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O43112 (PCKA_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxykinase [ATP]

EC=4.1.1.49
Gene names
Name:PCK1
Ordered Locus Names:KLLA0A00484g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2. HAMAP-Rule MF_00453

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00453

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [ATP] family.

Ontologies

Keywords
   Biological processGluconeogenesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoenolpyruvate carboxykinase (ATP) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Phosphoenolpyruvate carboxykinase [ATP] HAMAP-Rule MF_00453
PRO_0000203873

Regions

Nucleotide binding244 – 2518ATP Potential

Experimental info

Sequence conflict2361D → G in AAC27661. Ref.1
Sequence conflict2551A → G in AAC27661. Ref.1
Sequence conflict5001S → I in AAC27661. Ref.1
Sequence conflict5091K → N in AAC27661. Ref.1
Sequence conflict5201L → W in AAC27661. Ref.1
Sequence conflict5231E → K in AAC27661. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O43112 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: 35CD60147227B2A4

FASTA54360,429
        10         20         30         40         50         60 
MSPTKTQNSA EENIRAELGL SAEVVTIRRN APAALLYEDA LKERDTAISN AGALIAYSGD 

        70         80         90        100        110        120 
KTGRSPRDKR IVEEETSKDN VWWGPVNKPC SERTWEINRE RAADYLRTRD HIYIVDAYAG 

       130        140        150        160        170        180 
WDPRYRIKVR VVCARAYHAL FMTNMLIRPS KEELENFGEP DFTVWNAGQF PANTHTSGMT 

       190        200        210        220        230        240 
SKTTVEINFK QMEMVILGTE YAGEMKKGIF TVMFYLMPVN HNVLTLHSSA NQGIQDNDVT 

       250        260        270        280        290        300 
LFFGLSGTGK TTLSADPHRL LIGDDEHCWS DHGVFNIEGG CYAKCLGLSA EKEPEIFNAI 

       310        320        330        340        350        360 
KFGSVLENII YDPNTREVDY EDSTITENTR CAYPIEYIPS AKIPCLADHH PKNIVLLTCD 

       370        380        390        400        410        420 
ASGVLPPVSK LTPDQVMYHF ISGYTSKMAG TEQGVTEPEA TFSSCFGQPF LSLHPMKYAT 

       430        440        450        460        470        480 
MLAEKMAEHN ANAWLINTGW TGSSYVAGGK RCPLKYTRAI LDAIHDGSLA KEEYEVLPIF 

       490        500        510        520        530        540 
NLQIPKAVGD KVPASLLNPS KNWAEGEAKY TSNVKSLANL FVENFKTYQD KATEQVLAAG 


PQL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U88575 Genomic DNA. Translation: AAC27661.1.
CR382121 Genomic DNA. Translation: CAH02607.1.
RefSeqXP_451019.1. XM_451019.1.

3D structure databases

ProteinModelPortalO43112.
SMRO43112. Positions 26-543.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.O43112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896341.
KEGGkla:KLLA0A00484g.

Phylogenomic databases

eggNOGCOG1866.
HOGENOMHOG000271471.
KOK01610.
OMAGADPEHY.
OrthoDBEOG7MKWFS.

Enzyme and pathway databases

UniPathwayUPA00138.

Family and domain databases

Gene3D3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPMF_00453. PEPCK_ATP.
InterProIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMSSF68923. SSF68923. 1 hit.
TIGRFAMsTIGR00224. pckA. 1 hit.
PROSITEPS00532. PEPCK_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePCKA_KLULA
AccessionPrimary (citable) accession number: O43112
Secondary accession number(s): Q6CYH0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 27, 2004
Last modified: May 14, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways