Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43187

- IRAK2_HUMAN

UniProt

O43187 - IRAK2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Interleukin-1 receptor-associated kinase-like 2

Gene

IRAK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei237 – 2371ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi216 – 2249ATPPROSITE-ProRule annotation
Nucleotide bindingi337 – 3404ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: BHF-UCL
  3. protein homodimerization activity Source: BHF-UCL
  4. protein kinase activity Source: InterPro

GO - Biological processi

  1. activation of MAPK activity Source: Reactome
  2. I-kappaB kinase/NF-kappaB signaling Source: ProtInc
  3. inflammatory response Source: ProtInc
  4. innate immune response Source: Reactome
  5. interleukin-1-mediated signaling pathway Source: BHF-UCL
  6. JNK cascade Source: Reactome
  7. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  8. MyD88-dependent toll-like receptor signaling pathway Source: BHF-UCL
  9. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  10. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  11. nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Source: Reactome
  12. nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
  13. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  14. protein phosphorylation Source: ProtInc
  15. regulation of cytokine-mediated signaling pathway Source: BHF-UCL
  16. response to interleukin-1 Source: BHF-UCL
  17. stress-activated MAPK cascade Source: Reactome
  18. toll-like receptor 10 signaling pathway Source: Reactome
  19. toll-like receptor 2 signaling pathway Source: Reactome
  20. toll-like receptor 3 signaling pathway Source: Reactome
  21. toll-like receptor 4 signaling pathway Source: Reactome
  22. toll-like receptor 5 signaling pathway Source: Reactome
  23. toll-like receptor 9 signaling pathway Source: Reactome
  24. toll-like receptor signaling pathway Source: Reactome
  25. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  26. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  27. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2681.
ReactomeiREACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
REACT_22442. Interleukin-1 signaling.
REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_25222. MyD88 dependent cascade initiated on endosome.
REACT_25380. IRAK2 mediated activation of TAK1 complex.
REACT_27215. MyD88 cascade initiated on plasma membrane.
REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
REACT_75776. NOD1/2 Signaling Pathway.
SignaLinkiO43187.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase-like 2
Short name:
IRAK-2
Gene namesi
Name:IRAK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:6113. IRAK2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. endosome membrane Source: Reactome
  3. plasma membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29913.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 625625Interleukin-1 receptor-associated kinase-like 2PRO_0000086032Add
BLAST

Proteomic databases

MaxQBiO43187.
PaxDbiO43187.
PeptideAtlasiO43187.
PRIDEiO43187.

PTM databases

PhosphoSiteiO43187.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiO43187.
CleanExiHS_IRAK2.
GenevestigatoriO43187.

Organism-specific databases

HPAiCAB013483.

Interactioni

Subunit structurei

Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARAFP103982EBI-447733,EBI-365961
K7RP684672EBI-447733,EBI-8022707From a different organism.
Sarm1Q6PDS32EBI-447733,EBI-6117196From a different organism.
STT3AP469772EBI-447733,EBI-719212
TARDBPQ131482EBI-447733,EBI-372899
TIRAPP587532EBI-447733,EBI-528644
TOLLIPQ9H0E22EBI-447733,EBI-74615
ZC3H12AQ5D1E82EBI-447733,EBI-747793

Protein-protein interaction databases

BioGridi109865. 33 interactions.
DIPiDIP-31800N.
IntActiO43187. 30 interactions.
MINTiMINT-97184.
STRINGi9606.ENSP00000256458.

