Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43196

- MSH5_HUMAN

UniProt

O43196 - MSH5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

MutS protein homolog 5

Gene

MSH5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi592 – 5998ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA-dependent ATPase activity Source: RefGenome
  3. mismatched DNA binding Source: RefGenome

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. chiasma assembly Source: RefGenome
  3. homologous chromosome segregation Source: RefGenome
  4. mismatch repair Source: InterPro
  5. reciprocal meiotic recombination Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Meiosis

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_27271. Meiotic recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
MutS protein homolog 5
Short name:
hMSH5
Gene namesi
Name:MSH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:7328. MSH5.

Subcellular locationi

GO - Cellular componenti

  1. synaptonemal complex Source: RefGenome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834MutS protein homolog 5PRO_0000115202Add
BLAST

Proteomic databases

MaxQBiO43196.
PaxDbiO43196.
PRIDEiO43196.

PTM databases

PhosphoSiteiO43196.

Expressioni

Tissue specificityi

Ubiquitous, but highly expressed in testis, and thymus.

Gene expression databases

BgeeiO43196.
CleanExiHS_MSH5.
ExpressionAtlasiO43196. baseline.
GenevestigatoriO43196.

Interactioni

Subunit structurei

Heterooligomer of MSH4 and MSH5. Interacts with HJURP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P0051910EBI-6092730,EBI-375543
MSH4O154575EBI-6092730,EBI-6092777

Protein-protein interaction databases

BioGridi110576. 4 interactions.
IntActiO43196. 3 interactions.
MINTiMINT-2999175.
STRINGi9606.ENSP00000364894.

Structurei

3D structure databases

ProteinModelPortaliO43196.
SMRiO43196. Positions 178-802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiCOG0249.
GeneTreeiENSGT00550000074977.
HOVERGENiHBG001449.
InParanoidiO43196.
KOiK08741.
OMAiVESHAFM.
PhylomeDBiO43196.
TreeFamiTF314549.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43196-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLGANPRR TPQGPRPGAA SSGFPSPAPV PGPREAEEEE VEEEEELAEI
60 70 80 90 100
HLCVLWNSGY LGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV
110 120 130 140 150
VTSAKQDENM TRFLGKLASQ EHREPKRPEI IFLPSVDFGL EISKQRLLSG
160 170 180 190 200
NYSFIPDAMT ATEKILFLSS IIPFDCLLTV RALGGLLKFL GRRRIGVELE
210 220 230 240 250
DYNVSVPILG FKKFMLTHLV NIDQDTYSVL QIFKSESHPS VYKVASGLKE
260 270 280 290 300
GLSLFGILNR CHCKWGEKLL RLWFTRPTHD LGELSSRLDV IQFFLLPQNL
310 320 330 340 350
DMAQMLHRLL GHIKNVPLIL KRMKLSHTKV SDWQVLYKTV YSALGLRDAC
360 370 380 390 400
RSLPQSIQLF RDIAQEFSDD LHHIASLIGK VVDFEGSLAE NRFTVLPNID
410 420 430 440 450
PEIDEKKRRL MGLPSFLTEV ARKELENLDS RIPSCSVIYI PLIGFLLSIP
460 470 480 490 500
RLPSMVEASD FEINGLDFMF LSEEKLHYRS ARTKELDALL GDLHCEIRDQ
510 520 530 540 550
ETLLMYQLQC QVLARAAVLT RVLDLASRLD VLLALASAAR DYGYSRPRYS
560 570 580 590 600
PQVLGVRIQN GRHPLMELCA RTFVPNSTEC GGDKGRVKVI TGPNSSGKSI
610 620 630 640 650
YLKQVGLITF MALVGSFVPA EEAEIGAVDA IFTRIHSCES ISLGLSTFMI
660 670 680 690 700
DLNQVAKAVN NATAQSLVLI DEFGKGTNTV DGLALLAAVL RHWLARGPTC
710 720 730 740 750
PHIFVATNFL SLVQLQLLPQ GPLVQYLTME TCEDGNDLVF FYQVCEGVAK
760 770 780 790 800
ASHASHTAAQ AGLPDKLVAR GKEVSDLIRS GKPIKPVKDL LKKNQMENCQ
810 820 830
TLVDKFMKLD LEDPNLDLNV FMSQEVLPAA TSIL
Length:834
Mass (Da):92,875
Last modified:June 1, 1998 - v1
Checksum:i89E747F5361870E2
GO
Isoform 2 (identifier: O43196-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     654-654: Q → QQ

Show »
Length:835
Mass (Da):93,004
Checksum:i242182205EEF15D2
GO
Isoform 3 (identifier: O43196-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: T → TPPGDLRFTPIPLLIPSQ

Note: No experimental confirmation available.

