Reviewed,
UniProtKB/Swiss-Prot O43169 (CYB5B_HUMAN)
Last modified
July 7, 2009.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cytochrome b5 type B Alternative name(s): Cytochrome b5 outer mitochondrial membrane isoform | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 146 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases By similarity. |
| Subunit structure | Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2 By similarity. |
| Subcellular location | Mitochondrion outer membrane By similarity. |
| Sequence similarities | Belongs to the cytochrome b5 family. Contains 1 cytochrome b5 heme-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Transport |
| Cellular component | Membrane Mitochondrion Mitochondrion outer membrane |
| Domain | Transmembrane |
| Ligand | Heme Iron Metal-binding |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | heme binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Propeptide | 1 – 11 | 11 | By similarity | PRO_0000006471 | |||||
| Chain | 12 – 146 | 135 | Cytochrome b5 type B | PRO_0000006472 | |||||
Regions | |||||||||
| Transmembrane | 119 – 136 | 18 | Potential | ||||||
| Domain | 20 – 96 | 77 | Cytochrome b5 heme-binding | ||||||
Sites | |||||||||
| Metal binding | 55 | 1 | Iron (heme axial ligand) By similarity | ||||||
| Metal binding | 79 | 1 | Iron (heme axial ligand) By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 33 | 1 | Phosphoserine Ref.4 | ||||||
Experimental info | |||||||||
| Sequence conflict | 111 | 1 | K → Q in BAA23735. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cytochrome b5 and aquaporins share the last transmembrane amino acids sequence." Ishibashi K. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph and Pancreas. |
| [4] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, MASS SPECTROMETRY. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB009282 mRNA. Translation: BAA23735.1. AK291576 mRNA. Translation: BAF84265.1. BC004373 mRNA. Translation: AAH04373.1. BC014431 mRNA. Translation: AAH14431.2. | |
| IPI | IPI00641334. |
| RefSeq | NP_085056.2. |
| UniGene | Hs.461131 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B5M based on UniProtKB P04166. |
| SMR | O43169. Positions 17-102. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | O43169. |
Genome annotation databases | |
| Ensembl | ENSG00000103018. Homo sapiens. [Contig view] |
| GeneID | 80777. |
| KEGG | hsa:80777. |
Organism-specific databases | |
| GeneCards | GC16P068017. |
| HGNC | HGNC:24374. CYB5B. |
| HPA | HPA007893. |
| MIM | 611964. gene. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O43169. |
| HOVERGEN | O43169. |
Gene expression databases | |
| ArrayExpress | O43169. |
| Bgee | O43169. |
| CleanEx | HS_CYB5B. |
| GermOnline | ENSG00000103018. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001199. Cyt_B5. IPR018506. Cyt_B5_heme-BS. [Graphical view] |
| Gene3D | G3DSA:3.10.120.10. Cyt_B5. 1 hit. |
| Pfam | PF00173. Cyt-b5. 1 hit. [Graphical view] |
| PRINTS | PR00363. CYTOCHROMEB5. |
| ProDom | PD000612. Cyt_B5. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00191. CYTOCHROME_B5_1. 1 hit. PS50255. CYTOCHROME_B5_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 71179. |
| PMAP-CutDB | O43169. |
| SOURCE | Search... |
Entry information
| Entry name | CYB5B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O43169 Secondary accession number(s): A8K6B1, Q96CC3, Q9BT35 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


