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O43157

- PLXB1_HUMAN

UniProt

O43157 - PLXB1_HUMAN

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Protein
Plexin-B1
Gene
PLXNB1, KIAA0407, PLXN5, SEP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1305 – 13062Cleavage; by proprotein convertases
Sitei1815 – 18151Important for interaction with RAC1 and RND1

GO - Molecular functioni

  1. GTPase activating protein binding Source: BHF-UCL
  2. protein binding Source: UniProtKB
  3. receptor activity Source: ProtInc
  4. semaphorin receptor activity Source: UniProtKB
  5. semaphorin receptor binding Source: UniProtKB
  6. transmembrane signaling receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. axon guidance Source: Reactome
  2. cell migration Source: UniProtKB
  3. intracellular signal transduction Source: UniProtKB
  4. negative regulation of cell adhesion Source: UniProtKB
  5. negative regulation of osteoblast proliferation Source: BHF-UCL
  6. neuron projection morphogenesis Source: UniProtKB
  7. ossification involved in bone maturation Source: BHF-UCL
  8. positive regulation of Rho GTPase activity Source: UniProtKB
  9. positive regulation of axonogenesis Source: Ensembl
  10. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  11. regulation of cell shape Source: UniProtKB
  12. regulation of cytoskeleton organization Source: UniProtKB
  13. semaphorin-plexin signaling pathway Source: UniProtKB
  14. semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis Source: BHF-UCL
  15. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_18407. G alpha (12/13) signalling events.
REACT_19266. Sema4D mediated inhibition of cell attachment and migration.
REACT_19277. Sema4D induced cell migration and growth-cone collapse.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-B1
Alternative name(s):
Semaphorin receptor SEP
Gene namesi
Name:PLXNB1
Synonyms:KIAA0407, PLXN5, SEP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:9103. PLXNB1.

Subcellular locationi

Isoform 1 : Cell membrane; Single-pass type I membrane protein 2 Publications
Isoform 2 : Secreted 2 Publications
Isoform 3 : Secreted 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 14901471Extracellular Reviewed prediction
Add
BLAST
Transmembranei1491 – 151121Helical; Reviewed prediction
Add
BLAST
Topological domaini1512 – 2135624Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: UniProtKB
  3. intracellular Source: InterPro
  4. plasma membrane Source: Reactome
  5. semaphorin receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi139 – 1391D → K: Strongly reduced interaction with SEMA4D. 2 Publications
Mutagenesisi1302 – 13054RRRR → AAAA: Abolishes cleavage by proprotein convertases. 2 Publications
Mutagenesisi1815 – 18151L → F or P: Abolishes interaction with RAC1 and RND1. 2 Publications
Mutagenesisi1884 – 18852WH → SS: Loss of cytoskeleton remodeling in response to SEMA4D. 1 Publication

Organism-specific databases

PharmGKBiPA33429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 21352116Plexin-B1
PRO_0000024671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi79 ↔ 88 By similarity
Disulfide bondi111 ↔ 119 By similarity
Disulfide bondi252 ↔ 377 By similarity
Disulfide bondi268 ↔ 322 By similarity
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi340 ↔ 364 By similarity
Disulfide bondi482 ↔ 499 By similarity
Disulfide bondi488 ↔ 533 By similarity
Disulfide bondi491 ↔ 508 By similarity
Disulfide bondi502 ↔ 514 By similarity
Glycosylationi543 – 5431N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi570 ↔ 588 By similarity
Glycosylationi1183 – 11831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1253 – 12531N-linked (GlcNAc...)3 Publications
Glycosylationi1330 – 13301N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.2 Publications
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO43157.
PaxDbiO43157.
PRIDEiO43157.

PTM databases

PhosphoSiteiO43157.

Expressioni

Tissue specificityi

Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.1 Publication

Gene expression databases

ArrayExpressiO43157.
BgeeiO43157.
CleanExiHS_PLXNB1.
GenevestigatoriO43157.

Organism-specific databases

HPAiHPA040586.

