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Protein

Plexin-B1

Gene

PLXNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1815Important for interaction with RAC1 and RND11

GO - Molecular functioni

  • GTPase activating protein binding Source: BHF-UCL
  • GTPase activator activity Source: Reactome
  • receptor activity Source: ProtInc
  • semaphorin receptor activity Source: UniProtKB
  • semaphorin receptor binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-416482. G alpha (12/13) signalling events.
R-HSA-416550. Sema4D mediated inhibition of cell attachment and migration.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
SIGNORiO43157.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-B1
Alternative name(s):
Semaphorin receptor SEP
Gene namesi
Name:PLXNB1
Synonyms:KIAA0407, PLXN5, SEP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9103. PLXNB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1490ExtracellularSequence analysisAdd BLAST1471
Transmembranei1491 – 1511HelicalSequence analysisAdd BLAST21
Topological domaini1512 – 2135CytoplasmicSequence analysisAdd BLAST624

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
  • semaphorin receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi139D → K: Strongly reduced interaction with SEMA4D. 1 Publication1
Mutagenesisi1302 – 1305RRRR → AAAA: Abolishes cleavage by proprotein convertases. 1 Publication4
Mutagenesisi1815L → F or P: Abolishes interaction with RAC1 and RND1. 1 Publication1
Mutagenesisi1884 – 1885WH → SS: Loss of cytoskeleton remodeling in response to SEMA4D. 1 Publication2

Organism-specific databases

DisGeNETi5364.
OpenTargetsiENSG00000164050.
PharmGKBiPA33429.

Polymorphism and mutation databases

BioMutaiPLXNB1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002467120 – 2135Plexin-B1Add BLAST2116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi79 ↔ 88PROSITE-ProRule annotation
Disulfide bondi111 ↔ 119PROSITE-ProRule annotation
Disulfide bondi252 ↔ 377PROSITE-ProRule annotation
Disulfide bondi268 ↔ 322PROSITE-ProRule annotation
Glycosylationi334N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi340 ↔ 364PROSITE-ProRule annotation
Disulfide bondi482 ↔ 499PROSITE-ProRule annotation
Disulfide bondi488 ↔ 533PROSITE-ProRule annotation
Disulfide bondi491 ↔ 508PROSITE-ProRule annotation
Disulfide bondi502 ↔ 514PROSITE-ProRule annotation
Glycosylationi543N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi570 ↔ 588PROSITE-ProRule annotation
Glycosylationi1183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1253N-linked (GlcNAc...)3 Publications1
Glycosylationi1330N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.2 Publications
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1305 – 1306Cleavage; by proprotein convertases2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO43157.
PaxDbiO43157.
PeptideAtlasiO43157.
PRIDEiO43157.

PTM databases

iPTMnetiO43157.
PhosphoSitePlusiO43157.

Expressioni

Tissue specificityi

Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.1 Publication

Gene expression databases

BgeeiENSG00000164050.
CleanExiHS_PLXNB1.
GenevisibleiO43157. HS.

Organism-specific databases

HPAiHPA040586.

Interactioni

Subunit structurei

Monomer, and heterodimer with PLXNB2 after proteolytic processing. Binds RAC1 that has been activated by GTP binding. Interaction with SEMA4D promotes binding of cytoplasmic ligands. Binds PLXNA1 (By similarity). Interacts with ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RRAS, RHOD, RND1, NRP1 and NRP2.By similarity13 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
METP085817EBI-1111488,EBI-1039152
MST1RQ049123EBI-1111488,EBI-2637518
RND1Q927302EBI-1111488,EBI-448618

GO - Molecular functioni

  • GTPase activating protein binding Source: BHF-UCL
  • semaphorin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111377. 22 interactors.
DIPiDIP-36742N.
IntActiO43157. 18 interactors.
MINTiMINT-245604.
STRINGi9606.ENSP00000296440.

