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Protein

TATA-box-binding protein

Gene

TBP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

GO - Molecular functioni

  • DNA binding Source: CGD
  • sequence-specific DNA binding transcription factor activity Source: CGD

GO - Biological processi

  • regulation of transcription, DNA-templated Source: GOC
  • transcription initiation from RNA polymerase II promoter Source: CGD
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
Short name:
TBP
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:TBP1
Synonyms:TBP
ORF Names:CaO19.1837, CaO19.9395
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001658. TBP1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • transcription factor complex Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238TATA-box-binding proteinPRO_0000153987Add
BLAST

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.

Protein-protein interaction databases

STRINGi5476.CAL0001658.

Structurei

3D structure databases

ProteinModelPortaliO43133.
SMRiO43133. Positions 59-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati65 – 141771Add
BLAST
Repeati155 – 232782Add
BLAST

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2101.
InParanoidiO43133.
KOiK03120.
OrthoDBiEOG77T1GJ.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKLPPTNP TNPQQAKTFM KSIEEDEKNK AEDLDIIKKE DIDEPKQEDT
60 70 80 90 100
TDGNGGGGIG IVPTLQNIVA TVNLDCRLDL KTIALHARNA EYNPKRFAAV
110 120 130 140 150
IMRIRDPKTT ALIFASGKMV VTGAKSEDDS KLASRKYARI IQKLGFNAKF
160 170 180 190 200
CDFKIQNIVG STDVKFAIRL EGLAFAHGTF SSYEPELFPG LIYRMVKPKI
210 220 230
VLLIFVSGKI VLTGAKKREE IYDAFESIYP VLNEFRKN
Length:238
Mass (Da):26,601
Last modified:June 1, 1998 - v1
Checksum:iCA0C3F666FBF20FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95550 mRNA. Translation: AAC49986.1.
U95549 Genomic DNA. Translation: AAC49985.1.
AACQ01000244 Genomic DNA. Translation: EAK91473.1.
AACQ01000240 Genomic DNA. Translation: EAK91511.1.
RefSeqiXP_710721.1. XM_705629.1.
XP_710759.1. XM_705667.1.

Genome annotation databases

GeneIDi3647641.
3647675.
KEGGical:CaO19.1837.
cal:CaO19.9395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95550 mRNA. Translation: AAC49986.1.
U95549 Genomic DNA. Translation: AAC49985.1.
AACQ01000244 Genomic DNA. Translation: EAK91473.1.
AACQ01000240 Genomic DNA. Translation: EAK91511.1.
RefSeqiXP_710721.1. XM_705629.1.
XP_710759.1. XM_705667.1.

3D structure databases

ProteinModelPortaliO43133.
SMRiO43133. Positions 59-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5476.CAL0001658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3647641.
3647675.
KEGGical:CaO19.1837.
cal:CaO19.9395.

Organism-specific databases

CGDiCAL0001658. TBP1.

Phylogenomic databases

eggNOGiCOG2101.
InParanoidiO43133.
KOiK03120.
OrthoDBiEOG77T1GJ.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The TATA-binding protein (TBP) from the human fungal pathogen Candida albicans can complement defects in human and yeast TBPs."
    Leng P., Carter P.E., Brown A.J.P.
    J. Bacteriol. 180:1771-1776(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: ATCC 10261 / 3153.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTBP_CANAL
AccessioniPrimary (citable) accession number: O43133
Secondary accession number(s): Q59LW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: April 1, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.