotation databases

    EnsembliENST00000382932; ENSP00000372390; ENSG00000099960.
    ENST00000403586; ENSP00000384278; ENSG00000099960.
    GeneIDi6545.
    KEGGihsa:6545.
    UCSCiuc002zud.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ000730 mRNA. Translation: CAA04263.1 .
    CR456580 mRNA. Translation: CAG30466.1 .
    BC008814 mRNA. Translation: AAH08814.1 .
    BC062565 mRNA. Translation: AAH62565.1 .
    BC107160 mRNA. Translation: AAI07161.1 .
    BC107161 mRNA. Translation: AAI07162.1 .
    CCDSi CCDS33608.1.
    RefSeqi NP_004164.2. NM_004173.2.
    XP_005261773.1. XM_005261716.1.
    XP_005261774.1. XM_005261717.2.
    UniGenei Hs.197116.

    3D structure databases

    ProteinModelPortali O43246.
    SMRi O43246. Positions 37-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-2999274.

    Chemistry

    BindingDBi O43246.
    DrugBanki DB00125. L-Arginine.
    DB00123. L-Lysine.
    DB00129. L-Ornithine.

    Protein family/group databases

    TCDBi 2.A.3.3.6. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei O43246.

    Proteomic databases

    PaxDbi O43246.
    PRIDEi O43246.

    Protocols and materials databases

    DNASUi 6545.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382932 ; ENSP00000372390 ; ENSG00000099960 .
    ENST00000403586 ; ENSP00000384278 ; ENSG00000099960 .
    GeneIDi 6545.
    KEGGi hsa:6545.
    UCSCi uc002zud.3. human.

    Organism-specific databases

    CTDi 6545.
    GeneCardsi GC22M021383.
    HGNCi HGNC:11062. SLC7A4.
    HPAi HPA031023.
    MIMi 603752. gene.
    neXtProti NX_O43246.
    PharmGKBi PA35922.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0531.
    HOGENOMi HOG000250623.
    HOVERGENi HBG000280.
    InParanoidi O43246.
    KOi K13866.
    OMAi DHLQLVG.
    OrthoDBi EOG72C501.
    PhylomeDBi O43246.
    TreeFami TF315212.

    Miscellaneous databases

    GeneWikii SLC7A4.
    GenomeRNAii 6545.
    NextBioi 25465.
    PROi O43246.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43246.
    Bgeei O43246.
    CleanExi HS_SLC7A4.
    Genevestigatori O43246.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR029485. CAT_C.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome."
      Sperandeo M.P., Borsani G., Incerti B., Zollo M., Rossi E., Zuffardi O., Castaldo P., Taglialatela M., Andria G., Sebastio G.
      Genomics 49:230-236(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-28 AND THR-349.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-28 AND THR-349.
      Tissue: Brain and Placenta.

    Entry informationi

    Entry nameiCTR4_HUMAN
    AccessioniPrimary (citable) accession number: O43246
    Secondary accession number(s): Q0P5U2
    , Q3KNQ6, Q4VC45, Q6IBY8, Q96H88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3