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Protein

Zinc finger ZZ-type and EF-hand domain-containing protein 1

Gene

ZZEF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1777 – 182549ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1826 – 187247ZZ-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger ZZ-type and EF-hand domain-containing protein 1
Gene namesi
Name:ZZEF1
Synonyms:KIAA0399
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29027. ZZEF1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134938508.

Polymorphism and mutation databases

BioMutaiZZEF1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 29612960Zinc finger ZZ-type and EF-hand domain-containing protein 1PRO_0000289000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei1475 – 14751PhosphoserineCombined sources
Modified residuei1488 – 14881PhosphoserineBy similarity
Modified residuei1509 – 15091PhosphoserineCombined sources
Modified residuei1512 – 15121PhosphothreonineCombined sources
Modified residuei1518 – 15181PhosphoserineCombined sources
Modified residuei1521 – 15211PhosphothreonineBy similarity
Modified residuei1523 – 15231PhosphothreonineCombined sources
Modified residuei1540 – 15401PhosphoserineBy similarity
Modified residuei2444 – 24441PhosphoserineBy similarity
Modified residuei2667 – 26671N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiO43149.
MaxQBiO43149.
PaxDbiO43149.
PRIDEiO43149.

PTM databases

iPTMnetiO43149.
PhosphoSiteiO43149.

Expressioni

Tissue specificityi

Expressed at low levels in cerebellum.1 Publication

Gene expression databases

BgeeiO43149.
CleanExiHS_ZZEF1.
ExpressionAtlasiO43149. baseline and differential.
GenevisibleiO43149. HS.

Organism-specific databases

HPAiHPA031778.
HPA031790.

Interactioni

Protein-protein interaction databases

BioGridi116757. 60 interactions.
IntActiO43149. 13 interactions.
MINTiMINT-1191246.
STRINGi9606.ENSP00000371051.