Structurei

Secondary structure

12135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 28Combined sources3
Beta strandi35 – 40Combined sources6
Turni42 – 44Combined sources3
Beta strandi47 – 51Combined sources5
Beta strandi54 – 58Combined sources5
Beta strandi64 – 69Combined sources6
Beta strandi73 – 75Combined sources3
Turni85 – 87Combined sources3
Beta strandi92 – 94Combined sources3
Beta strandi98 – 103Combined sources6
Beta strandi105 – 114Combined sources10
Helixi115 – 117Combined sources3
Beta strandi119 – 123Combined sources5
Beta strandi126 – 132Combined sources7
Helixi139 – 141Combined sources3
Beta strandi152 – 158Combined sources7
Beta strandi164 – 170Combined sources7
Beta strandi183 – 190Combined sources8
Helixi194 – 196Combined sources3
Beta strandi202 – 205Combined sources4
Helixi211 – 214Combined sources4
Beta strandi217 – 224Combined sources8
Beta strandi227 – 235Combined sources9
Beta strandi244 – 254Combined sources11
Beta strandi262 – 268Combined sources7
Turni269 – 272Combined sources4
Beta strandi275 – 283Combined sources9
Beta strandi291 – 298Combined sources8
Helixi314 – 316Combined sources3
Beta strandi319 – 325Combined sources7
Helixi326 – 342Combined sources17
Turni344 – 346Combined sources3
Beta strandi348 – 350Combined sources3
Beta strandi354 – 356Combined sources3
Helixi371 – 374Combined sources4
Beta strandi385 – 390Combined sources6
Beta strandi397 – 400Combined sources4
Beta strandi405 – 413Combined sources9
Beta strandi416 – 423Combined sources8
Beta strandi426 – 432Combined sources7
Beta strandi434 – 436Combined sources3
Beta strandi442 – 448Combined sources7
Beta strandi463 – 469Combined sources7
Beta strandi474 – 479Combined sources6
Helixi482 – 484Combined sources3
Helixi488 – 493Combined sources6
Beta strandi500 – 502Combined sources3
Turni503 – 506Combined sources4
Beta strandi507 – 509Combined sources3
Helixi511 – 513Combined sources3
Beta strandi523 – 525Combined sources3
Helixi1568 – 1576Combined sources9
Beta strandi1580 – 1582Combined sources3
Helixi1593 – 1595Combined sources3
Helixi1596 – 1610Combined sources15
Helixi1613 – 1625Combined sources13
Beta strandi1627 – 1629Combined sources3
Helixi1631 – 1644Combined sources14
Turni1645 – 1647Combined sources3
Helixi1649 – 1668Combined sources20
Helixi1672 – 1674Combined sources3
Beta strandi1677 – 1679Combined sources3
Helixi1682 – 1701Combined sources20
Helixi1704 – 1719Combined sources16
Turni1725 – 1727Combined sources3
Beta strandi1730 – 1732Combined sources3
Beta strandi1736 – 1739Combined sources4
Beta strandi1748 – 1755Combined sources8
Beta strandi1757 – 1759Combined sources3
Beta strandi1767 – 1772Combined sources6
Helixi1777 – 1788Combined sources12
Turni1789 – 1791Combined sources3
Helixi1794 – 1796Combined sources3
Helixi1800 – 1802Combined sources3
Beta strandi1803 – 1808Combined sources6
Beta strandi1810 – 1812Combined sources3
Beta strandi1814 – 1817Combined sources4
Beta strandi1819 – 1821Combined sources3
Beta strandi1825 – 1827Combined sources3
Beta strandi1830 – 1832Combined sources3
Helixi1836 – 1839Combined sources4
Beta strandi1846 – 1851Combined sources6
Beta strandi1882 – 1887Combined sources6
Helixi1916 – 1941Combined sources26
Beta strandi1943 – 1945Combined sources3
Helixi1949 – 1964Combined sources16
Helixi1970 – 1980Combined sources11
Turni1981 – 1985Combined sources5
Helixi1986 – 1991Combined sources6
Helixi1993 – 1995Combined sources3
Helixi2003 – 2020Combined sources18
Helixi2033 – 2037Combined sources5
Turni2038 – 2041Combined sources4
Helixi2042 – 2058Combined sources17
Helixi2064 – 2076Combined sources13
Helixi2084 – 2097Combined sources14
Helixi2099 – 2107Combined sources9
Helixi2110 – 2114Combined sources5
Helixi2117 – 2128Combined sources12
Beta strandi2132 – 2134Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JPHNMR-A1743-1862[»]
2OS6NMR-B2128-2135[»]
2R2OX-ray2.00A/B1743-1862[»]
2REXX-ray2.30A/C1743-1862[»]
3HM6X-ray2.40X1511-2135[»]
3OL2X-ray2.99B20-535[»]
3SU8X-ray3.20X1533-2135[»]
3SUAX-ray4.39D/E/F1511-2135[»]
ProteinModelPortaliO43157.
SMRiO43157.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43157.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 479SemaPROSITE-ProRule annotationAdd BLAST460
Domaini1070 – 1160IPT/TIG 1Add BLAST91
Domaini1162 – 1249IPT/TIG 2Add BLAST88
Domaini1252 – 1375IPT/TIG 3Add BLAST124

