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Protein

Signal-induced proliferation-associated 1-like protein 1

Gene

SIPA1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:G66-33916-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 1
Short name:
SIPA1-like protein 1
Alternative name(s):
High-risk human papilloma viruses E6 oncoproteins targeted protein 1
Short name:
E6-targeted protein 1
Gene namesi
Name:SIPA1L1
Synonyms:E6TP1, KIAA0440
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20284. SIPA1L1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi26037.
OpenTargetsiENSG00000197555.
PharmGKBiPA134940118.

Polymorphism and mutation databases

BioMutaiSIPA1L1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567461 – 1804Signal-induced proliferation-associated 1-like protein 1Add BLAST1804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei1078PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1116PhosphoserineCombined sources1
Modified residuei1127PhosphoserineBy similarity1
Modified residuei1149PhosphoserineCombined sources1
Modified residuei1170PhosphoserineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1255PhosphoserineCombined sources1
Modified residuei1270PhosphoserineCombined sources1
Modified residuei1326Phosphoserine; by PLK2By similarity1
Modified residuei1330Phosphothreonine; by PLK2By similarity1
Modified residuei1349Phosphoserine; by CDK5By similarity1
Modified residuei1366PhosphoserineCombined sources1
Modified residuei1390PhosphoserineCombined sources1
Modified residuei1391PhosphoserineCombined sources1
Modified residuei1412PhosphoserineCombined sources1
Modified residuei1431PhosphoserineCombined sources1
Modified residuei1433PhosphoserineCombined sources1
Modified residuei1528PhosphoserineCombined sources1
Modified residuei1549PhosphoserineCombined sources1
Modified residuei1551PhosphothreonineCombined sources1
Modified residuei1554PhosphoserineCombined sources1
Modified residuei1565PhosphoserineCombined sources1
Modified residuei1568PhosphoserineCombined sources1
Modified residuei1585PhosphoserineCombined sources1
Modified residuei1588PhosphoserineCombined sources1
Modified residuei1601Asymmetric dimethylarginineBy similarity1
Modified residuei1603PhosphoserineBy similarity1
Modified residuei1645PhosphoserineBy similarity1
Modified residuei1647PhosphoserineBy similarity1
Modified residuei1650PhosphoserineBy similarity1
Modified residuei1708PhosphoserineBy similarity1
Modified residuei1711PhosphoserineBy similarity1
Modified residuei1728PhosphoserineBy similarity1
Modified residuei1729PhosphoserineBy similarity1
Modified residuei1734PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.By similarity
Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43166.
MaxQBiO43166.
PaxDbiO43166.
PeptideAtlasiO43166.
PRIDEiO43166.

PTM databases

iPTMnetiO43166.
PhosphoSitePlusiO43166.

Miscellaneous databases

PMAP-CutDBO43166.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000197555.
CleanExiHS_SIPA1L1.
ExpressionAtlasiO43166. baseline and differential.
GenevisibleiO43166. HS.

Organism-specific databases

HPAiHPA002875.

Interactioni

Subunit structurei

Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6.By similarity2 Publications

Protein-protein interaction databases

BioGridi117503. 30 interactors.
IntActiO43166. 22 interactors.
MINTiMINT-1177792.
STRINGi9606.ENSP00000450832.

Structurei

3D structure databases

ProteinModelPortaliO43166.
SMRiO43166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini613 – 830Rap-GAPPROSITE-ProRule annotationAdd BLAST218
Domaini967 – 1045PDZPROSITE-ProRule annotationAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1735 – 1795Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi107 – 143Ser-richAdd BLAST37
Compositional biasi1154 – 1157Poly-Ser4
Compositional biasi1291 – 1486Ser-richAdd BLAST196