Interactioni

Subunit structurei

Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 By similarity. Interacts with ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2.14 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
METP085817EBI-1111488,EBI-1039152
MST1RQ049123EBI-1111488,EBI-2637518
RND1Q927302EBI-1111488,EBI-448618

Protein-protein interaction databases

BioGridi111377. 11 interactions.
DIPiDIP-36742N.
IntActiO43157. 11 interactions.
MINTiMINT-245604.
STRINGi9606.ENSP00000296440.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 283
Beta strandi35 – 406
Turni42 – 443
Beta strandi47 – 515
Beta strandi54 – 585
Beta strandi64 – 696
Beta strandi73 – 753
Turni85 – 873
Beta strandi92 – 943
Beta strandi98 – 1036
Beta strandi105 – 11410
Helixi115 – 1173
Beta strandi119 – 1235
Beta strandi126 – 1327
Helixi139 – 1413
Beta strandi152 – 1587
Beta strandi164 – 1707
Beta strandi183 – 1908
Helixi194 – 1963
Beta strandi202 – 2054
Helixi211 – 2144
Beta strandi217 – 2248
Beta strandi227 – 2359
Beta strandi244 – 25411
Beta strandi262 – 2687
Turni269 – 2724
Beta strandi275 – 2839
Beta strandi291 – 2988
Helixi314 – 3163
Beta strandi319 – 3257
Helixi326 – 34217
Turni344 – 3463
Beta strandi348 – 3503
Beta strandi354 – 3563
Helixi371 – 3744
Beta strandi385 – 3906
Beta strandi397 – 4004
Beta strandi405 – 4139
Beta strandi416 – 4238
Beta strandi426 – 4327
Beta strandi434 – 4363
Beta strandi442 – 4487
Beta strandi463 – 4697
Beta strandi474 – 4796
Helixi482 – 4843
Helixi488 – 4936
Beta strandi500 – 5023
Turni503 – 5064
Beta strandi507 – 5093
Helixi511 – 5133
Beta strandi523 – 5253
Helixi1568 – 15769
Beta strandi1580 – 15823
Helixi1593 – 15953
Helixi1596 – 161015
Helixi1613 – 162513
Beta strandi1627 – 16293
Helixi1631 – 164414
Turni1645 – 16473
Helixi1649 – 166820
Helixi1672 – 16743
Beta strandi1677 – 16793
Helixi1682 – 170120
Helixi1704 – 171916
Turni1725 – 17273
Beta strandi1730 – 17323
Beta strandi1736 – 17394
Beta strandi1748 – 17558
Beta strandi1757 – 17593
Beta strandi1767 – 17726
Helixi1777 – 178812
Turni1789 – 17913
Helixi1794 – 17963
Helixi1800 – 18023
Beta strandi1803 – 18086
Beta strandi1810 – 18123
Beta strandi1814 – 18174
Beta strandi1819 – 18213
Beta strandi1825 – 18273
Beta strandi1830 – 18323
Helixi1836 – 18394
Beta strandi1846 – 18516
Beta strandi1882 – 18876
Helixi1916 – 194126
Beta strandi1943 – 19453
Helixi1949 – 196416
Helixi1970 – 198011
Turni1981 – 19855
Helixi1986 – 19916
Helixi1993 – 19953
Helixi2003 – 202018
Helixi2033 – 20375
Turni2038 – 20414
Helixi2042 – 205817
Helixi2064 – 207613
Helixi2084 – 209714
Helixi2099 – 21079
Helixi2110 – 21145
Helixi2117 – 212812
Beta strandi2132 – 21343

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JPHNMR-A1743-1862[»]
2OS6NMR-B2128-2135[»]
2R2OX-ray2.00A/B1743-1862[»]
2REXX-ray2.30A/C1743-1862[»]
3HM6X-ray2.40X1511-2135[»]
3OL2X-ray2.99B20-535[»]
3SU8X-ray3.20X1533-2135[»]
3SUAX-ray4.39D/E/F1511-2135[»]
ProteinModelPortaliO43157.
SMRiO43157. Positions 23-533, 1560-2129.

Miscellaneous databases

EvolutionaryTraceiO43157.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 479460Sema
Add
BLAST
Domaini1070 – 116091IPT/TIG 1
Add
BLAST
Domaini1162 – 124988IPT/TIG 2
Add
BLAST
Domaini1252 – 1375124IPT/TIG 3
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1507 – 153933 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi678 – 829152Pro-rich
Add
BLAST
Compositional biasi1302 – 13054Poly-Arg

Sequence similaritiesi

Belongs to the plexin family.
Contains 3 IPT/TIG domains.
Contains 1 Sema domain.

