O43099 (PMP20_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative peroxiredoxin pmp20
EC=1.11.1.15

Alternative name(s):
Peroxisomal membrane protein pmp20
Thioredoxin reductase
Allergen=Asp f 3

Gene names

Name:	pmp20
ORF Names:	AFUA_6G02280

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
Subcellular location	Peroxisome Potential.
Allergenic properties	Causes an allergic reaction in human. Shares common IgE-binding epitopes with allergen Cand b 2 of Candida boidinii.
Sequence similarities	Belongs to the peroxiredoxin 2 family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Peroxisome
Disease	Allergen
Domain	Redox-active center
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Putative peroxiredoxin pmp20		PRO_0000056603
Regions
	Domain	4 – 158	155	Thioredoxin

Sequences

	Sequence		Length	Mass (Da)
	O43099 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: AFFCD72C5A1CCBB2	FASTA	168	18,453
	10 20 30 40 50 60 MSGLKAGDSF PSDVVFSYIP WSEDKGEITA CGIPINYNAS KEWADKKVIL FALPGAFTPV 70 80 90 100 110 120 CSARHVPEYI EKLPEIRAKG VDVVAVLAYN DAYVMSAWGK ANQVTGDDIL FLSDPDARFS 130 140 150 160 KSIGWADEEG RTKRYALVID HGKITYAALE PAKNHLEFSS AETVLKHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes." Hemmann S., Blaser K., Crameri R. Am. J. Respir. Crit. Care Med. 156:1956-1962(1997) [PubMed: 9412580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 42202 / AF-102 / Ag 507.
[2]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U58050 mRNA. Translation: AAB95638.1. AAHF01000012 Genomic DNA. Translation: EAL85811.1.
RefSeq	XP_747849.1. XM_742756.1.
3D structure databases
ProteinModelPortal	O43099.
ModBase	Search...
Protein family/group databases
Allergome	3121. Asp f 3.0101. 73. Asp f 3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFUAT00000470; CADAFUAP00000470; CADAFUAG00000470.
GeneID	3505266.
GenomeReviews	Gene locus pmp20 in contig CM000174_GR.
KEGG	afm:AFUA_6G02280.
Phylogenomic databases
eggNOG	fuNOG11394.
GeneTree	EFGT00050000004003.
HOGENOM	HBG493509.
OMA	EGGQFTI.
OrthoDB	EOG4H75N5.
Family and domain databases
InterPro	IPR013740. Redoxin. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K14171.
Pfam	PF08534. Redoxin. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PMP20_ASPFU

Accession

Primary (citable) accession number: O43099
Secondary accession number(s): Q4WCS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	December 14, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program