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O43193 (MTLR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Motilin receptor
Alternative name(s):
G-protein coupled receptor 38
Gene names
Name:MLNR
Synonyms:GPR38, MTLR, MTLR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for motilin. Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed only in thyroid, stomach, and bone marrow.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: O43193-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: O43193-2)

The sequence of this isoform differs from the canonical sequence as follows:
     301-412: LVVVLAFIIC...ETSANVKTMG → RKWSRRGSKD...FADDVLLSVL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Motilin receptor
PRO_0000069860

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5621Helical; Name=1; Potential
Topological domain57 – 7418Cytoplasmic Potential
Transmembrane75 – 9420Helical; Name=2; Potential
Topological domain95 – 11218Extracellular Potential
Transmembrane113 – 13422Helical; Name=3; Potential
Topological domain135 – 15723Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=4; Potential
Topological domain179 – 24668Extracellular Potential
Transmembrane247 – 27024Helical; Name=5; Potential
Topological domain271 – 29828Cytoplasmic Potential
Transmembrane299 – 32022Helical; Name=6; Potential
Topological domain321 – 33414Extracellular Potential
Transmembrane335 – 35824Helical; Name=7; Potential
Topological domain359 – 41254Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 235 By similarity

Natural variations

Alternative sequence301 – 412112LVVVL…VKTMG → RKWSRRGSKDACLQSAPPGT AQTLGPLPLLAQLWAPLPAP FPISIPASTRRGGGSGIYNL LVALPRWQNHLHKHGRFADD VLLSVL in isoform B.
VSP_001894

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: C13FF6165012DEF3

FASTA41245,344
        10         20         30         40         50         60 
MGSPWNGSDG PEGAREPPWP ALPPCDERRC SPFPLGALVP VTAVCLCLFV VGVSGNVVTV 

        70         80         90        100        110        120 
MLIGRYRDMR TTTNLYLGSM AVSDLLILLG LPFDLYRLWR SRPWVFGPLL CRLSLYVGEG 

       130        140        150        160        170        180 
CTYATLLHMT ALSVERYLAI CRPLRARVLV TRRRVRALIA VLWAVALLSA GPFLFLVGVE 

       190        200        210        220        230        240 
QDPGISVVPG LNGTARIASS PLASSPPLWL SRAPPPSPPS GPETAEAAAL FSRECRPSPA 

       250        260        270        280        290        300 
QLGALRVMLW VTTAYFFLPF LCLSILYGLI GRELWSSRRP LRGPAASGRE RGHRQTVRVL 

       310        320        330        340        350        360 
LVVVLAFIIC WLPFHVGRII YINTEDSRMM YFSQYFNIVA LQLFYLSASI NPILYNLISK 

       370        380        390        400        410 
KYRAAAFKLL LARKSRPRGF HRSRDTAGEV AGDTGGDTVG YTETSANVKT MG 

« Hide

Isoform B [UniParc].

Checksum: 40D07BB0CDD22BCB
Show »

FASTA38642,026

References

« Hide 'large scale' references
[1]"Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors."
McKee K.K., Tan C.P., Palyha O.C., Liu J., Feighner S.D., Hreniuk D.L., Smith R.G., Howard A.D., van der Ploeg L.H.T.
Genomics 46:426-434(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
[2]"Receptor for motilin identified in the human gastrointestinal system."
Feighner S.D., Tan C.P., McKee K.K., Palyha O.C., Hreniuk D.L., Pong S.-S., Austin C.P., Figueroa D., MacNeil D., Cascieri M.A., Nargund R., Bakshi R., Abramovitz M., Stocco R., Kargman S., O'Neill G., van Der Ploeg L.H.T., Evans J. expand/collapse author list , Patchett A.A., Smith R.G., Howard A.D.
Science 284:2184-2188(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS A AND B).
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
King M.M., Aronstam R.S., Sharma S.V.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Tissue: Stomach.
[4]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Growth hormone secretagogue receptor family members and ligands."
Smith R.G., Leonard R., Bailey A.R.T., Palyha O.C., Feighner S.D., Tan C.P., Mckee K.K., Pong S.-S., Griffin P.R., Howard A.D.
Endocrine 14:9-14(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF034632 Genomic DNA. Translation: AAC26081.1.
AY603964 mRNA. Translation: AAT35806.1.
AL137000 Genomic DNA. Translation: CAC19107.1.
CCDSCCDS9414.1. [O43193-1]
RefSeqNP_001498.1. NM_001507.1. [O43193-1]
UniGeneHs.248126.

3D structure databases

ProteinModelPortalO43193.
SMRO43193. Positions 39-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109120. 1 interaction.
STRING9606.ENSP00000218721.

Chemistry

BindingDBO43193.
ChEMBLCHEMBL2203.
GuidetoPHARMACOLOGY297.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO43193.

Proteomic databases

PaxDbO43193.
PRIDEO43193.

Protocols and materials databases

DNASU2862.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000218721; ENSP00000218721; ENSG00000102539. [O43193-1]
ENST00000398307; ENSP00000381352; ENSG00000102539. [O43193-2]
GeneID2862.
KEGGhsa:2862.
UCSCuc010tgj.2. human. [O43193-1]

Organism-specific databases

CTD2862.
GeneCardsGC13P049794.
HGNCHGNC:4495. MLNR.
MIM602885. gene.
neXtProtNX_O43193.
PharmGKBPA28884.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303294.
HOGENOMHOG000272571.
HOVERGENHBG006538.
InParanoidO43193.
KOK05266.
OMADSRMMYF.
OrthoDBEOG7992QV.
PhylomeDBO43193.
TreeFamTF336314.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO43193.
CleanExHS_MLNR.
GenevestigatorO43193.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR003905. GHS-R.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSPR01417. GHSRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMotilin_receptor.
GenomeRNAi2862.
NextBio11285.
PROO43193.
SOURCESearch...

Entry information

Entry nameMTLR_HUMAN
AccessionPrimary (citable) accession number: O43193
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries