O43236 (SEPT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Septin-4

Alternative name(s):
Apoptosis-related protein in the TGF-beta signaling pathway
Short name=ARTS
Bradeion beta
Brain protein H5
CE5B3 beta
Cell division control-related protein 2
Short name=hCDCREL-2
Cerebral protein 7
Peanut-like protein 2

Gene names

Name:	SEPT4
Synonyms:	ARTS, PNUTL2, SEP4
ORF Names:	hucep-7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Filament-forming cytoskeletal GTPase By similarity. May play a role in cytokinesis Potential. May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. Ref.1 Ref.3 Ref.11 Ref.13 Ref.17
Subunit structure	Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity. Interacts with SEPT8. In a mesenchymal cell line, interacts with SEPT9 isoform 2 variants HNA Trp-106 and Phe-111, but not the wild type SEPT9. Isoform ARTS, but no other isoforms, interacts with XIAP after the induction of apoptosis. Ref.11 Ref.16 Ref.17
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Note: In platelets, found in areas surrounding alpha-granules. Ref.3 Ref.11 Ref.17 Isoform ARTS: Mitochondrion. Nucleus. Note: While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction. Ref.3 Ref.11 Ref.17
Tissue specificity	Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets. Ref.1 Ref.2 Ref.3 Ref.4 Ref.11 Ref.14
Sequence similarities	Belongs to the septin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm Cytoskeleton Mitochondrion Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Non-traceable author statement Ref.3. Source: UniProtKB brain development Inferred from electronic annotation. Source: Compara cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Traceable author statement Ref.1. Source: ProtInc positive regulation of apoptotic process Inferred from direct assay PubMed 21185211. Source: UniProtKB positive regulation of intrinsic apoptotic signaling pathway Inferred from mutant phenotype PubMed 21185211. Source: UniProtKB positive regulation of protein ubiquitination Inferred from direct assay PubMed 21185211. Source: UniProtKB sperm capacitation Inferred from electronic annotation. Source: Compara sperm mitochondrion organization Inferred from electronic annotation. Source: Compara
Cellular_component	cell projection Inferred from electronic annotation. Source: Compara cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Non-traceable author statement Ref.3. Source: UniProtKB nucleus Non-traceable author statement Ref.3. Source: UniProtKB
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement Ref.1. Source: ProtInc structural molecule activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SIAH1	Q8IUQ4	2	EBI-4372019,EBI-747107
XIAP	P98170	4	EBI-4372019,EBI-517127

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43236-1)

Also known as: PNUTL2; PNUTL2a; H5/CDCrel2; SEPT4_i1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43236-2)

Also known as: PNUTL2b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDRSLGWQGNSVPEDRTEAG → M

Isoform 3 (identifier: O43236-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDRSLGWQGNSVPEDRTEAG → MPGFYSVMTDEE

Note: No experimental confirmation available.

Isoform 4 (identifier: O43236-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDRSLGWQGNSVPEDRTEAG → MRSSPALFSSRAAPQKPRKEGSQAAGLLVFSDSLE

Note: No experimental confirmation available.

Isoform 5 (identifier: O43236-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-147: Missing.

Note: No experimental confirmation available.

Isoform ARTS (identifier: O43236-6)

Also known as: SEPT4_i2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDRSLGWQGNSVPEDRTEAG → M
     267-293: LRPLDVEFMKALHQRVNIVPILAKADT → YGPSLRLLAPPGAVKGTGQEHQGQGCH
     294-478: Missing.

