Reviewed, UniProtKB/Swiss-Prot O43236 (SEPT4_HUMAN)

Names and origin

Protein names

Recommended name:
    Septin-4
Alternative name(s):
    Peanut-like protein 2
    Brain protein H5
    Cell division control-related protein 2
      Short name=hCDCREL-2
    Bradeion beta
    CE5B3 beta
    Cerebral protein 7

Gene names

Name:	SEPT4
Synonyms:	PNUTL2, SEP4
ORF Names:	hucep-7

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential. May play a role in platelet secretion. Isoform 6, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. Ref.1 Ref.3 Ref.11 Ref.13 Ref.16
Subunit structure	Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity. Interacts with SEPT8. In a mesenchymal cell line, interacts with SEPT9 isoform 2 variants HNA Trp-106 and Phe-111, but not the wild type SEPT9. Isoform 6, but no other isoforms, interacts with XIAP after the induction of apoptosis. Ref.11 Ref.16 Ref.15
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Note: In platelets, found in areas surrounding alpha-granules. Ref.3 Ref.11 Ref.16 Isoform 6: Mitochondrion. Nucleus. Note: While predominantly localized in the mitochondria under resting conditions, isoform 6 translocates into the nucleus after TGF-beta treatment and apoptosis induction. Ref.3 Ref.11 Ref.16
Tissue specificity	Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets. Ref.1 Ref.3 Ref.11 Ref.2 Ref.4 Ref.14
Sequence similarities	Belongs to the septin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm Cytoskeleton Mitochondrion Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	apoptosis Ref.3 Non-traceable author statement. Source: UniProtKB cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Ref.1 Traceable author statement. Source: ProtInc regulation of apoptosis Ref.3 Non-traceable author statement. Source: UniProtKB
Cellular component	cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Ref.3 Non-traceable author statement. Source: UniProtKB nucleus Ref.3 Non-traceable author statement. Source: UniProtKB
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Ref.1 Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: UniProtKB structural molecule activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43236-1)

Also known as: PNUTL2a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43236-2)

Also known as: PNUTL2b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDRSLGWQGNSVPEDRTEAG → M

Isoform 3 (identifier: O43236-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDRSLGWQGNSVPEDRTEAG → MPGFYSVMTDEE

Note: No experimental confirmation available.

Isoform 4 (identifier: O43236-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDRSLGWQGNSVPEDRTEAG → MRSSPALFSSRAAPQKPRKEGSQAAGLLVFSDSLE

Note: No experimental confirmation available.

Isoform 5 (identifier: O43236-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-147: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: O43236-6)

Also known as: Apoptosis-related protein in the TGF-beta signaling pathway; ARTS;

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDRSLGWQGNSVPEDRTEAG → M
     267-293: LRPLDVEFMKALHQRVNIVPILAKADT → YGPSLRLLAPPGAVKGTGQEHQGQGCH
     294-478: Missing.

