Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Motilin receptor

Gene

MLNR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for motilin.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • growth hormone-releasing hormone receptor activity Source: InterPro

GO - Biological processi

  • digestion Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102539-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiO43193.

Names & Taxonomyi

Protein namesi
Recommended name:
Motilin receptor
Alternative name(s):
G-protein coupled receptor 38
Gene namesi
Name:MLNR
Synonyms:GPR38, MTLR, MTLR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:4495. MLNR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini57 – 74CytoplasmicSequence analysisAdd BLAST18
Transmembranei75 – 94Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini95 – 112ExtracellularSequence analysisAdd BLAST18
Transmembranei113 – 134Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini135 – 157CytoplasmicSequence analysisAdd BLAST23
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 246ExtracellularSequence analysisAdd BLAST68
Transmembranei247 – 270Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini271 – 298CytoplasmicSequence analysisAdd BLAST28
Transmembranei299 – 320Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini321 – 334ExtracellularSequence analysisAdd BLAST14
Transmembranei335 – 358Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini359 – 412CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2862.
OpenTargetsiENSG00000102539.
PharmGKBiPA28884.

Chemistry databases

ChEMBLiCHEMBL2203.
DrugBankiDB00199. Erythromycin.
GuidetoPHARMACOLOGYi297.

Polymorphism and mutation databases

BioMutaiMLNR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698601 – 412Motilin receptorAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 235PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43193.
PRIDEiO43193.

PTM databases

iPTMnetiO43193.
PhosphoSitePlusiO43193.

Expressioni

Tissue specificityi

Expressed only in thyroid, stomach, and bone marrow.

Gene expression databases

BgeeiENSG00000102539.
CleanExiHS_MLNR.
GenevisibleiO43193. HS.

Interactioni

Protein-protein interaction databases

BioGridi109120. 1 interactor.
STRINGi9606.ENSP00000218721.

Chemistry databases

BindingDBiO43193.

Structurei

3D structure databases

ProteinModelPortaliO43193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000272571.
HOVERGENiHBG006538.
InParanoidiO43193.
KOiK05266.
OMAiDSRMMYF.
OrthoDBiEOG091G09KB.
PhylomeDBiO43193.
TreeFamiTF336314.

Family and domain databases

InterProiIPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: O43193-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV
60 70 80 90 100
VGVSGNVVTV MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR
110 120 130 140 150
SRPWVFGPLL CRLSLYVGEG CTYATLLHMT ALSVERYLAI CRPLRARVLV
160 170 180 190 200
TRRRVRALIA VLWAVALLSA GPFLFLVGVE QDPGISVVPG LNGTARIASS
210 220 230 240 250
PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA QLGALRVMLW
260 270 280 290 300
VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL
310 320 330 340 350
LVVVLAFIIC WLPFHVGRII YINTEDSRMM YFSQYFNIVA LQLFYLSASI
360 370 380 390 400
NPILYNLISK KYRAAAFKLL LARKSRPRGF HRSRDTAGEV AGDTGGDTVG
410
YTETSANVKT MG
Length:412
Mass (Da):45,344
Last modified:June 1, 1998 - v1
Checksum:iC13FF6165012DEF3
GO
Isoform B (identifier: O43193-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-412: LVVVLAFIIC...ETSANVKTMG → RKWSRRGSKD...FADDVLLSVL

Show »
Length:386
Mass (Da):42,026
Checksum:i40D07BB0CDD22BCB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001894301 – 412LVVVL…VKTMG → RKWSRRGSKDACLQSAPPGT AQTLGPLPLLAQLWAPLPAP FPISIPASTRRGGGSGIYNL LVALPRWQNHLHKHGRFADD VLLSVL in isoform B. CuratedAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034632 Genomic DNA. Translation: AAC26081.1.
AY603964 mRNA. Translation: AAT35806.1.
AL137000 Genomic DNA. Translation: CAC19107.1.
CCDSiCCDS9414.1. [O43193-1]
RefSeqiNP_001498.1. NM_001507.1. [O43193-1]
UniGeneiHs.248126.

Genome annotation databases

EnsembliENST00000218721; ENSP00000218721; ENSG00000102539. [O43193-1]
GeneIDi2862.
KEGGihsa:2862.
UCSCiuc010tgj.2. human. [O43193-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034632 Genomic DNA. Translation: AAC26081.1.
AY603964 mRNA. Translation: AAT35806.1.
AL137000 Genomic DNA. Translation: CAC19107.1.
CCDSiCCDS9414.1. [O43193-1]
RefSeqiNP_001498.1. NM_001507.1. [O43193-1]
UniGeneiHs.248126.

3D structure databases

ProteinModelPortaliO43193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109120. 1 interactor.
STRINGi9606.ENSP00000218721.

Chemistry databases

BindingDBiO43193.
ChEMBLiCHEMBL2203.
DrugBankiDB00199. Erythromycin.
GuidetoPHARMACOLOGYi297.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO43193.
PhosphoSitePlusiO43193.

Polymorphism and mutation databases

BioMutaiMLNR.

Proteomic databases

PaxDbiO43193.
PRIDEiO43193.

Protocols and materials databases

DNASUi2862.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218721; ENSP00000218721; ENSG00000102539. [O43193-1]
GeneIDi2862.
KEGGihsa:2862.
UCSCiuc010tgj.2. human. [O43193-1]

Organism-specific databases

CTDi2862.
DisGeNETi2862.
GeneCardsiMLNR.
HGNCiHGNC:4495. MLNR.
MIMi602885. gene.
neXtProtiNX_O43193.
OpenTargetsiENSG00000102539.
PharmGKBiPA28884.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000272571.
HOVERGENiHBG006538.
InParanoidiO43193.
KOiK05266.
OMAiDSRMMYF.
OrthoDBiEOG091G09KB.
PhylomeDBiO43193.
TreeFamiTF336314.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102539-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiO43193.

Miscellaneous databases

GeneWikiiMotilin_receptor.
GenomeRNAii2862.
PROiO43193.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102539.
CleanExiHS_MLNR.
GenevisibleiO43193. HS.

Family and domain databases

InterProiIPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTLR_HUMAN
AccessioniPrimary (citable) accession number: O43193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.