Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cationic amino acid transporter 4

Gene

SLC7A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

GO - Molecular functioni

  1. antiporter activity Source: GO_Central
  2. arginine transmembrane transporter activity Source: GO_Central
  3. basic amino acid transmembrane transporter activity Source: ProtInc
  4. L-lysine transmembrane transporter activity Source: GO_Central
  5. L-ornithine transmembrane transporter activity Source: GO_Central

GO - Biological processi

  1. cellular amino acid metabolic process Source: ProtInc
  2. L-arginine import across plasma membrane Source: GO_Central
  3. L-lysine transmembrane transport Source: GO_Central
  4. L-ornithine transmembrane transport Source: GO_Central
  5. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.3.6. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 4
Short name:
CAT-4
Short name:
CAT4
Alternative name(s):
Solute carrier family 7 member 4
Gene namesi
Name:SLC7A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:11062. SLC7A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence AnalysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence AnalysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence AnalysisAdd
BLAST
Transmembranei508 – 52821HelicalSequence AnalysisAdd
BLAST
Transmembranei539 – 55921HelicalSequence AnalysisAdd
BLAST
Transmembranei567 – 58721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35922.

Chemistry

DrugBankiDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Polymorphism and mutation databases

BioMutaiSLC7A4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Cationic amino acid transporter 4PRO_0000054269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO43246.
PRIDEiO43246.

PTM databases

PhosphoSiteiO43246.

Expressioni

Gene expression databases

BgeeiO43246.
CleanExiHS_SLC7A4.
ExpressionAtlasiO43246. baseline and differential.
GenevestigatoriO43246.

Organism-specific databases

HPAiHPA031023.

Interactioni

Protein-protein interaction databases

MINTiMINT-2999274.

Structurei

3D structure databases

ProteinModelPortaliO43246.
SMRiO43246. Positions 37-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiO43246.
KOiK13866.
OMAiDHLQLVG.
OrthoDBiEOG72C501.
PhylomeDBiO43246.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGLPTIAS LARLCQKLNR LKPLEDSTME TSLRRCLSTL DLTLLGVGGM
60 70 80 90 100
VGSGLYVLTG AVAKEVAGPA VLLSFGVAAV ASLLAALCYA EFGARVPRTG
110 120 130 140 150
SAYLFTYVSM GELWAFLIGW NVLLEYIIGG AAVARAWSGY LDSMFSHSIR
160 170 180 190 200
NFTETHVGSW QVPLLGHYPD FLAAGIILLA SAFVSCGARV SSWLNHTFSA
210 220 230 240 250
ISLLVILFIV ILGFILAQPH NWSADEGGFA PFGFSGVMAG TASCFYAFVG
260 270 280 290 300
FDVIAASSEE AQNPRRSVPL AIAISLAIAA GAYILVSTVL TLMVPWHSLD
310 320 330 340 350
PDSALADAFY QRGYRWAGFI VAAGSICAMN TVLLSLLFSL PRIVYAMAAD
360 370 380 390 400
GLFFQVFAHV HPRTQVPVAG TLAFGLLTAF LALLLDLESL VQFLSLGTLL
410 420 430 440 450
AYTFVATSII VLRFQKSSPP SSPGPASPGP LTKQQSSFSD HLQLVGTVHA
460 470 480 490 500
SVPEPGELKP ALRPYLGFLD GYSPGAVVTW ALGVMLASAI TIGCVLVFGN
510 520 530 540 550
STLHLPHWGY ILLLLLTSVM FLLSLLVLGA HQQQYREDLF QIPMVPLIPA
560 570 580 590 600
LSIVLNICLM LKLSYLTWVR FSIWLLMGLA VYFGYGIRHS KENQRELPGL
610 620 630
NSTHYVVFPR GSLEETVQAM QPPSQAPAQD PGHME
Length:635
Mass (Da):68,268
Last modified:March 15, 2005 - v3
Checksum:i2E36605489C6EFE9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 19238THVGS…ARVSS → DPRGFLAGAPPGPLPGLPGC WHHPPWPLPLSPVEPACPP in CAA04263 (PubMed:9598310).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281T → I.2 Publications
Corresponds to variant rs2072550 [ dbSNP | Ensembl ].
VAR_048155
Natural varianti349 – 3491A → T.2 Publications
Corresponds to variant rs2270384 [ dbSNP | Ensembl ].
VAR_048156
Natural varianti608 – 6081F → Y.
Corresponds to variant rs55700350 [ dbSNP | Ensembl ].
VAR_060989

