O43174 (CP26A_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 97.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cytochrome P450 26A1 EC=1.14.-.- Alternative name(s): Cytochrome P450 retinoic acid-inactivating 1 Short name=Cytochrome P450RAI Short name=hP450RAI Retinoic acid 4-hydroxylase Retinoic acid-metabolizing cytochrome | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 497 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. |
| Cofactor | Heme group By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Tissue specificity | Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain. Ref.5 |
| Induction | By retinoic acid. |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF005418 mRNA. Translation: AAB88881.1. AL358613 Genomic DNA. Translation: CAH72803.1. CH471066 Genomic DNA. Translation: EAW50079.1. |
| IPI | IPI00304967. |
| RefSeq | NP_000774.2. NM_000783.3. |
| UniGene | Hs.150595. |
3D structure databases | |
| ProteinModelPortal | O43174. |
| SMR | O43174. Positions 41-493. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O43174. |
Proteomic databases | |
| PRIDE | O43174. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000224356; ENSP00000224356; ENSG00000095596. |
| GeneID | 1592. |
| KEGG | hsa:1592. |
Organism-specific databases | |
| CTD | 1592. |
| GeneCards | GC10P094823. |
| HGNC | HGNC:2603. CYP26A1. |
| HPA | CAB015447. |
| MIM | 602239. gene. |
| neXtProt | NX_O43174. |
| PharmGKB | PA27098. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG13087. |
| HOGENOM | HBG744016. |
| HOVERGEN | HBG051099. |
| InParanoid | O43174. |
| OMA | CYVPVIT. |
| PhylomeDB | O43174. |
Enzyme and pathway databases | |
| Reactome | REACT_111217. Metabolism. |
Gene expression databases | |
| ArrayExpress | O43174. |
| Bgee | O43174. |
| CleanEx | HS_CYP26A1. |
| Genevestigator | O43174. |
| GermOnline | ENSG00000095596. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002403. Cyt_P450_E_grp-IV. [Graphical view] |
| Gene3D | G3DSA:1.10.630.10. Cyt_P450. 1 hit. |
| KO | K07437. |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00465. EP450IV. PR00385. P450. |
| SUPFAM | SSF48264. Cytochrome_P450. 1 hit. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| SOURCE | Search... |
Entry information
| Entry name | CP26A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O43174 Secondary accession number(s): Q5VXI0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with