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254546.
HOGENOMiHOG000231376.
HOVERGENiHBG053404.
InParanoidiO43157.
KOiK06821.
OMAiGVMCPSP.
OrthoDBiEOG7Q8CM9.
PhylomeDBiO43157.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43157-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPALGPALLQ ALWAGWVLTL QPLPPTAFTP NGTYLQHLAR DPTSGTLYLG     50
ATNFLFQLSP GLQLEATVST GPVLDSRDCL PPVMPDECPQ AQPTNNPNQL 100
LLVSPGALVV CGSVHQGVCE QRRLGQLEQL LLRPERPGDT QYVAANDPAV 150
STVGLVAQGL AGEPLLFVGR GYTSRGVGGG IPPITTRALW PPDPQAAFSY 200
EETAKLAVGR LSEYSHHFVS AFARGASAYF LFLRRDLQAQ SRAFRAYVSR 250
VCLRDQHYYS YVELPLACEG GRYGLIQAAA VATSREVAHG EVLFAAFSSA 300
APPTVGRPPS AAAGASGASA LCAFPLDEVD RLANRTRDAC YTREGRAEDG 350
TEVAYIEYDV NSDCAQLPVD TLDAYPCGSD HTPSPMASRV PLEATPILEW 400
PGIQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGSDGH PYSTQSIQQG 450
SAVSRDLTFD GTFEHLYVMT QSTLLKVPVA SCAQHLDCAS CLAHRDPYCG 500
WCVLLGRCSR RSECSRGQGP EQWLWSFQPE LGCLQVAAMS PANISREETR 550
EVFLSVPDLP PLWPGESYSC HFGEHQSPAL LTGSGVMCPS PDPSEAPVLP 600
RGADYVSVSV ELRFGAVVIA KTSLSFYDCV AVTELRPSAQ CQACVSSRWG 650
CNWCVWQHLC THKASCDAGP MVASHQSPLV SPDPPARGGP SPSPPTAPKA 700
LATPAPDTLP VEPGAPSTAT ASDISPGASP SLLSPWGPWA GSGSISSPGS 750
TGSPLHEEPS PPSPQNGPGT AVPAPTDFRP SATPEDLLAS PLSPSEVAAV 800
PPADPGPEAL HPTVPLDLPP ATVPATTFPG AMGSVKPALD WLTREGGELP 850
EADEWTGGDA PAFSTSTLLS GDGDSAELEG PPAPLILPSS LDYQYDTPGL 900
WELEEATLGA SSCPCVESVQ GSTLMPVHVE REIRLLGRNL HLFQDGPGDN 950
ECVMELEGLE VVVEARVECE PPPDTQCHVT CQQHQLSYEA LQPELRVGLF 1000
LRRAGRLRVD SAEGLHVVLY DCSVGHGDCS RCQTAMPQYG CVWCEGERPR 1050
CVTREACGEA EAVATQCPAP LIHSVEPLTG PVDGGTRVTI RGSNLGQHVQ 1100
DVLGMVTVAG VPCAVDAQEY EVSSSLVCIT GASGEEVAGA TAVEVPGRGR 1150
GVSEHDFAYQ DPKVHSIFPA RGPRAGGTRL TLNGSKLLTG RLEDIRVVVG 1200
DQPCHLLPEQ QSEQLRCETS PRPTPATLPV AVWFGATERR LQRGQFKYTL 1250
DPNITSAGPT KSFLSGGREI CVRGQNLDVV QTPRIRVTVV SRMLQPSQGL 1300
GRRRRVVPET ACSLGPSCSS QQFEEPCHVN SSQLITCRTP ALPGLPEDPW 1350
VRVEFILDNL VFDFATLNPT PFSYEADPTL QPLNPEDPTM PFRHKPGSVF 1400
SVEGENLDLA MSKEEVVAMI GDGPCVVKTL TRHHLYCEPP VEQPLPRHHA 1450
LREAPDSLPE FTVQMGNLRF SLGHVQYDGE SPGAFPVAAQ VGLGVGTSLL 1500
ALGVIIIVLM YRRKSKQALR DYKKVQIQLE NLESSVRDRC KKEFTDLMTE 1550
MTDLTSDLLG SGIPFLDYKV YAERIFFPGH RESPLHRDLG VPESRRPTVE 1600
QGLGQLSNLL NSKLFLTKFI HTLESQRTFS ARDRAYVASL LTVALHGKLE 1650
YFTDILRTLL SDLVAQYVAK NPKLMLRRTE TVVEKLLTNW MSICLYTFVR 1700
DSVGEPLYML FRGIKHQVDK GPVDSVTGKA KYTLNDNRLL REDVEYRPLT 1750
LNALLAVGPG AGEAQGVPVK VLDCDTISQA KEKMLDQLYK GVPLTQRPDP 1800
RTLDVEWRSG VAGHLILSDE DVTSEVQGLW RRLNTLQHYK VPDGATVALV 1850
PCLTKHVLRE NQDYVPGERT PMLEDVDEGG IRPWHLVKPS DEPEPPRPRR 1900
GSLRGGERER AKAIPEIYLT RLLSMKGTLQ KFVDDLFQVI LSTSRPVPLA 1950
VKYFFDLLDE QAQQHGISDQ DTIHIWKTNS LPLRFWINII KNPQFVFDVQ 2000
TSDNMDAVLL VIAQTFMDAC TLADHKLGRD SPINKLLYAR DIPRYKRMVE 2050
RYYADIRQTV PASDQEMNSV LAELSWNYSG DLGARVALHE LYKYINKYYD 2100
QIITALEEDG TAQKMQLGYR LQQIAAAVEN KVTDL 2135
Length:2,135
Mass (Da):232,298
Last modified:August 31, 2004 - v3
Checksum:i12A81B68AF1D340F
GO
Isoform 2 (identifier: O43157-2) [UniParc]FASTAAdd to Basket