Note: While predominantly localized in the mitochondria under resting conditions, isoform 6 translocates into the nucleus after TGF-beta treatment and apoptosis induction. Ref.3 Ref.11 Ref.16 May be defective in GTP-binding.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Septin-4		PRO_0000173519
Regions
	Nucleotide binding	151 – 158	8	GTP By similarity
	Nucleotide binding	292 – 298	7	GTP By similarity
	Coiled coil	447 – 478	32	Potential
Sites
	Binding site	348	1	GTP; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	365	1	GTP By similarity
Amino acid modifications
	Modified residue	325	1	Phosphoserine Ref.17
Natural variations
	Alternative sequence	1 – 147	147	Missing in isoform 5.		VSP_038302
	Alternative sequence	1 – 20	20	MDRSL…RTEAG → M in isoform 2 and isoform 6.		VSP_006050
	Alternative sequence	1 – 20	20	MDRSL…RTEAG → MPGFYSVMTDEE in isoform 3.		VSP_038303
	Alternative sequence	1 – 20	20	MDRSL…RTEAG → MRSSPALFSSRAAPQKPRKE GSQAAGLLVFSDSLE in isoform 4.		VSP_038304
	Alternative sequence	267 – 293	27	LRPLD…AKADT → YGPSLRLLAPPGAVKGTGQE HQGQGCH in isoform 6.		VSP_038305
	Alternative sequence	294 – 478	185	Missing in isoform 6.		VSP_038306
	Natural variant	311	1	E → V: dbSNP rs17741424.		VAR_051935
Experimental info
	Mutagenesis	156 – 158	3	GKS → ENP: Loss of TGF-beta-induced apoptosis. No translocation to the nucleus following TGF-beta treatment. Loss of XIAP-binding. Ref.3
	Sequence conflict	156	1	G → D in BAG37789. Ref.7
	Sequence conflict	382	1	K → E in BAG63517. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PNUTL2a) [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 2F08D3611EF6523D	FASTA	478	55,098
	10 20 30 40 50 60 MDRSLGWQGN SVPEDRTEAG IKRFLEDTTD DGELSKFVKD FSGNASCHPP EAKTWASRPQ 70 80 90 100 110 120 VPEPRPQAPD LYDDDLEFRP PSRPQSSDNQ QYFCAPAPLS PSARPRSPWG KLDPYDSSED 130 140 150 160 170 180 DKEYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL VNSLFLTDLY RDRKLLGAEE 190 200 210 220 230 240 RIMQTVEITK HAVDIEEKGV RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE 250 260 270 280 290 300 SGLNRKNIQD NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD 310 320 330 340 350 360 HKKRKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN TVVEARGRRV 370 380 390 400 410 420 RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR ETHYENYRAQ CIQSMTRLVV 430 440 450 460 470 KERNRNKLTR ESGTDFPIPA VPPGTDPETE KLIREKDEEL RRMQEMLHKI QKQMKENY
	Isoform 2 (PNUTL2b). Checksum: C0779A770DC7415A	FASTA	459	53,042
	10 20 30 40 50 60 MIKRFLEDTT DDGELSKFVK DFSGNASCHP PEAKTWASRP QVPEPRPQAP DLYDDDLEFR 70 80 90 100 110 120 PPSRPQSSDN QQYFCAPAPL SPSARPRSPW GKLDPYDSSE DDKEYVGFAT LPNQVHRKSV 130 140 150 160 170 180 KKGFDFTLMV AGESGLGKST LVNSLFLTDL YRDRKLLGAE ERIMQTVEIT KHAVDIEEKG 190 200 210 220 230 240 VRLRLTIVDT PGFGDAVNNT ECWKPVAEYI DQQFEQYFRD ESGLNRKNIQ DNRVHCCLYF 250 260 270 280 290 300 ISPFGHGLRP LDVEFMKALH QRVNIVPILA KADTLTPPEV DHKKRKIREE IEHFGIKIYQ 310 320 330 340 350 360 FPDCDSDEDE DFKLQDQALK ESIPFAVIGS NTVVEARGRR VRGRLYPWGI VEVENPGHCD 370 380 390 400 410 420 FVKLRTMLVR THMQDLKDVT RETHYENYRA QCIQSMTRLV VKERNRNKLT RESGTDFPIP 430 440 450 AVPPGTDPET EKLIREKDEE LRRMQEMLHK IQKQMKENY
	Isoform 3. Checksum: BDBB6EB9570D9913	FASTA	470	54,298
	10 20 30 40 50 60 MPGFYSVMTD EEIKRFLEDT TDDGELSKFV KDFSGNASCH PPEAKTWASR PQVPEPRPQA 70 80 90 100 110 120 PDLYDDDLEF RPPSRPQSSD NQQYFCAPAP LSPSARPRSP WGKLDPYDSS EDDKEYVGFA 130 140 150 160 170 180 TLPNQVHRKS VKKGFDFTLM VAGESGLGKS TLVNSLFLTD LYRDRKLLGA EERIMQTVEI 190 200 210 220 230 240 TKHAVDIEEK GVRLRLTIVD TPGFGDAVNN TECWKPVAEY IDQQFEQYFR DESGLNRKNI 250 260 270 280 290 300 QDNRVHCCLY FISPFGHGLR PLDVEFMKAL HQRVNIVPIL AKADTLTPPE VDHKKRKIRE 310 320 330 340 350 360 EIEHFGIKIY QFPDCDSDED EDFKLQDQAL KESIPFAVIG SNTVVEARGR RVRGRLYPWG 370 380 390 400 410 420 IVEVENPGHC DFVKLRTMLV RTHMQDLKDV TRETHYENYR AQCIQSMTRL VVKERNRNKL 430 440 450 460 470 TRESGTDFPI PAVPPGTDPE TEKLIREKDE ELRRMQEMLH KIQKQMKENY
