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O43112

- PCKA_KLULA

UniProt

O43112 - PCKA_KLULA

Protein

Phosphoenolpyruvate carboxykinase [ATP]

Gene

PCK1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (27 Sep 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi244 – 2518ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [ATP] (EC:4.1.1.49)
    Gene namesi
    Name:PCK1
    Ordered Locus Names:KLLA0A00484g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome A

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Phosphoenolpyruvate carboxykinase [ATP]PRO_0000203873Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.O43112.

    Structurei

    3D structure databases

    ProteinModelPortaliO43112.
    SMRiO43112. Positions 26-543.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1866.
    HOGENOMiHOG000271471.
    KOiK01610.
    OMAiGADPEHY.
    OrthoDBiEOG7MKWFS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00453. PEPCK_ATP.
    InterProiIPR001272. PEP_carboxykinase_ATP.
    IPR013035. PEP_carboxykinase_C.
    IPR008210. PEP_carboxykinase_N.
    IPR015994. PEPCK_ATP_CS.
    [Graphical view]
    PfamiPF01293. PEPCK_ATP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    TIGRFAMsiTIGR00224. pckA. 1 hit.
    PROSITEiPS00532. PEPCK_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43112-1 [UniParc]FASTAAdd to Basket

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    MSPTKTQNSA EENIRAELGL SAEVVTIRRN APAALLYEDA LKERDTAISN    50
    AGALIAYSGD KTGRSPRDKR IVEEETSKDN VWWGPVNKPC SERTWEINRE 100
    RAADYLRTRD HIYIVDAYAG WDPRYRIKVR VVCARAYHAL FMTNMLIRPS 150
    KEELENFGEP DFTVWNAGQF PANTHTSGMT SKTTVEINFK QMEMVILGTE 200
    YAGEMKKGIF TVMFYLMPVN HNVLTLHSSA NQGIQDNDVT LFFGLSGTGK 250
    TTLSADPHRL LIGDDEHCWS DHGVFNIEGG CYAKCLGLSA EKEPEIFNAI 300
    KFGSVLENII YDPNTREVDY EDSTITENTR CAYPIEYIPS AKIPCLADHH 350
    PKNIVLLTCD ASGVLPPVSK LTPDQVMYHF ISGYTSKMAG TEQGVTEPEA 400
    TFSSCFGQPF LSLHPMKYAT MLAEKMAEHN ANAWLINTGW TGSSYVAGGK 450
    RCPLKYTRAI LDAIHDGSLA KEEYEVLPIF NLQIPKAVGD KVPASLLNPS 500
    KNWAEGEAKY TSNVKSLANL FVENFKTYQD KATEQVLAAG PQL 543
    Length:543
    Mass (Da):60,429
    Last modified:September 27, 2004 - v2
    Checksum:i35CD60147227B2A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti236 – 2361D → G in AAC27661. (PubMed:9717242)Curated
    Sequence conflicti255 – 2551A → G in AAC27661. (PubMed:9717242)Curated
    Sequence conflicti500 – 5001S → I in AAC27661. (PubMed:9717242)Curated
    Sequence conflicti509 – 5091K → N in AAC27661. (PubMed:9717242)Curated
    Sequence conflicti520 – 5201L → W in AAC27661. (PubMed:9717242)Curated
    Sequence conflicti523 – 5231E → K in AAC27661. (PubMed:9717242)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88575 Genomic DNA. Translation: AAC27661.1.
    CR382121 Genomic DNA. Translation: CAH02607.1.
    RefSeqiXP_451019.1. XM_451019.1.

    Genome annotation databases

    GeneIDi2896341.
    KEGGikla:KLLA0A00484g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88575 Genomic DNA. Translation: AAC27661.1 .
    CR382121 Genomic DNA. Translation: CAH02607.1 .
    RefSeqi XP_451019.1. XM_451019.1.

    3D structure databases

    ProteinModelPortali O43112.
    SMRi O43112. Positions 26-543.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.O43112.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2896341.
    KEGGi kla:KLLA0A00484g.

    Phylogenomic databases

    eggNOGi COG1866.
    HOGENOMi HOG000271471.
    KOi K01610.
    OMAi GADPEHY.
    OrthoDBi EOG7MKWFS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00453. PEPCK_ATP.
    InterProi IPR001272. PEP_carboxykinase_ATP.
    IPR013035. PEP_carboxykinase_C.
    IPR008210. PEP_carboxykinase_N.
    IPR015994. PEPCK_ATP_CS.
    [Graphical view ]
    Pfami PF01293. PEPCK_ATP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006294. PEP_crbxkin. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    TIGRFAMsi TIGR00224. pckA. 1 hit.
    PROSITEi PS00532. PEPCK_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and nucleotide sequence of the gene encoding phosphoenolpyruvate carboxykinase from Kluyveromyces lactis."
      Kitamoto H.K., Ohmomo S., Iimura Y.
      Yeast 14:963-967(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

    Entry informationi

    Entry nameiPCKA_KLULA
    AccessioniPrimary (citable) accession number: O43112
    Secondary accession number(s): Q6CYH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: September 27, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3