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Protein

Kallikrein-10

Gene

KLK10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Charge relay systemBy similarity1
Active sitei137Charge relay systemBy similarity1
Active sitei229Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129451-MONOMER.
BRENDAi3.4.21.B41. 2681.

Protein family/group databases

MEROPSiS01.246.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-10 (EC:3.4.21.-)
Alternative name(s):
Normal epithelial cell-specific 1
Protease serine-like 1
Gene namesi
Name:KLK10
Synonyms:NES1, PRSSL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6358. KLK10.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi5655.
OpenTargetsiENSG00000129451.
PharmGKBiPA30147.

Polymorphism and mutation databases

BioMutaiKLK10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000002795331 – 276Kallikrein-10Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi? ↔ 263PROSITE-ProRule annotation
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi52 ↔ 162PROSITE-ProRule annotation
Disulfide bondi71 ↔ 87PROSITE-ProRule annotation
Disulfide bondi169 ↔ 235PROSITE-ProRule annotation
Disulfide bondi201 ↔ 215PROSITE-ProRule annotation
Disulfide bondi225 ↔ 250PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO43240.
PaxDbiO43240.
PeptideAtlasiO43240.
PRIDEiO43240.

PTM databases

PhosphoSitePlusiO43240.

Expressioni

Tissue specificityi

Expressed in breast, ovary and prostate.

Developmental stagei

Down-regulated during breast cancer progression.

Gene expression databases

BgeeiENSG00000129451.
CleanExiHS_KLK10.
HS_PRSSL1.
ExpressionAtlasiO43240. baseline and differential.
GenevisibleiO43240. HS.

Organism-specific databases

HPAiCAB017133.
HPA017195.

Interactioni

Protein-protein interaction databases

BioGridi111636. 16 interactors.
IntActiO43240. 2 interactors.
MINTiMINT-1406798.
STRINGi9606.ENSP00000311746.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LPEX-ray2.65A/B43-276[»]
5LPFX-ray2.70A/B43-276[»]
ProteinModelPortaliO43240.
SMRiO43240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 274Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO43240.
KOiK09619.
OMAiQLWAAEA.
OrthoDBiEOG091G0DF7.
PhylomeDBiO43240.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGS
60 70 80 90 100
PCARGSQPWQ VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH
110 120 130 140 150
LLLLQGEQLR RTTRSVVHPK YHQGSGPILP RRTDEHDLML LKLARPVVLG
160 170 180 190 200
PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR RVKYNKGLTC SSITILSPKE
210 220 230 240 250
CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ GILSWGVYPC
260 270
GSAQHPAVYT QICKYMSWIN KVIRSN
Length:276
Mass (Da):30,170
Last modified:January 11, 2011 - v3
Checksum:i4CFB32E0AF686E96
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02797950S → A.3 PublicationsCorresponds to variant rs3745535dbSNPEnsembl.1
Natural variantiVAR_027980149L → P.3 PublicationsCorresponds to variant rs2075690dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024605 mRNA. Translation: AAB81602.1.
AF055481 Genomic DNA. Translation: AAC14266.1.
AF243527 Genomic DNA. Translation: AAG33363.1.
AY561635 mRNA. Translation: AAS66976.1.
AC011473 Genomic DNA. Translation: AAG23256.1.
BC002710 mRNA. Translation: AAH02710.1.
CCDSiCCDS12817.1.
RefSeqiNP_001070968.1. NM_001077500.1.
NP_002767.2. NM_002776.4.
NP_665895.1. NM_145888.2.
XP_005259118.1. XM_005259061.3.
XP_005259119.1. XM_005259062.3.
XP_006723350.1. XM_006723287.3.
XP_006723352.1. XM_006723289.3.
XP_016882482.1. XM_017026993.1.
UniGeneiHs.275464.

Genome annotation databases

EnsembliENST00000309958; ENSP00000311746; ENSG00000129451.
ENST00000358789; ENSP00000351640; ENSG00000129451.
ENST00000391805; ENSP00000375681; ENSG00000129451.
GeneIDi5655.
KEGGihsa:5655.
UCSCiuc002puy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF024605 mRNA. Translation: AAB81602.1.
AF055481 Genomic DNA. Translation: AAC14266.1.
AF243527 Genomic DNA. Translation: AAG33363.1.
AY561635 mRNA. Translation: AAS66976.1.
AC011473 Genomic DNA. Translation: AAG23256.1.
BC002710 mRNA. Translation: AAH02710.1.
CCDSiCCDS12817.1.
RefSeqiNP_001070968.1. NM_001077500.1.
NP_002767.2. NM_002776.4.
NP_665895.1. NM_145888.2.
XP_005259118.1. XM_005259061.3.
XP_005259119.1. XM_005259062.3.
XP_006723350.1. XM_006723287.3.
XP_006723352.1. XM_006723289.3.
XP_016882482.1. XM_017026993.1.
UniGeneiHs.275464.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LPEX-ray2.65A/B43-276[»]
5LPFX-ray2.70A/B43-276[»]
ProteinModelPortaliO43240.
SMRiO43240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111636. 16 interactors.
IntActiO43240. 2 interactors.
MINTiMINT-1406798.
STRINGi9606.ENSP00000311746.

Protein family/group databases

MEROPSiS01.246.

PTM databases

PhosphoSitePlusiO43240.

Polymorphism and mutation databases

BioMutaiKLK10.

Proteomic databases

MaxQBiO43240.
PaxDbiO43240.
PeptideAtlasiO43240.
PRIDEiO43240.

Protocols and materials databases

DNASUi5655.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309958; ENSP00000311746; ENSG00000129451.
ENST00000358789; ENSP00000351640; ENSG00000129451.
ENST00000391805; ENSP00000375681; ENSG00000129451.
GeneIDi5655.
KEGGihsa:5655.
UCSCiuc002puy.4. human.

Organism-specific databases

CTDi5655.
DisGeNETi5655.
GeneCardsiKLK10.
H-InvDBHIX0015374.
HGNCiHGNC:6358. KLK10.
HPAiCAB017133.
HPA017195.
MIMi602673. gene.
neXtProtiNX_O43240.
OpenTargetsiENSG00000129451.
PharmGKBiPA30147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO43240.
KOiK09619.
OMAiQLWAAEA.
OrthoDBiEOG091G0DF7.
PhylomeDBiO43240.
TreeFamiTF331065.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129451-MONOMER.
BRENDAi3.4.21.B41. 2681.

Miscellaneous databases

ChiTaRSiKLK10. human.
GeneWikiiKLK10.
GenomeRNAii5655.
PROiO43240.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129451.
CleanExiHS_KLK10.
HS_PRSSL1.
ExpressionAtlasiO43240. baseline and differential.
GenevisibleiO43240. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLK10_HUMAN
AccessioniPrimary (citable) accession number: O43240
Secondary accession number(s): A6NC12
, Q53YL3, Q99920, Q9GZW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.