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O43133

- TBP_CANAL

UniProt

O43133 - TBP_CANAL

Protein

TATA-box-binding protein

Gene

TBP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

    GO - Molecular functioni

    1. DNA binding Source: CGD
    2. sequence-specific DNA binding transcription factor activity Source: CGD

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: GOC
    2. transcription initiation from RNA polymerase II promoter Source: CGD

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TATA-box-binding protein
    Alternative name(s):
    TATA sequence-binding protein
    Short name:
    TBP
    TATA-binding factor
    TATA-box factor
    Transcription initiation factor TFIID TBP subunit
    Gene namesi
    Name:TBP1
    Synonyms:TBP
    ORF Names:CaO19.1837, CaO19.9395
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001658. TBP1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: CGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238TATA-box-binding proteinPRO_0000153987Add
    BLAST

    Interactioni

    Subunit structurei

    Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.

    Protein-protein interaction databases

    STRINGi5476.CAL0001658.

    Structurei

    3D structure databases

    ProteinModelPortaliO43133.
    SMRiO43133. Positions 59-237.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati65 – 141771Add
    BLAST
    Repeati155 – 232782Add
    BLAST

    Sequence similaritiesi

    Belongs to the TBP family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2101.
    KOiK03120.
    OrthoDBiEOG77T1GJ.

    Family and domain databases

    Gene3Di3.30.310.10. 2 hits.
    HAMAPiMF_00408. TATA_bind_prot_arch.
    InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view]
    PANTHERiPTHR10126. PTHR10126. 1 hit.
    PfamiPF00352. TBP. 2 hits.
    [Graphical view]
    PRINTSiPR00686. TIFACTORIID.
    PROSITEiPS00351. TFIID. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43133-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLKLPPTNP TNPQQAKTFM KSIEEDEKNK AEDLDIIKKE DIDEPKQEDT    50
    TDGNGGGGIG IVPTLQNIVA TVNLDCRLDL KTIALHARNA EYNPKRFAAV 100
    IMRIRDPKTT ALIFASGKMV VTGAKSEDDS KLASRKYARI IQKLGFNAKF 150
    CDFKIQNIVG STDVKFAIRL EGLAFAHGTF SSYEPELFPG LIYRMVKPKI 200
    VLLIFVSGKI VLTGAKKREE IYDAFESIYP VLNEFRKN 238
    Length:238
    Mass (Da):26,601
    Last modified:June 1, 1998 - v1
    Checksum:iCA0C3F666FBF20FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95550 mRNA. Translation: AAC49986.1.
    U95549 Genomic DNA. Translation: AAC49985.1.
    AACQ01000244 Genomic DNA. Translation: EAK91473.1.
    AACQ01000240 Genomic DNA. Translation: EAK91511.1.
    RefSeqiXP_710721.1. XM_705629.1.
    XP_710759.1. XM_705667.1.

    Genome annotation databases

    GeneIDi3647641.
    3647675.
    KEGGical:CaO19.1837.
    cal:CaO19.9395.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95550 mRNA. Translation: AAC49986.1 .
    U95549 Genomic DNA. Translation: AAC49985.1 .
    AACQ01000244 Genomic DNA. Translation: EAK91473.1 .
    AACQ01000240 Genomic DNA. Translation: EAK91511.1 .
    RefSeqi XP_710721.1. XM_705629.1.
    XP_710759.1. XM_705667.1.

    3D structure databases

    ProteinModelPortali O43133.
    SMRi O43133. Positions 59-237.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647641.
    3647675.
    KEGGi cal:CaO19.1837.
    cal:CaO19.9395.

    Organism-specific databases

    CGDi CAL0001658. TBP1.

    Phylogenomic databases

    eggNOGi COG2101.
    KOi K03120.
    OrthoDBi EOG77T1GJ.

    Family and domain databases

    Gene3Di 3.30.310.10. 2 hits.
    HAMAPi MF_00408. TATA_bind_prot_arch.
    InterProi IPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view ]
    PANTHERi PTHR10126. PTHR10126. 1 hit.
    Pfami PF00352. TBP. 2 hits.
    [Graphical view ]
    PRINTSi PR00686. TIFACTORIID.
    PROSITEi PS00351. TFIID. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The TATA-binding protein (TBP) from the human fungal pathogen Candida albicans can complement defects in human and yeast TBPs."
      Leng P., Carter P.E., Brown A.J.P.
      J. Bacteriol. 180:1771-1776(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: ATCC 10261 / 3153.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiTBP_CANAL
    AccessioniPrimary (citable) accession number: O43133
    Secondary accession number(s): Q59LW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3