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O43240

- KLK10_HUMAN

UniProt

O43240 - KLK10_HUMAN

Protein

Kallikrein-10

Gene

KLK10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Has a tumor-suppressor role for NES1 in breast and prostate cancer.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Charge relay systemBy similarity
    Active sitei137 – 1371Charge relay systemBy similarity
    Active sitei229 – 2291Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. serine-type peptidase activity Source: ProtInc

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Cell cycle

    Protein family/group databases

    MEROPSiS01.246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-10 (EC:3.4.21.-)
    Alternative name(s):
    Normal epithelial cell-specific 1
    Protease serine-like 1
    Gene namesi
    Name:KLK10
    Synonyms:NES1, PRSSL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6358. KLK10.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA30147.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 276246Kallikrein-10PRO_0000027953Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 263PROSITE-ProRule annotation
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi52 ↔ 162PROSITE-ProRule annotation
    Disulfide bondi71 ↔ 87PROSITE-ProRule annotation
    Disulfide bondi169 ↔ 235PROSITE-ProRule annotation
    Disulfide bondi201 ↔ 215PROSITE-ProRule annotation
    Disulfide bondi225 ↔ 250PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiO43240.
    PaxDbiO43240.
    PRIDEiO43240.

    Expressioni

    Tissue specificityi

    Expressed in breast, ovary and prostate.

    Developmental stagei

    Down-regulated during breast cancer progression.

    Gene expression databases

    ArrayExpressiO43240.
    BgeeiO43240.
    CleanExiHS_KLK10.
    HS_PRSSL1.
    GenevestigatoriO43240.

    Organism-specific databases

    HPAiCAB017133.
    HPA017195.

    Interactioni

    Protein-protein interaction databases

    BioGridi111636. 2 interactions.
    IntActiO43240. 2 interactions.
    MINTiMINT-1406798.
    STRINGi9606.ENSP00000311746.

    Structurei

    3D structure databases

    ProteinModelPortaliO43240.
    SMRiO43240. Positions 49-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 274228Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiO43240.
    KOiK09619.
    OMAiRVKYNKG.
    OrthoDBiEOG75B84T.
    PhylomeDBiO43240.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O43240-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGS    50
    PCARGSQPWQ VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH 100
    LLLLQGEQLR RTTRSVVHPK YHQGSGPILP RRTDEHDLML LKLARPVVLG 150
    PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR RVKYNKGLTC SSITILSPKE 200
    CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ GILSWGVYPC 250
    GSAQHPAVYT QICKYMSWIN KVIRSN 276
    Length:276
    Mass (Da):30,170
    Last modified:January 11, 2011 - v3
    Checksum:i4CFB32E0AF686E96
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501S → A.3 Publications
    Corresponds to variant rs3745535 [ dbSNP | Ensembl ].
    VAR_027979
    Natural varianti149 – 1491L → P.3 Publications
    Corresponds to variant rs2075690 [ dbSNP | Ensembl ].
    VAR_027980

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024605 mRNA. Translation: AAB81602.1.
    AF055481 Genomic DNA. Translation: AAC14266.1.
    AF243527 Genomic DNA. Translation: AAG33363.1.
    AY561635 mRNA. Translation: AAS66976.1.
    AC011473 Genomic DNA. Translation: AAG23256.1.
    BC002710 mRNA. Translation: AAH02710.1.
    CCDSiCCDS12817.1.
    RefSeqiNP_001070968.1. NM_001077500.1.
    NP_002767.2. NM_002776.4.
    NP_665895.1. NM_145888.2.
    XP_005259118.1. XM_005259061.1.
    XP_005259119.1. XM_005259062.1.
    XP_006723350.1. XM_006723287.1.
    XP_006723351.1. XM_006723288.1.
    XP_006723352.1. XM_006723289.1.
    UniGeneiHs.275464.

