O43133 (TBP_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TATA-box-binding protein

Alternative name(s):
TATA sequence-binding protein
Short name=TBP
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit

Gene names

Name:	TBP1
Synonyms:	TBP
ORF Names:	CaO19.1837, CaO19.9395

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Subunit structure	Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the TBP family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	Nucleus
Domain	Repeat
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription initiation from RNA polymerase II promoter Inferred from genetic interaction Ref.1. Source: CGD
Cellular_component	transcription factor complex Inferred from genetic interaction Ref.1. Source: CGD
Molecular_function	DNA binding Inferred from direct assay Ref.1. Source: CGD sequence-specific DNA binding transcription factor activity Inferred from genetic interaction Ref.1. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	TATA-box-binding protein		PRO_0000153987
Regions
	Repeat	65 – 141	77	1
	Repeat	155 – 232	78	2

Sequences

	Sequence		Length	Mass (Da)
	O43133 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: CA0C3F666FBF20FE	FASTA	238	26,601
	10 20 30 40 50 60 MDLKLPPTNP TNPQQAKTFM KSIEEDEKNK AEDLDIIKKE DIDEPKQEDT TDGNGGGGIG 70 80 90 100 110 120 IVPTLQNIVA TVNLDCRLDL KTIALHARNA EYNPKRFAAV IMRIRDPKTT ALIFASGKMV 130 140 150 160 170 180 VTGAKSEDDS KLASRKYARI IQKLGFNAKF CDFKIQNIVG STDVKFAIRL EGLAFAHGTF 190 200 210 220 230 SSYEPELFPG LIYRMVKPKI VLLIFVSGKI VLTGAKKREE IYDAFESIYP VLNEFRKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The TATA-binding protein (TBP) from the human fungal pathogen Candida albicans can complement defects in human and yeast TBPs." Leng P., Carter P.E., Brown A.J.P. J. Bacteriol. 180:1771-1776(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: ATCC 10261 / 3153.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U95550 mRNA. Translation: AAC49986.1. U95549 Genomic DNA. Translation: AAC49985.1. AACQ01000244 Genomic DNA. Translation: EAK91473.1. AACQ01000240 Genomic DNA. Translation: EAK91511.1.
RefSeq	XP_710721.1. XM_705629.1. XP_710759.1. XM_705667.1.
3D structure databases
ProteinModelPortal	O43133.
SMR	O43133. Positions 59-237.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0001658.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3647641. 3647675.
KEGG	cal:CaO19.1837. cal:CaO19.9395.
Organism-specific databases
CGD	CAL0001658. TBP1.
Phylogenomic databases
eggNOG	COG2101.
KO	K03120.
Family and domain databases
Gene3D	3.30.310.10. 2 hits.
InterPro	IPR012295. Beta2_adaptin/TBP_C_dom. IPR000814. TBP. [Graphical view]
PANTHER	PTHR10126. PTHR10126. 1 hit.
Pfam	PF00352. TBP. 2 hits. [Graphical view]
PRINTS	PR00686. TIFACTORIID.
PROSITE	PS00351. TFIID. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TBP_CANAL

Accession

Primary (citable) accession number: O43133
Secondary accession number(s): Q59LW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program