	Isoform 4. Checksum: D015198B93C0ED49	FASTA	493	56,613
	10 20 30 40 50 60 MRSSPALFSS RAAPQKPRKE GSQAAGLLVF SDSLEIKRFL EDTTDDGELS KFVKDFSGNA 70 80 90 100 110 120 SCHPPEAKTW ASRPQVPEPR PQAPDLYDDD LEFRPPSRPQ SSDNQQYFCA PAPLSPSARP 130 140 150 160 170 180 RSPWGKLDPY DSSEDDKEYV GFATLPNQVH RKSVKKGFDF TLMVAGESGL GKSTLVNSLF 190 200 210 220 230 240 LTDLYRDRKL LGAEERIMQT VEITKHAVDI EEKGVRLRLT IVDTPGFGDA VNNTECWKPV 250 260 270 280 290 300 AEYIDQQFEQ YFRDESGLNR KNIQDNRVHC CLYFISPFGH GLRPLDVEFM KALHQRVNIV 310 320 330 340 350 360 PILAKADTLT PPEVDHKKRK IREEIEHFGI KIYQFPDCDS DEDEDFKLQD QALKESIPFA 370 380 390 400 410 420 VIGSNTVVEA RGRRVRGRLY PWGIVEVENP GHCDFVKLRT MLVRTHMQDL KDVTRETHYE 430 440 450 460 470 480 NYRAQCIQSM TRLVVKERNR NKLTRESGTD FPIPAVPPGT DPETEKLIRE KDEELRRMQE 490 MLHKIQKQMK ENY
	Isoform 5. Checksum: A860BD705573901C	FASTA	331	38,542
	10 20 30 40 50 60 MVAGESGLGK STLVNSLFLT DLYRDRKLLG AEERIMQTVE ITKHAVDIEE KGVRLRLTIV 70 80 90 100 110 120 DTPGFGDAVN NTECWKPVAE YIDQQFEQYF RDESGLNRKN IQDNRVHCCL YFISPFGHGL 130 140 150 160 170 180 RPLDVEFMKA LHQRVNIVPI LAKADTLTPP EVDHKKRKIR EEIEHFGIKI YQFPDCDSDE 190 200 210 220 230 240 DEDFKLQDQA LKESIPFAVI GSNTVVEARG RRVRGRLYPW GIVEVENPGH CDFVKLRTML 250 260 270 280 290 300 VRTHMQDLKD VTRETHYENY RAQCIQSMTR LVVKERNRNK LTRESGTDFP IPAVPPGTDP 310 320 330 ETEKLIREKD EELRRMQEML HKIQKQMKEN Y
	Isoform 6 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS). Checksum: 7FA8D55492E9348F	FASTA	274	30,809
	10 20 30 40 50 60 MIKRFLEDTT DDGELSKFVK DFSGNASCHP PEAKTWASRP QVPEPRPQAP DLYDDDLEFR 70 80 90 100 110 120 PPSRPQSSDN QQYFCAPAPL SPSARPRSPW GKLDPYDSSE DDKEYVGFAT LPNQVHRKSV 130 140 150 160 170 180 KKGFDFTLMV AGESGLGKST LVNSLFLTDL YRDRKLLGAE ERIMQTVEIT KHAVDIEEKG 190 200 210 220 230 240 VRLRLTIVDT PGFGDAVNNT ECWKPVAEYI DQQFEQYFRD ESGLNRKNIQ DNRVHCCLYF 250 260 270 ISPFGHGYGP SLRLLAPPGA VKGTGQEHQG QGCH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene." Paavola P., Horelli-Kuitunen N., Palotie A., Peltonen L. Genomics 55:122-125(1999) [PubMed: 9889007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[2]	"Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2." Zieger B., Tran H., Hainmann I., Wunderle D., Zgaga-Griesz A., Blaeser S., Ware J. Gene 261:197-203(2000) [PubMed: 11167005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Tissue: Brain and Fetal brain.
[3]	"A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif." Larisch S., Yi Y., Lotan R., Kerner H., Eimerl S., Parks W.T., Yossi G., Reffey S.B., de Caestecker M.P., Danielpour D., Book-Melamed N., Timberg R., Duckett C., Lechleider R.J., Steller H., Orly J., Kim S.-J., Roberts A.B. Nat. Cell Biol. 2:915-921(2000) [PubMed: 11146656] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF 156-GLY--SER-158. Tissue: Fetal brain.
[4]	"Characterization of tissue- and cell-type-specific expression of a novel human septin family gene, Bradeion." Tanaka M., Tanaka T., Kijima H., Itoh J., Matsuda T., Hori S., Yamamoto M. Biochem. Biophys. Res. Commun. 286:547-553(2001) [PubMed: 11511094] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Brain.
[5]	"Molecular cloning of a new GTP binding protein from human brain." Yoshimoto M., Yazaki M., Matsumoto K., Takayama K. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[6]	Zha D., Hu G. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5). Tissue: Amygdala, Brain cortex, Subthalamic nucleus and Testis.
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Hippocampus.