Structurei

Secondary structure

1
625
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 73
Helixi10 – 167
Turni17 – 226
Helixi25 – 328
Turni33 – 364
Helixi39 – 479
Helixi48 – 503
Helixi56 – 6510
Turni66 – 683
Helixi72 – 765
Turni77 – 815
Helixi84 – 874
Turni88 – 914

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MOPX-ray3.40K/L/M/N2-112[»]
ProteinModelPortaliO43187.
SMRiO43187. Positions 2-94, 215-457.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43187.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 9482DeathAdd
BLAST
Domaini210 – 489280Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 death domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00530000063073.
HOGENOMiHOG000113102.
HOVERGENiHBG052145.
InParanoidiO43187.
KOiK04731.
OMAiLSEWDWM.
OrthoDBiEOG747PHP.
PhylomeDBiO43187.
TreeFamiTF328924.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43187-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MACYIYQLPS WVLDDLCRNM DALSEWDWME FASYVITDLT QLRKIKSMER
60 70 80 90 100
VQGVSITREL LWWWGMRQAT VQQLVDLLCR LELYRAAQII LNWKPAPEIR
110 120 130 140 150
CPIPAFPDSV KPEKPLAASV RKAEDEQEEG QPVRMATFPG PGSSPARAHQ
160 170 180 190 200
PAFLQPPEED APHSLRSDLP TSSDSKDFST SIPKQEKLLS LAGDSLFWSE
210 220 230 240 250
ADVVQATDDF NQNRKISQGT FADVYRGHRH GKPFVFKKLR ETACSSPGSI
260 270 280 290 300
ERFFQAELQI CLRCCHPNVL PVLGFCAARQ FHSFIYPYMA NGSLQDRLQG
310 320 330 340 350
QGGSDPLPWP QRVSICSGLL CAVEYLHGLE IIHSNVKSSN VLLDQNLTPK
360 370 380 390 400
LAHPMAHLCP VNKRSKYTMM KTHLLRTSAA YLPEDFIRVG QLTKRVDIFS
410 420 430 440 450
CGIVLAEVLT GIPAMDNNRS PVYLKDLLLS DIPSSTASLC SRKTGVENVM
460 470 480 490 500
AKEICQKYLE KGAGRLPEDC AEALATAACL CLRRRNTSLQ EVCGSVAAVE
510 520 530 540 550
ERLRGRETLL PWSGLSEGTG SSSNTPEETD DVDNSSLDAS SSMSVAPWAG
560 570 580 590 600
AATPLLPTEN GEGRLRVIVG READSSSEAC VGLEPPQDVT ETSWQIEINE
610 620
AKRKLMENIL LYKEEKVDSI ELFGP
Length:625
Mass (Da):69,433
Last modified:February 6, 2007 - v2
Checksum:i715C954BC9452710
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431R → Q.1 Publication
Corresponds to variant rs34945585 [ dbSNP | Ensembl ].
VAR_041342
Natural varianti47 – 471S → Y.1 Publication
Corresponds to variant rs11465864 [ dbSNP | Ensembl ].
VAR_030527
Natural varianti99 – 991I → V.1 Publication
Corresponds to variant rs55898544 [ dbSNP | Ensembl ].
VAR_041343
Natural varianti147 – 1471R → T.1 Publication
Corresponds to variant rs56053222 [ dbSNP | Ensembl ].
VAR_041344
Natural varianti214 – 2141R → G.1 Publication
Corresponds to variant rs35060588 [ dbSNP | Ensembl ].
VAR_041345
Natural varianti249 – 2491S → L in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041346
Natural varianti392 – 3921L → V.1 Publication
Corresponds to variant rs3844283 [ dbSNP | Ensembl ].
VAR_030528
Natural varianti421 – 4211P → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041347
Natural varianti431 – 4311D → E.3 Publications
Corresponds to variant rs708035 [ dbSNP | Ensembl ].
VAR_030529
Natural varianti439 – 4391L → V.1 Publication
Corresponds to variant rs11465927 [ dbSNP | Ensembl ].
VAR_030530
Natural varianti469 – 4691D → N.1 Publication
Corresponds to variant rs56242986 [ dbSNP | Ensembl ].
VAR_041348
Natural varianti503 – 5031L → I.1 Publication
Corresponds to variant rs9854688 [ dbSNP | Ensembl ].
VAR_030531
Natural varianti566 – 5661R → W.1 Publication
Corresponds to variant rs55740652 [ dbSNP | Ensembl ].
VAR_041349
Natural varianti574 – 5741D → H.
Corresponds to variant rs11465930 [ dbSNP | Ensembl ].
VAR_030532

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ496794 mRNA. Translation: CAD43180.3.
AK299033 mRNA. Translation: BAG61108.1.
BC125184 mRNA. Translation: AAI25185.1.
AF026273 mRNA. Translation: AAB87669.1.
CCDSiCCDS33697.1.
RefSeqiNP_001561.3. NM_001570.3.
UniGeneiHs.449207.