Note: May be defective in GTP-binding.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Septin-4		PRO_0000173519
Regions
	Nucleotide binding	151 – 158	8	GTP By similarity
	Nucleotide binding	290 – 298	9	GTP By similarity
	Coiled coil	447 – 478	32	Potential
Sites
	Binding site	185	1	GTP By similarity
	Binding site	211	1	GTP; via amide nitrogen By similarity
	Binding site	348	1	GTP; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	363	1	GTP By similarity
Amino acid modifications
	Modified residue	325	1	Phosphoserine Ref.15
Natural variations
	Alternative sequence	1 – 147	147	Missing in isoform 5.		VSP_038302
	Alternative sequence	1 – 20	20	MDRSL…RTEAG → M in isoform 2 and isoform ARTS.		VSP_006050
	Alternative sequence	1 – 20	20	MDRSL…RTEAG → MPGFYSVMTDEE in isoform 3.		VSP_038303
	Alternative sequence	1 – 20	20	MDRSL…RTEAG → MRSSPALFSSRAAPQKPRKE GSQAAGLLVFSDSLE in isoform 4.		VSP_038304
	Alternative sequence	267 – 293	27	LRPLD…AKADT → YGPSLRLLAPPGAVKGTGQE HQGQGCH in isoform ARTS.		VSP_038305
	Alternative sequence	294 – 478	185	Missing in isoform ARTS.		VSP_038306
	Natural variant	311	1	E → V. Corresponds to variant rs17741424 [ dbSNP | Ensembl ].		VAR_051935
Experimental info
	Mutagenesis	156 – 158	3	GKS → ENP: Loss of TGF-beta-induced apoptosis. No translocation to the nucleus following TGF-beta treatment. Loss of XIAP-binding. Ref.3
	Sequence conflict	156	1	G → D in BAG37789. Ref.7
	Sequence conflict	382	1	K → E in BAG63517. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PNUTL2) (PNUTL2a) (H5/CDCrel2) (SEPT4_i1) [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 2F08D3611EF6523D	FASTA	478	55,098
	10 20 30 40 50 60 MDRSLGWQGN SVPEDRTEAG IKRFLEDTTD DGELSKFVKD FSGNASCHPP EAKTWASRPQ 70 80 90 100 110 120 VPEPRPQAPD LYDDDLEFRP PSRPQSSDNQ QYFCAPAPLS PSARPRSPWG KLDPYDSSED 130 140 150 160 170 180 DKEYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL VNSLFLTDLY RDRKLLGAEE 190 200 210 220 230 240 RIMQTVEITK HAVDIEEKGV RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE 250 260 270 280 290 300 SGLNRKNIQD NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD 310 320 330 340 350 360 HKKRKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN TVVEARGRRV 370 380 390 400 410 420 RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR ETHYENYRAQ CIQSMTRLVV 430 440 450 460 470 KERNRNKLTR ESGTDFPIPA VPPGTDPETE KLIREKDEEL RRMQEMLHKI QKQMKENY
	Isoform 2 (PNUTL2b) [UniParc]. Checksum: C0779A770DC7415A	FASTA	459	53,042
	10 20 30 40 50 60 MIKRFLEDTT DDGELSKFVK DFSGNASCHP PEAKTWASRP QVPEPRPQAP DLYDDDLEFR 70 80 90 100 110 120 PPSRPQSSDN QQYFCAPAPL SPSARPRSPW GKLDPYDSSE DDKEYVGFAT LPNQVHRKSV 130 140 150 160 170 180 KKGFDFTLMV AGESGLGKST LVNSLFLTDL YRDRKLLGAE ERIMQTVEIT KHAVDIEEKG 190 200 210 220 230 240 VRLRLTIVDT PGFGDAVNNT ECWKPVAEYI DQQFEQYFRD ESGLNRKNIQ DNRVHCCLYF 250 260 270 280 290 300 ISPFGHGLRP LDVEFMKALH QRVNIVPILA KADTLTPPEV DHKKRKIREE IEHFGIKIYQ 310 320 330 340 350 360 FPDCDSDEDE DFKLQDQALK ESIPFAVIGS NTVVEARGRR VRGRLYPWGI VEVENPGHCD 370 380 390 400 410 420 FVKLRTMLVR THMQDLKDVT RETHYENYRA QCIQSMTRLV VKERNRNKLT RESGTDFPIP 430 440 450 AVPPGTDPET EKLIREKDEE LRRMQEMLHK IQKQMKENY
	Isoform 3 [UniParc]. Checksum: BDBB6EB9570D9913	FASTA	470	54,298
	10 20 30 40 50 60 MPGFYSVMTD EEIKRFLEDT TDDGELSKFV KDFSGNASCH PPEAKTWASR PQVPEPRPQA 70 80 90 100 110 120 PDLYDDDLEF RPPSRPQSSD NQQYFCAPAP LSPSARPRSP WGKLDPYDSS EDDKEYVGFA 130 140 150 160 170 180 TLPNQVHRKS VKKGFDFTLM VAGESGLGKS TLVNSLFLTD LYRDRKLLGA EERIMQTVEI 190 200 210 220 230 240 TKHAVDIEEK GVRLRLTIVD TPGFGDAVNN TECWKPVAEY IDQQFEQYFR DESGLNRKNI 250 260 270 280 290 300 QDNRVHCCLY FISPFGHGLR PLDVEFMKAL HQRVNIVPIL AKADTLTPPE VDHKKRKIRE 310 320 330 340 350 360 EIEHFGIKIY QFPDCDSDED EDFKLQDQAL KESIPFAVIG SNTVVEARGR RVRGRLYPWG 370 380 390 400 410 420 IVEVENPGHC DFVKLRTMLV RTHMQDLKDV TRETHYENYR AQCIQSMTRL VVKERNRNKL 430 440 450 460 470 TRESGTDFPI PAVPPGTDPE TEKLIREKDE ELRRMQEMLH KIQKQMKENY
