O43099 (PMP20_ASPFU) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 74.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Putative peroxiredoxin pmp20 EC=1.11.1.15 Alternative name(s): Peroxisomal membrane protein pmp20 Thioredoxin reductase Allergen=Asp f 3 | ||||
| Gene names |
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| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) | ||||
| Taxonomic identifier | 330879 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus |
Protein attributes
| Sequence length | 168 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. |
| Subcellular location | Peroxisome Potential. |
| Allergenic properties | Causes an allergic reaction in human. Shares common IgE-binding epitopes with allergen Cand b 2 of Candida boidinii. |
| Sequence similarities | Belongs to the peroxiredoxin 2 family. Contains 1 thioredoxin domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Peroxisome |
| Disease | Allergen |
| Domain | Redox-active center |
| Molecular function | Oxidoreductase Peroxidase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes." Hemmann S., Blaser K., Crameri R. Am. J. Respir. Crit. Care Med. 156:1956-1962(1997) [PubMed: 9412580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 42202 / AF-102 / Ag 507. |
| [2] | "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. Denning D.W.Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U58050 mRNA. Translation: AAB95638.1. AAHF01000012 Genomic DNA. Translation: EAL85811.1. |
| RefSeq | XP_747849.1. XM_742756.1. |
3D structure databases | |
| ProteinModelPortal | O43099. |
| ModBase | Search... |
Protein family/group databases | |
| Allergome | 3121. Asp f 3.0101. 73. Asp f 3. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | CADAFUAT00000470; CADAFUAP00000470; CADAFUAG00000470. |
| GeneID | 3505266. |
| GenomeReviews | Gene locus pmp20 in contig CM000174_GR. |
| KEGG | afm:AFUA_6G02280. |
Phylogenomic databases | |
| eggNOG | fuNOG11394. |
| GeneTree | EFGT00050000004003. |
| HOGENOM | HBG493509. |
| OMA | EGGQFTI. |
| OrthoDB | EOG4H75N5. |
Family and domain databases | |
| InterPro | IPR013740. Redoxin. IPR012336. Thioredoxin-like_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| KO | K14171. |
| Pfam | PF08534. Redoxin. 1 hit. [Graphical view] |
| SUPFAM | SSF52833. Thiordxn-like_fd. 1 hit. |
| PROSITE | PS51352. THIOREDOXIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PMP20_ASPFU | ||||||||
| Accession | Primary (citable) accession number: O43099 Secondary accession number(s): Q4WCS7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Allergens Nomenclature of allergens and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with