Genome annotation databases

EnsembliENST00000256458; ENSP00000256458; ENSG00000134070.
GeneIDi3656.
KEGGihsa:3656.
UCSCiuc003bve.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ496794 mRNA. Translation: CAD43180.3 .
AK299033 mRNA. Translation: BAG61108.1 .
BC125184 mRNA. Translation: AAI25185.1 .
AF026273 mRNA. Translation: AAB87669.1 .
CCDSi CCDS33697.1.
RefSeqi NP_001561.3. NM_001570.3.
UniGenei Hs.449207.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3MOP X-ray 3.40 K/L/M/N 2-112 [» ]
ProteinModelPortali O43187.
SMRi O43187. Positions 2-94, 215-457.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109865. 33 interactions.
DIPi DIP-31800N.
IntActi O43187. 30 interactions.
MINTi MINT-97184.
STRINGi 9606.ENSP00000256458.

PTM databases

PhosphoSitei O43187.

Proteomic databases

MaxQBi O43187.
PaxDbi O43187.
PeptideAtlasi O43187.
PRIDEi O43187.

Protocols and materials databases

DNASUi 3656.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256458 ; ENSP00000256458 ; ENSG00000134070 .
GeneIDi 3656.
KEGGi hsa:3656.
UCSCi uc003bve.1. human.

Organism-specific databases

CTDi 3656.
GeneCardsi GC03P010206.
HGNCi HGNC:6113. IRAK2.
HPAi CAB013483.
MIMi 603304. gene.
neXtProti NX_O43187.
PharmGKBi PA29913.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00530000063073.
HOGENOMi HOG000113102.
HOVERGENi HBG052145.
InParanoidi O43187.
KOi K04731.
OMAi LSEWDWM.
OrthoDBi EOG747PHP.
PhylomeDBi O43187.
TreeFami TF328924.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2681.
Reactomei REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
REACT_22442. Interleukin-1 signaling.
REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_25222. MyD88 dependent cascade initiated on endosome.
REACT_25380. IRAK2 mediated activation of TAK1 complex.
REACT_27215. MyD88 cascade initiated on plasma membrane.
REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
REACT_75776. NOD1/2 Signaling Pathway.
SignaLinki O43187.

Miscellaneous databases

EvolutionaryTracei O43187.
GeneWikii IRAK2.
GenomeRNAii 3656.
NextBioi 14303.
PROi O43187.
SOURCEi Search...

Gene expression databases

Bgeei O43187.
CleanExi HS_IRAK2.
Genevestigatori O43187.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Exon 13 and the 3'UTR region of human IRAK-2 and characterisation of the full length gene."
    Rosati O., Martin M.U.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-431.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling."
    Muzio M., Ni J., Feng P., Dixit V.M.
    Science 278:1612-1615(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-590, FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH TRAF6; MYD88 AND IL1R1, VARIANT GLU-431.
    Tissue: Endothelial cell.
  5. "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family."
    Wesche H., Gao X., Li X., Kirschning C.J., Stark G.R., Cao Z.
    J. Biol. Chem. 274:19403-19410(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling."
    Lin S.-C., Lo Y.-C., Wu H.
    Nature 465:885-890(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 2-112.
  7. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-43; TYR-47; VAL-99; THR-147; GLY-214; LEU-249; VAL-392; THR-421; GLU-431; VAL-439; ASN-469; ILE-503 AND TRP-566.

Entry informationi

Entry nameiIRAK2_HUMAN
AccessioniPrimary (citable) accession number: O43187
Secondary accession number(s): B4DQZ6, Q08AG6, Q5K546
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3