O43193 (MTLR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Motilin receptor

Alternative name(s):
G-protein coupled receptor 38

Gene names

Name:	MLNR
Synonyms:	GPR38, MTLR, MTLR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for motilin. Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed only in thyroid, stomach, and bone marrow.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	digestion Traceable author statement Ref.2. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.2. Source: ProtInc growth hormone-releasing hormone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: O43193-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: O43193-2)

The sequence of this isoform differs from the canonical sequence as follows:
     301-412: LVVVLAFIIC...ETSANVKTMG → RKWSRRGSKD...FADDVLLSVL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 412	412	Motilin receptor		PRO_0000069860
Regions
	Topological domain	1 – 35	35	Extracellular Potential
	Transmembrane	36 – 56	21	Helical; Name=1; Potential
	Topological domain	57 – 74	18	Cytoplasmic Potential
	Transmembrane	75 – 94	20	Helical; Name=2; Potential
	Topological domain	95 – 112	18	Extracellular Potential
	Transmembrane	113 – 134	22	Helical; Name=3; Potential
	Topological domain	135 – 157	23	Cytoplasmic Potential
	Transmembrane	158 – 178	21	Helical; Name=4; Potential
	Topological domain	179 – 246	68	Extracellular Potential
	Transmembrane	247 – 270	24	Helical; Name=5; Potential
	Topological domain	271 – 298	28	Cytoplasmic Potential
	Transmembrane	299 – 320	22	Helical; Name=6; Potential
	Topological domain	321 – 334	14	Extracellular Potential
	Transmembrane	335 – 358	24	Helical; Name=7; Potential
	Topological domain	359 – 412	54	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Disulfide bond	111 ↔ 235		By similarity
Natural variations
	Alternative sequence	301 – 412	112	LVVVL…VKTMG → RKWSRRGSKDACLQSAPPGT AQTLGPLPLLAQLWAPLPAP FPISIPASTRRGGGSGIYNL LVALPRWQNHLHKHGRFADD VLLSVL in isoform B.		VSP_001894

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified June 1, 1998. Version 1. Checksum: C13FF6165012DEF3	FASTA	412	45,344
	10 20 30 40 50 60 MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV VGVSGNVVTV 70 80 90 100 110 120 MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR SRPWVFGPLL CRLSLYVGEG 130 140 150 160 170 180 CTYATLLHMT ALSVERYLAI CRPLRARVLV TRRRVRALIA VLWAVALLSA GPFLFLVGVE 190 200 210 220 230 240 QDPGISVVPG LNGTARIASS PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA 250 260 270 280 290 300 QLGALRVMLW VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL 310 320 330 340 350 360 LVVVLAFIIC WLPFHVGRII YINTEDSRMM YFSQYFNIVA LQLFYLSASI NPILYNLISK 370 380 390 400 410 KYRAAAFKLL LARKSRPRGF HRSRDTAGEV AGDTGGDTVG YTETSANVKT MG
	Isoform B [UniParc]. Checksum: 40D07BB0CDD22BCB	FASTA	386	42,026
	10 20 30 40 50 60 MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV VGVSGNVVTV 70 80 90 100 110 120 MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR SRPWVFGPLL CRLSLYVGEG 130 140 150 160 170 180 CTYATLLHMT ALSVERYLAI CRPLRARVLV TRRRVRALIA VLWAVALLSA GPFLFLVGVE 190 200 210 220 230 240 QDPGISVVPG LNGTARIASS PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA 250 260 270 280 290 300 QLGALRVMLW VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL 310 320 330 340 350 360 RKWSRRGSKD ACLQSAPPGT AQTLGPLPLL AQLWAPLPAP FPISIPASTR RGGGSGIYNL 370 380 LVALPRWQNH LHKHGRFADD VLLSVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors." McKee K.K., Tan C.P., Palyha O.C., Liu J., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D., van der Ploeg L.H.T. Genomics 46:426-434(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
[2]	"Receptor for motilin identified in the human gastrointestinal system." Feighner S.D., Tan C.P., McKee K.K., Palyha O.C., Hreniuk D.L., Pong S.-S., Austin C.P., Figueroa D., MacNeil D., Cascieri M.A., Nargund R., Bakshi R., Abramovitz M., Stocco R., Kargman S., O'Neill G., van Der Ploeg L.H.T., Evans J. , Patchett A.A., Smith R.G., Howard A.D. Science 284:2184-2188(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS A AND B).
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." King M.M., Aronstam R.S., Sharma S.V. Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Stomach.
[4]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Growth hormone secretagogue receptor family members and ligands." Smith R.G., Leonard R., Bailey A.R.T., Palyha O.C., Feighner S.D., Tan C.P., Mckee K.K., Pong S.-S., Griffin P.R., Howard A.D. Endocrine 14:9-14(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF034632 Genomic DNA. Translation: AAC26081.1. AY603964 mRNA. Translation: AAT35806.1. AL137000 Genomic DNA. Translation: CAC19107.1.
IPI	IPI00011240. IPI00219128.
RefSeq	NP_001498.1. NM_001507.1.
UniGene	Hs.248126.
3D structure databases
ProteinModelPortal	O43193.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000218721.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O43193.
Proteomic databases
PaxDb	O43193.
PRIDE	O43193.
Protocols and materials databases
DNASU	2862.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000218721; ENSP00000218721; ENSG00000102539. ENST00000398307; ENSP00000381352; ENSG00000102539.
GeneID	2862.
KEGG	hsa:2862.
UCSC	uc010tgj.2. human.
Organism-specific databases
CTD	2862.
GeneCards	GC13P049794.
HGNC	HGNC:4495. MLNR.
MIM	602885. gene.
neXtProt	NX_O43193.
PharmGKB	PA28884.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303294.
HOGENOM	HOG000272571.
HOVERGEN	HBG006538.
InParanoid	O43193.
KO	K05266.
OMA	DSRMMYF.
OrthoDB	EOG4FFD28.
PhylomeDB	O43193.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O43193.
CleanEx	HS_MLNR.
Genevestigator	O43193.
GermOnline	ENSG00000102539. Homo sapiens.
Family and domain databases
InterPro	IPR003905. GHS-R. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 2 hits. [Graphical view]
PRINTS	PR01417. GHSRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O43193.
ChEMBL	CHEMBL2203.
GenomeRNAi	2862.
NextBio	11285.
SOURCE	Search...

Entry information

Entry name

MTLR_HUMAN

Accession

Primary (citable) accession number: O43193

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.