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O43112

- PCKA_KLULA

UniProt

O43112 - PCKA_KLULA

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Protein
Phosphoenolpyruvate carboxykinase [ATP]
Gene
PCK1, KLLA0A00484g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi244 – 2518ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP] (EC:4.1.1.49)
Gene namesi
Name:PCK1
Ordered Locus Names:KLLA0A00484g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome A

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation
PRO_0000203873Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.O43112.

Structurei

3D structure databases

ProteinModelPortaliO43112.
SMRiO43112. Positions 26-543.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1866.
HOGENOMiHOG000271471.
KOiK01610.
OMAiGADPEHY.
OrthoDBiEOG7MKWFS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43112-1 [UniParc]FASTAAdd to Basket

« Hide

MSPTKTQNSA EENIRAELGL SAEVVTIRRN APAALLYEDA LKERDTAISN    50
AGALIAYSGD KTGRSPRDKR IVEEETSKDN VWWGPVNKPC SERTWEINRE 100
RAADYLRTRD HIYIVDAYAG WDPRYRIKVR VVCARAYHAL FMTNMLIRPS 150
KEELENFGEP DFTVWNAGQF PANTHTSGMT SKTTVEINFK QMEMVILGTE 200
YAGEMKKGIF TVMFYLMPVN HNVLTLHSSA NQGIQDNDVT LFFGLSGTGK 250
TTLSADPHRL LIGDDEHCWS DHGVFNIEGG CYAKCLGLSA EKEPEIFNAI 300
KFGSVLENII YDPNTREVDY EDSTITENTR CAYPIEYIPS AKIPCLADHH 350
PKNIVLLTCD ASGVLPPVSK LTPDQVMYHF ISGYTSKMAG TEQGVTEPEA 400
TFSSCFGQPF LSLHPMKYAT MLAEKMAEHN ANAWLINTGW TGSSYVAGGK 450
RCPLKYTRAI LDAIHDGSLA KEEYEVLPIF NLQIPKAVGD KVPASLLNPS 500
KNWAEGEAKY TSNVKSLANL FVENFKTYQD KATEQVLAAG PQL 543
Length:543
Mass (Da):60,429
Last modified:September 27, 2004 - v2
Checksum:i35CD60147227B2A4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361D → G in AAC27661. 1 Publication
Sequence conflicti255 – 2551A → G in AAC27661. 1 Publication
Sequence conflicti500 – 5001S → I in AAC27661. 1 Publication
Sequence conflicti509 – 5091K → N in AAC27661. 1 Publication
Sequence conflicti520 – 5201L → W in AAC27661. 1 Publication
Sequence conflicti523 – 5231E → K in AAC27661. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U88575 Genomic DNA. Translation: AAC27661.1.
CR382121 Genomic DNA. Translation: CAH02607.1.
RefSeqiXP_451019.1. XM_451019.1.

Genome annotation databases

GeneIDi2896341.
KEGGikla:KLLA0A00484g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U88575 Genomic DNA. Translation: AAC27661.1 .
CR382121 Genomic DNA. Translation: CAH02607.1 .
RefSeqi XP_451019.1. XM_451019.1.

3D structure databases

ProteinModelPortali O43112.
SMRi O43112. Positions 26-543.
ModBasei Search...

Protein-protein interaction databases

STRINGi 28985.O43112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2896341.
KEGGi kla:KLLA0A00484g.

Phylogenomic databases

eggNOGi COG1866.
HOGENOMi HOG000271471.
KOi K01610.
OMAi GADPEHY.
OrthoDBi EOG7MKWFS.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00453. PEPCK_ATP.
InterProi IPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view ]
Pfami PF01293. PEPCK_ATP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
TIGRFAMsi TIGR00224. pckA. 1 hit.
PROSITEi PS00532. PEPCK_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and nucleotide sequence of the gene encoding phosphoenolpyruvate carboxykinase from Kluyveromyces lactis."
    Kitamoto H.K., Ohmomo S., Iimura Y.
    Yeast 14:963-967(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiPCKA_KLULA
AccessioniPrimary (citable) accession number: O43112
Secondary accession number(s): Q6CYH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 27, 2004
Last modified: May 14, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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