Show »
Length:851
Mass (Da):94,719
Checksum:i5B1AEE179D863E41
GO
Isoform 4 (identifier: O43196-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: T → TPPGDLRFTPIPLLIPSQ
     654-654: Q → QQ
     745-774: Missing.

Note: No experimental confirmation available.

Show »
Length:822
Mass (Da):91,862
Checksum:i1D4A762D52173D03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti764 – 7641P → L in AAC62533. (PubMed:9740671)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291P → S.1 Publication
Corresponds to variant rs2075789 [ dbSNP | Ensembl ].
VAR_025082
Natural varianti85 – 851L → F.1 Publication
Corresponds to variant rs28381349 [ dbSNP | Ensembl ].
VAR_025083
Natural varianti202 – 2021Y → C.1 Publication
Corresponds to variant rs28381358 [ dbSNP | Ensembl ].
VAR_025084
Natural varianti206 – 2061V → F.1 Publication
Corresponds to variant rs28381359 [ dbSNP | Ensembl ].
VAR_025085
Natural varianti351 – 3511R → G.1 Publication
Corresponds to variant rs28399976 [ dbSNP | Ensembl ].
VAR_025086
Natural varianti377 – 3771L → F.1 Publication
Corresponds to variant rs28399977 [ dbSNP | Ensembl ].
VAR_025087
Natural varianti786 – 7861P → S.1 Publication
Corresponds to variant rs1802127 [ dbSNP | Ensembl ].
VAR_025088

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei179 – 1791T → TPPGDLRFTPIPLLIPSQ in isoform 3 and isoform 4. 1 PublicationVSP_017113
Alternative sequencei654 – 6541Q → QQ in isoform 2 and isoform 4. 2 PublicationsVSP_017114
Alternative sequencei745 – 77430Missing in isoform 4. 1 PublicationVSP_017115Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048986 mRNA. Translation: AAC62533.1.
AF048991
, AF048988, AF048989, AF048990 Genomic DNA. Translation: AAC62534.1.
AF034759 mRNA. Translation: AAB87632.1.
AF070071 mRNA. Translation: AAC70066.1.
AF070079
, AF070072, AF070073, AF070074, AF070075, AF070076, AF070077, AF070078 Genomic DNA. Translation: AAC70067.1.
BT007200 mRNA. Translation: AAP35864.1.
AY943816 Genomic DNA. Translation: AAX20111.1.
BA000025 Genomic DNA. Translation: BAB63375.1.
AF129756 Genomic DNA. Translation: AAD18072.1.
AF134726 Genomic DNA. Translation: AAD21822.1.
AL662834 Genomic DNA. Translation: CAI17723.1.
AL662834 Genomic DNA. Translation: CAI17724.1.
AL662899 Genomic DNA. Translation: CAI18423.1.
AL662899 Genomic DNA. Translation: CAI18424.1.
CR936239, CR925765 Genomic DNA. Translation: CAQ08900.1.
CR936239, CR925765 Genomic DNA. Translation: CAQ08901.1.
CR759787 Genomic DNA. Translation: CAQ10116.1.
CR759787 Genomic DNA. Translation: CAQ10117.1.
CR925765, CR936239 Genomic DNA. Translation: CAQ10619.1.
CR925765, CR936239 Genomic DNA. Translation: CAQ10620.1.
CH471081 Genomic DNA. Translation: EAX03512.1.
CH471081 Genomic DNA. Translation: EAX03514.1.
BC001358 mRNA. Translation: AAH01358.1.
BC002498 mRNA. Translation: AAH02498.1.
BC041031 mRNA. Translation: AAH41031.1.
CCDSiCCDS34409.2. [O43196-4]
CCDS34410.1. [O43196-2]
CCDS4720.1. [O43196-1]
RefSeqiNP_002432.1. NM_002441.4. [O43196-1]
NP_079535.4. NM_025259.5. [O43196-4]
NP_751897.1. NM_172165.3. [O43196-2]
NP_751898.1. NM_172166.3. [O43196-1]
UniGeneiHs.647011.

Genome annotation databases

EnsembliENST00000375703; ENSP00000364855; ENSG00000204410. [O43196-2]
ENST00000375740; ENSP00000364892; ENSG00000204410. [O43196-4]
ENST00000375750; ENSP00000364903; ENSG00000204410. [O43196-1]
ENST00000375755; ENSP00000364908; ENSG00000204410. [O43196-1]
ENST00000412070; ENSP00000404892; ENSG00000230961.
ENST00000416549; ENSP00000399721; ENSG00000235222. [O43196-1]
ENST00000419269; ENSP00000394649; ENSG00000235222. [O43196-2]
ENST00000420731; ENSP00000400187; ENSG00000230961.
ENST00000427735; ENSP00000388037; ENSG00000230293. [O43196-1]
ENST00000435700; ENSP00000407047; ENSG00000230293. [O43196-2]
ENST00000436091; ENSP00000396509; ENSG00000230961.
ENST00000436192; ENSP00000406868; ENSG00000227314. [O43196-2]
ENST00000441395; ENSP00000402659; ENSG00000227314. [O43196-1]
ENST00000441401; ENSP00000406269; ENSG00000227314. [O43196-1]
ENST00000448617; ENSP00000387609; ENSG00000227314. [O43196-4]
ENST00000456839; ENSP00000394017; ENSG00000235222. [O43196-1]
ENST00000457742; ENSP00000409181; ENSG00000230293. [O43196-1]
GeneIDi4439.
KEGGihsa:4439.
UCSCiuc003nwu.2. human. [O43196-2]
uc003nwv.2. human. [O43196-1]
uc003nwx.2. human. [O43196-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF048986 mRNA. Translation: AAC62533.1 .
AF048991
, AF048988 , AF048989 , AF048990 Genomic DNA. Translation: AAC62534.1 .
AF034759 mRNA. Translation: AAB87632.1 .
AF070071 mRNA. Translation: AAC70066.1 .
AF070079
, AF070072 , AF070073 , AF070074 , AF070075 , AF070076 , AF070077 , AF070078 Genomic DNA. Translation: AAC70067.1 .
BT007200 mRNA. Translation: AAP35864.1 .
AY943816 Genomic DNA. Translation: AAX20111.1 .
BA000025 Genomic DNA. Translation: BAB63375.1 .
AF129756 Genomic DNA. Translation: AAD18072.1 .
AF134726 Genomic DNA. Translation: AAD21822.1 .
AL662834 Genomic DNA. Translation: CAI17723.1 .
AL662834 Genomic DNA. Translation: CAI17724.1 .
AL662899 Genomic DNA. Translation: CAI18423.1 .
AL662899 Genomic DNA. Translation: CAI18424.1 .
CR936239 , CR925765 Genomic DNA. Translation: CAQ08900.1 .
CR936239 , CR925765 Genomic DNA. Translation: CAQ08901.1 .
CR759787 Genomic DNA. Translation: CAQ10116.1 .
CR759787 Genomic DNA. Translation: CAQ10117.1 .
CR925765 , CR936239 Genomic DNA. Translation: CAQ10619.1 .
CR925765 , CR936239 Genomic DNA. Translation: CAQ10620.1 .
CH471081 Genomic DNA. Translation: EAX03512.1 .
CH471081 Genomic DNA. Translation: EAX03514.1 .
BC001358 mRNA. Translation: AAH01358.1 .
BC002498 mRNA. Translation: AAH02498.1 .
BC041031 mRNA. Translation: AAH41031.1 .
CCDSi CCDS34409.2. [O43196-4 ]
CCDS34410.1. [O43196-2 ]
CCDS4720.1. [O43196-1 ]
RefSeqi NP_002432.1. NM_002441.4. [O43196-1 ]
NP_079535.4. NM_025259.5. [O43196-4 ]
NP_751897.1. NM_172165.3. [O43196-2 ]
NP_751898.1. NM_172166.3. [O43196-1 ]
UniGenei Hs.647011.

3D structure databases

ProteinModelPortali O43196.
SMRi O43196. Positions 178-802.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110576. 4 interactions.
IntActi O43196. 3 interactions.
MINTi MINT-2999175.
STRINGi 9606.ENSP00000364894.

PTM databases

PhosphoSitei O43196.

