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O43187

- IRAK2_HUMAN

UniProt

O43187 - IRAK2_HUMAN

Protein

Interleukin-1 receptor-associated kinase-like 2

Gene

IRAK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei237 – 2371ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi216 – 2249ATPPROSITE-ProRule annotation
    Nucleotide bindingi337 – 3404ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein heterodimerization activity Source: BHF-UCL
    4. protein homodimerization activity Source: BHF-UCL
    5. protein kinase activity Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: Reactome
    2. I-kappaB kinase/NF-kappaB signaling Source: ProtInc
    3. inflammatory response Source: ProtInc
    4. innate immune response Source: Reactome
    5. interleukin-1-mediated signaling pathway Source: BHF-UCL
    6. JNK cascade Source: Reactome
    7. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    8. MyD88-dependent toll-like receptor signaling pathway Source: BHF-UCL
    9. MyD88-independent toll-like receptor signaling pathway Source: Reactome
    10. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    11. nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Source: Reactome
    12. nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
    13. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    14. protein phosphorylation Source: ProtInc
    15. regulation of cytokine-mediated signaling pathway Source: BHF-UCL
    16. response to interleukin-1 Source: BHF-UCL
    17. stress-activated MAPK cascade Source: Reactome
    18. toll-like receptor 10 signaling pathway Source: Reactome
    19. toll-like receptor 2 signaling pathway Source: Reactome
    20. toll-like receptor 3 signaling pathway Source: Reactome
    21. toll-like receptor 4 signaling pathway Source: Reactome
    22. toll-like receptor 5 signaling pathway Source: Reactome
    23. toll-like receptor 9 signaling pathway Source: Reactome
    24. toll-like receptor signaling pathway Source: Reactome
    25. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
    26. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
    27. TRIF-dependent toll-like receptor signaling pathway Source: Reactome

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2681.
    ReactomeiREACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_21399. activated TAK1 mediates p38 MAPK activation.
    REACT_22442. Interleukin-1 signaling.
    REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
    REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
    REACT_25222. MyD88 dependent cascade initiated on endosome.
    REACT_25380. IRAK2 mediated activation of TAK1 complex.
    REACT_27215. MyD88 cascade initiated on plasma membrane.
    REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    REACT_75776. NOD1/2 Signaling Pathway.
    SignaLinkiO43187.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 receptor-associated kinase-like 2
    Short name:
    IRAK-2
    Gene namesi
    Name:IRAK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:6113. IRAK2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. endosome membrane Source: Reactome
    3. plasma membrane Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29913.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 625625Interleukin-1 receptor-associated kinase-like 2PRO_0000086032Add
    BLAST

    Proteomic databases

    MaxQBiO43187.
    PaxDbiO43187.
    PeptideAtlasiO43187.
    PRIDEiO43187.

    PTM databases

    PhosphoSiteiO43187.

    Expressioni

    Tissue specificityi

    Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.1 Publication

    Gene expression databases

    BgeeiO43187.
    CleanExiHS_IRAK2.
    GenevestigatoriO43187.

    Organism-specific databases

    HPAiCAB013483.

    Interactioni

    Subunit structurei

    Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARAFP103982EBI-447733,EBI-365961
    K7RP684672EBI-447733,EBI-8022707From a different organism.
    Sarm1Q6PDS32EBI-447733,EBI-6117196From a different organism.
    STT3AP469772EBI-447733,EBI-719212
    TARDBPQ131482EBI-447733,EBI-372899
    TIRAPP587532EBI-447733,EBI-528644
    TOLLIPQ9H0E22EBI-447733,EBI-74615
    ZC3H12AQ5D1E82EBI-447733,EBI-747793

    Protein-protein interaction databases

    BioGridi109865. 33 interactions.
    DIPiDIP-31800N.
    IntActiO43187. 30 interactions.
    MINTiMINT-97184.
    STRINGi9606.ENSP00000256458.