	Isoform 4 [UniParc]. Checksum: D015198B93C0ED49	FASTA	493	56,613
	10 20 30 40 50 60 MRSSPALFSS RAAPQKPRKE GSQAAGLLVF SDSLEIKRFL EDTTDDGELS KFVKDFSGNA 70 80 90 100 110 120 SCHPPEAKTW ASRPQVPEPR PQAPDLYDDD LEFRPPSRPQ SSDNQQYFCA PAPLSPSARP 130 140 150 160 170 180 RSPWGKLDPY DSSEDDKEYV GFATLPNQVH RKSVKKGFDF TLMVAGESGL GKSTLVNSLF 190 200 210 220 230 240 LTDLYRDRKL LGAEERIMQT VEITKHAVDI EEKGVRLRLT IVDTPGFGDA VNNTECWKPV 250 260 270 280 290 300 AEYIDQQFEQ YFRDESGLNR KNIQDNRVHC CLYFISPFGH GLRPLDVEFM KALHQRVNIV 310 320 330 340 350 360 PILAKADTLT PPEVDHKKRK IREEIEHFGI KIYQFPDCDS DEDEDFKLQD QALKESIPFA 370 380 390 400 410 420 VIGSNTVVEA RGRRVRGRLY PWGIVEVENP GHCDFVKLRT MLVRTHMQDL KDVTRETHYE 430 440 450 460 470 480 NYRAQCIQSM TRLVVKERNR NKLTRESGTD FPIPAVPPGT DPETEKLIRE KDEELRRMQE 490 MLHKIQKQMK ENY
	Isoform 5 [UniParc]. Checksum: A860BD705573901C	FASTA	331	38,542
	10 20 30 40 50 60 MVAGESGLGK STLVNSLFLT DLYRDRKLLG AEERIMQTVE ITKHAVDIEE KGVRLRLTIV 70 80 90 100 110 120 DTPGFGDAVN NTECWKPVAE YIDQQFEQYF RDESGLNRKN IQDNRVHCCL YFISPFGHGL 130 140 150 160 170 180 RPLDVEFMKA LHQRVNIVPI LAKADTLTPP EVDHKKRKIR EEIEHFGIKI YQFPDCDSDE 190 200 210 220 230 240 DEDFKLQDQA LKESIPFAVI GSNTVVEARG RRVRGRLYPW GIVEVENPGH CDFVKLRTML 250 260 270 280 290 300 VRTHMQDLKD VTRETHYENY RAQCIQSMTR LVVKERNRNK LTRESGTDFP IPAVPPGTDP 310 320 330 ETEKLIREKD EELRRMQEML HKIQKQMKEN Y
	Isoform ARTS (SEPT4_i2) [UniParc]. Checksum: 7FA8D55492E9348F	FASTA	274	30,809
	10 20 30 40 50 60 MIKRFLEDTT DDGELSKFVK DFSGNASCHP PEAKTWASRP QVPEPRPQAP DLYDDDLEFR 70 80 90 100 110 120 PPSRPQSSDN QQYFCAPAPL SPSARPRSPW GKLDPYDSSE DDKEYVGFAT LPNQVHRKSV 130 140 150 160 170 180 KKGFDFTLMV AGESGLGKST LVNSLFLTDL YRDRKLLGAE ERIMQTVEIT KHAVDIEEKG 190 200 210 220 230 240 VRLRLTIVDT PGFGDAVNNT ECWKPVAEYI DQQFEQYFRD ESGLNRKNIQ DNRVHCCLYF 250 260 270 ISPFGHGYGP SLRLLAPPGA VKGTGQEHQG QGCH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene." Paavola P., Horelli-Kuitunen N., Palotie A., Peltonen L. Genomics 55:122-125(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[2]	"Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2." Zieger B., Tran H., Hainmann I., Wunderle D., Zgaga-Griesz A., Blaeser S., Ware J. Gene 261:197-203(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Tissue: Brain and Fetal brain.
[3]	"A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif." Larisch S., Yi Y., Lotan R., Kerner H., Eimerl S., Parks W.T., Yossi G., Reffey S.B., de Caestecker M.P., Danielpour D., Book-Melamed N., Timberg R., Duckett C., Lechleider R.J., Steller H., Orly J., Kim S.-J., Roberts A.B. Nat. Cell Biol. 2:915-921(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ARTS), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MUTAGENESIS OF 156-GLY--SER-158. Tissue: Fetal brain.
[4]	"Characterization of tissue- and cell-type-specific expression of a novel human septin family gene, Bradeion." Tanaka M., Tanaka T., Kijima H., Itoh J., Matsuda T., Hori S., Yamamoto M. Biochem. Biophys. Res. Commun. 286:547-553(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Brain.
[5]	"Molecular cloning of a new GTP binding protein from human brain." Yoshimoto M., Yazaki M., Matsumoto K., Takayama K. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[6]	Zha D., Hu G. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5). Tissue: Amygdala, Brain cortex, Subthalamic nucleus and Testis.
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Hippocampus.
[11]	"The novel human platelet septin SEPT8 is an interaction partner of SEPT4." Blaeser S., Horn J., Wuermell P., Bauer H., Struempell S., Nurden P., Pagenstecher A., Busse A., Wunderle D., Hainmann I., Zieger B. Thromb. Haemost. 91:959-966(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SEPT8, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[12]	Lubec G., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 141-157 AND 282-290, MASS SPECTROMETRY. Tissue: Fetal brain.
