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O43133 (TBP_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
Short name=TBP
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene names
Name:TBP1
Synonyms:TBP
ORF Names:CaO19.1837, CaO19.9395
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. HAMAP-Rule MF_00408

Subunit structure

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.

Subcellular location

Nucleus HAMAP-Rule MF_00408.

Sequence similarities

Belongs to the TBP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238TATA-box-binding protein HAMAP-Rule MF_00408
PRO_0000153987

Regions

Repeat65 – 141771 HAMAP-Rule MF_00408
Repeat155 – 232782 HAMAP-Rule MF_00408

Sequences

Sequence LengthMass (Da)Tools
O43133 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: CA0C3F666FBF20FE

FASTA23826,601
        10         20         30         40         50         60 
MDLKLPPTNP TNPQQAKTFM KSIEEDEKNK AEDLDIIKKE DIDEPKQEDT TDGNGGGGIG 

        70         80         90        100        110        120 
IVPTLQNIVA TVNLDCRLDL KTIALHARNA EYNPKRFAAV IMRIRDPKTT ALIFASGKMV 

       130        140        150        160        170        180 
VTGAKSEDDS KLASRKYARI IQKLGFNAKF CDFKIQNIVG STDVKFAIRL EGLAFAHGTF 

       190        200        210        220        230 
SSYEPELFPG LIYRMVKPKI VLLIFVSGKI VLTGAKKREE IYDAFESIYP VLNEFRKN 

« Hide

References

« Hide 'large scale' references
[1]"The TATA-binding protein (TBP) from the human fungal pathogen Candida albicans can complement defects in human and yeast TBPs."
Leng P., Carter P.E., Brown A.J.P.
J. Bacteriol. 180:1771-1776(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: ATCC 10261 / 3153.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U95550 mRNA. Translation: AAC49986.1.
U95549 Genomic DNA. Translation: AAC49985.1.
AACQ01000244 Genomic DNA. Translation: EAK91473.1.
AACQ01000240 Genomic DNA. Translation: EAK91511.1.
RefSeqXP_710721.1. XM_705629.1.
XP_710759.1. XM_705667.1.

3D structure databases

ProteinModelPortalO43133.
SMRO43133. Positions 59-237.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001658.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647641.
3647675.
KEGGcal:CaO19.1837.
cal:CaO19.9395.

Organism-specific databases

CGDCAL0001658. TBP1.

Phylogenomic databases

eggNOGCOG2101.
KOK03120.
OrthoDBEOG77T1GJ.

Family and domain databases

Gene3D3.30.310.10. 2 hits.
HAMAPMF_00408. TATA_bind_prot_arch.
InterProIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
[Graphical view]
PANTHERPTHR10126. PTHR10126. 1 hit.
PfamPF00352. TBP. 2 hits.
[Graphical view]
PRINTSPR00686. TIFACTORIID.
PROSITEPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTBP_CANAL
AccessionPrimary (citable) accession number: O43133
Secondary accession number(s): Q59LW4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names