    Structurei

    Secondary structure

    1
    625
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 73
    Helixi10 – 167
    Turni17 – 226
    Helixi25 – 328
    Turni33 – 364
    Helixi39 – 479
    Helixi48 – 503
    Helixi56 – 6510
    Turni66 – 683
    Helixi72 – 765
    Turni77 – 815
    Helixi84 – 874
    Turni88 – 914

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3MOPX-ray3.40K/L/M/N2-112[»]
    ProteinModelPortaliO43187.
    SMRiO43187. Positions 2-94, 197-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43187.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 9482DeathAdd
    BLAST
    Domaini210 – 489280Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Contains 1 death domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000113102.
    HOVERGENiHBG052145.
    InParanoidiO43187.
    KOiK04731.
    OMAiLSEWDWM.
    OrthoDBiEOG747PHP.
    PhylomeDBiO43187.
    TreeFamiTF328924.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43187-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACYIYQLPS WVLDDLCRNM DALSEWDWME FASYVITDLT QLRKIKSMER    50
    VQGVSITREL LWWWGMRQAT VQQLVDLLCR LELYRAAQII LNWKPAPEIR 100
    CPIPAFPDSV KPEKPLAASV RKAEDEQEEG QPVRMATFPG PGSSPARAHQ 150
    PAFLQPPEED APHSLRSDLP TSSDSKDFST SIPKQEKLLS LAGDSLFWSE 200
    ADVVQATDDF NQNRKISQGT FADVYRGHRH GKPFVFKKLR ETACSSPGSI 250
    ERFFQAELQI CLRCCHPNVL PVLGFCAARQ FHSFIYPYMA NGSLQDRLQG 300
    QGGSDPLPWP QRVSICSGLL CAVEYLHGLE IIHSNVKSSN VLLDQNLTPK 350
    LAHPMAHLCP VNKRSKYTMM KTHLLRTSAA YLPEDFIRVG QLTKRVDIFS 400
    CGIVLAEVLT GIPAMDNNRS PVYLKDLLLS DIPSSTASLC SRKTGVENVM 450
    AKEICQKYLE KGAGRLPEDC AEALATAACL CLRRRNTSLQ EVCGSVAAVE 500
    ERLRGRETLL PWSGLSEGTG SSSNTPEETD DVDNSSLDAS SSMSVAPWAG 550
    AATPLLPTEN GEGRLRVIVG READSSSEAC VGLEPPQDVT ETSWQIEINE 600
    AKRKLMENIL LYKEEKVDSI ELFGP 625
    Length:625
    Mass (Da):69,433
    Last modified:February 6, 2007 - v2
    Checksum:i715C954BC9452710
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431R → Q.1 Publication
    Corresponds to variant rs34945585 [ dbSNP | Ensembl ].
    VAR_041342
    Natural varianti47 – 471S → Y.1 Publication
    Corresponds to variant rs11465864 [ dbSNP | Ensembl ].
    VAR_030527
    Natural varianti99 – 991I → V.1 Publication
    Corresponds to variant rs55898544 [ dbSNP | Ensembl ].
    VAR_041343
    Natural varianti147 – 1471R → T.1 Publication
    Corresponds to variant rs56053222 [ dbSNP | Ensembl ].
    VAR_041344
    Natural varianti214 – 2141R → G.1 Publication
    Corresponds to variant rs35060588 [ dbSNP | Ensembl ].
    VAR_041345
    Natural varianti249 – 2491S → L in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041346
    Natural varianti392 – 3921L → V.1 Publication
    Corresponds to variant rs3844283 [ dbSNP | Ensembl ].
    VAR_030528
    Natural varianti421 – 4211P → T in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041347
    Natural varianti431 – 4311D → E.3 Publications
    Corresponds to variant rs708035 [ dbSNP | Ensembl ].
    VAR_030529
    Natural varianti439 – 4391L → V.1 Publication
    Corresponds to variant rs11465927 [ dbSNP | Ensembl ].
    VAR_030530
    Natural varianti469 – 4691D → N.1 Publication
    Corresponds to variant rs56242986 [ dbSNP | Ensembl ].
    VAR_041348
    Natural varianti503 – 5031L → I.1 Publication
    Corresponds to variant rs9854688 [ dbSNP | Ensembl ].
    VAR_030531
    Natural varianti566 – 5661R → W.1 Publication
    Corresponds to variant rs55740652 [ dbSNP | Ensembl ].
    VAR_041349
    Natural varianti574 – 5741D → H.
    Corresponds to variant rs11465930 [ dbSNP | Ensembl ].
    VAR_030532

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ496794 mRNA. Translation: CAD43180.3.
    AK299033 mRNA. Translation: BAG61108.1.
    BC125184 mRNA. Translation: AAI25185.1.
    AF026273 mRNA. Translation: AAB87669.1.
    CCDSiCCDS33697.1.
    RefSeqiNP_001561.3. NM_001570.3.
    UniGeneiHs.449207.