Also known as: Isoform R

The sequence of this isoform differs from the canonical sequence as follows:
     688-870: Missing.

Show »
Length:1,952
Mass (Da):214,411
Checksum:iFCAD0630E128EE9C
GO
Isoform 3 (identifier: O43157-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-729: SPLVSPDPPA...TASDISPGAS → VMETQQSLRA...PVWRAFRAPR
     730-2135: Missing.

Show »
Length:729
Mass (Da):78,395
Checksum:i4AE56E0EDBAE6D75
GO

Sequence cautioni

The sequence BAA23703.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti389 – 3891R → W.
Corresponds to variant rs34050056 [ dbSNP | Ensembl ].
VAR_050598
Natural varianti753 – 7531S → L.
Corresponds to variant rs35592743 [ dbSNP | Ensembl ].
VAR_050599
Natural varianti1891 – 18911D → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036074

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei677 – 72953SPLVS…SPGAS → VMETQQSLRALPPPSSSRPA STTSMTPPGSGSWKRRPWGQ APAPVWRAFRAPR in isoform 3.
VSP_011513Add
BLAST
Alternative sequencei688 – 870183Missing in isoform 2.
VSP_011514Add
BLAST
Alternative sequencei730 – 21351406Missing in isoform 3.
VSP_011515Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1297 – 12971S → N in CAB57277. 1 Publication
Sequence conflicti1625 – 16251S → T in CAB57277. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007867 mRNA. Translation: BAA23703.2. Different initiation.
AJ011414 mRNA. Translation: CAB56221.1.
AJ011415 mRNA. Translation: CAB56222.1.
X87904 mRNA. Translation: CAB57277.1.
CH471055 Genomic DNA. Translation: EAW64865.1.
BC146793 mRNA. Translation: AAI46794.1.
CCDSiCCDS2765.1. [O43157-1]
RefSeqiNP_001123554.1. NM_001130082.2. [O43157-1]
NP_002664.2. NM_002673.5. [O43157-1]
UniGeneiHs.476209.