    Genome annotation databases

    EnsembliENST00000309958; ENSP00000311746; ENSG00000129451.
    ENST00000358789; ENSP00000351640; ENSG00000129451.
    ENST00000391805; ENSP00000375681; ENSG00000129451.
    GeneIDi5655.
    KEGGihsa:5655.
    UCSCiuc002puy.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024605 mRNA. Translation: AAB81602.1 .
    AF055481 Genomic DNA. Translation: AAC14266.1 .
    AF243527 Genomic DNA. Translation: AAG33363.1 .
    AY561635 mRNA. Translation: AAS66976.1 .
    AC011473 Genomic DNA. Translation: AAG23256.1 .
    BC002710 mRNA. Translation: AAH02710.1 .
    CCDSi CCDS12817.1.
    RefSeqi NP_001070968.1. NM_001077500.1.
    NP_002767.2. NM_002776.4.
    NP_665895.1. NM_145888.2.
    XP_005259118.1. XM_005259061.1.
    XP_005259119.1. XM_005259062.1.
    XP_006723350.1. XM_006723287.1.
    XP_006723351.1. XM_006723288.1.
    XP_006723352.1. XM_006723289.1.
    UniGenei Hs.275464.

    3D structure databases

    ProteinModelPortali O43240.
    SMRi O43240. Positions 49-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111636. 2 interactions.
    IntActi O43240. 2 interactions.
    MINTi MINT-1406798.
    STRINGi 9606.ENSP00000311746.

    Chemistry

    BindingDBi O43240.

    Protein family/group databases

    MEROPSi S01.246.

    Proteomic databases

    MaxQBi O43240.
    PaxDbi O43240.
    PRIDEi O43240.

    Protocols and materials databases

    DNASUi 5655.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309958 ; ENSP00000311746 ; ENSG00000129451 .
    ENST00000358789 ; ENSP00000351640 ; ENSG00000129451 .
    ENST00000391805 ; ENSP00000375681 ; ENSG00000129451 .
    GeneIDi 5655.
    KEGGi hsa:5655.
    UCSCi uc002puy.3. human.

    Organism-specific databases

    CTDi 5655.
    GeneCardsi GC19M051516.
    H-InvDB HIX0015374.
    HGNCi HGNC:6358. KLK10.
    HPAi CAB017133.
    HPA017195.
    MIMi 602673. gene.
    neXtProti NX_O43240.
    PharmGKBi PA30147.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi O43240.
    KOi K09619.
    OMAi RVKYNKG.
    OrthoDBi EOG75B84T.
    PhylomeDBi O43240.
    TreeFami TF331065.

    Miscellaneous databases

    ChiTaRSi KLK10. human.
    GeneWikii KLK10.
    GenomeRNAii 5655.
    NextBioi 21978.
    PROi O43240.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43240.
    Bgeei O43240.
    CleanExi HS_KLK10.
    HS_PRSSL1.
    Genevestigatori O43240.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression."
      Liu X.-L., Wazer D.E., Watanabe K., Band V.
      Cancer Res. 56:3371-3379(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-50 AND PRO-149.
      Tissue: Epithelium.
    2. "Structural characterization and mapping of the normal epithelial cell-specific 1 gene."
      Luo L.-Y., Herbrick J.A., Scherer S.W., Beatty B., Squire J., Diamandis E.P.
      Biochem. Biophys. Res. Commun. 247:580-586(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-50 AND PRO-149.
    3. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
      Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
      Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker."
      Yousef G.M., White N.M.A., Michael I.P., Cho J.C.-K., Robb J.D., Kurlender L., Khan S., Diamandis E.P.
      Tumor Biol. 26:227-235(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-50 AND PRO-149.
      Tissue: Uterus.
    7. "The role for NES1 serine protease as a novel tumor suppressor."
      Goyal J., Smith K.M., Cowan J.M., Wazer D.E., Lee S.W., Band V.
      Cancer Res. 58:4782-4786(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiKLK10_HUMAN
    AccessioniPrimary (citable) accession number: O43240
    Secondary accession number(s): A6NC12
    , Q53YL3, Q99920, Q9GZW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3