    Genome annotation databases

    EnsembliENST00000256458; ENSP00000256458; ENSG00000134070.
    GeneIDi3656.
    KEGGihsa:3656.
    UCSCiuc003bve.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ496794 mRNA. Translation: CAD43180.3 .
    AK299033 mRNA. Translation: BAG61108.1 .
    BC125184 mRNA. Translation: AAI25185.1 .
    AF026273 mRNA. Translation: AAB87669.1 .
    CCDSi CCDS33697.1.
    RefSeqi NP_001561.3. NM_001570.3.
    UniGenei Hs.449207.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3MOP X-ray 3.40 K/L/M/N 2-112 [» ]
    ProteinModelPortali O43187.
    SMRi O43187. Positions 2-94, 197-499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109865. 33 interactions.
    DIPi DIP-31800N.
    IntActi O43187. 30 interactions.
    MINTi MINT-97184.
    STRINGi 9606.ENSP00000256458.

    PTM databases

    PhosphoSitei O43187.

    Proteomic databases

    MaxQBi O43187.
    PaxDbi O43187.
    PeptideAtlasi O43187.
    PRIDEi O43187.

    Protocols and materials databases

    DNASUi 3656.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256458 ; ENSP00000256458 ; ENSG00000134070 .
    GeneIDi 3656.
    KEGGi hsa:3656.
    UCSCi uc003bve.1. human.

    Organism-specific databases

    CTDi 3656.
    GeneCardsi GC03P010206.
    HGNCi HGNC:6113. IRAK2.
    HPAi CAB013483.
    MIMi 603304. gene.
    neXtProti NX_O43187.
    PharmGKBi PA29913.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000113102.
    HOVERGENi HBG052145.
    InParanoidi O43187.
    KOi K04731.
    OMAi LSEWDWM.
    OrthoDBi EOG747PHP.
    PhylomeDBi O43187.
    TreeFami TF328924.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2681.
    Reactomei REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_21399. activated TAK1 mediates p38 MAPK activation.
    REACT_22442. Interleukin-1 signaling.
    REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
    REACT_25024. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
    REACT_25222. MyD88 dependent cascade initiated on endosome.
    REACT_25380. IRAK2 mediated activation of TAK1 complex.
    REACT_27215. MyD88 cascade initiated on plasma membrane.
    REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    REACT_75776. NOD1/2 Signaling Pathway.
    SignaLinki O43187.

    Miscellaneous databases

    EvolutionaryTracei O43187.
    GeneWikii IRAK2.
    GenomeRNAii 3656.
    NextBioi 14303.
    PROi O43187.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43187.
    CleanExi HS_IRAK2.
    Genevestigatori O43187.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of Exon 13 and the 3'UTR region of human IRAK-2 and characterisation of the full length gene."
      Rosati O., Martin M.U.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-431.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling."
      Muzio M., Ni J., Feng P., Dixit V.M.
      Science 278:1612-1615(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-590, FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH TRAF6; MYD88 AND IL1R1, VARIANT GLU-431.
      Tissue: Endothelial cell.
    5. "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family."
      Wesche H., Gao X., Li X., Kirschning C.J., Stark G.R., Cao Z.
      J. Biol. Chem. 274:19403-19410(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling."
      Lin S.-C., Lo Y.-C., Wu H.
      Nature 465:885-890(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 2-112.
    7. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-43; TYR-47; VAL-99; THR-147; GLY-214; LEU-249; VAL-392; THR-421; GLU-431; VAL-439; ASN-469; ILE-503 AND TRP-566.

    Entry informationi

    Entry nameiIRAK2_HUMAN
    AccessioniPrimary (citable) accession number: O43187
    Secondary accession number(s): B4DQZ6, Q08AG6, Q5K546
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3