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Protein

G-protein coupled receptor 39

Gene

GPR39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Zn2+ acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17Zinc1 Publication1
Metal bindingi19Zinc1 Publication1

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 39
Gene namesi
Name:GPR39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000183840.6.
HGNCiHGNC:4496. GPR39.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularBy similarityAdd BLAST34
Transmembranei35 – 55Helical; Name=1By similarityAdd BLAST21
Topological domaini56 – 69CytoplasmicBy similarityAdd BLAST14
Transmembranei70 – 89Helical; Name=2By similarityAdd BLAST20
Topological domaini90 – 109ExtracellularBy similarityAdd BLAST20
Transmembranei110 – 131Helical; Name=3By similarityAdd BLAST22
Topological domaini132 – 151CytoplasmicBy similarityAdd BLAST20
Transmembranei152 – 172Helical; Name=4By similarityAdd BLAST21
Topological domaini173 – 217ExtracellularBy similarityAdd BLAST45
Transmembranei218 – 242Helical; Name=5By similarityAdd BLAST25
Topological domaini243 – 283CytoplasmicBy similarityAdd BLAST41
Transmembranei284 – 305Helical; Name=6By similarityAdd BLAST22
Topological domaini306 – 323ExtracellularBy similarityAdd BLAST18
Transmembranei324 – 344Helical; Name=7By similarityAdd BLAST21
Topological domaini345 – 453CytoplasmicBy similarityAdd BLAST109

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi17H → A: Decreases activation by Zn(2+). Abolishes activation by Zn(2+); when associated with A-19. 1 Publication1
Mutagenesisi19H → A: Decreases activation by Zn(2+). Abolishes activation by Zn(2+); when associated with A-17. 1 Publication1
Mutagenesisi312H → A: Not affect constitutive or Zn(2+)-induced activation. 1 Publication1
Mutagenesisi313D → A: Induces very high constitutive activity and eliminates Zn(2+)-induced activation. 1 Publication1

Organism-specific databases

DisGeNETi2863.
OpenTargetsiENSG00000183840.
PharmGKBiPA28885.

Chemistry databases

ChEMBLiCHEMBL3091266.
GuidetoPHARMACOLOGYi105.

Polymorphism and mutation databases

BioMutaiGPR39.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695651 – 453G-protein coupled receptor 39Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 191PROSITE-ProRule annotation1 Publication
Disulfide bondi108 ↔ 210PROSITE-ProRule annotation1 Publication
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei396PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO43194.
PaxDbiO43194.
PeptideAtlasiO43194.
PRIDEiO43194.

PTM databases

iPTMnetiO43194.
PhosphoSitePlusiO43194.
SwissPalmiO43194.

Expressioni

Tissue specificityi

Expressed in many tissues, including the stomach, intestine and hypothalamus.1 Publication

Gene expression databases

BgeeiENSG00000183840.
CleanExiHS_GPR39.
ExpressionAtlasiO43194. baseline and differential.
GenevisibleiO43194. HS.

Organism-specific databases

HPAiHPA022111.

Interactioni

Protein-protein interaction databases

BioGridi109121. 1 interactor.
IntActiO43194. 1 interactor.
MINTiMINT-8247496.
STRINGi9606.ENSP00000327417.

Chemistry databases

BindingDBiO43194.

Structurei

3D structure databases

ProteinModelPortaliO43194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000077769.
HOVERGENiHBG051809.
InParanoidiO43194.
KOiK08412.
OMAiLFAMGTE.
OrthoDBiEOG091G06JQ.
PhylomeDBiO43194.
TreeFamiTF331140.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O43194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSLPGSD CSQIIDHSHV PEFEVATWIK ITLILVYLII FVMGLLGNSA
60 70 80 90 100
TIRVTQVLQK KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT
110 120 130 140 150
TSSYTLSCKL HTFLFEACSY ATLLHVLTLS FERYIAICHP FRYKAVSGPC
160 170 180 190 200
QVKLLIGFVW VTSALVALPL LFAMGTEYPL VNVPSHRGLT CNRSSTRHHE
210 220 230 240 250
QPETSNMSIC TNLSSRWTVF QSSIFGAFVV YLVVLLSVAF MCWNMMQVLM
260 270 280 290 300
KSQKGSLAGG TRPPQLRKSE SEESRTARRQ TIIFLRLIVV TLAVCWMPNQ
310 320 330 340 350
IRRIMAAAKP KHDWTRSYFR AYMILLPFSE TFFYLSSVIN PLLYTVSSQQ
360 370 380 390 400
FRRVFVQVLC CRLSLQHANH EKRLRVHAHS TTDSARFVQR PLLFASRRQS
410 420 430 440 450
SARRTEKIFL STFQSEAEPQ SKSQSLSLES LEPNSGAKPA NSAAENGFQE

HEV
Length:453
Mass (Da):51,329
Last modified:June 1, 1998 - v1
Checksum:i8E3A233420D9021E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02206750A → V1 PublicationCorresponds to variant dbSNP:rs2241764Ensembl.1
Natural variantiVAR_049393390R → C. Corresponds to variant dbSNP:rs16838944Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034633 mRNA. Translation: AAC26082.1.
FJ348258 mRNA. Translation: ACI96302.1.
AK314895 mRNA. Translation: BAG37409.1.
AC098800 Genomic DNA. Translation: AAY24154.1.
AC079773 Genomic DNA. No translation available.
BC125046 mRNA. Translation: AAI25047.1.
CCDSiCCDS2170.1.
RefSeqiNP_001499.1. NM_001508.2.
UniGeneiHs.432395.
Hs.744392.

Genome annotation databases

EnsembliENST00000329321; ENSP00000327417; ENSG00000183840.
GeneIDi2863.
KEGGihsa:2863.
UCSCiuc002ttl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGPR39_HUMAN
AccessioniPrimary (citable) accession number: O43194
Secondary accession number(s): B2RC12
, B6V9G4, Q08AS2, Q53R01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families