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O43240 (KLK10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kallikrein-10

EC=3.4.21.-
Alternative name(s):
Normal epithelial cell-specific 1
Protease serine-like 1
Gene names
Name:KLK10
Synonyms:NES1, PRSSL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a tumor-suppressor role for NES1 in breast and prostate cancer.

Subcellular location

Secreted Probable.

Tissue specificity

Expressed in breast, ovary and prostate.

Developmental stage

Down-regulated during breast cancer progression.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DiseaseTumor suppressor
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type peptidase activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 276246Kallikrein-10
PRO_0000027953

Regions

Domain47 – 274228Peptidase S1

Sites

Active site861Charge relay system By similarity
Active site1371Charge relay system By similarity
Active site2291Charge relay system By similarity

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Disulfide bond52 ↔ 162 By similarity
Disulfide bond71 ↔ 87 By similarity
Disulfide bond169 ↔ 235 By similarity
Disulfide bond201 ↔ 215 By similarity
Disulfide bond225 ↔ 250 By similarity
Disulfide bond? ↔ 263 By similarity

Natural variations

Natural variant501S → A. Ref.1 Ref.2 Ref.6
Corresponds to variant rs3745535 [ dbSNP | Ensembl ].
VAR_027979
Natural variant1491L → P. Ref.1 Ref.2 Ref.6
Corresponds to variant rs2075690 [ dbSNP | Ensembl ].
VAR_027980

Sequences

Sequence LengthMass (Da)Tools
O43240 [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: 4CFB32E0AF686E96

FASTA27630,170
        10         20         30         40         50         60 
MRAPHLHLSA ASGARALAKL LPLLMAQLWA AEAALLPQND TRLDPEAYGS PCARGSQPWQ 

        70         80         90        100        110        120 
VSLFNGLSFH CAGVLVDQSW VLTAAHCGNK PLWARVGDDH LLLLQGEQLR RTTRSVVHPK 

       130        140        150        160        170        180 
YHQGSGPILP RRTDEHDLML LKLARPVVLG PRVRALQLPY RCAQPGDQCQ VAGWGTTAAR 

       190        200        210        220        230        240 
RVKYNKGLTC SSITILSPKE CEVFYPGVVT NNMICAGLDR GQDPCQSDSG GPLVCDETLQ 

       250        260        270 
GILSWGVYPC GSAQHPAVYT QICKYMSWIN KVIRSN 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression."
Liu X.-L., Wazer D.E., Watanabe K., Band V.
Cancer Res. 56:3371-3379(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-50 AND PRO-149.
Tissue: Epithelium.
[2]"Structural characterization and mapping of the normal epithelial cell-specific 1 gene."
Luo L.-Y., Herbrick J.A., Scherer S.W., Beatty B., Squire J., Diamandis E.P.
Biochem. Biophys. Res. Commun. 247:580-586(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-50 AND PRO-149.
[3]"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker."
Yousef G.M., White N.M.A., Michael I.P., Cho J.C.-K., Robb J.D., Kurlender L., Khan S., Diamandis E.P.
Tumor Biol. 26:227-235(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-50 AND PRO-149.
Tissue: Uterus.
[7]"The role for NES1 serine protease as a novel tumor suppressor."
Goyal J., Smith K.M., Cowan J.M., Wazer D.E., Lee S.W., Band V.
Cancer Res. 58:4782-4786(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF024605 mRNA. Translation: AAB81602.1.
AF055481 Genomic DNA. Translation: AAC14266.1.
AF243527 Genomic DNA. Translation: AAG33363.1.
AY561635 mRNA. Translation: AAS66976.1.
AC011473 Genomic DNA. Translation: AAG23256.1.
BC002710 mRNA. Translation: AAH02710.1.
CCDSCCDS12817.1.
RefSeqNP_001070968.1. NM_001077500.1.
NP_002767.2. NM_002776.4.
NP_665895.1. NM_145888.2.
XP_005259118.1. XM_005259061.1.
XP_005259119.1. XM_005259062.1.
XP_006723350.1. XM_006723287.1.
XP_006723351.1. XM_006723288.1.
XP_006723352.1. XM_006723289.1.
UniGeneHs.275464.

3D structure databases

ProteinModelPortalO43240.
SMRO43240. Positions 49-276.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111636. 2 interactions.
IntActO43240. 2 interactions.
MINTMINT-1406798.
STRING9606.ENSP00000311746.

Chemistry

BindingDBO43240.

Protein family/group databases

MEROPSS01.246.

Proteomic databases

MaxQBO43240.
PaxDbO43240.
PRIDEO43240.

Protocols and materials databases

DNASU5655.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309958; ENSP00000311746; ENSG00000129451.
ENST00000358789; ENSP00000351640; ENSG00000129451.
ENST00000391805; ENSP00000375681; ENSG00000129451.
GeneID5655.
KEGGhsa:5655.
UCSCuc002puy.3. human.

Organism-specific databases

CTD5655.
GeneCardsGC19M051516.
H-InvDBHIX0015374.
HGNCHGNC:6358. KLK10.
HPACAB017133.
HPA017195.
MIM602673. gene.
neXtProtNX_O43240.
PharmGKBPA30147.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidO43240.
KOK09619.
OMARVKYNKG.
OrthoDBEOG75B84T.
PhylomeDBO43240.
TreeFamTF331065.

Gene expression databases

ArrayExpressO43240.
BgeeO43240.
CleanExHS_KLK10.
HS_PRSSL1.
GenevestigatorO43240.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLK10. human.
GeneWikiKLK10.
GenomeRNAi5655.
NextBio21978.
PROO43240.
SOURCESearch...

Entry information

Entry nameKLK10_HUMAN
AccessionPrimary (citable) accession number: O43240
Secondary accession number(s): A6NC12 expand/collapse secondary AC list , Q53YL3, Q99920, Q9GZW9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM