O43196 (MSH5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MutS protein homolog 5
Short name=hMSH5

Gene names

Name:

MSH5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	834 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis By similarity.
Subunit structure	Heterooligomer of MSH4 and MSH5. Interacts with HJURP. Ref.11
Tissue specificity	Ubiquitous, but highly expressed in testis, and thymus.
Sequence similarities	Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
Biological process	Meiosis
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chiasma assembly Inferred from Biological aspect of Ancestor. Source: RefGenome homologous chromosome segregation Inferred from Biological aspect of Ancestor. Source: RefGenome meiotic prophase II Traceable author statement PubMed 9916805. Source: ProtInc mismatch repair Traceable author statement Ref.1. Source: ProtInc reciprocal meiotic recombination Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	synaptonemal complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-dependent ATPase activity Inferred from Biological aspect of Ancestor. Source: RefGenome mismatched DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43196-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43196-2)

The sequence of this isoform differs from the canonical sequence as follows:
     654-654: Q → QQ

Isoform 3 (identifier: O43196-3)

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: T → TPPGDLRFTPIPLLIPSQ

Note: No experimental confirmation available.

Isoform 4 (identifier: O43196-4)

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: T → TPPGDLRFTPIPLLIPSQ
     654-654: Q → QQ
     745-774: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 834	834	MutS protein homolog 5		PRO_0000115202
Regions
	Nucleotide binding	592 – 599	8	ATP Potential
Natural variations
	Alternative sequence	179	1	T → TPPGDLRFTPIPLLIPSQ in isoform 3 and isoform 4.		VSP_017113
	Alternative sequence	654	1	Q → QQ in isoform 2 and isoform 4.		VSP_017114
	Alternative sequence	745 – 774	30	Missing in isoform 4.		VSP_017115
	Natural variant	29	1	P → S. Ref.5 Corresponds to variant rs2075789 [ dbSNP | Ensembl ].		VAR_025082
	Natural variant	85	1	L → F. Ref.5 Corresponds to variant rs28381349 [ dbSNP | Ensembl ].		VAR_025083
	Natural variant	202	1	Y → C. Ref.5 Corresponds to variant rs28381358 [ dbSNP | Ensembl ].		VAR_025084
	Natural variant	206	1	V → F. Ref.5 Corresponds to variant rs28381359 [ dbSNP | Ensembl ].		VAR_025085
	Natural variant	351	1	R → G. Ref.5 Corresponds to variant rs28399976 [ dbSNP | Ensembl ].		VAR_025086
	Natural variant	377	1	L → F. Ref.5 Corresponds to variant rs28399977 [ dbSNP | Ensembl ].		VAR_025087
	Natural variant	786	1	P → S. Ref.5 Corresponds to variant rs1802127 [ dbSNP | Ensembl ].		VAR_025088
Experimental info
	Sequence conflict	764	1	P → L in AAC62533. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 89E747F5361870E2	FASTA	834	92,875
	10 20 30 40 50 60 MASLGANPRR TPQGPRPGAA SSGFPSPAPV PGPREAEEEE VEEEEELAEI HLCVLWNSGY 70 80 90 100 110 120 LGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV VTSAKQDENM TRFLGKLASQ 130 140 150 160 170 180 EHREPKRPEI IFLPSVDFGL EISKQRLLSG NYSFIPDAMT ATEKILFLSS IIPFDCLLTV 190 200 210 220 230 240 RALGGLLKFL GRRRIGVELE DYNVSVPILG FKKFMLTHLV NIDQDTYSVL QIFKSESHPS 250 260 270 280 290 300 VYKVASGLKE GLSLFGILNR CHCKWGEKLL RLWFTRPTHD LGELSSRLDV IQFFLLPQNL 310 320 330 340 350 360 DMAQMLHRLL GHIKNVPLIL KRMKLSHTKV SDWQVLYKTV YSALGLRDAC RSLPQSIQLF 370 380 390 400 410 420 RDIAQEFSDD LHHIASLIGK VVDFEGSLAE NRFTVLPNID PEIDEKKRRL MGLPSFLTEV 430 440 450 460 470 480 ARKELENLDS RIPSCSVIYI PLIGFLLSIP RLPSMVEASD FEINGLDFMF LSEEKLHYRS 490 500 510 520 530 540 ARTKELDALL GDLHCEIRDQ ETLLMYQLQC QVLARAAVLT RVLDLASRLD VLLALASAAR 550 560 570 580 590 600 DYGYSRPRYS PQVLGVRIQN GRHPLMELCA RTFVPNSTEC GGDKGRVKVI TGPNSSGKSI 610 620 630 640 650 660 YLKQVGLITF MALVGSFVPA EEAEIGAVDA IFTRIHSCES ISLGLSTFMI DLNQVAKAVN 670 680 690 700 710 720 NATAQSLVLI DEFGKGTNTV DGLALLAAVL RHWLARGPTC PHIFVATNFL SLVQLQLLPQ 730 740 750 760 770 780 GPLVQYLTME TCEDGNDLVF FYQVCEGVAK ASHASHTAAQ AGLPDKLVAR GKEVSDLIRS 790 800 810 820 830 GKPIKPVKDL LKKNQMENCQ TLVDKFMKLD LEDPNLDLNV FMSQEVLPAA TSIL
	Isoform 2 [UniParc]. Checksum: 242182205EEF15D2	FASTA	835	93,004
	10 20 30 40 50 60 MASLGANPRR TPQGPRPGAA SSGFPSPAPV PGPREAEEEE VEEEEELAEI HLCVLWNSGY 70 80 90 100 110 120 LGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV VTSAKQDENM TRFLGKLASQ 130 140 150 160 170 180 EHREPKRPEI IFLPSVDFGL EISKQRLLSG NYSFIPDAMT ATEKILFLSS IIPFDCLLTV 190 200 210 220 230 240 RALGGLLKFL GRRRIGVELE DYNVSVPILG FKKFMLTHLV NIDQDTYSVL QIFKSESHPS 250 260 270 280 290 300 VYKVASGLKE GLSLFGILNR CHCKWGEKLL RLWFTRPTHD LGELSSRLDV IQFFLLPQNL 310 320 330 340 350 360 DMAQMLHRLL GHIKNVPLIL KRMKLSHTKV SDWQVLYKTV YSALGLRDAC RSLPQSIQLF 370 380 390 400 410 420 RDIAQEFSDD LHHIASLIGK VVDFEGSLAE NRFTVLPNID PEIDEKKRRL MGLPSFLTEV 430 440 450 460 470 480 ARKELENLDS RIPSCSVIYI PLIGFLLSIP RLPSMVEASD FEINGLDFMF LSEEKLHYRS 490 500 510 520 530 540 ARTKELDALL GDLHCEIRDQ ETLLMYQLQC QVLARAAVLT RVLDLASRLD VLLALASAAR 550 560 570 580 590 600 DYGYSRPRYS PQVLGVRIQN GRHPLMELCA RTFVPNSTEC GGDKGRVKVI TGPNSSGKSI 610 620 630 640 650 660 YLKQVGLITF MALVGSFVPA EEAEIGAVDA IFTRIHSCES ISLGLSTFMI DLNQQVAKAV 670 680 690 700 710 720 NNATAQSLVL IDEFGKGTNT VDGLALLAAV LRHWLARGPT CPHIFVATNF LSLVQLQLLP 730 740 750 760 770 780 QGPLVQYLTM ETCEDGNDLV FFYQVCEGVA KASHASHTAA QAGLPDKLVA RGKEVSDLIR 790 800 810 820 830 SGKPIKPVKD LLKKNQMENC QTLVDKFMKL DLEDPNLDLN VFMSQEVLPA ATSIL
	Isoform 3 [UniParc]. Checksum: 5B1AEE179D863E41	FASTA	851	94,719
	10 20 30 40 50 60 MASLGANPRR TPQGPRPGAA SSGFPSPAPV PGPREAEEEE VEEEEELAEI HLCVLWNSGY 70 80 90 100 110 120 LGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV VTSAKQDENM TRFLGKLASQ 130 140 150 160 170 180 EHREPKRPEI IFLPSVDFGL EISKQRLLSG NYSFIPDAMT ATEKILFLSS IIPFDCLLTP 190 200 210 220 230 240 PGDLRFTPIP LLIPSQVRAL GGLLKFLGRR RIGVELEDYN VSVPILGFKK FMLTHLVNID 250 260 270 280 290 300 QDTYSVLQIF KSESHPSVYK VASGLKEGLS LFGILNRCHC KWGEKLLRLW FTRPTHDLGE 310 320 330 340 350 360 LSSRLDVIQF FLLPQNLDMA QMLHRLLGHI KNVPLILKRM KLSHTKVSDW QVLYKTVYSA 370 380 390 400 410 420 LGLRDACRSL PQSIQLFRDI AQEFSDDLHH IASLIGKVVD FEGSLAENRF TVLPNIDPEI 430 440 450 460 470 480 DEKKRRLMGL PSFLTEVARK ELENLDSRIP SCSVIYIPLI GFLLSIPRLP SMVEASDFEI 490 500 510 520 530 540 NGLDFMFLSE EKLHYRSART KELDALLGDL HCEIRDQETL LMYQLQCQVL ARAAVLTRVL 550 560 570 580 590 600 DLASRLDVLL ALASAARDYG YSRPRYSPQV LGVRIQNGRH PLMELCARTF VPNSTECGGD 610 620 630 640 650 660 KGRVKVITGP NSSGKSIYLK QVGLITFMAL VGSFVPAEEA EIGAVDAIFT RIHSCESISL 670 680 690 700 710 720 GLSTFMIDLN QVAKAVNNAT AQSLVLIDEF GKGTNTVDGL ALLAAVLRHW LARGPTCPHI 730 740 750 760 770 780 FVATNFLSLV QLQLLPQGPL VQYLTMETCE DGNDLVFFYQ VCEGVAKASH ASHTAAQAGL 790 800 810 820 830 840 PDKLVARGKE VSDLIRSGKP IKPVKDLLKK NQMENCQTLV DKFMKLDLED PNLDLNVFMS 850 QEVLPAATSI L
	Isoform 4 [UniParc]. Checksum: 1D4A762D52173D03	FASTA	822	91,862
	10 20 30 40 50 60 MASLGANPRR TPQGPRPGAA SSGFPSPAPV PGPREAEEEE VEEEEELAEI HLCVLWNSGY 70 80 90 100 110 120 LGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV VTSAKQDENM TRFLGKLASQ 130 140 150 160 170 180 EHREPKRPEI IFLPSVDFGL EISKQRLLSG NYSFIPDAMT ATEKILFLSS IIPFDCLLTP 190 200 210 220 230 240 PGDLRFTPIP LLIPSQVRAL GGLLKFLGRR RIGVELEDYN VSVPILGFKK FMLTHLVNID 250 260 270 280 290 300 QDTYSVLQIF KSESHPSVYK VASGLKEGLS LFGILNRCHC KWGEKLLRLW FTRPTHDLGE 310 320 330 340 350 360 LSSRLDVIQF FLLPQNLDMA QMLHRLLGHI KNVPLILKRM KLSHTKVSDW QVLYKTVYSA 370 380 390 400 410 420 LGLRDACRSL PQSIQLFRDI AQEFSDDLHH IASLIGKVVD FEGSLAENRF TVLPNIDPEI 430 440 450 460 470 480 DEKKRRLMGL PSFLTEVARK ELENLDSRIP SCSVIYIPLI GFLLSIPRLP SMVEASDFEI 490 500 510 520 530 540 NGLDFMFLSE EKLHYRSART KELDALLGDL HCEIRDQETL LMYQLQCQVL ARAAVLTRVL 550 560 570 580 590 600 DLASRLDVLL ALASAARDYG YSRPRYSPQV LGVRIQNGRH PLMELCARTF VPNSTECGGD 610 620 630 640 650 660 KGRVKVITGP NSSGKSIYLK QVGLITFMAL VGSFVPAEEA EIGAVDAIFT RIHSCESISL 670 680 690 700 710 720 GLSTFMIDLN QQVAKAVNNA TAQSLVLIDE FGKGTNTVDG LALLAAVLRH WLARGPTCPH 730 740 750 760 770 780 IFVATNFLSL VQLQLLPQGP LVQYLTMETC EDGNDLVFFY QVSDLIRSGK PIKPVKDLLK 790 800 810 820 KNQMENCQTL VDKFMKLDLE DPNLDLNVFM SQEVLPAATS IL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene." Her C., Doggett N.A. Genomics 52:50-61(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]	"hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis." Bocker T., Barusevicius A., Snowden T., Rasio D., Guerrette S., Robbins D., Schmidt C., Burczak J., Croce C.M., Copeland T., Kovatich A.J., Fishel R. Cancer Res. 59:816-822(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene." Winand N.J., Panzer J.A., Kolodner R.D. Genomics 53:69-80(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	NIEHS SNPs program Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-29; PHE-85; CYS-202; PHE-206; GLY-351; PHE-377 AND SER-786.
[6]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Hirakawa M., Yamaguchi H., Imai K., Shimada J., Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Kidney and Skin.
[11]	"Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells." Kato T., Sato N., Hayama S., Yamabuki T., Ito T., Miyamoto M., Kondo S., Nakamura Y., Daigo Y. Cancer Res. 67:8544-8553(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HJURP.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF048986 mRNA. Translation: AAC62533.1. AF048991 , AF048988, AF048989, AF048990 Genomic DNA. Translation: AAC62534.1. AF034759 mRNA. Translation: AAB87632.1. AF070071 mRNA. Translation: AAC70066.1. AF070079 , AF070072, AF070073, AF070074, AF070075, AF070076, AF070077, AF070078 Genomic DNA. Translation: AAC70067.1. BT007200 mRNA. Translation: AAP35864.1. AY943816 Genomic DNA. Translation: AAX20111.1. BA000025 Genomic DNA. Translation: BAB63375.1. AF129756 Genomic DNA. Translation: AAD18072.1. AF134726 Genomic DNA. Translation: AAD21822.1. AL662834 Genomic DNA. Translation: CAI17723.1. AL662834 Genomic DNA. Translation: CAI17724.1. AL662899 Genomic DNA. Translation: CAI18423.1. AL662899 Genomic DNA. Translation: CAI18424.1. CR936239, CR925765 Genomic DNA. Translation: CAQ08900.1. CR936239, CR925765 Genomic DNA. Translation: CAQ08901.1. CR759787 Genomic DNA. Translation: CAQ10116.1. CR759787 Genomic DNA. Translation: CAQ10117.1. CR925765, CR936239 Genomic DNA. Translation: CAQ10619.1. CR925765, CR936239 Genomic DNA. Translation: CAQ10620.1. CH471081 Genomic DNA. Translation: EAX03512.1. CH471081 Genomic DNA. Translation: EAX03514.1. BC001358 mRNA. Translation: AAH01358.1. BC002498 mRNA. Translation: AAH02498.1. BC041031 mRNA. Translation: AAH41031.1.
IPI	IPI00172593. IPI00219362. IPI00297780. IPI00647584.
RefSeq	NP_002432.1. NM_002441.4. NP_079535.4. NM_025259.5. NP_751897.1. NM_172165.3. NP_751898.1. NM_172166.3.
UniGene	Hs.647011.
3D structure databases
ProteinModelPortal	O43196.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43196. 2 interactions.
STRING	9606.ENSP00000364894.
PTM databases
PhosphoSite	O43196.
Proteomic databases
PaxDb	O43196.
PRIDE	O43196.
Protocols and materials databases
DNASU	4439.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375703; ENSP00000364855; ENSG00000204410. ENST00000375740; ENSP00000364892; ENSG00000204410. ENST00000375742; ENSP00000364894; ENSG00000204410. ENST00000375750; ENSP00000364903; ENSG00000204410. ENST00000375755; ENSP00000364908; ENSG00000204410. ENST00000416549; ENSP00000399721; ENSG00000235222. ENST00000419269; ENSP00000394649; ENSG00000235222. ENST00000427735; ENSP00000388037; ENSG00000230293. ENST00000435700; ENSP00000407047; ENSG00000230293. ENST00000436192; ENSP00000406868; ENSG00000227314. ENST00000441395; ENSP00000402659; ENSG00000227314. ENST00000441401; ENSP00000406269; ENSG00000227314. ENST00000448617; ENSP00000387609; ENSG00000227314. ENST00000456839; ENSP00000394017; ENSG00000235222. ENST00000457742; ENSP00000409181; ENSG00000230293. ENST00000497157; ENSP00000464260; ENSG00000230293. ENST00000534153; ENSP00000431693; ENSG00000204410. ENST00000578225; ENSP00000463730; ENSG00000227314.
GeneID	4439.
KEGG	hsa:4439.
UCSC	uc003nwu.2. human. uc003nwv.2. human. uc003nwx.2. human.
Organism-specific databases
CTD	4439.
GeneCards	GC06P031707.
H-InvDB	HIX0165917. HIX0166738. HIX0167237. HIX0167372.
HGNC	HGNC:7328. MSH5.
MIM	603382. gene.
neXtProt	NX_O43196.
PharmGKB	PA31136.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0249.
HOVERGEN	HBG001449.
KO	K08741.
OMA	NDLVFFY.
OrthoDB	EOG4WSW8Z.
PhylomeDB	O43196.
Enzyme and pathway databases
Reactome	REACT_111183. Meiosis.
Gene expression databases
ArrayExpress	O43196.
Bgee	O43196.
CleanEx	HS_MSH5.
Genevestigator	O43196.
GermOnline	ENSG00000204410. Homo sapiens.
Family and domain databases
InterPro	IPR000432. DNA_mismatch_repair_MutS_C. IPR007861. DNA_mismatch_repair_MutS_clamp. IPR007696. DNA_mismatch_repair_MutS_core. [Graphical view]
Pfam	PF05192. MutS_III. 1 hit. PF05190. MutS_IV. 1 hit. PF00488. MutS_V. 1 hit. [Graphical view]
SMART	SM00534. MUTSac. 1 hit. SM00533. MUTSd. 1 hit. [Graphical view]
SUPFAM	SSF48334. DNA_repair_MutS_domIII. 1 hit.
PROSITE	PS00486. DNA_MISMATCH_REPAIR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MSH5. human.
GenomeRNAi	4439.
NextBio	17301.
SOURCE	Search...

Entry information

Entry name

MSH5_HUMAN

Accession

Primary (citable) accession number: O43196
Secondary accession number(s): B0V033 , B0V034, O60586, Q5BLU9, Q5SSR1, Q8IW44, Q9BQC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.