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O43099

- PMP20_ASPFU

UniProt

O43099 - PMP20_ASPFU

Protein

Putative peroxiredoxin pmp20

Gene

pmp20

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

    GO - Molecular functioni

    1. IgE binding Source: ASPGD
    2. peroxidase activity Source: UniProtKB-KW
    3. peroxiredoxin activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative peroxiredoxin pmp20 (EC:1.11.1.15)
    Alternative name(s):
    Peroxisomal membrane protein pmp20
    Thioredoxin reductase
    Allergen: Asp f 3
    Gene namesi
    Name:pmp20
    ORF Names:AFUA_6G02280
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 6

    Subcellular locationi

    Peroxisome Curated

    GO - Cellular componenti

    1. intracellular Source: ASPGD
    2. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Shares common IgE-binding epitopes with allergen Cand b 2 of Candida boidinii.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3121. Asp f 3.0101.
    73. Asp f 3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168Putative peroxiredoxin pmp20PRO_0000056603Add
    BLAST

    Proteomic databases

    PRIDEiO43099.

    Interactioni

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00000470.

    Structurei

    3D structure databases

    ProteinModelPortaliO43099.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 158155ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peroxiredoxin 2 family.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0678.
    HOGENOMiHOG000255884.
    KOiK14171.
    OMAiARHVPEY.
    OrthoDBiEOG7X3R3F.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR013740. Redoxin.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF08534. Redoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43099-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGLKAGDSF PSDVVFSYIP WSEDKGEITA CGIPINYNAS KEWADKKVIL    50
    FALPGAFTPV CSARHVPEYI EKLPEIRAKG VDVVAVLAYN DAYVMSAWGK 100
    ANQVTGDDIL FLSDPDARFS KSIGWADEEG RTKRYALVID HGKITYAALE 150
    PAKNHLEFSS AETVLKHL 168
    Length:168
    Mass (Da):18,453
    Last modified:June 1, 1998 - v1
    Checksum:iAFFCD72C5A1CCBB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58050 mRNA. Translation: AAB95638.1.
    AAHF01000012 Genomic DNA. Translation: EAL85811.1.
    RefSeqiXP_747849.1. XM_742756.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00000470; CADAFUAP00000470; CADAFUAG00000470.
    GeneIDi3505266.
    KEGGiafm:AFUA_6G02280.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58050 mRNA. Translation: AAB95638.1 .
    AAHF01000012 Genomic DNA. Translation: EAL85811.1 .
    RefSeqi XP_747849.1. XM_742756.1.

    3D structure databases

    ProteinModelPortali O43099.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00000470.

    Protein family/group databases

    Allergomei 3121. Asp f 3.0101.
    73. Asp f 3.

    Proteomic databases

    PRIDEi O43099.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00000470 ; CADAFUAP00000470 ; CADAFUAG00000470 .
    GeneIDi 3505266.
    KEGGi afm:AFUA_6G02280.

    Phylogenomic databases

    eggNOGi COG0678.
    HOGENOMi HOG000255884.
    KOi K14171.
    OMAi ARHVPEY.
    OrthoDBi EOG7X3R3F.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR013740. Redoxin.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF08534. Redoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes."
      Hemmann S., Blaser K., Crameri R.
      Am. J. Respir. Crit. Care Med. 156:1956-1962(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ATCC 42202 / AF-102 / Ag 507.
    2. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiPMP20_ASPFU
    AccessioniPrimary (citable) accession number: O43099
    Secondary accession number(s): Q4WCS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3