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1507 – 1539Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi678 – 829Pro-richAdd BLAST152
Compositional biasi1302 – 1305Poly-Arg4

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 3 IPT/TIG domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231376.
HOVERGENiHBG053404.
InParanoidiO43157.
KOiK06821.
OMAiDAQEYEV.
OrthoDBiEOG091G00EK.
PhylomeDBiO43157.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 3 hits.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43157-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPALGPALLQ ALWAGWVLTL QPLPPTAFTP NGTYLQHLAR DPTSGTLYLG
60 70 80 90 100
ATNFLFQLSP GLQLEATVST GPVLDSRDCL PPVMPDECPQ AQPTNNPNQL
110 120 130 140 150
LLVSPGALVV CGSVHQGVCE QRRLGQLEQL LLRPERPGDT QYVAANDPAV
160 170 180 190 200
STVGLVAQGL AGEPLLFVGR GYTSRGVGGG IPPITTRALW PPDPQAAFSY
210 220 230 240 250
EETAKLAVGR LSEYSHHFVS AFARGASAYF LFLRRDLQAQ SRAFRAYVSR
260 270 280 290 300
VCLRDQHYYS YVELPLACEG GRYGLIQAAA VATSREVAHG EVLFAAFSSA
310 320 330 340 350
APPTVGRPPS AAAGASGASA LCAFPLDEVD RLANRTRDAC YTREGRAEDG
360 370 380 390 400
TEVAYIEYDV NSDCAQLPVD TLDAYPCGSD HTPSPMASRV PLEATPILEW
410 420 430 440 450
PGIQLTAVAV TMEDGHTIAF LGDSQGQLHR VYLGPGSDGH PYSTQSIQQG
460 470 480 490 500
SAVSRDLTFD GTFEHLYVMT QSTLLKVPVA SCAQHLDCAS CLAHRDPYCG
510 520 530 540 550
WCVLLGRCSR RSECSRGQGP EQWLWSFQPE LGCLQVAAMS PANISREETR
560 570 580 590 600
EVFLSVPDLP PLWPGESYSC HFGEHQSPAL LTGSGVMCPS PDPSEAPVLP
610 620 630 640 650
RGADYVSVSV ELRFGAVVIA KTSLSFYDCV AVTELRPSAQ CQACVSSRWG
660 670 680 690 700
CNWCVWQHLC THKASCDAGP MVASHQSPLV SPDPPARGGP SPSPPTAPKA
710 720 730 740 750
LATPAPDTLP VEPGAPSTAT ASDISPGASP SLLSPWGPWA GSGSISSPGS
760 770 780 790 800
TGSPLHEEPS PPSPQNGPGT AVPAPTDFRP SATPEDLLAS PLSPSEVAAV
810 820 830 840 850
PPADPGPEAL HPTVPLDLPP ATVPATTFPG AMGSVKPALD WLTREGGELP
860 870 880 890 900
EADEWTGGDA PAFSTSTLLS GDGDSAELEG PPAPLILPSS LDYQYDTPGL
910 920 930 940 950
WELEEATLGA SSCPCVESVQ GSTLMPVHVE REIRLLGRNL HLFQDGPGDN
960 970 980 990 1000
ECVMELEGLE VVVEARVECE PPPDTQCHVT CQQHQLSYEA LQPELRVGLF
1010 1020 1030 1040 1050
LRRAGRLRVD SAEGLHVVLY DCSVGHGDCS RCQTAMPQYG CVWCEGERPR
1060 1070 1080 1090 1100
CVTREACGEA EAVATQCPAP LIHSVEPLTG PVDGGTRVTI RGSNLGQHVQ
1110 1120 1130 1140 1150
DVLGMVTVAG VPCAVDAQEY EVSSSLVCIT GASGEEVAGA TAVEVPGRGR
1160 1170 1180 1190 1200
GVSEHDFAYQ DPKVHSIFPA RGPRAGGTRL TLNGSKLLTG RLEDIRVVVG
1210 1220 1230 1240 1250
DQPCHLLPEQ QSEQLRCETS PRPTPATLPV AVWFGATERR LQRGQFKYTL
1260 1270 1280 1290 1300
DPNITSAGPT KSFLSGGREI CVRGQNLDVV QTPRIRVTVV SRMLQPSQGL
1310 1320 1330 1340 1350
GRRRRVVPET ACSLGPSCSS QQFEEPCHVN SSQLITCRTP ALPGLPEDPW
1360 1370 1380 1390 1400
VRVEFILDNL VFDFATLNPT PFSYEADPTL QPLNPEDPTM PFRHKPGSVF
1410 1420 1430 1440 1450
SVEGENLDLA MSKEEVVAMI GDGPCVVKTL TRHHLYCEPP VEQPLPRHHA
1460 1470 1480 1490 1500
LREAPDSLPE FTVQMGNLRF SLGHVQYDGE SPGAFPVAAQ VGLGVGTSLL
1510 1520 1530 1540 1550
ALGVIIIVLM YRRKSKQALR DYKKVQIQLE NLESSVRDRC KKEFTDLMTE
1560 1570 1580 1590 1600
MTDLTSDLLG SGIPFLDYKV YAERIFFPGH RESPLHRDLG VPESRRPTVE
1610 1620 1630 1640 1650
QGLGQLSNLL NSKLFLTKFI HTLESQRTFS ARDRAYVASL LTVALHGKLE
1660 1670 1680 1690 1700
YFTDILRTLL SDLVAQYVAK NPKLMLRRTE TVVEKLLTNW MSICLYTFVR
1710 1720 1730 1740 1750
DSVGEPLYML FRGIKHQVDK GPVDSVTGKA KYTLNDNRLL REDVEYRPLT
1760 1770 1780 1790 1800
LNALLAVGPG AGEAQGVPVK VLDCDTISQA KEKMLDQLYK GVPLTQRPDP
1810 1820 1830 1840 1850
RTLDVEWRSG VAGHLILSDE DVTSEVQGLW RRLNTLQHYK VPDGATVALV
1860 1870 1880 1890 1900
PCLTKHVLRE NQDYVPGERT PMLEDVDEGG IRPWHLVKPS DEPEPPRPRR
1910 1920 1930 1940 1950
GSLRGGERER AKAIPEIYLT RLLSMKGTLQ KFVDDLFQVI LSTSRPVPLA
1960 1970 1980 1990 2000
VKYFFDLLDE QAQQHGISDQ DTIHIWKTNS LPLRFWINII KNPQFVFDVQ
2010 2020 2030 2040 2050
TSDNMDAVLL VIAQTFMDAC TLADHKLGRD SPINKLLYAR DIPRYKRMVE
2060 2070 2080 2090 2100
RYYADIRQTV PASDQEMNSV LAELSWNYSG DLGARVALHE LYKYINKYYD
2110 2120 2130
QIITALEEDG TAQKMQLGYR LQQIAAAVEN KVTDL
Length:2,135
Mass (Da):232,298
Last modified:August 31, 2004 - v3
Checksum:i12A81B68AF1D340F
GO
Isoform 2 (identifier: O43157-2) [UniParc]FASTAAdd to basket
Also known as: Isoform R