Genome annotation databases

EnsembliENST00000296440; ENSP00000296440; ENSG00000164050. [O43157-1]
ENST00000358459; ENSP00000351242; ENSG00000164050. [O43157-2]
ENST00000358536; ENSP00000351338; ENSG00000164050. [O43157-1]
ENST00000449094; ENSP00000395987; ENSG00000164050. [O43157-3]
ENST00000456774; ENSP00000414199; ENSG00000164050. [O43157-2]
GeneIDi5364.
KEGGihsa:5364.
UCSCiuc003csu.2. human. [O43157-2]
uc003csw.2. human. [O43157-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007867 mRNA. Translation: BAA23703.2 . Different initiation.
AJ011414 mRNA. Translation: CAB56221.1 .
AJ011415 mRNA. Translation: CAB56222.1 .
X87904 mRNA. Translation: CAB57277.1 .
CH471055 Genomic DNA. Translation: EAW64865.1 .
BC146793 mRNA. Translation: AAI46794.1 .
CCDSi CCDS2765.1. [O43157-1 ]
RefSeqi NP_001123554.1. NM_001130082.2. [O43157-1 ]
NP_002664.2. NM_002673.5. [O43157-1 ]
UniGenei Hs.476209.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JPH NMR - A 1743-1862 [» ]
2OS6 NMR - B 2128-2135 [» ]
2R2O X-ray 2.00 A/B 1743-1862 [» ]
2REX X-ray 2.30 A/C 1743-1862 [» ]
3HM6 X-ray 2.40 X 1511-2135 [» ]
3OL2 X-ray 2.99 B 20-535 [» ]
3SU8 X-ray 3.20 X 1533-2135 [» ]
3SUA X-ray 4.39 D/E/F 1511-2135 [» ]
ProteinModelPortali O43157.
SMRi O43157. Positions 23-533, 1560-2129.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111377. 11 interactions.
DIPi DIP-36742N.
IntActi O43157. 11 interactions.
MINTi MINT-245604.
STRINGi 9606.ENSP00000296440.

PTM databases

PhosphoSitei O43157.

Proteomic databases

MaxQBi O43157.
PaxDbi O43157.
PRIDEi O43157.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296440 ; ENSP00000296440 ; ENSG00000164050 . [O43157-1 ]
ENST00000358459 ; ENSP00000351242 ; ENSG00000164050 . [O43157-2 ]
ENST00000358536 ; ENSP00000351338 ; ENSG00000164050 . [O43157-1 ]
ENST00000449094 ; ENSP00000395987 ; ENSG00000164050 . [O43157-3 ]
ENST00000456774 ; ENSP00000414199 ; ENSG00000164050 . [O43157-2 ]
GeneIDi 5364.
KEGGi hsa:5364.
UCSCi uc003csu.2. human. [O43157-2 ]
uc003csw.2. human. [O43157-1 ]

Organism-specific databases

CTDi 5364.
GeneCardsi GC03M048420.
HGNCi HGNC:9103. PLXNB1.
HPAi HPA040586.
MIMi 601053. gene.
neXtProti NX_O43157.
PharmGKBi PA33429.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254546.
HOGENOMi HOG000231376.
HOVERGENi HBG053404.
InParanoidi O43157.
KOi K06821.
OMAi GVMCPSP.
OrthoDBi EOG7Q8CM9.
PhylomeDBi O43157.
TreeFami TF312962.

Enzyme and pathway databases

Reactomei REACT_18407. G alpha (12/13) signalling events.
REACT_19266. Sema4D mediated inhibition of cell attachment and migration.
REACT_19277. Sema4D induced cell migration and growth-cone collapse.

Miscellaneous databases

EvolutionaryTracei O43157.
GeneWikii PLXNB1.
GenomeRNAii 5364.
NextBioi 20792.
PROi O43157.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43157.
Bgeei O43157.
CleanExi HS_PLXNB1.
Genevestigatori O43157.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view ]
SMARTi SM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
    Tamagnone L., Artigiani S., Chen H., He Z., Ming G.-L., Song H.-L., Chedotal A., Winberg M.L., Goodman C.S., Poo M.-M., Tessier-Lavigne M., Comoglio P.M.
    Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), PHOSPHORYLATION, SUBCELLULAR LOCATION, INTERACTION WITH SEMA4D; NRP1 AND NRP2.
    Tissue: Gastric carcinoma.
  3. "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor."
    Maestrini E., Tamagnone L., Longati P., Cremona O., Gulisano M., Bione S., Tamanini F., Neel B.G., Toniolo D., Comoglio P.M.
    Proc. Natl. Acad. Sci. U.S.A. 93:674-678(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner."
    Vikis H.G., Li W., He Z., Guan K.-L.
    Proc. Natl. Acad. Sci. U.S.A. 97:12457-12462(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAC1.
  7. "The semaphorin 4D receptor controls invasive growth by coupling with Met."
    Giordano S., Corso S., Conrotto P., Artigiani S., Gilestro G., Barberis D., Tamagnone L., Comoglio P.M.
    Nat. Cell Biol. 4:720-724(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEMA4D AND MET, FUNCTION.
  8. "The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG."
    Aurandt J., Vikis H.G., Gutkind J.S., Ahn N., Guan K.-L.
    Proc. Natl. Acad. Sci. U.S.A. 99:12085-12090(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARHGEF11 AND ARHGEF12, FUNCTION.
  9. Cited for: HETERODIMERIZATION WITH PLXNB2, MUTAGENESIS OF 1302-ARG--ARG-1305, PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION.
  10. "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells."
    Oinuma I., Katoh H., Harada A., Negishi M.
    J. Biol. Chem. 278:25671-25677(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RND1.
  11. "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2."
    Swiercz J.M., Kuner R., Offermanns S.
    J. Cell Biol. 165:869-880(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ERBB2, PHOSPHORYLATION, FUNCTION.
  12. "Interplay between scatter factor receptors and B plexins controls invasive growth."
    Conrotto P., Corso S., Gamberini S., Comoglio P.M., Giordano S.
    Oncogene 23:5131-5137(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MET AND MST1R.
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1253.
    Tissue: Plasma.
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1253 AND ASN-1330.
    Tissue: Liver.
  15. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1253.
    Tissue: Leukemic T-cell.
  16. "Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain."
    Tong Y., Chugha P., Hota P.K., Alviani R.S., Li M., Tempel W., Shen L., Park H.W., Buck M.
    J. Biol. Chem. 282:37215-37224(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1743-1862, SUBUNIT, INTERACTION WITH RAC1; RND1 AND RHOD.
  17. "Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor."
    Liu J., Zhang J., Yang Y., Huang H., Shen W., Hu Q., Wang X., Wu J., Shi Y.
    Protein Sci. 17:1003-1014(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2128-2135 IN COMPLEX WITH ARHGEF12, SUBUNIT.
  18. "Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain."
    Tong Y., Hota P.K., Hamaneh M.B., Buck M.
    Structure 16:246-258(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1743-1862, MUTAGENESIS OF LEU-1815, SUBUNIT, INTERACTION WITH RAC1 AND RND1.
  19. "Structure and function of the intracellular region of the plexin-B1 transmembrane receptor."
    Tong Y., Hota P.K., Penachioni J.Y., Hamaneh M.B., Kim S., Alviani R.S., Shen L., He H., Tempel W., Tamagnone L., Park H.W., Buck M.
    J. Biol. Chem. 284:35962-35972(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1511-2135 IN COMPLEX WITH RND1, FUNCTION, SUBUNIT, INTERACTION WITH SEMA4D; RND1; RAC1 AND RRAS, MUTAGENESIS OF 1884-TRP-HIS-1885.
  20. Cited for: X-RAY CRYSTALLOGRAPHY (2.99 ANGSTROMS) OF 20-535 IN COMPLEX WITH SEMA4D, FUNCTION, SUBUNIT, MUTAGENESIS OF ASP-139, GLYCOSYLATION AT ASN-334, DISULFIDE BONDS.
  21. "A dual binding mode for RhoGTPases in plexin signalling."
    Bell C.H., Aricescu A.R., Jones E.Y., Siebold C.
    PLoS Biol. 9:E1001134-E1001134(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 1533-2135 IN COMPLEX WITH RAC1, SUBUNIT, FUNCTION.
  22. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-1891.

Entry informationi

Entry nameiPLXB1_HUMAN
AccessioniPrimary (citable) accession number: O43157
Secondary accession number(s): A6H8Y2
, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 3, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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