Structurei

3D structure databases

ProteinModelPortaliO43149.
SMRiO43149. Positions 239-380, 1780-1863.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 14636EF-handPROSITE-ProRule annotationAdd
BLAST
Domaini226 – 405180DOCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DOC domain.PROSITE-ProRule annotation
Contains 1 EF-hand domain.PROSITE-ProRule annotation
Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1777 – 182549ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1826 – 187247ZZ-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410II3P. Eukaryota.
ENOG410XS5C. LUCA.
GeneTreeiENSGT00780000121942.
HOGENOMiHOG000155817.
HOVERGENiHBG108782.
InParanoidiO43149.
OMAiNEWGYKF.
OrthoDBiEOG76MK7D.
PhylomeDBiO43149.
TreeFamiTF331572.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR000859. CUB_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR008979. Galactose-bd-like.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
PF00569. ZZ. 2 hits.
[Graphical view]
SMARTiSM01337. APC10. 1 hit.
SM00054. EFh. 1 hit.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43149-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNAPSHSSE DEAAAAGGEG WGPHQDWAAV SGTTPGPGVA APALPPAAAL
60 70 80 90 100
LEPARLREAA AALLPTPPCE SLVSRHRGAL FRWLEERLGR GEESVTLEQF
110 120 130 140 150
RELLEARGAG CSSEQFEEAF AQFDAEGDGT VDAENMLEAL KNSSGANLQG
160 170 180 190 200
ELSHIIRQLQ ACSLVPGFTD IFSESKEGLD IHSSMILRFL HRNRLSSAVM
210 220 230 240 250
PYPMLEHCNN MCTMRSSVLK ESLDQLVQKE KESPGDLTRS PEMDKLKSVA
260 270 280 290 300
KCYAYIETSS NSADIDKMTN GETSSYWQSD GSACSHWIRL KMKPDVVLRH
310 320 330 340 350
LSIAVAATDQ SYMPQQVTVA VGRNASDLQE VRDVHIPSNV TGYVTLLENA
360 370 380 390 400
NVSQLYVQIN IKRCLSDGCD TRIHGLRAVG FQRVKKSGVS VSDASAIWYW
410 420 430 440 450
SLLTSLVTAS METNPAFVQT VLHNTQKALR HMPPLSLSPG STDFSTFLSP
460 470 480 490 500
NVLEEVDSFL IRITSCCSTP EVELTLLAFA LARGSVAKVM SSLCTITDHL
510 520 530 540 550
DTQYDASSLI LSMASVRQNL LLKYGKPLQL TLQACDVKGK EDKSGPENLL
560 570 580 590 600
VEPWTRDGFL TETGKTRAST IFSTGTESAF QVTQIRIMVR RGGIGAQCGL
610 620 630 640 650
VFAYNSSSDK FCAEEHFKRF EKYDKWKLQE LRQFVKSRIG CSSDDLGEDD
660 670 680 690 700
PIGWFELEEE WDEADVKLQQ CRVAKYLMVK FLCTRQESAE RLGVQGLTIS
710 720 730 740 750
GYLRPARAEA EQSVTCAHCR KDTEESVCGA TLLLRTLQFI QQLAHDLVQQ
760 770 780 790 800
KESGLKYKSF LDFAGLDLQI FWNFYSKLKQ NPREECVSAQ TLLLQLLQSC
810 820 830 840 850
FSVLQGDVLA ASEEEKAPIQ SPKGVEAAKE LYTHLCDVVD KVDGDSVPME
860 870 880 890 900
ILKQEVRNTL LNGAAIFFPN RQTRRNHLFT MMNVTEQEHK QSLQLTFRSL
910 920 930 940 950
CTYFSDKDPG GLLLLPEKND LAKMNISEVL AVMDTLVSVA ARECELLMLS
960 970 980 990 1000
GAPGEVGSVL FSLFWSVQGS LLSWCYLQLK STDSGAKDLA VDLIEKYVGQ
1010 1020 1030 1040 1050
FLASMRAILE SLFSQYSGKT IVERLCNSVF SMAARQLVIF LLDFCTLDIP
1060 1070 1080 1090 1100
HCVLLREFSV LTELLKKLCS GPEGGLRKLD VETWQQEQPV VLHTWTKESA
1110 1120 1130 1140 1150
HNYENNCHEV SVFVSPGATY FEVEFDDRCE TEKRYDYLEF TDARGRKTRY
1160 1170 1180 1190 1200
DTKVGTDKWP KKVTFKAGPR LQFLFHSDSS HNEWGYKFTV TACGLPDVAV
1210 1220 1230 1240 1250
SWGLDLQLLV SRLMGRLASQ CMALKSVRQL GSNMVVPQAK MALVLSSPLW
1260 1270 1280 1290 1300
KPVFRHQVCP ELELEASWPT HPHRNSKEVK NIPDDPCRHF LLDFAQSEPA
1310 1320 1330 1340 1350
QNFCGPYSEL FKGFIQACRK QAPKTDIVAG STIDQAVNAT FAALVYRTPD
1360 1370 1380 1390 1400
LYEKLQKYVN SGGKIALSEE FAQVYSLADG IRIWMLEMKQ KSLMSLGNEA
1410 1420 1430 1440 1450
EEKHSSEATE VNPESLAKEC IEKSLLLLKF LPTGISSKES CEKLETADET
1460 1470 1480 1490 1500
SHLQPLNKRQ RTSSVVEEHF QASVSPTEAA PPATGDQSPG LGTQPKLPSS
1510 1520 1530 1540 1550
SGLPAADVSP ATAEEPLSPS TPTRRPPFTR GRLRLLSFRS MEEARLVPTV
1560 1570 1580 1590 1600
KEKYPVLKDV MDFIKDQSLS HRSVVKVLSL RKAQAQSILE VLKITQHCAE
1610 1620 1630 1640 1650
SLGQPHCFHP PFILFLLELL TCQKDFTNYF GHLEGCGADL HKEIRDTYYQ
1660 1670 1680 1690 1700
LVLFLVKAVK GFSSLNDRSL LPALSCVQTA LLHLLDMGWE PNDLAFFVDI
1710 1720 1730 1740 1750
QLPDLLMKMS QENISVHDSV ISQWSEEDEL ADAKQNSEWM DECQDGMFEA
1760 1770 1780 1790 1800
WYEKIAQEDP EKQRKMHMFI ARYCDLLNVD ISCDGCDEIA PWHRYRCLQC
1810 1820 1830 1840 1850
SDMDLCKTCF LGGVKPEGHG DDHEMVNMEF TCDHCQGLII GRRMNCNVCD
1860 1870 1880 1890 1900
DFDLCYGCYA AKKYSYGHLP THSITAHPMV TIRISDRQRL IQPYIHNYSW
1910 1920 1930 1940 1950
LLFAALALYS AHLASAEDVD GEKLDPQTRS SATTLRSQCM QLVGDCLMKA
1960 1970 1980 1990 2000
HQGKGLKALA LLGVLPDGDS SLEDQALPVT VPTGASEEQL EKKAVQGAEL
2010 2020 2030 2040 2050
SEAGNGKRAV HEEIRPVDFK QRNKADKGVS LSKDPSCQTQ ISDSPADASP
2060 2070 2080 2090 2100
PTGLPDAEDS EVSSQKPIEE KAVTPSPEQV FAECSQKRIL GLLAAMLPPL
2110 2120 2130 2140 2150
KSGPTVPLID LEHVLPLMFQ VVISNAGHLN ETYHLTLGLL GQLIIRLLPA
2160 2170 2180 2190 2200
EVDAAVIKVL SAKHNLFAAG DSSIVPDGWK TTHLLFSLGA VCLDSRVGLD
2210 2220 2230 2240 2250
WACSMAEILR SLNSAPLWRD VIATFTDHCI KQLPFQLKHT NIFTLLVLVG
2260 2270 2280 2290 2300
FPQVLCVGTR CVYMDNANEP HNVIILKHFT EKNRAVIVDV KTRKRKTVKD
2310 2320 2330 2340 2350
YQLVQKGGGQ ECGDSRAQLS QYSQHFAFIA SHLLQSSMDS HCPEAVEATW
2360 2370 2380 2390 2400
VLSLALKGLY KTLKAHGFEE IRATFLQTDL LKLLVKKCSK GTGFSKTWLL
2410 2420 2430 2440 2450
RDLEILSIML YSSKKEINAL AEHGDLELDE RGDREEEVER PVSSPGDPEQ
2460 2470 2480 2490 2500
KKLDPLEGLD EPTRICFLMA HDALNAPLHI LRAIYELQMK KTDYFFLEVQ
2510 2520 2530 2540 2550
KRFDGDELTT DERIRSLAQR WQPSKSLRLE EQSAKAVDTD MIILPCLSRP
2560 2570 2580 2590 2600
ARCDQATAES NPVTQKLISS TESELQQSYA KQRRSKSAAL LHKELNCKSK
2610 2620 2630 2640 2650
RAVRDYLFRV NEATAVLYAR HVLASLLAEW PSHVPVSEDI LELSGPAHMT
2660 2670 2680 2690 2700
YILDMFMQLE EKHEWEKILQ KVLQGCREDM LGTMALAACQ FMEEPGMEVQ
2710 2720 2730 2740 2750
VRESKHPYNN NTNFEDKVHI PGAIYLSIKF DSQCNTEEGC DELAMSSSSD
2760 2770 2780 2790 2800
FQQDRHSFSG SQQKWKDFEL PGDTLYYRFT SDMSNTEWGY RFTVTAGHLG
2810 2820 2830 2840 2850
RFQTGFEILK QMLSEERVVP HLPLAKIWEW LVGVACRQTG HQRLKAIHLL
2860 2870 2880 2890 2900
LRIVRCCGHS DLCDLALLKP LWQLFTHMEY GLFEDVTQPG ILLPLHRALT
2910 2920 2930 2940 2950
ELFFVTENRA QELGVLQDYL LALTTDDHLL RCAAQALQNI AAISLAINYP
2960
NKATRLWNVE C
Length:2,961
Mass (Da):331,075
Last modified:May 5, 2009 - v6
Checksum:i0DB2EB72C16BC168
GO
Isoform 2 (identifier: O43149-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1613: Missing.
     2405-2424: ILSIMLYSSKKEINALAEHG → VRDERDSCSSFLVQMCWPRS
     2425-2961: Missing.

