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O43196

- MSH5_HUMAN

UniProt

O43196 - MSH5_HUMAN

Protein

MutS protein homolog 5

Gene

MSH5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi592 – 5998ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA-dependent ATPase activity Source: RefGenome
    3. mismatched DNA binding Source: RefGenome
    4. protein binding Source: IntAct

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. chiasma assembly Source: RefGenome
    3. homologous chromosome segregation Source: RefGenome
    4. meiotic nuclear division Source: ProtInc
    5. meiotic prophase II Source: ProtInc
    6. mismatch repair Source: ProtInc
    7. reciprocal meiotic recombination Source: RefGenome

    Keywords - Biological processi

    Meiosis

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_27271. Meiotic recombination.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MutS protein homolog 5
    Short name:
    hMSH5
    Gene namesi
    Name:MSH5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:7328. MSH5.

    Subcellular locationi

    GO - Cellular componenti

    1. synaptonemal complex Source: RefGenome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31136.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834MutS protein homolog 5PRO_0000115202Add
    BLAST

    Proteomic databases

    MaxQBiO43196.
    PaxDbiO43196.
    PRIDEiO43196.

    PTM databases

    PhosphoSiteiO43196.

    Expressioni

    Tissue specificityi

    Ubiquitous, but highly expressed in testis, and thymus.

    Gene expression databases

    BgeeiO43196.
    CleanExiHS_MSH5.
    GenevestigatoriO43196.

    Interactioni

    Subunit structurei

    Heterooligomer of MSH4 and MSH5. Interacts with HJURP.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABL1P0051910EBI-6092730,EBI-375543
    MSH4O154575EBI-6092730,EBI-6092777

    Protein-protein interaction databases

    BioGridi110576. 4 interactions.
    IntActiO43196. 3 interactions.
    MINTiMINT-2999175.
    STRINGi9606.ENSP00000364894.

    Structurei

    3D structure databases

    ProteinModelPortaliO43196.
    SMRiO43196. Positions 178-802.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family.Curated

    Phylogenomic databases

    eggNOGiCOG0249.
    HOVERGENiHBG001449.
    KOiK08741.
    OMAiVESHAFM.
    PhylomeDBiO43196.
    TreeFamiTF314549.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view]
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43196-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASLGANPRR TPQGPRPGAA SSGFPSPAPV PGPREAEEEE VEEEEELAEI    50
    HLCVLWNSGY LGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV 100
    VTSAKQDENM TRFLGKLASQ EHREPKRPEI IFLPSVDFGL EISKQRLLSG 150
    NYSFIPDAMT ATEKILFLSS IIPFDCLLTV RALGGLLKFL GRRRIGVELE 200
    DYNVSVPILG FKKFMLTHLV NIDQDTYSVL QIFKSESHPS VYKVASGLKE 250
    GLSLFGILNR CHCKWGEKLL RLWFTRPTHD LGELSSRLDV IQFFLLPQNL 300
    DMAQMLHRLL GHIKNVPLIL KRMKLSHTKV SDWQVLYKTV YSALGLRDAC 350
    RSLPQSIQLF RDIAQEFSDD LHHIASLIGK VVDFEGSLAE NRFTVLPNID 400
    PEIDEKKRRL MGLPSFLTEV ARKELENLDS RIPSCSVIYI PLIGFLLSIP 450
    RLPSMVEASD FEINGLDFMF LSEEKLHYRS ARTKELDALL GDLHCEIRDQ 500
    ETLLMYQLQC QVLARAAVLT RVLDLASRLD VLLALASAAR DYGYSRPRYS 550
    PQVLGVRIQN GRHPLMELCA RTFVPNSTEC GGDKGRVKVI TGPNSSGKSI 600
    YLKQVGLITF MALVGSFVPA EEAEIGAVDA IFTRIHSCES ISLGLSTFMI 650
    DLNQVAKAVN NATAQSLVLI DEFGKGTNTV DGLALLAAVL RHWLARGPTC 700
    PHIFVATNFL SLVQLQLLPQ GPLVQYLTME TCEDGNDLVF FYQVCEGVAK 750
    ASHASHTAAQ AGLPDKLVAR GKEVSDLIRS GKPIKPVKDL LKKNQMENCQ 800
    TLVDKFMKLD LEDPNLDLNV FMSQEVLPAA TSIL 834
    Length:834
    Mass (Da):92,875
    Last modified:June 1, 1998 - v1
    Checksum:i89E747F5361870E2
    GO
    Isoform 2 (identifier: O43196-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         654-654: Q → QQ

    Show »
    Length:835
    Mass (Da):93,004
    Checksum:i242182205EEF15D2
    GO
    Isoform 3 (identifier: O43196-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         179-179: T → TPPGDLRFTPIPLLIPSQ

    Note: No experimental confirmation available.

    Show »
    Length:851
    Mass (Da):94,719
    Checksum:i5B1AEE179D863E41
    GO
    Isoform 4 (identifier: O43196-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         179-179: T → TPPGDLRFTPIPLLIPSQ
         654-654: Q → QQ
         745-774: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:822
    Mass (Da):91,862
    Checksum:i1D4A762D52173D03
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti764 – 7641P → L in AAC62533. (PubMed:9740671)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291P → S.1 Publication
    Corresponds to variant rs2075789 [ dbSNP | Ensembl ].
    VAR_025082
    Natural varianti85 – 851L → F.1 Publication
    Corresponds to variant rs28381349 [ dbSNP | Ensembl ].
    VAR_025083
    Natural varianti202 – 2021Y → C.1 Publication
    Corresponds to variant rs28381358 [ dbSNP | Ensembl ].
    VAR_025084
    Natural varianti206 – 2061V → F.1 Publication
    Corresponds to variant rs28381359 [ dbSNP | Ensembl ].
    VAR_025085
    Natural varianti351 – 3511R → G.1 Publication
    Corresponds to variant rs28399976 [ dbSNP | Ensembl ].
    VAR_025086
    Natural varianti377 – 3771L → F.1 Publication
    Corresponds to variant rs28399977 [ dbSNP | Ensembl ].
    VAR_025087
    Natural varianti786 – 7861P → S.1 Publication
    Corresponds to variant rs1802127 [ dbSNP | Ensembl ].
    VAR_025088

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei179 – 1791T → TPPGDLRFTPIPLLIPSQ in isoform 3 and isoform 4. 1 PublicationVSP_017113
    Alternative sequencei654 – 6541Q → QQ in isoform 2 and isoform 4. 2 PublicationsVSP_017114
    Alternative sequencei745 – 77430Missing in isoform 4. 1 PublicationVSP_017115Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF048986 mRNA. Translation: AAC62533.1.
    AF048991
    , AF048988, AF048989, AF048990 Genomic DNA. Translation: AAC62534.1.
    AF034759 mRNA. Translation: AAB87632.1.
    AF070071 mRNA. Translation: AAC70066.1.
    AF070079
    , AF070072, AF070073, AF070074, AF070075, AF070076, AF070077, AF070078 Genomic DNA. Translation: AAC70067.1.
    BT007200 mRNA. Translation: AAP35864.1.
    AY943816 Genomic DNA. Translation: AAX20111.1.
    BA000025 Genomic DNA. Translation: BAB63375.1.
    AF129756 Genomic DNA. Translation: AAD18072.1.
    AF134726 Genomic DNA. Translation: AAD21822.1.
    AL662834 Genomic DNA. Translation: CAI17723.1.
    AL662834 Genomic DNA. Translation: CAI17724.1.
    AL662899 Genomic DNA. Translation: CAI18423.1.
    AL662899 Genomic DNA. Translation: CAI18424.1.
    CR936239, CR925765 Genomic DNA. Translation: CAQ08900.1.
    CR936239, CR925765 Genomic DNA. Translation: CAQ08901.1.
    CR759787 Genomic DNA. Translation: CAQ10116.1.
    CR759787 Genomic DNA. Translation: CAQ10117.1.
    CR925765, CR936239 Genomic DNA. Translation: CAQ10619.1.
    CR925765, CR936239 Genomic DNA. Translation: CAQ10620.1.
    CH471081 Genomic DNA. Translation: EAX03512.1.
    CH471081 Genomic DNA. Translation: EAX03514.1.
    BC001358 mRNA. Translation: AAH01358.1.
    BC002498 mRNA. Translation: AAH02498.1.
    BC041031 mRNA. Translation: AAH41031.1.
    CCDSiCCDS34409.2. [O43196-4]
    CCDS34410.1. [O43196-2]
    CCDS4720.1. [O43196-1]
    RefSeqiNP_002432.1. NM_002441.4. [O43196-1]
    NP_079535.4. NM_025259.5. [O43196-4]
    NP_751897.1. NM_172165.3. [O43196-2]
    NP_751898.1. NM_172166.3. [O43196-1]
    UniGeneiHs.647011.