[13]	"Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation." Lotan R., Rotem A., Gonen H., Finberg J.P.M., Kemeny S., Steller H., Ciechanover A., Larisch S. J. Biol. Chem. 280:25802-25810(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[14]	"Expression profiling the human septin gene family." Hall P.A., Jung K., Hillan K.J., Russell S.E.H. J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[15]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325, MASS SPECTROMETRY. Tissue: Liver.
[16]	"SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling." Sudo K., Ito H., Iwamoto I., Morishita R., Asano T., Nagata K. Hum. Mutat. 28:1005-1013(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SEPT9 HNA VARIANTS.
[17]	"The mitochondrial ARTS protein promotes apoptosis through targeting XIAP." Gottfried Y., Rotem A., Lotan R., Steller H., Larisch S. EMBO J. 23:1627-1635(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH XIAP.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF073312 mRNA. Translation: AAC25673.1. U88829 mRNA. Translation: AAD00653.1. U88870 mRNA. Translation: AAD00657.1. AF176379 mRNA. Translation: AAG45673.1. AB008753 mRNA. Translation: BAB70695.1. D89278 mRNA. Translation: BAB46922.1. AF035811 mRNA. Translation: AAB88512.1. CR457111 mRNA. Translation: CAG33392.1. AK315396 mRNA. Translation: BAG37789.1. AK094579 mRNA. Translation: BAG52891.1. AK294094 mRNA. Translation: BAG57432.1. AK301914 mRNA. Translation: BAG63338.1. AK302146 mRNA. Translation: BAG63517.1. CH471109 Genomic DNA. Translation: EAW94440.1. CH471109 Genomic DNA. Translation: EAW94442.1. BC018056 mRNA. Translation: AAH18056.3.
IPI	IPI00011589. IPI00026430. IPI00183878. IPI00939537. IPI00952695. IPI00953305.
RefSeq	NP_001185642.1. NM_001198713.1. NP_001243711.1. NM_001256782.1. NP_001243751.1. NM_001256822.1. NP_004565.1. NM_004574.3. NP_536340.1. NM_080415.2. NP_536341.1. NM_080416.2.
UniGene	Hs.287518.
3D structure databases
ProteinModelPortal	O43236.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43236. 5 interactions.
MINT	MINT-2999234.
STRING	9606.ENSP00000321674.
PTM databases
PhosphoSite	O43236.
Proteomic databases
PaxDb	O43236.
PRIDE	O43236.
Protocols and materials databases
DNASU	5414.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317256; ENSP00000321071; ENSG00000108387. ENST00000317268; ENSP00000321674; ENSG00000108387. ENST00000393086; ENSP00000376801; ENSG00000108387. ENST00000412945; ENSP00000414779; ENSG00000108387. ENST00000426861; ENSP00000402348; ENSG00000108387. ENST00000457347; ENSP00000402000; ENSG00000108387. ENST00000583114; ENSP00000463768; ENSG00000108387.
GeneID	5414.
KEGG	hsa:5414.
UCSC	uc002iwk.2. human. uc002iwo.2. human. uc002iwp.2. human. uc010wnx.2. human. uc010wny.2. human.
Organism-specific databases
CTD	5414.
GeneCards	GC17M056597.
HGNC	HGNC:9165. SEPT4.
HPA	CAB006855. HPA021587. HPA022905.
MIM	603696. gene.
neXtProt	NX_O43236.
PharmGKB	PA33487.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5019.
HOVERGEN	HBG065093.
InParanoid	O43236.
Gene expression databases
ArrayExpress	O43236.
Bgee	O43236.
CleanEx	HS_SEPT4.
Genevestigator	O43236.
GermOnline	ENSG00000108387. Homo sapiens.
Family and domain databases
InterPro	IPR000038. Cell_div_GTP-bd. [Graphical view]
PANTHER	PTHR18884. PTHR18884. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5414.
NextBio	20961.
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Entry information

Entry name

SEPT4_HUMAN

Accession

Primary (citable) accession number: O43236
Secondary accession number(s): B2RD42 , B3KSX9, B4DXC6, B4DXV5, Q6IAP3, Q9H315, Q9UM58

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.