Proteomic databases

MaxQBi O43196.
PaxDbi O43196.
PRIDEi O43196.

Protocols and materials databases

DNASUi 4439.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375703 ; ENSP00000364855 ; ENSG00000204410 . [O43196-2 ]
ENST00000375740 ; ENSP00000364892 ; ENSG00000204410 . [O43196-4 ]
ENST00000375750 ; ENSP00000364903 ; ENSG00000204410 . [O43196-1 ]
ENST00000375755 ; ENSP00000364908 ; ENSG00000204410 . [O43196-1 ]
ENST00000412070 ; ENSP00000404892 ; ENSG00000230961 .
ENST00000416549 ; ENSP00000399721 ; ENSG00000235222 . [O43196-1 ]
ENST00000419269 ; ENSP00000394649 ; ENSG00000235222 . [O43196-2 ]
ENST00000420731 ; ENSP00000400187 ; ENSG00000230961 .
ENST00000427735 ; ENSP00000388037 ; ENSG00000230293 . [O43196-1 ]
ENST00000435700 ; ENSP00000407047 ; ENSG00000230293 . [O43196-2 ]
ENST00000436091 ; ENSP00000396509 ; ENSG00000230961 .
ENST00000436192 ; ENSP00000406868 ; ENSG00000227314 . [O43196-2 ]
ENST00000441395 ; ENSP00000402659 ; ENSG00000227314 . [O43196-1 ]
ENST00000441401 ; ENSP00000406269 ; ENSG00000227314 . [O43196-1 ]
ENST00000448617 ; ENSP00000387609 ; ENSG00000227314 . [O43196-4 ]
ENST00000456839 ; ENSP00000394017 ; ENSG00000235222 . [O43196-1 ]
ENST00000457742 ; ENSP00000409181 ; ENSG00000230293 . [O43196-1 ]
GeneIDi 4439.
KEGGi hsa:4439.
UCSCi uc003nwu.2. human. [O43196-2 ]
uc003nwv.2. human. [O43196-1 ]
uc003nwx.2. human. [O43196-4 ]

Organism-specific databases

CTDi 4439.
GeneCardsi GC06P031707.
GC06Pj31696.
GC06Pk31690.
GC06Pl31747.
GC06Pm31785.
H-InvDB HIX0165917.
HIX0166738.
HIX0167237.
HIX0167372.
HGNCi HGNC:7328. MSH5.
MIMi 603382. gene.
neXtProti NX_O43196.
PharmGKBi PA31136.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0249.
GeneTreei ENSGT00550000074977.
HOVERGENi HBG001449.
InParanoidi O43196.
KOi K08741.
OMAi VESHAFM.
PhylomeDBi O43196.
TreeFami TF314549.

Enzyme and pathway databases

Reactomei REACT_27271. Meiotic recombination.

Miscellaneous databases

ChiTaRSi MSH5. human.
GeneWikii MSH5.
GenomeRNAii 4439.
NextBioi 17301.
PROi O43196.
SOURCEi Search...

Gene expression databases

Bgeei O43196.
CleanExi HS_MSH5.
ExpressionAtlasi O43196. baseline.
Genevestigatori O43196.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view ]
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene."
    Her C., Doggett N.A.
    Genomics 52:50-61(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis."
    Bocker T., Barusevicius A., Snowden T., Rasio D., Guerrette S., Robbins D., Schmidt C., Burczak J., Croce C.M., Copeland T., Kovatich A.J., Fishel R.
    Cancer Res. 59:816-822(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene."
    Winand N.J., Panzer J.A., Kolodner R.D.
    Genomics 53:69-80(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. NIEHS SNPs program
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-29; PHE-85; CYS-202; PHE-206; GLY-351; PHE-377 AND SER-786.
  6. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Hirakawa M., Yamaguchi H., Imai K., Shimada J., Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Kidney and Skin.
  11. "Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells."
    Kato T., Sato N., Hayama S., Yamabuki T., Ito T., Miyamoto M., Kondo S., Nakamura Y., Daigo Y.
    Cancer Res. 67:8544-8553(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HJURP.

Entry informationi

Entry nameiMSH5_HUMAN
AccessioniPrimary (citable) accession number: O43196
Secondary accession number(s): B0V033
, B0V034, O60586, Q5BLU9, Q5SSR1, Q8IW44, Q9BQC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3