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Protein

Cytoplasmic dynein 1 light intermediate chain 2

Gene

DYNC1LI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi61 – 68ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 light intermediate chain 2
Alternative name(s):
Dynein light intermediate chain 2, cytosolic
Short name:
LIC-2
LIC53/55
Gene namesi
Name:DYNC1LI2
Synonyms:DNCLI2, LIC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000135720.12
HGNCiHGNC:2966 DYNC1LI2
MIMi611406 gene
neXtProtiNX_O43237

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi1783
OpenTargetsiENSG00000135720
PharmGKBiPA27438

Polymorphism and mutation databases

BioMutaiDYNC1LI2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146701 – 492Cytoplasmic dynein 1 light intermediate chain 2Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei397Omega-N-methylarginineCombined sources1
Modified residuei441PhosphothreonineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO43237
MaxQBiO43237
PaxDbiO43237
PeptideAtlasiO43237
PRIDEiO43237

PTM databases

iPTMnetiO43237
PhosphoSitePlusiO43237

Expressioni

Gene expression databases

BgeeiENSG00000135720
CleanExiHS_DYNC1LI2
ExpressionAtlasiO43237 baseline and differential
GenevisibleiO43237 HS

Organism-specific databases

HPAiHPA057201

Interactioni

Subunit structurei

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108120, 43 interactors
IntActiO43237, 21 interactors
MINTiO43237
STRINGi9606.ENSP00000258198

Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi39 – 45Combined sources7
Beta strandi55 – 60Combined sources6
Helixi67 – 74Combined sources8
Beta strandi83 – 85Combined sources3
Beta strandi89 – 93Combined sources5
Beta strandi96 – 98Combined sources3
Beta strandi102 – 106Combined sources5
Helixi116 – 120Combined sources5
Turni125 – 127Combined sources3
Beta strandi128 – 135Combined sources8
Beta strandi139 – 141Combined sources3
Helixi142 – 163Combined sources22
Beta strandi164 – 166Combined sources3
Helixi169 – 181Combined sources13
Beta strandi184 – 186Combined sources3
Beta strandi225 – 230Combined sources6
Helixi237 – 243Combined sources7
Helixi248 – 265Combined sources18
Helixi280 – 288Combined sources9
Beta strandi303 – 307Combined sources5
Helixi319 – 323Combined sources5
Beta strandi326 – 328Combined sources3
Helixi336 – 339Combined sources4
Helixi362 – 370Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6F1Telectron microscopy3.50i/j/q/r1-492[»]
6F1Yelectron microscopy3.40j37-373[»]
6F38electron microscopy6.70i/j/q/r1-492[»]
6F3Aelectron microscopy8.20j1-492[»]
ProteinModelPortaliO43237
SMRiO43237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3905 Eukaryota
ENOG410XQS4 LUCA
GeneTreeiENSGT00390000008295
HOGENOMiHOG000236263
HOVERGENiHBG005546
InParanoidiO43237
KOiK10416
OMAiFQDYIEP
OrthoDBiEOG091G0B3J
PhylomeDBiO43237
TreeFamiTF352602

Family and domain databases

InterProiView protein in InterPro
IPR008467 Dynein1_light_intermed_chain
IPR022780 Dynein_light_int_chain
IPR027417 P-loop_NTPase
PANTHERiPTHR12688 PTHR12688, 1 hit
PfamiView protein in Pfam
PF05783 DLIC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43237-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK
60 70 80 90 100
LPSGKNILVF GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD
110 120 130 140 150
HTRCNVWILD GDLYHKGLLK FAVSAESLPE TLVIFVADMS RPWTVMESLQ
160 170 180 190 200
KWASVLREHI DKMKIPPEKM RELERKFVKD FQDYMEPEEG CQGSPQRRGP
210 220 230 240 250
LTSGSDEENV ALPLGDNVLT HNLGIPVLVV CTKCDAVSVL EKEHDYRDEH
260 270 280 290 300
LDFIQSHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTTPA
310 320 330 340 350
LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH
360 370 380 390 400
DKELAAEDEQ VFLMKQQSLL AKQPATPTRA SESPARGPSG SPRTQGRGGP
410 420 430 440 450
ASVPSSSPGT SVKKPDPNIK NNAASEGVLA SFFNSLLSKK TGSPGSPGAG
460 470 480 490
GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD SMVTNSSTEN EA
Length:492
Mass (Da):54,099
Last modified:June 1, 1998 - v1
Checksum:iAF7B4E49E3983DCC
GO
Isoform 2 (identifier: O43237-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-177: DHTRCNVWIL...EKMRELERKF → V

Note: No experimental confirmation available.
Show »
Length:415
Mass (Da):45,005
Checksum:i758F32BAD4482709
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti458K → N in AAH25959 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054663100 – 177DHTRC…LERKF → V in isoform 2. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035812 mRNA Translation: AAB88513.1
AK291766 mRNA Translation: BAF84455.1
AK303031 mRNA Translation: BAG64156.1
AC018557 Genomic DNA No translation available.
AC044802 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83039.1
BC025959 mRNA Translation: AAH25959.1
CCDSiCCDS10818.1 [O43237-1]
CCDS67049.1 [O43237-2]
RefSeqiNP_001273086.1, NM_001286157.1 [O43237-2]
NP_006132.1, NM_006141.2 [O43237-1]
UniGeneiHs.369068

Genome annotation databases

EnsembliENST00000258198; ENSP00000258198; ENSG00000135720 [O43237-1]
ENST00000443351; ENSP00000394289; ENSG00000135720 [O43237-2]
GeneIDi1783
KEGGihsa:1783
UCSCiuc002eqb.2 human [O43237-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDC1L2_HUMAN
AccessioniPrimary (citable) accession number: O43237
Secondary accession number(s): A8K6V1, B4DZP4, Q8TAT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health