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Protein

Kallikrein-10

Gene

KLK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Charge relay systemBy similarity
Active sitei137 – 1371Charge relay systemBy similarity
Active sitei229 – 2291Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type peptidase activity Source: ProtInc

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Cell cycle

Protein family/group databases

MEROPSiS01.246.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-10 (EC:3.4.21.-)
Alternative name(s):
Normal epithelial cell-specific 1
Protease serine-like 1
Gene namesi
Name:KLK10
Synonyms:NES1, PRSSL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6358. KLK10.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA30147.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 276246Kallikrein-10PRO_0000027953Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 263PROSITE-ProRule annotation
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi52 ↔ 162PROSITE-ProRule annotation
Disulfide bondi71 ↔ 87PROSITE-ProRule annotation
Disulfide bondi169 ↔ 235PROSITE-ProRule annotation
Disulfide bondi201 ↔ 215PROSITE-ProRule annotation
Disulfide bondi225 ↔ 250PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO43240.
PaxDbiO43240.
PRIDEiO43240.

Expressioni

Tissue specificityi

Expressed in breast, ovary and prostate.

Developmental stagei

Down-regulated during breast cancer progression.

Gene expression databases

BgeeiO43240.
CleanExiHS_KLK10.
HS_PRSSL1.
ExpressionAtlasiO43240. baseline and differential.
GenevestigatoriO43240.

Organism-specific databases

HPAiCAB017133.
HPA017195.

Interactioni

Protein-protein interaction databases

BioGridi111636. 9 interactions.
IntActiO43240. 2 interactions.
MINTiMINT-1406798.
STRINGi9606.ENSP00000311746.

Structurei

3D structure databases

ProteinModelPortaliO43240.
SMRiO43240. Positions 49-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 274228Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO43240.
KOiK09619.
OMAiRVKYNKG.
OrthoDBiEOG75B84T.
PhylomeDBiO43240.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43240-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGS
60 70 80 90 100
PCARGSQPWQ VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH
110 120 130 140 150
LLLLQGEQLR RTTRSVVHPK YHQGSGPILP RRTDEHDLML LKLARPVVLG
160 170 180 190 200
PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR RVKYNKGLTC SSITILSPKE
210 220 230 240 250
CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ GILSWGVYPC
260 270
GSAQHPAVYT QICKYMSWIN KVIRSN
Length:276
Mass (Da):30,170
Last modified:January 11, 2011 - v3
Checksum:i4CFB32E0AF686E96
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501S → A.3 Publications
Corresponds to variant rs3745535 [ dbSNP | Ensembl ].
VAR_027979
Natural varianti149 – 1491L → P.3 Publications
Corresponds to variant rs2075690 [ dbSNP | Ensembl ].
VAR_027980

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024605 mRNA. Translation: AAB81602.1.
AF055481 Genomic DNA. Translation: AAC14266.1.
AF243527 Genomic DNA. Translation: AAG33363.1.
AY561635 mRNA. Translation: AAS66976.1.
AC011473 Genomic DNA. Translation: AAG23256.1.
BC002710 mRNA. Translation: AAH02710.1.
CCDSiCCDS12817.1.
RefSeqiNP_001070968.1. NM_001077500.1.
NP_002767.2. NM_002776.4.
NP_665895.1. NM_145888.2.
XP_005259118.1. XM_005259061.1.
XP_005259119.1. XM_005259062.1.
XP_006723350.1. XM_006723287.1.
XP_006723351.1. XM_006723288.1.
XP_006723352.1. XM_006723289.1.
UniGeneiHs.275464.

Genome annotation databases

EnsembliENST00000309958; ENSP00000311746; ENSG00000129451.
ENST00000358789; ENSP00000351640; ENSG00000129451.
ENST00000391805; ENSP00000375681; ENSG00000129451.
GeneIDi5655.
KEGGihsa:5655.
UCSCiuc002puy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024605 mRNA. Translation: AAB81602.1.
AF055481 Genomic DNA. Translation: AAC14266.1.
AF243527 Genomic DNA. Translation: AAG33363.1.
AY561635 mRNA. Translation: AAS66976.1.
AC011473 Genomic DNA. Translation: AAG23256.1.
BC002710 mRNA. Translation: AAH02710.1.
CCDSiCCDS12817.1.
RefSeqiNP_001070968.1. NM_001077500.1.
NP_002767.2. NM_002776.4.
NP_665895.1. NM_145888.2.
XP_005259118.1. XM_005259061.1.
XP_005259119.1. XM_005259062.1.
XP_006723350.1. XM_006723287.1.
XP_006723351.1. XM_006723288.1.
XP_006723352.1. XM_006723289.1.
UniGeneiHs.275464.

3D structure databases

ProteinModelPortaliO43240.
SMRiO43240. Positions 49-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111636. 9 interactions.
IntActiO43240. 2 interactions.
MINTiMINT-1406798.
STRINGi9606.ENSP00000311746.

Protein family/group databases

MEROPSiS01.246.

Proteomic databases

MaxQBiO43240.
PaxDbiO43240.
PRIDEiO43240.

Protocols and materials databases

DNASUi5655.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309958; ENSP00000311746; ENSG00000129451.
ENST00000358789; ENSP00000351640; ENSG00000129451.
ENST00000391805; ENSP00000375681; ENSG00000129451.
GeneIDi5655.
KEGGihsa:5655.
UCSCiuc002puy.3. human.

Organism-specific databases

CTDi5655.
GeneCardsiGC19M051516.
H-InvDBHIX0015374.
HGNCiHGNC:6358. KLK10.
HPAiCAB017133.
HPA017195.
MIMi602673. gene.
neXtProtiNX_O43240.
PharmGKBiPA30147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO43240.
KOiK09619.
OMAiRVKYNKG.
OrthoDBiEOG75B84T.
PhylomeDBiO43240.
TreeFamiTF331065.

Miscellaneous databases

ChiTaRSiKLK10. human.
GeneWikiiKLK10.
GenomeRNAii5655.
NextBioi21978.
PROiO43240.
SOURCEiSearch...

Gene expression databases

BgeeiO43240.
CleanExiHS_KLK10.
HS_PRSSL1.
ExpressionAtlasiO43240. baseline and differential.
GenevestigatoriO43240.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression."
    Liu X.-L., Wazer D.E., Watanabe K., Band V.
    Cancer Res. 56:3371-3379(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-50 AND PRO-149.
    Tissue: Epithelium.
  2. "Structural characterization and mapping of the normal epithelial cell-specific 1 gene."
    Luo L.-Y., Herbrick J.A., Scherer S.W., Beatty B., Squire J., Diamandis E.P.
    Biochem. Biophys. Res. Commun. 247:580-586(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-50 AND PRO-149.
  3. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
    Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
    Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker."
    Yousef G.M., White N.M.A., Michael I.P., Cho J.C.-K., Robb J.D., Kurlender L., Khan S., Diamandis E.P.
    Tumor Biol. 26:227-235(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-50 AND PRO-149.
    Tissue: Uterus.
  7. "The role for NES1 serine protease as a novel tumor suppressor."
    Goyal J., Smith K.M., Cowan J.M., Wazer D.E., Lee S.W., Band V.
    Cancer Res. 58:4782-4786(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiKLK10_HUMAN
AccessioniPrimary (citable) accession number: O43240
Secondary accession number(s): A6NC12
, Q53YL3, Q99920, Q9GZW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: January 7, 2015
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.