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O43246 (CTR4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cationic amino acid transporter 4
Short name=CAT-4
Short name=CAT4
Alternative name(s):
Solute carrier family 7 member 4
Gene names
Name:SLC7A4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral to membrane

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionbasic amino acid transmembrane transporter activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635Cationic amino acid transporter 4
PRO_0000054269

Regions

Transmembrane42 – 6221Helical; Potential
Transmembrane66 – 8621Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane270 – 29021Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane365 – 38521Helical; Potential
Transmembrane391 – 41121Helical; Potential
Transmembrane478 – 49821Helical; Potential
Transmembrane508 – 52821Helical; Potential
Transmembrane539 – 55921Helical; Potential
Transmembrane567 – 58721Helical; Potential

Amino acid modifications

Modified residue4211Phosphoserine By similarity
Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation1951N-linked (GlcNAc...) Potential
Glycosylation2211N-linked (GlcNAc...) Potential
Glycosylation5001N-linked (GlcNAc...) Potential
Glycosylation6011N-linked (GlcNAc...) Potential

Natural variations

Natural variant281T → I. Ref.2 Ref.3
Corresponds to variant rs2072550 [ dbSNP | Ensembl ].
VAR_048155
Natural variant3491A → T. Ref.2 Ref.3
Corresponds to variant rs2270384 [ dbSNP | Ensembl ].
VAR_048156
Natural variant6081F → Y.
Corresponds to variant rs55700350 [ dbSNP | Ensembl ].
VAR_060989

Experimental info

Sequence conflict155 – 19238THVGS…ARVSS → DPRGFLAGAPPGPLPGLPGC WHHPPWPLPLSPVEPACPP in CAA04263. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O43246 [UniParc].

Last modified March 15, 2005. Version 3.
Checksum: 2E36605489C6EFE9

FASTA63568,268
        10         20         30         40         50         60 
MARGLPTIAS LARLCQKLNR LKPLEDSTME TSLRRCLSTL DLTLLGVGGM VGSGLYVLTG 

        70         80         90        100        110        120 
AVAKEVAGPA VLLSFGVAAV ASLLAALCYA EFGARVPRTG SAYLFTYVSM GELWAFLIGW 

       130        140        150        160        170        180 
NVLLEYIIGG AAVARAWSGY LDSMFSHSIR NFTETHVGSW QVPLLGHYPD FLAAGIILLA 

       190        200        210        220        230        240 
SAFVSCGARV SSWLNHTFSA ISLLVILFIV ILGFILAQPH NWSADEGGFA PFGFSGVMAG 

       250        260        270        280        290        300 
TASCFYAFVG FDVIAASSEE AQNPRRSVPL AIAISLAIAA GAYILVSTVL TLMVPWHSLD 

       310        320        330        340        350        360 
PDSALADAFY QRGYRWAGFI VAAGSICAMN TVLLSLLFSL PRIVYAMAAD GLFFQVFAHV 

       370        380        390        400        410        420 
HPRTQVPVAG TLAFGLLTAF LALLLDLESL VQFLSLGTLL AYTFVATSII VLRFQKSSPP 

       430        440        450        460        470        480 
SSPGPASPGP LTKQQSSFSD HLQLVGTVHA SVPEPGELKP ALRPYLGFLD GYSPGAVVTW 

       490        500        510        520        530        540 
ALGVMLASAI TIGCVLVFGN STLHLPHWGY ILLLLLTSVM FLLSLLVLGA HQQQYREDLF 

       550        560        570        580        590        600 
QIPMVPLIPA LSIVLNICLM LKLSYLTWVR FSIWLLMGLA VYFGYGIRHS KENQRELPGL 

       610        620        630 
NSTHYVVFPR GSLEETVQAM QPPSQAPAQD PGHME

« Hide

References

« Hide 'large scale' references
[1]"The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome."
Sperandeo M.P., Borsani G., Incerti B., Zollo M., Rossi E., Zuffardi O., Castaldo P., Taglialatela M., Andria G., Sebastio G.
Genomics 49:230-236(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-28 AND THR-349.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-28 AND THR-349.
Tissue: Brain and Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ000730 mRNA. Translation: CAA04263.1.
CR456580 mRNA. Translation: CAG30466.1.
BC008814 mRNA. Translation: AAH08814.1.
BC062565 mRNA. Translation: AAH62565.1.
BC107160 mRNA. Translation: AAI07161.1.
BC107161 mRNA. Translation: AAI07162.1.
IPIIPI00748296.
RefSeqNP_004164.2. NM_004173.2.
UniGeneHs.197116.

3D structure databases

ProteinModelPortalO43246.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-2999274.

PTM databases

PhosphoSiteO43246.

Proteomic databases

PaxDbO43246.
PRIDEO43246.

Protocols and materials databases

DNASU6545.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382932; ENSP00000372390; ENSG00000099960.
ENST00000403586; ENSP00000384278; ENSG00000099960.
GeneID6545.
KEGGhsa:6545.
UCSCuc002zud.3. human.

Organism-specific databases

CTD6545.
GeneCardsGC22M021383.
HGNCHGNC:11062. SLC7A4.
HPAHPA031023.
MIM603752. gene.
neXtProtNX_O43246.
PharmGKBPA35922.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0531.
HOGENOMHOG000250623.
HOVERGENHBG000280.
InParanoidO43246.
KOK13866.
OMAQDTFQIP.
OrthoDBEOG4K0QN6.

Gene expression databases

ArrayExpressO43246.
BgeeO43246.
CleanExHS_SLC7A4.
GenevestigatorO43246.
GermOnlineENSG00000099960. Homo sapiens.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR015606. Cat-AATrans.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PTHR11785:SF53. PTHR11785:SF53. 1 hit.
PIRSFPIRSF006060. AA_transporter. 1 hit.
ProtoNetSearch...

Other

BindingDBO43246.
ChEMBLCHEMBL5075.
DrugBankDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.
GenomeRNAi6545.
NextBio25465.
SOURCESearch...

Entry information

Entry nameCTR4_HUMAN
AccessionPrimary (citable) accession number: O43246
Secondary accession number(s): Q0P5U2 expand/collapse secondary AC list , Q3KNQ6, Q4VC45, Q6IBY8, Q96H88
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 15, 2005
Last modified: May 29, 2013
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents