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O43237

- DC1L2_HUMAN

UniProt

O43237 - DC1L2_HUMAN

Protein

Cytoplasmic dynein 1 light intermediate chain 2

Gene

DYNC1LI2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 688ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. centrosome localization Source: Ensembl
    3. microtubule-based movement Source: InterPro
    4. microtubule cytoskeleton organization Source: Ensembl
    5. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytoplasmic dynein 1 light intermediate chain 2
    Alternative name(s):
    Dynein light intermediate chain 2, cytosolic
    Short name:
    LIC-2
    LIC53/55
    Gene namesi
    Name:DYNC1LI2
    Synonyms:DNCLI2, LIC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:2966. DYNC1LI2.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasmic dynein complex Source: ProtInc
    3. cytosol Source: Reactome
    4. membrane Source: UniProtKB
    5. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Dynein, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27438.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Cytoplasmic dynein 1 light intermediate chain 2PRO_0000114670Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei194 – 1941Phosphoserine5 Publications
    Modified residuei383 – 3831Phosphoserine1 Publication
    Modified residuei391 – 3911Phosphoserine1 Publication
    Modified residuei441 – 4411Phosphothreonine1 Publication
    Modified residuei443 – 4431Phosphoserine2 Publications
    Modified residuei446 – 4461Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO43237.
    PaxDbiO43237.
    PeptideAtlasiO43237.
    PRIDEiO43237.

    PTM databases

    PhosphoSiteiO43237.

    Expressioni

    Gene expression databases

    ArrayExpressiO43237.
    BgeeiO43237.
    CleanExiHS_DYNC1LI2.
    GenevestigatoriO43237.

    Interactioni

    Subunit structurei

    Homodimer By similarity. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi108120. 26 interactions.
    IntActiO43237. 9 interactions.
    MINTiMINT-2999261.
    STRINGi9606.ENSP00000258198.

    Structurei

    3D structure databases

    ProteinModelPortaliO43237.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG265404.
    HOGENOMiHOG000236263.
    HOVERGENiHBG005546.
    InParanoidiO43237.
    KOiK10416.
    OMAiNIHDEDR.
    OrthoDBiEOG7V7668.
    PhylomeDBiO43237.
    TreeFamiTF352602.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR008467. Dynein1_light_intermed_chain.
    IPR022780. Dynein_light_int_chain.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR12688. PTHR12688. 1 hit.
    PfamiPF05783. DLIC. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43237-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK    50
    LPSGKNILVF GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD 100
    HTRCNVWILD GDLYHKGLLK FAVSAESLPE TLVIFVADMS RPWTVMESLQ 150
    KWASVLREHI DKMKIPPEKM RELERKFVKD FQDYMEPEEG CQGSPQRRGP 200
    LTSGSDEENV ALPLGDNVLT HNLGIPVLVV CTKCDAVSVL EKEHDYRDEH 250
    LDFIQSHLRR FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTTPA 300
    LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH 350
    DKELAAEDEQ VFLMKQQSLL AKQPATPTRA SESPARGPSG SPRTQGRGGP 400
    ASVPSSSPGT SVKKPDPNIK NNAASEGVLA SFFNSLLSKK TGSPGSPGAG 450
    GVQSTAKKSG QKTVLSNVQE ELDRMTRKPD SMVTNSSTEN EA 492
    Length:492
    Mass (Da):54,099
    Last modified:June 1, 1998 - v1
    Checksum:iAF7B4E49E3983DCC
    GO
    Isoform 2 (identifier: O43237-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         100-177: DHTRCNVWIL...EKMRELERKF → V

    Note: No experimental confirmation available.

    Show »
    Length:415
    Mass (Da):45,005
    Checksum:i758F32BAD4482709
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti458 – 4581K → N in AAH25959. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei100 – 17778DHTRC…LERKF → V in isoform 2. 1 PublicationVSP_054663Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035812 mRNA. Translation: AAB88513.1.
    AK291766 mRNA. Translation: BAF84455.1.
    AK303031 mRNA. Translation: BAG64156.1.
    AC018557 Genomic DNA. No translation available.
    AC044802 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW83039.1.
    BC025959 mRNA. Translation: AAH25959.1.
    CCDSiCCDS10818.1. [O43237-1]
    CCDS67049.1. [O43237-2]
    RefSeqiNP_001273086.1. NM_001286157.1. [O43237-2]
    NP_006132.1. NM_006141.2. [O43237-1]
    UniGeneiHs.369068.

    Genome annotation databases

    EnsembliENST00000258198; ENSP00000258198; ENSG00000135720. [O43237-1]
    ENST00000443351; ENSP00000394289; ENSG00000135720. [O43237-2]
    GeneIDi1783.
    KEGGihsa:1783.
    UCSCiuc002eqb.1. human. [O43237-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035812 mRNA. Translation: AAB88513.1 .
    AK291766 mRNA. Translation: BAF84455.1 .
    AK303031 mRNA. Translation: BAG64156.1 .
    AC018557 Genomic DNA. No translation available.
    AC044802 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW83039.1 .
    BC025959 mRNA. Translation: AAH25959.1 .
    CCDSi CCDS10818.1. [O43237-1 ]
    CCDS67049.1. [O43237-2 ]
    RefSeqi NP_001273086.1. NM_001286157.1. [O43237-2 ]
    NP_006132.1. NM_006141.2. [O43237-1 ]
    UniGenei Hs.369068.

    3D structure databases

    ProteinModelPortali O43237.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108120. 26 interactions.
    IntActi O43237. 9 interactions.
    MINTi MINT-2999261.
    STRINGi 9606.ENSP00000258198.

    PTM databases

    PhosphoSitei O43237.

    Proteomic databases

    MaxQBi O43237.
    PaxDbi O43237.
    PeptideAtlasi O43237.
    PRIDEi O43237.

    Protocols and materials databases

    DNASUi 1783.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258198 ; ENSP00000258198 ; ENSG00000135720 . [O43237-1 ]
    ENST00000443351 ; ENSP00000394289 ; ENSG00000135720 . [O43237-2 ]
    GeneIDi 1783.
    KEGGi hsa:1783.
    UCSCi uc002eqb.1. human. [O43237-1 ]

    Organism-specific databases

    CTDi 1783.
    GeneCardsi GC16M066754.
    HGNCi HGNC:2966. DYNC1LI2.
    MIMi 611406. gene.
    neXtProti NX_O43237.
    PharmGKBi PA27438.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265404.
    HOGENOMi HOG000236263.
    HOVERGENi HBG005546.
    InParanoidi O43237.
    KOi K10416.
    OMAi NIHDEDR.
    OrthoDBi EOG7V7668.
    PhylomeDBi O43237.
    TreeFami TF352602.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.

    Miscellaneous databases

    ChiTaRSi DYNC1LI2. human.
    GeneWikii DYNC1LI2.
    GenomeRNAii 1783.
    NextBioi 35476533.
    PROi O43237.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43237.
    Bgeei O43237.
    CleanExi HS_DYNC1LI2.
    Genevestigatori O43237.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR008467. Dynein1_light_intermed_chain.
    IPR022780. Dynein_light_int_chain.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR12688. PTHR12688. 1 hit.
    Pfami PF05783. DLIC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Zha D., Hu G.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta and Testis.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194 AND SER-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194; SER-383; SER-443 AND SER-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194; SER-391; THR-441; SER-443 AND SER-446, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDC1L2_HUMAN
    AccessioniPrimary (citable) accession number: O43237
    Secondary accession number(s): A8K6V1, B4DZP4, Q8TAT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3