Unreviewed, UniProtKB/TrEMBL O43209 (O43209_HUMAN)

Names and origin

Protein names	Submitted name:     Homo sapiens clone 23678 EMBL AAB88188.1
Organism	Homo sapiens (Human) EMBL AAB88188.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	342 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain By similarity. RuleBase RU003505V0 Spearmint SPM002453
Subunit structure	Dimer of alpha and beta chains By similarity. RuleBase RU003505V0 Spearmint SPM002453
Sequence similarities	Belongs to the tubulin family. RuleBase RU000352V1

Ontologies

Keywords
Cellular component	Microtubule RuleBase RU000352V1 Spearmint SPM000217
Ligand	GTP-binding RuleBase RU000351V1 Spearmint SPM000217 Nucleotide-binding
Gene Ontology (GO)
Biological process	microtubule-based movement Inferred from electronic annotation. Source: InterPro protein polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	microtubule Inferred from electronic annotation. Source: InterPro protein complex Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAB88188.1

Sequences

	Sequence		Length	Mass (Da)
	O43209-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 255FF7CC0B7464CC	FASTA	342	38,570
	10 20 30 40 50 60 GHYTEGAELV DSVLDVVRKE SESCDCLQGF QLTHSLGGGT GSGMGTLLIS KIREEYPDRI 70 80 90 100 110 120 MNTFSVMPSP KVSDTVVEPY NATLSVHQLV ENTDETYCID NEALYDICFR TLKLTTPTYG 130 140 150 160 170 180 DLNHLVSATM SGVTTCLRFP GQLNADLRKL AVNMVPFPRL HFFMPGFAPL TSRGSQQYRA 190 200 210 220 230 240 LTVPELTQQM FDSKNMMAAC DPRHGRYLTV AAIFRGRMSM KEVDEQMLNV QNKNSSYFVE 250 260 270 280 290 300 WIPNNVKTAV CDIPPRGLKM SATFIGNSTA IQELFKRISE QFTAMFRRKA FLHWYTGEGM 310 320 330 340 DEMEFTEAES NMNDLVSEYQ QYQDATADEQ GEFEEEEGED EA

References

[1]	"A "double adaptor" method for improved shotgun library construction." Andersson B., Wentland M.A., Ricafrente J.Y., Liu W., Gibbs R.A. Anal. Biochem. 236:107-113(1996) [PubMed: 8619474] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL AAB88188.1.
[2]	"Large-scale concatenation cDNA sequencing." Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Genome Res. 7:353-358(1997) [PubMed: 9110174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL AAB88188.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF035316 mRNA. Translation: AAB88188.1.
IPI	IPI00031370.
UniGene	Hs.300701
3D structure databases
HSSP	HSSP built from PDB template 1JFF based on UniProtKB P02554.
SMR	O43209. Positions 1-324.
ModBase	Search...
Proteomic databases
PRIDE	O43209.
Genome annotation databases
Ensembl	ENSG00000137285. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:30829. TUBB2B.
Phylogenomic databases
HOGENOM	O43209.
HOVERGEN	O43209.
Gene expression databases
ArrayExpress	O43209.
Bgee	O43209.
Family and domain databases
InterPro	IPR002453. Beta_tubulin. IPR010916. TonB_box_CS. IPR000217. Tubulin. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR017975. Tubulin_CS. IPR003008. Tubulin_FtsZ_GTPase. [Graphical view]
Gene3D	G3DSA:3.30.1330.20. Tubulin/FtsZ_2-layer-sand-dom. 1 hit. G3DSA:3.40.50.1440. Tubulin_FtsZ. 1 hit.
PANTHER	PTHR11588:SF9. Beta_tubulin. 1 hit. PTHR11588. Tubulin. 1 hit.
Pfam	PF00091. Tubulin. 1 hit. PF03953. Tubulin_C. 1 hit. [Graphical view]
PRINTS	PR01163. BETATUBULIN. PR01161. TUBULIN.
PROSITE	PS00430. TONB_DEPENDENT_REC_1. 1 hit. Uncertain. PS00227. TUBULIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O43209_HUMAN

Accession

Primary (citable) accession number: O43209

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	May 5, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)