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O43114 (ORC5_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Origin recognition complex subunit 5
Gene names
Name:orc5
Synonyms:orp5
ORF Names:SPBC646.14c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.

Subunit structure

ORC is composed of six subunits. ORC interacts with cdc18, recruiting it to the ars1 origin of replication. Ref.3 Ref.4

Subcellular location

Nucleus.

Sequence similarities

Belongs to the ORC5 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Origin recognition complex subunit 5
PRO_0000127095

Regions

Nucleotide binding42 – 498ATP Potential

Experimental info

Sequence conflict3281F → S in AAC49897. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O43114 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: B7A6AC2CFF7D2FB5

FASTA45551,762
        10         20         30         40         50         60 
MHLYQLEDEL KKNVFCREDQ IKKLSCLLFN KDCRVPSIVL YGVASTAKTF LLRTAFDLSK 

        70         80         90        100        110        120 
EENVWINLQD CFTVAHFWYR ILIKVGVDKD IALKKGINIS GFIYLLEQAM SKRDYHTFLV 

       130        140        150        160        170        180 
LDQIDDFAEA STILFSQLAQ LPIVANIPNL SIIFVLHSHP AQYLGTLSIA VIFFPQYTQA 

       190        200        210        220        230        240 
EILEICQKTP PNLDFLDRSG DSVFEDEIEL SVWMQYCSFL WSVFGVQCLN DYRSFRSVLD 

       250        260        270        280        290        300 
RYWPKFIQPI VEGDIHPADY AQLHKLAKNF LVSDATVTKR LHIINPTEIK NLLDSKSINL 

       310        320        330        340        350        360 
SLVSKYLLVS AFLASYNPSR LDAQFFSFSK TSKRRGRKRK QIQDEGVLFS KIPRTAGSKG 

       370        380        390        400        410        420 
RSAVKISQLT LGPKPFEVER LIAIYYAISS PVEKVLTADV FVQIATLASL KMILSASKGV 

       430        440        450 
LRSLDSPRYI VNVSREYVLK IADSLSFPLD SYLAG

« Hide

References

« Hide 'large scale' references
[1]"Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22."
Ishiai M., Dean F.B., Okumura K., Abe M., Moon K.-Y., Amin A.A., Kagotani K., Taguchi H., Murakami Y., Hanaoka F., O'Donnell M., Hurwitz J., Eki T.
Genomics 46:294-298(1997) [PubMed: 9417919] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Identification and reconstitution of the origin recognition complex from Schizosaccharomyces pombe."
Moon K.-Y., Kong D., Lee J.-K., Raychaudhuri S., Hurwitz J.
Proc. Natl. Acad. Sci. U.S.A. 96:12367-12372(1999) [PubMed: 10535928] [Abstract]
Cited for: SUBUNIT.
[4]"Purification and characterization of the Schizosaccharomyces pombe origin recognition complex: interaction with origin DNA and Cdc18 protein."
Chuang R.-Y., Chretien L., Dai J., Kelly T.J.
J. Biol. Chem. 277:16920-16927(2002) [PubMed: 11850415] [Abstract]
Cited for: CHARACTERIZATION OF ORC, INTERACTION WITH CDC18.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U92539 mRNA. Translation: AAC49897.1.
CU329671 Genomic DNA. Translation: CAA22818.1.
PIRT40590.
RefSeqNP_595372.1. NM_001021280.1.

3D structure databases

ProteinModelPortalO43114.
ModBaseSearch...

Protein-protein interaction databases

STRINGO43114.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC646.14c.1; SPBC646.14c.1:pep; SPBC646.14c.
GeneID2541107.
GenomeReviewsGene locus orc5 in contig CU329671_GR.
KEGGspo:SPBC646.14c.
NMPDRfig|4896.1.peg.1238.

Organism-specific databases

GeneDB_SpombeSPBC646.14c.

Phylogenomic databases

eggNOGfuNOG04845.
GeneTreeEFGT00050000003514.
OMAECITGRH.
OrthoDBEOG47WRXB.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-003448-MONOMER.

Gene expression databases

ArrayExpressO43114.

Family and domain databases

InterProIPR020796. ORC5.
[Graphical view]
KOK02607.
PANTHERPTHR12705. ORC5. 1 hit.
ProtoNetSearch...

Entry information

Entry nameORC5_SCHPO
AccessionPrimary (citable) accession number: O43114
Secondary accession number(s): Q9UQW3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 21, 2001
Last modified: December 14, 2011
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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