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Protein

Kallikrein-10

Gene

KLK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Charge relay systemBy similarity1
Active sitei137Charge relay systemBy similarity1
Active sitei229Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processCell cycle

Enzyme and pathway databases

BRENDAi3.4.21.B41. 2681.

Protein family/group databases

MEROPSiS01.246.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-10 (EC:3.4.21.-)
Alternative name(s):
Normal epithelial cell-specific 1
Protease serine-like 1
Gene namesi
Name:KLK10
Synonyms:NES1, PRSSL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000129451.11.
HGNCiHGNC:6358. KLK10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi5655.
OpenTargetsiENSG00000129451.
PharmGKBiPA30147.

Polymorphism and mutation databases

BioMutaiKLK10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000002795331 – 276Kallikrein-10Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi? ↔ 263PROSITE-ProRule annotation
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi52 ↔ 162PROSITE-ProRule annotation
Disulfide bondi71 ↔ 87PROSITE-ProRule annotation
Disulfide bondi169 ↔ 235PROSITE-ProRule annotation
Disulfide bondi201 ↔ 215PROSITE-ProRule annotation
Disulfide bondi225 ↔ 250PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO43240.
PaxDbiO43240.
PeptideAtlasiO43240.
PRIDEiO43240.

PTM databases

PhosphoSitePlusiO43240.

Expressioni

Tissue specificityi

Expressed in breast, ovary and prostate.

Developmental stagei

Down-regulated during breast cancer progression.

Gene expression databases

BgeeiENSG00000129451.
CleanExiHS_KLK10.
HS_PRSSL1.
ExpressionAtlasiO43240. baseline and differential.
GenevisibleiO43240. HS.

Organism-specific databases

HPAiHPA017195.

Interactioni

Protein-protein interaction databases

BioGridi111636. 17 interactors.
IntActiO43240. 2 interactors.
MINTiMINT-1406798.
STRINGi9606.ENSP00000311746.

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi60 – 65Combined sources6
Beta strandi68 – 77Combined sources10
Beta strandi80 – 83Combined sources4
Helixi85 – 87Combined sources3
Beta strandi93 – 96Combined sources4
Beta strandi107 – 117Combined sources11
Beta strandi139 – 145Combined sources7
Beta strandi151 – 153Combined sources3
Beta strandi168 – 173Combined sources6
Beta strandi189 – 195Combined sources7
Turni198 – 200Combined sources3
Helixi201 – 204Combined sources4
Beta strandi211 – 218Combined sources8
Helixi224 – 226Combined sources3
Beta strandi232 – 235Combined sources4
Beta strandi238 – 245Combined sources8
Beta strandi249 – 251Combined sources3
Beta strandi253 – 255Combined sources3
Beta strandi257 – 261Combined sources5
Helixi262 – 264Combined sources3
Helixi266 – 272Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LPEX-ray2.65A/B43-276[»]
5LPFX-ray2.70A/B43-276[»]
ProteinModelPortaliO43240.
SMRiO43240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 274Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO43240.
KOiK09619.
OMAiQLWAAEA.
OrthoDBiEOG091G0DF7.
PhylomeDBiO43240.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGS
60 70 80 90 100
PCARGSQPWQ VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH
110 120 130 140 150
LLLLQGEQLR RTTRSVVHPK YHQGSGPILP RRTDEHDLML LKLARPVVLG
160 170 180 190 200
PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR RVKYNKGLTC SSITILSPKE
210 220 230 240 250
CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ GILSWGVYPC
260 270
GSAQHPAVYT QICKYMSWIN KVIRSN
Length:276
Mass (Da):30,170
Last modified:January 11, 2011 - v3
Checksum:i4CFB32E0AF686E96
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02797950S → A3 PublicationsCorresponds to variant dbSNP:rs3745535Ensembl.1
Natural variantiVAR_027980149L → P3 PublicationsCorresponds to variant dbSNP:rs2075690Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024605 mRNA. Translation: AAB81602.1.
AF055481 Genomic DNA. Translation: AAC14266.1.
AF243527 Genomic DNA. Translation: AAG33363.1.
AY561635 mRNA. Translation: AAS66976.1.
AC011473 Genomic DNA. Translation: AAG23256.1.
BC002710 mRNA. Translation: AAH02710.1.
CCDSiCCDS12817.1.
RefSeqiNP_001070968.1. NM_001077500.1.
NP_002767.2. NM_002776.4.
NP_665895.1. NM_145888.2.
XP_005259118.1. XM_005259061.3.
XP_005259119.1. XM_005259062.3.
XP_006723350.1. XM_006723287.3.
XP_006723352.1. XM_006723289.3.
XP_016882482.1. XM_017026993.1.
UniGeneiHs.275464.

Genome annotation databases

EnsembliENST00000309958; ENSP00000311746; ENSG00000129451.
ENST00000358789; ENSP00000351640; ENSG00000129451.
ENST00000391805; ENSP00000375681; ENSG00000129451.
GeneIDi5655.
KEGGihsa:5655.
UCSCiuc002puy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLK10_HUMAN
AccessioniPrimary (citable) accession number: O43240
Secondary accession number(s): A6NC12
, Q53YL3, Q99920, Q9GZW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: September 27, 2017
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families