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Protein

Cytochrome b5 type B

Gene

CYB5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi55Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi79Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • heme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-211945 Phase I - Functionalization of compounds

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b5 type B
Alternative name(s):
Cytochrome b5 outer mitochondrial membrane isoform
Gene namesi
Name:CYB5B
Synonyms:CYB5M, OMB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103018.16
HGNCiHGNC:24374 CYB5B
MIMi611964 gene
neXtProtiNX_O43169

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei119 – 136HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80777
OpenTargetsiENSG00000103018
PharmGKBiPA143485445

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
PropeptideiPRO_00000064712 – 11By similarity10
ChainiPRO_000000647212 – 146Cytochrome b5 type BAdd BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei30N6-acetyllysineCombined sources1
Modified residuei33PhosphoserineBy similarity1
Modified residuei35N6-methyllysineCombined sources1
Modified residuei80PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO43169
MaxQBiO43169
PaxDbiO43169
PeptideAtlasiO43169
PRIDEiO43169
TopDownProteomicsiO43169

PTM databases

iPTMnetiO43169
PhosphoSitePlusiO43169
SwissPalmiO43169

Miscellaneous databases

PMAP-CutDBO43169

Expressioni

Gene expression databases

BgeeiENSG00000103018
CleanExiHS_CYB5B
ExpressionAtlasiO43169 baseline and differential
GenevisibleiO43169 HS

Organism-specific databases

HPAiHPA007893

Interactioni

Subunit structurei

Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB85EBI-1058710,EBI-6928570From Hepatitis C virus genotype 2a (isolate JFH-1).

Protein-protein interaction databases

BioGridi123309, 131 interactors
IntActiO43169, 14 interactors
STRINGi9606.ENSP00000308430

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 28Combined sources4
Beta strandi36 – 41Combined sources6
Beta strandi44 – 47Combined sources4
Helixi49 – 51Combined sources3
Turni52 – 54Combined sources3
Helixi60 – 63Combined sources4
Turni64 – 67Combined sources4
Helixi71 – 76Combined sources6
Helixi81 – 87Combined sources7
Helixi88 – 90Combined sources3
Beta strandi91 – 95Combined sources5
Helixi97 – 99Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NERX-ray1.45A/B12-103[»]
ProteinModelPortaliO43169
SMRiO43169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 96Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the cytochrome b5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0537 Eukaryota
COG5274 LUCA
GeneTreeiENSGT00510000046507
HOGENOMiHOG000039853
HOVERGENiHBG002653
InParanoidiO43169
PhylomeDBiO43169

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAEASGSD GKGQEVETSV TYYRLEEVAK RNSLKELWLV IHGRVYDVTR
60 70 80 90 100
FLNEHPGGEE VLLEQAGVDA SESFEDVGHS SDAREMLKQY YIGDIHPSDL
110 120 130 140
KPESGSKDPS KNDTCKSCWA YWILPIIGAV LLGFLYRYYT SESKSS
Length:146
Mass (Da):16,332
Last modified:June 7, 2005 - v2
Checksum:i2FF7DBB62859AE19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111K → Q in BAA23735 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009282 mRNA Translation: BAA23735.1
AK291576 mRNA Translation: BAF84265.1
AC026464 Genomic DNA No translation available.
BC004373 mRNA Translation: AAH04373.1
BC014431 mRNA Translation: AAH14431.2
RefSeqiNP_085056.2, NM_030579.2
UniGeneiHs.461131

Genome annotation databases

EnsembliENST00000512062; ENSP00000423679; ENSG00000103018
GeneIDi80777
KEGGihsa:80777
UCSCiuc059wli.1 human

Similar proteinsi

Entry informationi

Entry nameiCYB5B_HUMAN
AccessioniPrimary (citable) accession number: O43169
Secondary accession number(s): A8K6B1, Q96CC3, Q9BT35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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