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O43193

- MTLR_HUMAN

UniProt

O43193 - MTLR_HUMAN

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Protein

Motilin receptor

Gene
MLNR, GPR38, MTLR, MTLR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for motilin.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. growth hormone-releasing hormone receptor activity Source: InterPro

GO - Biological processi

  1. digestion Source: ProtInc
  2. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Motilin receptor
Alternative name(s):
G-protein coupled receptor 38
Gene namesi
Name:MLNR
Synonyms:GPR38, MTLR, MTLR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:4495. MLNR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Extracellular Reviewed predictionAdd
BLAST
Transmembranei36 – 5621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini57 – 7418Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei75 – 9420Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini95 – 11218Extracellular Reviewed predictionAdd
BLAST
Transmembranei113 – 13422Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini135 – 15723Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei158 – 17821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini179 – 24668Extracellular Reviewed predictionAdd
BLAST
Transmembranei247 – 27024Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini271 – 29828Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei299 – 32022Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini321 – 33414Extracellular Reviewed predictionAdd
BLAST
Transmembranei335 – 35824Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini359 – 41254Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Motilin receptorPRO_0000069860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi111 ↔ 235 By similarity
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43193.
PRIDEiO43193.

PTM databases

PhosphoSiteiO43193.

Expressioni

Tissue specificityi

Expressed only in thyroid, stomach, and bone marrow.

Gene expression databases

BgeeiO43193.
CleanExiHS_MLNR.
GenevestigatoriO43193.

Interactioni

Protein-protein interaction databases

BioGridi109120. 1 interaction.
STRINGi9606.ENSP00000218721.

Structurei

3D structure databases

ProteinModelPortaliO43193.
SMRiO43193. Positions 39-405.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303294.
HOGENOMiHOG000272571.
HOVERGENiHBG006538.
InParanoidiO43193.
KOiK05266.
OMAiDSRMMYF.
OrthoDBiEOG7992QV.
PhylomeDBiO43193.
TreeFamiTF336314.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: O43193-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV    50
VGVSGNVVTV MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR 100
SRPWVFGPLL CRLSLYVGEG CTYATLLHMT ALSVERYLAI CRPLRARVLV 150
TRRRVRALIA VLWAVALLSA GPFLFLVGVE QDPGISVVPG LNGTARIASS 200
PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA QLGALRVMLW 250
VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL 300
LVVVLAFIIC WLPFHVGRII YINTEDSRMM YFSQYFNIVA LQLFYLSASI 350
NPILYNLISK KYRAAAFKLL LARKSRPRGF HRSRDTAGEV AGDTGGDTVG 400
YTETSANVKT MG 412
Length:412
Mass (Da):45,344
Last modified:June 1, 1998 - v1
Checksum:iC13FF6165012DEF3
GO
Isoform B (identifier: O43193-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-412: LVVVLAFIIC...ETSANVKTMG → RKWSRRGSKD...FADDVLLSVL

Show »
Length:386
Mass (Da):42,026
Checksum:i40D07BB0CDD22BCB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei301 – 412112LVVVL…VKTMG → RKWSRRGSKDACLQSAPPGT AQTLGPLPLLAQLWAPLPAP FPISIPASTRRGGGSGIYNL LVALPRWQNHLHKHGRFADD VLLSVL in isoform B. VSP_001894Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034632 Genomic DNA. Translation: AAC26081.1.
AY603964 mRNA. Translation: AAT35806.1.
AL137000 Genomic DNA. Translation: CAC19107.1.
CCDSiCCDS9414.1. [O43193-1]
RefSeqiNP_001498.1. NM_001507.1. [O43193-1]
UniGeneiHs.248126.

Genome annotation databases

EnsembliENST00000218721; ENSP00000218721; ENSG00000102539. [O43193-1]
ENST00000398307; ENSP00000381352; ENSG00000102539. [O43193-2]
GeneIDi2862.
KEGGihsa:2862.
UCSCiuc010tgj.2. human. [O43193-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF034632 Genomic DNA. Translation: AAC26081.1 .
AY603964 mRNA. Translation: AAT35806.1 .
AL137000 Genomic DNA. Translation: CAC19107.1 .
CCDSi CCDS9414.1. [O43193-1 ]
RefSeqi NP_001498.1. NM_001507.1. [O43193-1 ]
UniGenei Hs.248126.

3D structure databases

ProteinModelPortali O43193.
SMRi O43193. Positions 39-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109120. 1 interaction.
STRINGi 9606.ENSP00000218721.

Chemistry

BindingDBi O43193.
ChEMBLi CHEMBL2203.
GuidetoPHARMACOLOGYi 297.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O43193.

Proteomic databases

PaxDbi O43193.
PRIDEi O43193.

Protocols and materials databases

DNASUi 2862.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000218721 ; ENSP00000218721 ; ENSG00000102539 . [O43193-1 ]
ENST00000398307 ; ENSP00000381352 ; ENSG00000102539 . [O43193-2 ]
GeneIDi 2862.
KEGGi hsa:2862.
UCSCi uc010tgj.2. human. [O43193-1 ]

Organism-specific databases

CTDi 2862.
GeneCardsi GC13P049794.
HGNCi HGNC:4495. MLNR.
MIMi 602885. gene.
neXtProti NX_O43193.
PharmGKBi PA28884.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303294.
HOGENOMi HOG000272571.
HOVERGENi HBG006538.
InParanoidi O43193.
KOi K05266.
OMAi DSRMMYF.
OrthoDBi EOG7992QV.
PhylomeDBi O43193.
TreeFami TF336314.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Motilin_receptor.
GenomeRNAii 2862.
NextBioi 11285.
PROi O43193.
SOURCEi Search...

Gene expression databases

Bgeei O43193.
CleanExi HS_MLNR.
Genevestigatori O43193.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 2 hits.
[Graphical view ]
PRINTSi PR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors."
    McKee K.K., Tan C.P., Palyha O.C., Liu J., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D., van der Ploeg L.H.T.
    Genomics 46:426-434(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
  2. Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS A AND B).
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Tissue: Stomach.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: FUNCTION.

Entry informationi

Entry nameiMTLR_HUMAN
AccessioniPrimary (citable) accession number: O43193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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