[11]	"The novel human platelet septin SEPT8 is an interaction partner of SEPT4." Blaeser S., Horn J., Wuermell P., Bauer H., Struempell S., Nurden P., Pagenstecher A., Busse A., Wunderle D., Hainmann I., Zieger B. Thromb. Haemost. 91:959-966(2004) [PubMed: 15116257] [Abstract] Cited for: FUNCTION, INTERACTION WITH SEPT8, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[12]	Lubec G., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 141-157 AND 282-290, MASS SPECTROMETRY. Tissue: Fetal brain.
[13]	"Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation." Lotan R., Rotem A., Gonen H., Finberg J.P.M., Kemeny S., Steller H., Ciechanover A., Larisch S. J. Biol. Chem. 280:25802-25810(2005) [PubMed: 15837787] [Abstract] Cited for: FUNCTION.
[14]	"Expression profiling the human septin gene family." Hall P.A., Jung K., Hillan K.J., Russell S.E.H. J. Pathol. 206:269-278(2005) [PubMed: 15915442] [Abstract] Cited for: TISSUE SPECIFICITY.
[15]	"SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling." Sudo K., Ito H., Iwamoto I., Morishita R., Asano T., Nagata K. Hum. Mutat. 28:1005-1013(2007) [PubMed: 17546647] [Abstract] Cited for: INTERACTION WITH SEPT9 HNA VARIANTS.
[16]	"The mitochondrial ARTS protein promotes apoptosis through targeting XIAP." Gottfried Y., Rotem A., Lotan R., Steller H., Larisch S. EMBO J. 23:1627-1635(2004) [PubMed: 15029247] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH XIAP.
[17]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF073312 mRNA. Translation: AAC25673.1. U88829 mRNA. Translation: AAD00653.1. U88870 mRNA. Translation: AAD00657.1. AF176379 mRNA. Translation: AAG45673.1. AB008753 mRNA. Translation: BAB70695.1. D89278 mRNA. Translation: BAB46922.1. AF035811 mRNA. Translation: AAB88512.1. CR457111 mRNA. Translation: CAG33392.1. AK315396 mRNA. Translation: BAG37789.1. AK094579 mRNA. Translation: BAG52891.1. AK294094 mRNA. Translation: BAG57432.1. AK301914 mRNA. Translation: BAG63338.1. AK302146 mRNA. Translation: BAG63517.1. CH471109 Genomic DNA. Translation: EAW94440.1. CH471109 Genomic DNA. Translation: EAW94442.1. BC018056 mRNA. Translation: AAH18056.3.
IPI	IPI00011589. IPI00026430. IPI00183878. IPI00939537. IPI00952695. IPI00953305.
RefSeq	NP_004565.1. NP_536340.1. NP_536341.1.
UniGene	Hs.287518
3D structure databases
SMR	O43236. Positions 127-410.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43236. 2 interactions.
STRING	O43236.
PTM databases
PhosphoSite	O43236.
Proteomic databases
PRIDE	O43236.
Genome annotation databases
Ensembl	ENST00000317268; ENSP00000321674; ENSG00000108387; Homo sapiens. [Genome view]
GeneID	5414.
KEGG	hsa:5414.
UCSC	uc002iwk.1. human. uc002iwm.1. human.
Organism-specific databases
CTD	5414.
GeneCards	GC17M053953.
H-InvDB	HIX0014033.
HGNC	HGNC:9165. SEPT4.
HPA	CAB006855. HPA021587. HPA022905.
MIM	603696. gene.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17220.
HOVERGEN	O43236.
InParanoid	O43236.
PhylomeDB	O43236.
Gene expression databases
ArrayExpress	O43236.
Bgee	O43236.
CleanEx	HS_SEPT4.
Genevestigator	O43236.
GermOnline	ENSG00000108387. Homo sapiens.
Family and domain databases
InterPro	IPR000038. Cell_Div_GTP_bd. [Graphical view]
PANTHER	PTHR18884. Cell_Div_GTP_bd. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	20961.
SOURCE	Search...

Entry information

Entry name

SEPT4_HUMAN

Accession

Primary (citable) accession number: O43236
Secondary accession number(s): B2RD42 , B3KSX9, B4DXC6, B4DXV5, Q6IAP3, Q9H315, Q9UM58

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	June 1, 1998
Last modified:	January 19, 2010
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.