    Genome annotation databases

    EnsembliENST00000375703; ENSP00000364855; ENSG00000204410. [O43196-2]
    ENST00000375740; ENSP00000364892; ENSG00000204410. [O43196-4]
    ENST00000375750; ENSP00000364903; ENSG00000204410. [O43196-1]
    ENST00000375755; ENSP00000364908; ENSG00000204410. [O43196-1]
    ENST00000412070; ENSP00000404892; ENSG00000230961.
    ENST00000416549; ENSP00000399721; ENSG00000235222. [O43196-1]
    ENST00000419269; ENSP00000394649; ENSG00000235222. [O43196-2]
    ENST00000420731; ENSP00000400187; ENSG00000230961.
    ENST00000427735; ENSP00000388037; ENSG00000230293. [O43196-1]
    ENST00000435700; ENSP00000407047; ENSG00000230293. [O43196-2]
    ENST00000436091; ENSP00000396509; ENSG00000230961.
    ENST00000436192; ENSP00000406868; ENSG00000227314. [O43196-2]
    ENST00000441395; ENSP00000402659; ENSG00000227314. [O43196-1]
    ENST00000441401; ENSP00000406269; ENSG00000227314. [O43196-1]
    ENST00000448617; ENSP00000387609; ENSG00000227314. [O43196-4]
    ENST00000456839; ENSP00000394017; ENSG00000235222. [O43196-1]
    ENST00000457742; ENSP00000409181; ENSG00000230293. [O43196-1]
    GeneIDi4439.
    KEGGihsa:4439.
    UCSCiuc003nwu.2. human. [O43196-2]
    uc003nwv.2. human. [O43196-1]
    uc003nwx.2. human. [O43196-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF048986 mRNA. Translation: AAC62533.1 .
    AF048991
    , AF048988 , AF048989 , AF048990 Genomic DNA. Translation: AAC62534.1 .
    AF034759 mRNA. Translation: AAB87632.1 .
    AF070071 mRNA. Translation: AAC70066.1 .
    AF070079
    , AF070072 , AF070073 , AF070074 , AF070075 , AF070076 , AF070077 , AF070078 Genomic DNA. Translation: AAC70067.1 .
    BT007200 mRNA. Translation: AAP35864.1 .
    AY943816 Genomic DNA. Translation: AAX20111.1 .
    BA000025 Genomic DNA. Translation: BAB63375.1 .
    AF129756 Genomic DNA. Translation: AAD18072.1 .
    AF134726 Genomic DNA. Translation: AAD21822.1 .
    AL662834 Genomic DNA. Translation: CAI17723.1 .
    AL662834 Genomic DNA. Translation: CAI17724.1 .
    AL662899 Genomic DNA. Translation: CAI18423.1 .
    AL662899 Genomic DNA. Translation: CAI18424.1 .
    CR936239 , CR925765 Genomic DNA. Translation: CAQ08900.1 .
    CR936239 , CR925765 Genomic DNA. Translation: CAQ08901.1 .
    CR759787 Genomic DNA. Translation: CAQ10116.1 .
    CR759787 Genomic DNA. Translation: CAQ10117.1 .
    CR925765 , CR936239 Genomic DNA. Translation: CAQ10619.1 .
    CR925765 , CR936239 Genomic DNA. Translation: CAQ10620.1 .
    CH471081 Genomic DNA. Translation: EAX03512.1 .
    CH471081 Genomic DNA. Translation: EAX03514.1 .
    BC001358 mRNA. Translation: AAH01358.1 .
    BC002498 mRNA. Translation: AAH02498.1 .
    BC041031 mRNA. Translation: AAH41031.1 .
    CCDSi CCDS34409.2. [O43196-4 ]
    CCDS34410.1. [O43196-2 ]
    CCDS4720.1. [O43196-1 ]
    RefSeqi NP_002432.1. NM_002441.4. [O43196-1 ]
    NP_079535.4. NM_025259.5. [O43196-4 ]
    NP_751897.1. NM_172165.3. [O43196-2 ]
    NP_751898.1. NM_172166.3. [O43196-1 ]
    UniGenei Hs.647011.

    3D structure databases

    ProteinModelPortali O43196.
    SMRi O43196. Positions 178-802.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110576. 4 interactions.
    IntActi O43196. 3 interactions.
    MINTi MINT-2999175.
    STRINGi 9606.ENSP00000364894.