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Rap-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000154319.
HOVERGENiHBG056135.
InParanoidiO43166.
KOiK17701.
OMAiPTCHLPA.
OrthoDBiEOG091G016P.
PhylomeDBiO43166.
TreeFamiTF318626.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR030770. SIPA1L1.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF10. PTHR15711:SF10. 4 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43166-1) [UniParc]FASTAAdd to basket
Also known as: E6TP1 beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSLKRSQTE RPLATDRASV VGTDGTPKVH TDDFYMRRFR SQNGSLGSSV
60 70 80 90 100
MAPVGPPRSE GSHHITSTPG VPKMGVRARI ADWPPRKENI KESSRSSQEI
110 120 130 140 150
ETSSCLDSLS SKSSPVSQGS SVSLNSNDSA MLKSIQNTLK NKTRPSENMD
160 170 180 190 200
SRFLMPEAYP SSPRKALRRI RQRSNSDITI SELDVDSFDE CISPTYKTGP
210 220 230 240 250
SLHREYGSTS SIDKQGTSGE SFFDLLKGYK DDKSDRGPTP TKLSDFLITG
260 270 280 290 300
GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR
310 320 330 340 350
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR
360 370 380 390 400
HNVIKRRNTT TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLSM
410 420 430 440 450
DQGDDKSNEL VMSCPYFRNE IGGEGERKIS LSKSNSGSFS GCESASFEST
460 470 480 490 500
LSSHCTNAGV AVLEVPKENL VLHLDRVKRY IVEHVDLGAY YYRKFFYQKE
510 520 530 540 550
HWNYFGADEN LGPVAVSIRR EKPDEMKENG SPYNYRIIFR TSELMTLRGS
560 570 580 590 600
VLEDAIPSTA KHSTARGLPL KEVLEHVVPE LNVQCLRLAF NTPKVTEQLM
610 620 630 640 650
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR
660 670 680 690 700
LKGFEKYRAQ LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL
710 720 730 740 750
LRKRHIGNDI VTIVFQEPGA QPFSPKNIRS HFQHVFVIVR VHNPCSDSVC
760 770 780 790 800
YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF RDFLLAKVIN AENAAHKSEK
810 820 830 840 850
FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK KKEKSKPYPG
860 870 880 890 900
AELSSMGAIV WAVRAEDYNK AMELDCLLGI SNEFIVLIEQ ETKSVVFNCS
910 920 930 940 950
CRDVIGWTST DTSLKIFYER GECVSVGSFI NIEEIKEIVK RLQFVSKGCE
960 970 980 990 1000
SVEMTLRRNG LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV
1010 1020 1030 1040 1050
AVATLSHEQM IDLLRTSVTV KVVIIPPHDD CTPRRSCSET YRMPVMEYKM
1060 1070 1080 1090 1100
NEGVSYEFKF PFRNNNKWQR NASKGPHSPQ VPSQVQSPMT SRLNAGKGDG
1110 1120 1130 1140 1150
KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA LARSQCRNSP
1160 1170 1180 1190 1200
SNLSSSSDTG SVGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDIGGSGKS
1210 1220 1230 1240 1250
TPSWQRSEDS IADQMAYSYR GPQDFNSFVL EQHEYTEPTC HLPAVSKVLP
1260 1270 1280 1290 1300
AFRESPSGRL MRQDPVVHLS PNKQGHSDSH YSSHSSSNTL SSNASSAHSD
1310 1320 1330 1340 1350
EKWYDGDRTE SELNSYNYLQ GTSADSGIDT TSYGPSHGST ASLGAATSSP
1360 1370 1380 1390 1400
RSGPGKEKVA PLWHSSSEVI SMADRTLETE SHGLDRKTES SLSLDIHSKS
1410 1420 1430 1440 1450
QAGSTPLTRE NSTFSINDAA SHTSTMSSRH SASPVVFTSA RSSPKEELHP
1460 1470 1480 1490 1500
AAPSQLAPSF SSSSSSSSGP RSFYPRQGAT SKYLIGWKKP EGTINSVGFM
1510 1520 1530 1540 1550
DTRKRHQSDG NEIAHTRLRA STRDLRASPK PTSKSTIEED LKKLIDLESP
1560 1570 1580 1590 1600
TPESQKSFKF HALSSPQSPF PSTPTSRRAL HRTLSDESIY NSQREHFFTS
1610 1620 1630 1640 1650
RASLLDQALP NDVLFSSTYP SLPKSLPLRR PSYTLGMKSL HGEFSASDSS
1660 1670 1680 1690 1700
LTDIQETRRQ PMPDPGLMPL PDTAADLDWS NLVDAAKAYE VQRASFFAAS
1710 1720 1730 1740 1750
DENHRPLSAA SNSDQLEDQA LAQMKPYSSS KDSSPTLASK VDQLEGMLKM
1760 1770 1780 1790 1800
LREDLKKEKE DKAHLQAEVQ HLREDNLRLQ EESQNASDKL KKFTEWVFNT

IDMS
Length:1,804
Mass (Da):200,029
Last modified:October 3, 2006 - v4
Checksum:i91AB6AB4E7F47B2F
GO
Isoform 2 (identifier: O43166-2) [UniParc]FASTAAdd to basket
Also known as: E6TP1 alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1216-1236: Missing.

Show »
Length:1,783
Mass (Da):197,495
Checksum:i8C9FB14DBD867FCC
GO
Isoform 3 (identifier: O43166-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1216-1236: Missing.
     1728-1728: Missing.

Note: No experimental confirmation available.
Show »
Length:1,782
Mass (Da):197,408
Checksum:iDFF4318DCB195EC5
GO

Sequence cautioni

The sequence BAA23712 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1387K → R in AK122930 (PubMed:14702039).Curated1
Sequence conflicti1722A → P in BAA23712 (PubMed:9455477).Curated1
Sequence conflicti1730Missing in BAA23712 (PubMed:9455477).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04915256P → T.Corresponds to variant rs12884638dbSNPEnsembl.1
Natural variantiVAR_035549996E → D in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0109171216 – 1236Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_0547741728Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090989 mRNA. Translation: AAD12543.1.
AF090990 mRNA. Translation: AAD12544.1.
AB007900 mRNA. Translation: BAA23712.2. Different initiation.
AK122930 mRNA. No translation available.
AC004974 Genomic DNA. Translation: AAC83179.1.
AC004900 Genomic DNA. No translation available.
AC004968 Genomic DNA. No translation available.
AC005476 Genomic DNA. No translation available.
AC005994 Genomic DNA. No translation available.
AL391735 Genomic DNA. No translation available.
CCDSiCCDS61490.1. [O43166-2]
CCDS61491.1. [O43166-3]
CCDS9807.1. [O43166-1]
RefSeqiNP_001271174.1. NM_001284245.1. [O43166-2]
NP_001271175.1. NM_001284246.1. [O43166-3]
NP_001271176.1. NM_001284247.1.
NP_056371.1. NM_015556.2. [O43166-1]
XP_005267573.1. XM_005267516.4. [O43166-1]
XP_011534932.1. XM_011536630.1. [O43166-1]
XP_011534933.1. XM_011536631.1. [O43166-1]
XP_011534934.1. XM_011536632.1. [O43166-1]
XP_011534937.1. XM_011536635.2. [O43166-1]
XP_016876648.1. XM_017021159.1. [O43166-1]
XP_016876649.1. XM_017021160.1. [O43166-1]
XP_016876650.1. XM_017021161.1. [O43166-1]
XP_016876651.1. XM_017021162.1. [O43166-1]
XP_016876652.1. XM_017021163.1. [O43166-1]
XP_016876653.1. XM_017021164.1. [O43166-1]
XP_016876654.1. XM_017021165.1. [O43166-1]
XP_016876655.1. XM_017021166.1. [O43166-1]
XP_016876656.1. XM_017021167.1. [O43166-1]
XP_016876657.1. XM_017021168.1. [O43166-1]
XP_016876658.1. XM_017021169.1. [O43166-1]
XP_016876659.1. XM_017021170.1. [O43166-1]
XP_016876660.1. XM_017021171.1. [O43166-1]
XP_016876661.1. XM_017021172.1. [O43166-1]
XP_016876662.1. XM_017021173.1. [O43166-1]
XP_016876663.1. XM_017021174.1. [O43166-1]
XP_016876664.1. XM_017021175.1. [O43166-1]
XP_016876665.1. XM_017021176.1. [O43166-1]
XP_016876666.1. XM_017021177.1. [O43166-1]
XP_016876667.1. XM_017021178.1. [O43166-1]
XP_016876668.1. XM_017021179.1. [O43166-1]
XP_016876669.1. XM_017021180.1. [O43166-1]
XP_016876675.1. XM_017021186.1. [O43166-2]
XP_016876676.1. XM_017021187.1. [O43166-2]
XP_016876677.1. XM_017021188.1. [O43166-2]
XP_016876678.1. XM_017021189.1. [O43166-2]
XP_016876679.1. XM_017021190.1. [O43166-3]
XP_016876680.1. XM_017021191.1. [O43166-3]
XP_016876681.1. XM_017021192.1. [O43166-3]
XP_016876682.1. XM_017021193.1. [O43166-3]
UniGeneiHs.654657.

Genome annotation databases

EnsembliENST00000358550; ENSP00000351352; ENSG00000197555. [O43166-3]
ENST00000381232; ENSP00000370630; ENSG00000197555. [O43166-2]
ENST00000555818; ENSP00000450832; ENSG00000197555. [O43166-1]
GeneIDi26037.
KEGGihsa:26037.
UCSCiuc001xms.5. human. [O43166-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090989 mRNA. Translation: AAD12543.1.
AF090990 mRNA. Translation: AAD12544.1.
AB007900 mRNA. Translation: BAA23712.2. Different initiation.
AK122930 mRNA. No translation available.
AC004974 Genomic DNA. Translation: AAC83179.1.
AC004900 Genomic DNA. No translation available.
AC004968 Genomic DNA. No translation available.
AC005476 Genomic DNA. No translation available.
AC005994 Genomic DNA. No translation available.
AL391735 Genomic DNA. No translation available.
CCDSiCCDS61490.1. [O43166-2]
CCDS61491.1. [O43166-3]
CCDS9807.1. [O43166-1]
RefSeqiNP_001271174.1. NM_001284245.1. [O43166-2]
NP_001271175.1. NM_001284246.1. [O43166-3]
NP_001271176.1. NM_001284247.1.
NP_056371.1. NM_015556.2. [O43166-1]
XP_005267573.1. XM_005267516.4. [O43166-1]
XP_011534932.1. XM_011536630.1. [O43166-1]
XP_011534933.1. XM_011536631.1. [O43166-1]
XP_011534934.1. XM_011536632.1. [O43166-1]
XP_011534937.1. XM_011536635.2. [O43166-1]
XP_016876648.1. XM_017021159.1. [O43166-1]
XP_016876649.1. XM_017021160.1. [O43166-1]
XP_016876650.1. XM_017021161.1. [O43166-1]
XP_016876651.1. XM_017021162.1. [O43166-1]
XP_016876652.1. XM_017021163.1. [O43166-1]
XP_016876653.1. XM_017021164.1. [O43166-1]
XP_016876654.1. XM_017021165.1. [O43166-1]
XP_016876655.1. XM_017021166.1. [O43166-1]
XP_016876656.1. XM_017021167.1. [O43166-1]
XP_016876657.1. XM_017021168.1. [O43166-1]
XP_016876658.1. XM_017021169.1. [O43166-1]
XP_016876659.1. XM_017021170.1. [O43166-1]
XP_016876660.1. XM_017021171.1. [O43166-1]
XP_016876661.1. XM_017021172.1. [O43166-1]
XP_016876662.1. XM_017021173.1. [O43166-1]
XP_016876663.1. XM_017021174.1. [O43166-1]
XP_016876664.1. XM_017021175.1. [O43166-1]
XP_016876665.1. XM_017021176.1. [O43166-1]
XP_016876666.1. XM_017021177.1. [O43166-1]
XP_016876667.1. XM_017021178.1. [O43166-1]
XP_016876668.1. XM_017021179.1. [O43166-1]
XP_016876669.1. XM_017021180.1. [O43166-1]
XP_016876675.1. XM_017021186.1. [O43166-2]
XP_016876676.1. XM_017021187.1. [O43166-2]
XP_016876677.1. XM_017021188.1. [O43166-2]
XP_016876678.1. XM_017021189.1. [O43166-2]
XP_016876679.1. XM_017021190.1. [O43166-3]
XP_016876680.1. XM_017021191.1. [O43166-3]
XP_016876681.1. XM_017021192.1. [O43166-3]
XP_016876682.1. XM_017021193.1. [O43166-3]
UniGeneiHs.654657.

3D structure databases

ProteinModelPortaliO43166.
SMRiO43166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117503. 30 interactors.
IntActiO43166. 22 interactors.
MINTiMINT-1177792.
STRINGi9606.ENSP00000450832.

PTM databases

iPTMnetiO43166.
PhosphoSitePlusiO43166.

Polymorphism and mutation databases

BioMutaiSIPA1L1.

Proteomic databases

EPDiO43166.
MaxQBiO43166.
PaxDbiO43166.
PeptideAtlasiO43166.
PRIDEiO43166.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358550; ENSP00000351352; ENSG00000197555. [O43166-3]
ENST00000381232; ENSP00000370630; ENSG00000197555. [O43166-2]
ENST00000555818; ENSP00000450832; ENSG00000197555. [O43166-1]
GeneIDi26037.
KEGGihsa:26037.
UCSCiuc001xms.5. human. [O43166-1]

Organism-specific databases

CTDi26037.
DisGeNETi26037.
GeneCardsiSIPA1L1.
HGNCiHGNC:20284. SIPA1L1.
HPAiHPA002875.
neXtProtiNX_O43166.
OpenTargetsiENSG00000197555.
PharmGKBiPA134940118.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3686. Eukaryota.
ENOG410XTIX. LUCA.
GeneTreeiENSGT00760000119182.
HOGENOMiHOG000154319.
HOVERGENiHBG056135.
InParanoidiO43166.
KOiK17701.
OMAiPTCHLPA.
OrthoDBiEOG091G016P.
PhylomeDBiO43166.
TreeFamiTF318626.

Enzyme and pathway databases

BioCyciZFISH:G66-33916-MONOMER.
ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

ChiTaRSiSIPA1L1. human.
GeneWikiiSIPA1L1.
GenomeRNAii26037.
PMAP-CutDBO43166.
PROiO43166.

Gene expression databases

BgeeiENSG00000197555.
CleanExiHS_SIPA1L1.
ExpressionAtlasiO43166. baseline and differential.
GenevisibleiO43166. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR000331. Rap_GAP_dom.
IPR030770. SIPA1L1.
IPR021818. SIPA1L_C.
[Graphical view]
PANTHERiPTHR15711:SF10. PTHR15711:SF10. 4 hits.
PfamiPF02145. Rap_GAP. 1 hit.
PF11881. SPAR_C. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSI1L1_HUMAN
AccessioniPrimary (citable) accession number: O43166
Secondary accession number(s): J3KP19
, O95321, Q9UDU4, Q9UNU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 147 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.