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:811
Mass (Da):90,468
Checksum:iA3138EDEFE4A6139
GO
Isoform 3 (identifier: O43149-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     882-882: M → MK
     1079-1084: LDVETW → VTRVST
     1085-2961: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:1,085
Mass (Da):119,964
Checksum:i276FA1193DC16093
GO

Sequence cautioni

The sequence BAA23695.4 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA91834.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti959 – 9591V → A in BAA23695 (PubMed:9455477).Curated
Sequence conflicti959 – 9591V → A in AAI51837 (PubMed:15489334).Curated
Sequence conflicti1929 – 19291R → H in BAA91834 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301V → A.1 Publication
Corresponds to variant rs1454121 [ dbSNP | Ensembl ].
VAR_032551
Natural varianti1021 – 10211I → V.
Corresponds to variant rs16953687 [ dbSNP | Ensembl ].
VAR_032552
Natural varianti1437 – 14371S → A.
Corresponds to variant rs4790555 [ dbSNP | Ensembl ].
VAR_032553
Natural varianti1972 – 19721L → P.2 Publications
Corresponds to variant rs781852 [ dbSNP | Ensembl ].
VAR_032554
Natural varianti2014 – 20141I → V.2 Publications
Corresponds to variant rs781831 [ dbSNP | Ensembl ].
VAR_032555
Natural varianti2051 – 20511P → S.
Corresponds to variant rs1006954 [ dbSNP | Ensembl ].
VAR_032556
Natural varianti2301 – 23011Y → H.
Corresponds to variant rs34357158 [ dbSNP | Ensembl ].
VAR_032557
Natural varianti2303 – 23031L → P.
Corresponds to variant rs35638819 [ dbSNP | Ensembl ].
VAR_032558
Natural varianti2369 – 23691E → Q.2 Publications
Corresponds to variant rs711177 [ dbSNP | Ensembl ].
VAR_032559
Natural varianti2421 – 24211A → T.
Corresponds to variant rs781861 [ dbSNP | Ensembl ].
VAR_032560

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 16131613Missing in isoform 2. 1 PublicationVSP_042268Add
BLAST
Alternative sequencei882 – 8821M → MK in isoform 3. 1 PublicationVSP_036989
Alternative sequencei1079 – 10846LDVETW → VTRVST in isoform 3. 1 PublicationVSP_025870
Alternative sequencei1085 – 29611877Missing in isoform 3. 1 PublicationVSP_025871Add
BLAST
Alternative sequencei2405 – 242420ILSIM…LAEHG → VRDERDSCSSFLVQMCWPRS in isoform 2. 1 PublicationVSP_042269Add
BLAST
Alternative sequencei2425 – 2961537Missing in isoform 2. 1 PublicationVSP_042270Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007859 mRNA. Translation: BAA23695.4. Different initiation.
AK001683 mRNA. Translation: BAA91834.1. Different initiation.
AK127482 mRNA. Translation: BAC86999.1.
AC067815 Genomic DNA. No translation available.
AC087292 Genomic DNA. No translation available.
BC067099 mRNA. Translation: AAH67099.1.
BC151836 mRNA. Translation: AAI51837.1.
CCDSiCCDS11043.1. [O43149-1]
PIRiT00048.
RefSeqiNP_055928.3. NM_015113.3. [O43149-1]
UniGeneiHs.277624.