    PTM databases

    PhosphoSitei O43196.

    Proteomic databases

    MaxQBi O43196.
    PaxDbi O43196.
    PRIDEi O43196.

    Protocols and materials databases

    DNASUi 4439.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375703 ; ENSP00000364855 ; ENSG00000204410 . [O43196-2 ]
    ENST00000375740 ; ENSP00000364892 ; ENSG00000204410 . [O43196-4 ]
    ENST00000375750 ; ENSP00000364903 ; ENSG00000204410 . [O43196-1 ]
    ENST00000375755 ; ENSP00000364908 ; ENSG00000204410 . [O43196-1 ]
    ENST00000412070 ; ENSP00000404892 ; ENSG00000230961 .
    ENST00000416549 ; ENSP00000399721 ; ENSG00000235222 . [O43196-1 ]
    ENST00000419269 ; ENSP00000394649 ; ENSG00000235222 . [O43196-2 ]
    ENST00000420731 ; ENSP00000400187 ; ENSG00000230961 .
    ENST00000427735 ; ENSP00000388037 ; ENSG00000230293 . [O43196-1 ]
    ENST00000435700 ; ENSP00000407047 ; ENSG00000230293 . [O43196-2 ]
    ENST00000436091 ; ENSP00000396509 ; ENSG00000230961 .
    ENST00000436192 ; ENSP00000406868 ; ENSG00000227314 . [O43196-2 ]
    ENST00000441395 ; ENSP00000402659 ; ENSG00000227314 . [O43196-1 ]
    ENST00000441401 ; ENSP00000406269 ; ENSG00000227314 . [O43196-1 ]
    ENST00000448617 ; ENSP00000387609 ; ENSG00000227314 . [O43196-4 ]
    ENST00000456839 ; ENSP00000394017 ; ENSG00000235222 . [O43196-1 ]
    ENST00000457742 ; ENSP00000409181 ; ENSG00000230293 . [O43196-1 ]
    GeneIDi 4439.
    KEGGi hsa:4439.
    UCSCi uc003nwu.2. human. [O43196-2 ]
    uc003nwv.2. human. [O43196-1 ]
    uc003nwx.2. human. [O43196-4 ]

    Organism-specific databases

    CTDi 4439.
    GeneCardsi GC06P031707.
    GC06Pj31696.
    GC06Pk31690.
    GC06Pm31785.
    H-InvDB HIX0165917.
    HIX0166738.
    HIX0167237.
    HIX0167372.
    HGNCi HGNC:7328. MSH5.
    MIMi 603382. gene.
    neXtProti NX_O43196.
    PharmGKBi PA31136.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0249.
    HOVERGENi HBG001449.
    KOi K08741.
    OMAi VESHAFM.
    PhylomeDBi O43196.
    TreeFami TF314549.

    Enzyme and pathway databases

    Reactomei REACT_27271. Meiotic recombination.

    Miscellaneous databases

    ChiTaRSi MSH5. human.
    GeneWikii MSH5.
    GenomeRNAii 4439.
    NextBioi 17301.
    PROi O43196.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43196.
    CleanExi HS_MSH5.
    Genevestigatori O43196.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view ]
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene."
      Her C., Doggett N.A.
      Genomics 52:50-61(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis."
      Bocker T., Barusevicius A., Snowden T., Rasio D., Guerrette S., Robbins D., Schmidt C., Burczak J., Croce C.M., Copeland T., Kovatich A.J., Fishel R.
      Cancer Res. 59:816-822(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene."
      Winand N.J., Panzer J.A., Kolodner R.D.
      Genomics 53:69-80(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. NIEHS SNPs program
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-29; PHE-85; CYS-202; PHE-206; GLY-351; PHE-377 AND SER-786.
    6. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Hirakawa M., Yamaguchi H., Imai K., Shimada J., Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
      Tissue: Kidney and Skin.
    11. "Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells."
      Kato T., Sato N., Hayama S., Yamabuki T., Ito T., Miyamoto M., Kondo S., Nakamura Y., Daigo Y.
      Cancer Res. 67:8544-8553(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HJURP.

    Entry informationi

    Entry nameiMSH5_HUMAN
    AccessioniPrimary (citable) accession number: O43196
    Secondary accession number(s): B0V033
    , B0V034, O60586, Q5BLU9, Q5SSR1, Q8IW44, Q9BQC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3