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Protein

Calcium-transporting ATPase 1

Gene

PMR1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway.

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 35314-aspartylphosphate intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase 1 (EC:3.6.3.8)
Alternative name(s):
P-type calcium ATPase
Gene namesi
Name:PMR1
Synonyms:SCA1
Ordered Locus Names:YALI0E09471g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Transmembranei718 – 73821HelicalSequence analysisAdd
BLAST
Transmembranei750 – 77021HelicalSequence analysisAdd
BLAST
Transmembranei799 – 81921HelicalSequence analysisAdd
BLAST
Transmembranei860 – 88021HelicalSequence analysisAdd
BLAST
Transmembranei887 – 90721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 928928Calcium-transporting ATPase 1PRO_0000046230Add
BLAST

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliO43108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000265621.
InParanoidiO43108.
KOiK01537.
OMAiTTSINER.
OrthoDBiEOG092C12IX.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF217. PTHR24093:SF217. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSHTSTEGV PLSETNNRSH ATPSAQYCQM TVEETCSKLQ TNPETGLTSS
60 70 80 90 100
QEAMHRRDIH GSNEFAQEEE DSLIKKFFEQ FSENPLLLLL IGAAAVSFFM
110 120 130 140 150
GNHDDAISIT LAILIVTTVG FVQEYRSEKS LEALNKLVPP EAHLIRAGNS
160 170 180 190 200
QTVLASTLVP GDLVEFSVGD RIPADCRIVK AVHLSIDESN LTGETTPVTK
210 220 230 240 250
DTNPVTGTPP IGLADRTNTA YMGTLVRDGN GTGIVVGTGS HTAFGAVYDM
260 270 280 290 300
VSEISTPKTP LQASMDNLGK DLSLVSFGVI GVICLIGMFQ GRDWLEMFTI
310 320 330 340 350
GVSLAVAAIP EGLPIIVTVT LALGVLRMSR QKAIVRKLPS VETLGSVNVI
360 370 380 390 400
CSDKTGTLTR NHMSCTTCWT VDMGDLANAV TLKPGQSHTE ADPKAVAALK
410 420 430 440 450
NSVSLANMLK VGNLCNNSKF NREAGHLVGN ATDIALIEVL DYFGLEDTRE
460 470 480 490 500
TRKRVAEVPF SSSRKWMLTS TTTGDSSTPM ISVKGAGEVI APFCEYYCKK
510 520 530 540 550
DGKTAPFNDD MRKKVTEIAS EMSNDGLRII AFAYKQGKYE EGSEEAPEGL
560 570 580 590 600
VFAGLMGLYD PPRPDVPRAI RRLTTGGVRV VMITGDSAAT ALSIGRRIGM
610 620 630 640 650
PLMPGTQSVV EGSKLATMSD QALDECLQTA SIFARTSPED KMKIVKGFQR
660 670 680 690 700
RGDVVAMTGD GVNDAPALKL ADIGIAMGQG GTDVAKEAAD MILTDDDFAT
710 720 730 740 750
ILSAIEEGKG IFNNIRNFIT FQLSTSMAAL SIVAVATIMG LENPLNPMQI
760 770 780 790 800
LWINILMDGP PAQSLGVEPV DPDVMNKPPR PRNEKVMTPD LVKKCVEAAV
810 820 830 840 850
IILVGTMLVY VTQMQDGVID KRDTTMTFTC FVFYDMFNAL ACRSATKSVF
860 870 880 890 900
EIGFFSNKMF LYACGASIIG QLAVVYVPFL QSVFQTEALS VKDLLSLVLI
910 920
SSSVWILDEA KKYFLKSRST NNYTNSVV
Length:928
Mass (Da):100,051
Last modified:June 1, 1998 - v1
Checksum:iCBA53B0DD075EBE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75447 Genomic DNA. Translation: AAC03419.1.
CR382131 Genomic DNA. Translation: CAG79326.1.
RefSeqiXP_503736.1. XM_503736.1.

Genome annotation databases

EnsemblFungiiCAG79326; CAG79326; YALI0_E09471g.
GeneIDi2911589.
KEGGiyli:YALI0E09471g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75447 Genomic DNA. Translation: AAC03419.1.
CR382131 Genomic DNA. Translation: CAG79326.1.
RefSeqiXP_503736.1. XM_503736.1.

3D structure databases

ProteinModelPortaliO43108.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG79326; CAG79326; YALI0_E09471g.
GeneIDi2911589.
KEGGiyli:YALI0E09471g.

Phylogenomic databases

HOGENOMiHOG000265621.
InParanoidiO43108.
KOiK01537.
OMAiTTSINER.
OrthoDBiEOG092C12IX.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF217. PTHR24093:SF217. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATC1_YARLI
AccessioniPrimary (citable) accession number: O43108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.