The sequence of this isoform differs from the canonical sequence as follows:
     688-870: Missing.

Show »
Length:1,952
Mass (Da):214,411
Checksum:iFCAD0630E128EE9C
GO
Isoform 3 (identifier: O43157-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     677-729: SPLVSPDPPA...TASDISPGAS → VMETQQSLRA...PVWRAFRAPR
     730-2135: Missing.

Show »
Length:729
Mass (Da):78,395
Checksum:i4AE56E0EDBAE6D75
GO

Sequence cautioni

The sequence BAA23703 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1297S → N in CAB57277 (PubMed:8570614).Curated1
Sequence conflicti1625S → T in CAB57277 (PubMed:8570614).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050598389R → W.Corresponds to variant rs34050056dbSNPEnsembl.1
Natural variantiVAR_050599753S → L.Corresponds to variant rs35592743dbSNPEnsembl.1
Natural variantiVAR_0360741891D → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011513677 – 729SPLVS…SPGAS → VMETQQSLRALPPPSSSRPA STTSMTPPGSGSWKRRPWGQ APAPVWRAFRAPR in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_011514688 – 870Missing in isoform 2. 1 PublicationAdd BLAST183
Alternative sequenceiVSP_011515730 – 2135Missing in isoform 3. 1 PublicationAdd BLAST1406

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007867 mRNA. Translation: BAA23703.2. Different initiation.
AJ011414 mRNA. Translation: CAB56221.1.
AJ011415 mRNA. Translation: CAB56222.1.
X87904 mRNA. Translation: CAB57277.1.
CH471055 Genomic DNA. Translation: EAW64865.1.
BC146793 mRNA. Translation: AAI46794.1.
CCDSiCCDS2765.1. [O43157-1]
RefSeqiNP_001123554.1. NM_001130082.2. [O43157-1]
NP_002664.2. NM_002673.5. [O43157-1]
XP_016862120.1. XM_017006631.1. [O43157-1]
UniGeneiHs.476209.