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000730 mRNA. Translation: CAA04263.1.
CR456580 mRNA. Translation: CAG30466.1.
BC008814 mRNA. Translation: AAH08814.1.
BC062565 mRNA. Translation: AAH62565.1.
BC107160 mRNA. Translation: AAI07161.1.
BC107161 mRNA. Translation: AAI07162.1.
CCDSiCCDS33608.1.
RefSeqiNP_004164.2. NM_004173.2.
UniGeneiHs.197116.

Genome annotation databases

EnsembliENST00000382932; ENSP00000372390; ENSG00000099960.
ENST00000403586; ENSP00000384278; ENSG00000099960.
GeneIDi6545.
KEGGihsa:6545.
UCSCiuc002zud.3. human.

Polymorphism and mutation databases

BioMutaiSLC7A4.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000730 mRNA. Translation: CAA04263.1.
CR456580 mRNA. Translation: CAG30466.1.
BC008814 mRNA. Translation: AAH08814.1.
BC062565 mRNA. Translation: AAH62565.1.
BC107160 mRNA. Translation: AAI07161.1.
BC107161 mRNA. Translation: AAI07162.1.
CCDSiCCDS33608.1.
RefSeqiNP_004164.2. NM_004173.2.
UniGeneiHs.197116.

3D structure databases

ProteinModelPortaliO43246.
SMRiO43246. Positions 37-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-2999274.

Chemistry

DrugBankiDB00125. L-Arginine.
DB00123. L-Lysine.
DB00129. L-Ornithine.

Protein family/group databases

TCDBi2.A.3.3.6. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteiO43246.

Polymorphism and mutation databases

BioMutaiSLC7A4.

Proteomic databases

PaxDbiO43246.
PRIDEiO43246.

Protocols and materials databases

DNASUi6545.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382932; ENSP00000372390; ENSG00000099960.
ENST00000403586; ENSP00000384278; ENSG00000099960.
GeneIDi6545.
KEGGihsa:6545.
UCSCiuc002zud.3. human.

Organism-specific databases

CTDi6545.
GeneCardsiGC22M021383.
HGNCiHGNC:11062. SLC7A4.
HPAiHPA031023.
MIMi603752. gene.
neXtProtiNX_O43246.
PharmGKBiPA35922.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiO43246.
KOiK13866.
OMAiDHLQLVG.
OrthoDBiEOG72C501.
PhylomeDBiO43246.
TreeFamiTF315212.

Miscellaneous databases

GeneWikiiSLC7A4.
GenomeRNAii6545.
NextBioi25465.
PROiO43246.
SOURCEiSearch...

Gene expression databases

BgeeiO43246.
CleanExiHS_SLC7A4.
ExpressionAtlasiO43246. baseline and differential.
GenevestigatoriO43246.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome."
    Sperandeo M.P., Borsani G., Incerti B., Zollo M., Rossi E., Zuffardi O., Castaldo P., Taglialatela M., Andria G., Sebastio G.
    Genomics 49:230-236(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-28 AND THR-349.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-28 AND THR-349.
    Tissue: Brain and Placenta.

Entry informationi

Entry nameiCTR4_HUMAN
AccessioniPrimary (citable) accession number: O43246
Secondary accession number(s): Q0P5U2
, Q3KNQ6, Q4VC45, Q6IBY8, Q96H88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: March 15, 2005
Last modified: April 29, 2015
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.