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Protein

TATA-box-binding protein

Gene

TBP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

GO - Molecular functioni

  • DNA binding Source: CGD
  • DNA binding transcription factor activity Source: CGD

GO - Biological processi

  • transcription initiation from RNA polymerase II promoter Source: CGD

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
Short name:
TBP
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:TBP1
Synonyms:TBP
Ordered Locus Names:CAALFM_C110660WA
ORF Names:CaO19.1837, CaO19.9395
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000189736 TBP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539871 – 238TATA-box-binding proteinAdd BLAST238

Proteomic databases

PRIDEiO43133

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.

Structurei

3D structure databases

ProteinModelPortaliO43133
SMRiO43133
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati65 – 1411Add BLAST77
Repeati155 – 2322Add BLAST78

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiO43133
KOiK03120
OMAiQAFEMIY
OrthoDBiEOG092C4LP2

Family and domain databases

CDDicd04516 TBP_eukaryotes, 1 hit
Gene3Di3.30.310.10, 2 hits
HAMAPiMF_00408 TATA_bind_prot_arch, 1 hit
InterProiView protein in InterPro
IPR000814 TBP
IPR030491 TBP_CS
IPR012295 TBP_dom_sf
IPR033710 TBP_eukaryotic
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
PROSITEiView protein in PROSITE
PS00351 TFIID, 2 hits

Sequencei

Sequence statusi: Complete.

O43133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKLPPTNP TNPQQAKTFM KSIEEDEKNK AEDLDIIKKE DIDEPKQEDT
60 70 80 90 100
TDGNGGGGIG IVPTLQNIVA TVNLDCRLDL KTIALHARNA EYNPKRFAAV
110 120 130 140 150
IMRIRDPKTT ALIFASGKMV VTGAKSEDDS KLASRKYARI IQKLGFNAKF
160 170 180 190 200
CDFKIQNIVG STDVKFAIRL EGLAFAHGTF SSYEPELFPG LIYRMVKPKI
210 220 230
VLLIFVSGKI VLTGAKKREE IYDAFESIYP VLNEFRKN
Length:238
Mass (Da):26,601
Last modified:June 1, 1998 - v1
Checksum:iCA0C3F666FBF20FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95550 mRNA Translation: AAC49986.1
U95549 Genomic DNA Translation: AAC49985.1
CP017623 Genomic DNA Translation: AOW26693.1
RefSeqiXP_710721.1, XM_705629.1

Genome annotation databases

EnsemblFungiiAOW26693; AOW26693; CAALFM_C110660WA
GeneIDi3647675
KEGGical:CAALFM_C110660WA

Similar proteinsi

Entry informationi

Entry nameiTBP_CANAL
AccessioniPrimary (citable) accession number: O43133
Secondary accession number(s): A0A1D8PEW8, Q59LW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health