Genome annotation databases

EnsembliENST00000296440; ENSP00000296440; ENSG00000164050. [O43157-1]
ENST00000358536; ENSP00000351338; ENSG00000164050. [O43157-1]
ENST00000449094; ENSP00000395987; ENSG00000164050. [O43157-3]
ENST00000456774; ENSP00000414199; ENSG00000164050. [O43157-2]
GeneIDi5364.
KEGGihsa:5364.
UCSCiuc003csu.3. human. [O43157-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007867 mRNA. Translation: BAA23703.2. Different initiation.
AJ011414 mRNA. Translation: CAB56221.1.
AJ011415 mRNA. Translation: CAB56222.1.
X87904 mRNA. Translation: CAB57277.1.
CH471055 Genomic DNA. Translation: EAW64865.1.
BC146793 mRNA. Translation: AAI46794.1.
CCDSiCCDS2765.1. [O43157-1]
RefSeqiNP_001123554.1. NM_001130082.2. [O43157-1]
NP_002664.2. NM_002673.5. [O43157-1]
XP_016862120.1. XM_017006631.1. [O43157-1]
UniGeneiHs.476209.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JPHNMR-A1743-1862[»]
2OS6NMR-B2128-2135[»]
2R2OX-ray2.00A/B1743-1862[»]
2REXX-ray2.30A/C1743-1862[»]
3HM6X-ray2.40X1511-2135[»]
3OL2X-ray2.99B20-535[»]
3SU8X-ray3.20X1533-2135[»]
3SUAX-ray4.39D/E/F1511-2135[»]
ProteinModelPortaliO43157.
SMRiO43157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111377. 22 interactors.
DIPiDIP-36742N.
IntActiO43157. 18 interactors.
MINTiMINT-245604.
STRINGi9606.ENSP00000296440.

PTM databases

iPTMnetiO43157.
PhosphoSitePlusiO43157.

Polymorphism and mutation databases

BioMutaiPLXNB1.

Proteomic databases

MaxQBiO43157.
PaxDbiO43157.
PeptideAtlasiO43157.
PRIDEiO43157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296440; ENSP00000296440; ENSG00000164050. [O43157-1]
ENST00000358536; ENSP00000351338; ENSG00000164050. [O43157-1]
ENST00000449094; ENSP00000395987; ENSG00000164050. [O43157-3]
ENST00000456774; ENSP00000414199; ENSG00000164050. [O43157-2]
GeneIDi5364.
KEGGihsa:5364.
UCSCiuc003csu.3. human. [O43157-1]

Organism-specific databases

CTDi5364.
DisGeNETi5364.
GeneCardsiPLXNB1.
HGNCiHGNC:9103. PLXNB1.
HPAiHPA040586.
MIMi601053. gene.
neXtProtiNX_O43157.
OpenTargetsiENSG00000164050.
PharmGKBiPA33429.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231376.
HOVERGENiHBG053404.
InParanoidiO43157.
KOiK06821.
OMAiDAQEYEV.
OrthoDBiEOG091G00EK.
PhylomeDBiO43157.
TreeFamiTF312962.

Enzyme and pathway databases

ReactomeiR-HSA-416482. G alpha (12/13) signalling events.
R-HSA-416550. Sema4D mediated inhibition of cell attachment and migration.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
SIGNORiO43157.

Miscellaneous databases

ChiTaRSiPLXNB1. human.
EvolutionaryTraceiO43157.
GeneWikiiPLXNB1.
GenomeRNAii5364.
PROiO43157.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164050.
CleanExiHS_PLXNB1.
GenevisibleiO43157. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 3 hits.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
PF01833. TIG. 3 hits.
[Graphical view]
SMARTiSM00429. IPT. 3 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLXB1_HUMAN
AccessioniPrimary (citable) accession number: O43157
Secondary accession number(s): A6H8Y2
, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 30, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.