ID   PMP20_ASPFU             Reviewed;         168 AA.
AC   O43099; Q4WCS7;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   16-JUN-2009, entry version 48.
DE   RecName: Full=Putative peroxiredoxin pmp20;
DE            EC=1.11.1.15;
DE   AltName: Full=Thioredoxin reductase;
DE   AltName: Full=Peroxisomal membrane protein pmp20;
DE   AltName: Allergen=Asp f 3;
GN   Name=pmp20; ORFNames=AFUA_6G02280;
OS   Aspergillus fumigatus (Sartorya fumigata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae;
OC   mitosporic Trichocomaceae; Aspergillus.
OX   NCBI_TaxID=5085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 42202 / AF-102 / Ag 507;
RX   MEDLINE=98074056; PubMed=9412580;
RA   Hemmann S., Blaser K., Crameri R.;
RT   "Allergens of Aspergillus fumigatus and Candida boidinii share IgE-
RT   binding epitopes.";
RL   Am. J. Respir. Crit. Care Med. 156:1956-1962(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
RA   Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W.,
RA   Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
RA   Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R.,
RA   Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
RA   Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J.,
RA   Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J.,
RA   Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
RA   Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A.,
RA   Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M.,
RA   Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I.,
RA   Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
RA   Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
RA   Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
RA   White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K.,
RA   Machida M., Hall N., Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
CC   -!- SUBCELLULAR LOCATION: Peroxisome (Potential).
CC   -!- ALLERGEN: Causes an allergic reaction in human. Shares common IgE-
CC       binding epitopes with allergen Cand b 2 of Candida boidinii.
CC   -!- SIMILARITY: Belongs to the peroxiredoxin 2 family.
CC   -!- SIMILARITY: Contains 1 thioredoxin domain.
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DR   EMBL; U58050; AAB95638.1; -; mRNA.
DR   EMBL; AAHF01000012; EAL85811.1; -; Genomic_DNA.
DR   RefSeq; XP_747849.1; -.
DR   HSSP; P30044; 1HD2.
DR   GeneID; 3505266; -.
DR   KEGG; afm:AFUA_6G02280; -.
DR   HOGENOM; O43099; -.
DR   OMA; O43099; DEVWCVS.
DR   BRENDA; 1.11.1.15; 18841.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0051920; F:peroxiredoxin activity; IEA:EC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013740; Redoxin.
DR   InterPro; IPR017936; Thioredoxin-like.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   Pfam; PF08534; Redoxin; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Complete proteome; Oxidoreductase; Peroxidase; Peroxisome;
KW   Redox-active center.
FT   CHAIN         1    168       Putative peroxiredoxin pmp20.
FT                                /FTId=PRO_0000056603.
FT   DOMAIN        4    158       Thioredoxin.
SQ   SEQUENCE   168 AA;  18453 MW;  AFFCD72C5A1CCBB2 CRC64;
     MSGLKAGDSF PSDVVFSYIP WSEDKGEITA CGIPINYNAS KEWADKKVIL FALPGAFTPV
     CSARHVPEYI EKLPEIRAKG VDVVAVLAYN DAYVMSAWGK ANQVTGDDIL FLSDPDARFS
     KSIGWADEEG RTKRYALVID HGKITYAALE PAKNHLEFSS AETVLKHL
//