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O43193

- MTLR_HUMAN

UniProt

O43193 - MTLR_HUMAN

Protein

Motilin receptor

Gene

MLNR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Receptor for motilin.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. growth hormone-releasing hormone receptor activity Source: InterPro

    GO - Biological processi

    1. digestion Source: ProtInc
    2. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Motilin receptor
    Alternative name(s):
    G-protein coupled receptor 38
    Gene namesi
    Name:MLNR
    Synonyms:GPR38, MTLR, MTLR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:4495. MLNR.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28884.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 412412Motilin receptorPRO_0000069860Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 235PROSITE-ProRule annotation
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO43193.
    PRIDEiO43193.

    PTM databases

    PhosphoSiteiO43193.

    Expressioni

    Tissue specificityi

    Expressed only in thyroid, stomach, and bone marrow.

    Gene expression databases

    BgeeiO43193.
    CleanExiHS_MLNR.
    GenevestigatoriO43193.

    Interactioni

    Protein-protein interaction databases

    BioGridi109120. 1 interaction.
    STRINGi9606.ENSP00000218721.

    Structurei

    3D structure databases

    ProteinModelPortaliO43193.
    SMRiO43193. Positions 39-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini57 – 7418CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini95 – 11218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 15723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 24668ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini271 – 29828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini321 – 33414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini359 – 41254CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9420Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13422Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 27024Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei299 – 32022Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35824Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303294.
    HOGENOMiHOG000272571.
    HOVERGENiHBG006538.
    InParanoidiO43193.
    KOiK05266.
    OMAiDSRMMYF.
    OrthoDBiEOG7992QV.
    PhylomeDBiO43193.
    TreeFamiTF336314.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR003905. GHS-R.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 2 hits.
    [Graphical view]
    PRINTSiPR01417. GHSRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: O43193-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV    50
    VGVSGNVVTV MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR 100
    SRPWVFGPLL CRLSLYVGEG CTYATLLHMT ALSVERYLAI CRPLRARVLV 150
    TRRRVRALIA VLWAVALLSA GPFLFLVGVE QDPGISVVPG LNGTARIASS 200
    PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA QLGALRVMLW 250
    VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL 300
    LVVVLAFIIC WLPFHVGRII YINTEDSRMM YFSQYFNIVA LQLFYLSASI 350
    NPILYNLISK KYRAAAFKLL LARKSRPRGF HRSRDTAGEV AGDTGGDTVG 400
    YTETSANVKT MG 412
    Length:412
    Mass (Da):45,344
    Last modified:June 1, 1998 - v1
    Checksum:iC13FF6165012DEF3
    GO
    Isoform B (identifier: O43193-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         301-412: LVVVLAFIIC...ETSANVKTMG → RKWSRRGSKD...FADDVLLSVL

    Show »
    Length:386
    Mass (Da):42,026
    Checksum:i40D07BB0CDD22BCB
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei301 – 412112LVVVL…VKTMG → RKWSRRGSKDACLQSAPPGT AQTLGPLPLLAQLWAPLPAP FPISIPASTRRGGGSGIYNL LVALPRWQNHLHKHGRFADD VLLSVL in isoform B. CuratedVSP_001894Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034632 Genomic DNA. Translation: AAC26081.1.
    AY603964 mRNA. Translation: AAT35806.1.
    AL137000 Genomic DNA. Translation: CAC19107.1.
    CCDSiCCDS9414.1. [O43193-1]
    RefSeqiNP_001498.1. NM_001507.1. [O43193-1]
    UniGeneiHs.248126.

    Genome annotation databases

    EnsembliENST00000218721; ENSP00000218721; ENSG00000102539. [O43193-1]
    GeneIDi2862.
    KEGGihsa:2862.
    UCSCiuc010tgj.2. human. [O43193-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034632 Genomic DNA. Translation: AAC26081.1 .
    AY603964 mRNA. Translation: AAT35806.1 .
    AL137000 Genomic DNA. Translation: CAC19107.1 .
    CCDSi CCDS9414.1. [O43193-1 ]
    RefSeqi NP_001498.1. NM_001507.1. [O43193-1 ]
    UniGenei Hs.248126.

    3D structure databases

    ProteinModelPortali O43193.
    SMRi O43193. Positions 39-405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109120. 1 interaction.
    STRINGi 9606.ENSP00000218721.

    Chemistry

    BindingDBi O43193.
    ChEMBLi CHEMBL2203.
    GuidetoPHARMACOLOGYi 297.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O43193.

    Proteomic databases

    PaxDbi O43193.
    PRIDEi O43193.

    Protocols and materials databases

    DNASUi 2862.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000218721 ; ENSP00000218721 ; ENSG00000102539 . [O43193-1 ]
    GeneIDi 2862.
    KEGGi hsa:2862.
    UCSCi uc010tgj.2. human. [O43193-1 ]

    Organism-specific databases

    CTDi 2862.
    GeneCardsi GC13P049794.
    HGNCi HGNC:4495. MLNR.
    MIMi 602885. gene.
    neXtProti NX_O43193.
    PharmGKBi PA28884.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303294.
    HOGENOMi HOG000272571.
    HOVERGENi HBG006538.
    InParanoidi O43193.
    KOi K05266.
    OMAi DSRMMYF.
    OrthoDBi EOG7992QV.
    PhylomeDBi O43193.
    TreeFami TF336314.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Motilin_receptor.
    GenomeRNAii 2862.
    NextBioi 11285.
    PROi O43193.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43193.
    CleanExi HS_MLNR.
    Genevestigatori O43193.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR003905. GHS-R.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 2 hits.
    [Graphical view ]
    PRINTSi PR01417. GHSRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors."
      McKee K.K., Tan C.P., Palyha O.C., Liu J., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D., van der Ploeg L.H.T.
      Genomics 46:426-434(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
    2. Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS A AND B).
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Tissue: Stomach.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: FUNCTION.

    Entry informationi

    Entry nameiMTLR_HUMAN
    AccessioniPrimary (citable) accession number: O43193
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3