Genome annotation databases

EnsembliENST00000381638; ENSP00000371051; ENSG00000074755. [O43149-1]
GeneIDi23140.
KEGGihsa:23140.
UCSCiuc002fxe.4. human. [O43149-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007859 mRNA. Translation: BAA23695.4. Different initiation.
AK001683 mRNA. Translation: BAA91834.1. Different initiation.
AK127482 mRNA. Translation: BAC86999.1.
AC067815 Genomic DNA. No translation available.
AC087292 Genomic DNA. No translation available.
BC067099 mRNA. Translation: AAH67099.1.
BC151836 mRNA. Translation: AAI51837.1.
CCDSiCCDS11043.1. [O43149-1]
PIRiT00048.
RefSeqiNP_055928.3. NM_015113.3. [O43149-1]
UniGeneiHs.277624.

3D structure databases

ProteinModelPortaliO43149.
SMRiO43149. Positions 239-380, 1780-1863.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116757. 60 interactions.
IntActiO43149. 13 interactions.
MINTiMINT-1191246.
STRINGi9606.ENSP00000371051.

PTM databases

iPTMnetiO43149.
PhosphoSiteiO43149.

Polymorphism and mutation databases

BioMutaiZZEF1.

Proteomic databases

EPDiO43149.
MaxQBiO43149.
PaxDbiO43149.
PRIDEiO43149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381638; ENSP00000371051; ENSG00000074755. [O43149-1]
GeneIDi23140.
KEGGihsa:23140.
UCSCiuc002fxe.4. human. [O43149-1]

Organism-specific databases

CTDi23140.
GeneCardsiZZEF1.
H-InvDBHIX0017584.
HGNCiHGNC:29027. ZZEF1.
HPAiHPA031778.
HPA031790.
neXtProtiNX_O43149.
PharmGKBiPA134938508.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II3P. Eukaryota.
ENOG410XS5C. LUCA.
GeneTreeiENSGT00780000121942.
HOGENOMiHOG000155817.
HOVERGENiHBG108782.
InParanoidiO43149.
OMAiNEWGYKF.
OrthoDBiEOG76MK7D.
PhylomeDBiO43149.
TreeFamiTF331572.

Miscellaneous databases

ChiTaRSiZZEF1. human.
GenomeRNAii23140.
NextBioi44414.
PROiO43149.

Gene expression databases

BgeeiO43149.
CleanExiHS_ZZEF1.
ExpressionAtlasiO43149. baseline and differential.
GenevisibleiO43149. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR004939. APC_su10/DOC_dom.
IPR000859. CUB_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR008979. Galactose-bd-like.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF03256. ANAPC10. 1 hit.
PF00569. ZZ. 2 hits.
[Graphical view]
SMARTiSM01337. APC10. 1 hit.
SM00054. EFh. 1 hit.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEiPS51284. DOC. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PRO-1972; VAL-2014 AND GLN-2369.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1614-2961 (ISOFORM 2), VARIANT ALA-30.
    Tissue: Teratocarcinoma and Thalamus.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PRO-1972; VAL-2014 AND GLN-2369.
    Tissue: Brain.
  6. "Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene."
    Cvekl A. Jr., Zavadil J., Birshtein B.K., Grotzer M.A., Cvekl A.
    Eur. J. Cancer 40:2525-2532(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1509 AND SER-1518, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1509 AND SER-1518, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1475, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2667, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
    Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T.
    Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1512 AND THR-1523, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiZZEF1_HUMAN
AccessioniPrimary (citable) accession number: O43149
Secondary accession number(s): A7MBM5
, Q6NXG0, Q6ZRA1, Q6ZSF4, Q9NVB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: May 11, 2016
This is version 121 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.